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PubMed code 14684325

Compile data set for download or QSAR
Found 154 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137576
PNG
(3-[1-{3-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-4,5,...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C26H34N4O4S/c1-27-35(33,34)18-8-9-24-21(15-18)22(26(32)29-24)16-25-20(19-5-2-3-7-23(19)28-25)6-4-12-30-13-10-17(31)11-14-30/h8-9,15-17,27-28,31H,2-7,10-14H2,1H3,(H,29,32)/b22-16-
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n/an/a 10n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137583
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C27H37N5O4S/c1-28-37(35,36)19-8-9-25-22(17-19)23(27(34)30-25)18-26-21(20-5-2-3-7-24(20)29-26)6-4-10-31-11-13-32(14-12-31)15-16-33/h8-9,17-18,28-29,33H,2-7,10-16H2,1H3,(H,30,34)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137587
PNG
(3-[1-(3-Morpholin-4-ylmethyl-4,5,6,7-tetrahydro-1H...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N4O4S/c1-24-32(29,30)15-6-7-21-17(12-15)18(23(28)26-21)13-22-19(14-27-8-10-31-11-9-27)16-4-2-3-5-20(16)25-22/h6-7,12-13,24-25H,2-5,8-11,14H2,1H3,(H,26,28)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137574
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H35N5O3S/c1-27-35(33,34)18-9-10-24-21(16-18)22(26(32)29-24)17-25-20(19-6-3-4-8-23(19)28-25)7-5-11-31-14-12-30(2)13-15-31/h9-10,16-17,27-28H,3-8,11-15H2,1-2H3,(H,29,32)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137582
PNG
(CHEMBL292930 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)17-26(33)34/h8-9,15-16,28-29H,2-7,10-14,17H2,1H3,(H,30,35)(H,33,34)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137578
PNG
(CHEMBL300853 | [4-(3-{2-[5-Ethanesulfonyl-2-oxo-1,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)18-27(33)34/h9-10,16-17,29H,2-8,11-15,18H2,1H3,(H,30,35)(H,33,34)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137571
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H30N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h10-11,13-14,24-25H,4-9,12H2,1-3H3,(H,26,28)/b19-14-
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n/an/a 10n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137573
PNG
(3-{2-[5-Methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C21H24N4O4S/c1-23-30(28,29)12-6-8-18-15(10-12)16(21(27)25-18)11-19-14(7-9-20(22)26)13-4-2-3-5-17(13)24-19/h6,8,10-11,23-24H,2-5,7,9H2,1H3,(H2,22,26)(H,25,27)/b16-11-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137584
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H31N3O3S/c1-4-31(29,30)16-11-12-22-19(14-16)20(24(28)26-22)15-23-18(9-7-13-27(2)3)17-8-5-6-10-21(17)25-23/h11-12,14-15,25H,4-10,13H2,1-3H3,(H,26,28)/b20-15-
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n/an/a 20n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137570
PNG
(CHEMBL291759 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CCOC(=O)CN1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C29H39N5O5S/c1-3-39-28(35)19-34-15-13-33(14-16-34)12-6-8-22-21-7-4-5-9-25(21)31-27(22)18-24-23-17-20(40(37,38)30-2)10-11-26(23)32-29(24)36/h10-11,17-18,30-31H,3-9,12-16,19H2,1-2H3,(H,32,36)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137582
PNG
(CHEMBL292930 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)17-26(33)34/h8-9,15-16,28-29H,2-7,10-14,17H2,1H3,(H,30,35)(H,33,34)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137581
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-hydroxy-piperidin-1...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C27H35N3O4S/c1-2-35(33,34)19-9-10-25-22(16-19)23(27(32)29-25)17-26-21(20-6-3-4-8-24(20)28-26)7-5-13-30-14-11-18(31)12-15-30/h9-10,16-18,28,31H,2-8,11-15H2,1H3,(H,29,32)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137580
PNG
(3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahyd...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N4O4S/c1-26-34(31,32)17-8-9-23-20(15-17)21(25(30)28-23)16-24-19(18-5-2-3-7-22(18)27-24)6-4-10-29-11-13-33-14-12-29/h8-9,15-16,26-27H,2-7,10-14H2,1H3,(H,28,30)/b21-16-
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n/an/a 30n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137573
PNG
(3-{2-[5-Methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C21H24N4O4S/c1-23-30(28,29)12-6-8-18-15(10-12)16(21(27)25-18)11-19-14(7-9-20(22)26)13-4-2-3-5-17(13)24-19/h6,8,10-11,23-24H,2-5,7,9H2,1H3,(H2,22,26)(H,25,27)/b16-11-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137583
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C27H37N5O4S/c1-28-37(35,36)19-8-9-25-22(17-19)23(27(34)30-25)18-26-21(20-5-2-3-7-24(20)29-26)6-4-10-31-11-13-32(14-12-31)15-16-33/h8-9,17-18,28-29,33H,2-7,10-16H2,1H3,(H,30,34)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137572
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C27H36N4O3S/c1-3-35(33,34)19-10-11-25-22(17-19)23(27(32)29-25)18-26-21(20-7-4-5-9-24(20)28-26)8-6-12-31-15-13-30(2)14-16-31/h10-11,17-18,28H,3-9,12-16H2,1-2H3,(H,29,32)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137569
PNG
(3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137591
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C28H38N4O4S/c1-2-37(35,36)20-9-10-26-23(18-20)24(28(34)30-26)19-27-22(21-6-3-4-8-25(21)29-27)7-5-11-31-12-14-32(15-13-31)16-17-33/h9-10,18-19,29,33H,2-8,11-17H2,1H3,(H,30,34)/b24-19-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137587
PNG
(3-[1-(3-Morpholin-4-ylmethyl-4,5,6,7-tetrahydro-1H...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N4O4S/c1-24-32(29,30)15-6-7-21-17(12-15)18(23(28)26-21)13-22-19(14-27-8-10-31-11-9-27)16-4-2-3-5-20(16)25-22/h6-7,12-13,24-25H,2-5,8-11,14H2,1H3,(H,26,28)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137569
PNG
(3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137576
PNG
(3-[1-{3-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-4,5,...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C26H34N4O4S/c1-27-35(33,34)18-8-9-24-21(15-18)22(26(32)29-24)16-25-20(19-5-2-3-7-23(19)28-25)6-4-12-30-13-10-17(31)11-14-30/h8-9,15-17,27-28,31H,2-7,10-14H2,1H3,(H,29,32)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137573
PNG
(3-{2-[5-Methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C21H24N4O4S/c1-23-30(28,29)12-6-8-18-15(10-12)16(21(27)25-18)11-19-14(7-9-20(22)26)13-4-2-3-5-17(13)24-19/h6,8,10-11,23-24H,2-5,7,9H2,1H3,(H2,22,26)(H,25,27)/b16-11-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137571
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H30N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h10-11,13-14,24-25H,4-9,12H2,1-3H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137587
PNG
(3-[1-(3-Morpholin-4-ylmethyl-4,5,6,7-tetrahydro-1H...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N4O4S/c1-24-32(29,30)15-6-7-21-17(12-15)18(23(28)26-21)13-22-19(14-27-8-10-31-11-9-27)16-4-2-3-5-20(16)25-22/h6-7,12-13,24-25H,2-5,8-11,14H2,1H3,(H,26,28)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137580
PNG
(3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahyd...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N4O4S/c1-26-34(31,32)17-8-9-23-20(15-17)21(25(30)28-23)16-24-19(18-5-2-3-7-22(18)27-24)6-4-10-29-11-13-33-14-12-29/h8-9,15-16,26-27H,2-7,10-14H2,1H3,(H,28,30)/b21-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137584
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H31N3O3S/c1-4-31(29,30)16-11-12-22-19(14-16)20(24(28)26-22)15-23-18(9-7-13-27(2)3)17-8-5-6-10-21(17)25-23/h11-12,14-15,25H,4-10,13H2,1-3H3,(H,26,28)/b20-15-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137591
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C28H38N4O4S/c1-2-37(35,36)20-9-10-26-23(18-20)24(28(34)30-26)19-27-22(21-6-3-4-8-25(21)29-27)7-5-11-31-12-14-32(15-13-31)16-17-33/h9-10,18-19,29,33H,2-8,11-17H2,1H3,(H,30,34)/b24-19-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137581
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-hydroxy-piperidin-1...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C27H35N3O4S/c1-2-35(33,34)19-9-10-25-22(16-19)23(27(32)29-25)17-26-21(20-6-3-4-8-24(20)28-26)7-5-13-30-14-11-18(31)12-15-30/h9-10,16-18,28,31H,2-8,11-15H2,1H3,(H,29,32)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137573
PNG
(3-{2-[5-Methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C21H24N4O4S/c1-23-30(28,29)12-6-8-18-15(10-12)16(21(27)25-18)11-19-14(7-9-20(22)26)13-4-2-3-5-17(13)24-19/h6,8,10-11,23-24H,2-5,7,9H2,1H3,(H2,22,26)(H,25,27)/b16-11-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137585
PNG
(5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137578
PNG
(CHEMBL300853 | [4-(3-{2-[5-Ethanesulfonyl-2-oxo-1,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)18-27(33)34/h9-10,16-17,29H,2-8,11-15,18H2,1H3,(H,30,35)(H,33,34)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137574
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H35N5O3S/c1-27-35(33,34)18-9-10-24-21(16-18)22(26(32)29-24)17-25-20(19-6-3-4-8-23(19)28-25)7-5-11-31-14-12-30(2)13-15-31/h9-10,16-17,27-28H,3-8,11-15H2,1-2H3,(H,29,32)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137570
PNG
(CHEMBL291759 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CCOC(=O)CN1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C29H39N5O5S/c1-3-39-28(35)19-34-15-13-33(14-16-34)12-6-8-22-21-7-4-5-9-25(21)31-27(22)18-24-23-17-20(40(37,38)30-2)10-11-26(23)32-29(24)36/h10-11,17-18,30-31H,3-9,12-16,19H2,1-2H3,(H,32,36)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137569
PNG
(3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137570
PNG
(CHEMBL291759 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CCOC(=O)CN1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C29H39N5O5S/c1-3-39-28(35)19-34-15-13-33(14-16-34)12-6-8-22-21-7-4-5-9-25(21)31-27(22)18-24-23-17-20(40(37,38)30-2)10-11-26(23)32-29(24)36/h10-11,17-18,30-31H,3-9,12-16,19H2,1-2H3,(H,32,36)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137587
PNG
(3-[1-(3-Morpholin-4-ylmethyl-4,5,6,7-tetrahydro-1H...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N4O4S/c1-24-32(29,30)15-6-7-21-17(12-15)18(23(28)26-21)13-22-19(14-27-8-10-31-11-9-27)16-4-2-3-5-20(16)25-22/h6-7,12-13,24-25H,2-5,8-11,14H2,1H3,(H,26,28)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137573
PNG
(3-{2-[5-Methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C21H24N4O4S/c1-23-30(28,29)12-6-8-18-15(10-12)16(21(27)25-18)11-19-14(7-9-20(22)26)13-4-2-3-5-17(13)24-19/h6,8,10-11,23-24H,2-5,7,9H2,1H3,(H2,22,26)(H,25,27)/b16-11-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137582
PNG
(CHEMBL292930 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)17-26(33)34/h8-9,15-16,28-29H,2-7,10-14,17H2,1H3,(H,30,35)(H,33,34)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137571
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H30N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h10-11,13-14,24-25H,4-9,12H2,1-3H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137571
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H30N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h10-11,13-14,24-25H,4-9,12H2,1-3H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137574
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H35N5O3S/c1-27-35(33,34)18-9-10-24-21(16-18)22(26(32)29-24)17-25-20(19-6-3-4-8-23(19)28-25)7-5-11-31-14-12-30(2)13-15-31/h9-10,16-17,27-28H,3-8,11-15H2,1-2H3,(H,29,32)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137585
PNG
(5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137583
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C27H37N5O4S/c1-28-37(35,36)19-8-9-25-22(17-19)23(27(34)30-25)18-26-21(20-5-2-3-7-24(20)29-26)6-4-10-31-11-13-32(14-12-31)15-16-33/h8-9,17-18,28-29,33H,2-7,10-16H2,1H3,(H,30,34)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137580
PNG
(3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahyd...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N4O4S/c1-26-34(31,32)17-8-9-23-20(15-17)21(25(30)28-23)16-24-19(18-5-2-3-7-22(18)27-24)6-4-10-29-11-13-33-14-12-29/h8-9,15-16,26-27H,2-7,10-14H2,1H3,(H,28,30)/b21-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137613
PNG
(5-Ethanesulfonyl-3-[1-[3-(3-morpholin-4-yl-propyl)...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C26H33N3O4S/c1-2-34(31,32)18-9-10-24-21(16-18)22(26(30)28-24)17-25-20(19-6-3-4-8-23(19)27-25)7-5-11-29-12-14-33-15-13-29/h9-10,16-17,27H,2-8,11-15H2,1H3,(H,28,30)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50137585
PNG
(5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Yes tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137576
PNG
(3-[1-{3-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-4,5,...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C26H34N4O4S/c1-27-35(33,34)18-8-9-24-21(15-18)22(26(32)29-24)16-25-20(19-5-2-3-7-23(19)28-25)6-4-12-30-13-10-17(31)11-14-30/h8-9,15-17,27-28,31H,2-7,10-14H2,1H3,(H,29,32)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137614
PNG
(2-Oxo-3-[1-[3-(3-piperazin-1-yl-propyl)-4,5,6,7-te...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCNCC3)c2c1
Show InChI InChI=1S/C25H33N5O3S/c1-26-34(32,33)17-8-9-23-20(15-17)21(25(31)29-23)16-24-19(18-5-2-3-7-22(18)28-24)6-4-12-30-13-10-27-11-14-30/h8-9,15-16,26-28H,2-7,10-14H2,1H3,(H,29,31)/b21-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137572
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C27H36N4O3S/c1-3-35(33,34)19-10-11-25-22(17-19)23(27(32)29-25)18-26-21(20-7-4-5-9-24(20)28-26)8-6-12-31-15-13-30(2)14-16-31/h10-11,17-18,28H,3-9,12-16H2,1-2H3,(H,29,32)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137569
PNG
(3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137587
PNG
(3-[1-(3-Morpholin-4-ylmethyl-4,5,6,7-tetrahydro-1H...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N4O4S/c1-24-32(29,30)15-6-7-21-17(12-15)18(23(28)26-21)13-22-19(14-27-8-10-31-11-9-27)16-4-2-3-5-20(16)25-22/h6-7,12-13,24-25H,2-5,8-11,14H2,1H3,(H,26,28)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137577
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-1H-indol-2-yl]-me...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4ccccc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H26N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h4-5,7,9-11,13-14,24-25H,6,8,12H2,1-3H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137582
PNG
(CHEMBL292930 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)17-26(33)34/h8-9,15-16,28-29H,2-7,10-14,17H2,1H3,(H,30,35)(H,33,34)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137584
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H31N3O3S/c1-4-31(29,30)16-11-12-22-19(14-16)20(24(28)26-22)15-23-18(9-7-13-27(2)3)17-8-5-6-10-21(17)25-23/h11-12,14-15,25H,4-10,13H2,1-3H3,(H,26,28)/b20-15-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137572
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C27H36N4O3S/c1-3-35(33,34)19-10-11-25-22(17-19)23(27(32)29-25)18-26-21(20-7-4-5-9-24(20)28-26)8-6-12-31-15-13-30(2)14-16-31/h10-11,17-18,28H,3-9,12-16H2,1-2H3,(H,29,32)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137600
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-acetyl)-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC3)C(=O)CO)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)27(34)18-33/h9-10,16-17,29,33H,2-8,11-15,18H2,1H3,(H,30,35)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137592
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CC(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C25H33N3O3S/c1-16(2)32(30,31)17-11-12-23-20(14-17)21(25(29)27-23)15-24-19(9-7-13-28(3)4)18-8-5-6-10-22(18)26-24/h11-12,14-16,26H,5-10,13H2,1-4H3,(H,27,29)/b21-15-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137594
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CC(C)CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C26H36N4O3S/c1-17(2)16-27-34(32,33)18-11-12-24-21(14-18)22(26(31)29-24)15-25-20(9-7-13-30(3)4)19-8-5-6-10-23(19)28-25/h11-12,14-15,17,27-28H,5-10,13,16H2,1-4H3,(H,29,31)/b22-15-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137601
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c2CCCCc2[nH]c1\C=C1/C(=O)Nc2ccc(cc12)S(=O)(=O)NCCO
Show InChI InChI=1S/C24H32N4O4S/c1-28(2)12-5-7-18-17-6-3-4-8-21(17)26-23(18)15-20-19-14-16(33(31,32)25-11-13-29)9-10-22(19)27-24(20)30/h9-10,14-15,25-26,29H,3-8,11-13H2,1-2H3,(H,27,30)/b20-15-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137593
PNG
(3-[1-{3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC3)C(C)=O)c2c1
Show InChI InChI=1S/C27H35N5O4S/c1-18(33)32-14-12-31(13-15-32)11-5-7-21-20-6-3-4-8-24(20)29-26(21)17-23-22-16-19(37(35,36)28-2)9-10-25(22)30-27(23)34/h9-10,16-17,28-29H,3-8,11-15H2,1-2H3,(H,30,34)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137579
PNG
(2-Oxo-3-[1-{3-[3-(4-propionyl-piperazin-1-yl)-prop...)
Show SMILES CCC(=O)N1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C28H37N5O4S/c1-3-27(34)33-15-13-32(14-16-33)12-6-8-21-20-7-4-5-9-24(20)30-26(21)18-23-22-17-19(38(36,37)29-2)10-11-25(22)31-28(23)35/h10-11,17-18,29-30H,3-9,12-16H2,1-2H3,(H,31,35)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137576
PNG
(3-[1-{3-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-4,5,...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C26H34N4O4S/c1-27-35(33,34)18-8-9-24-21(15-18)22(26(32)29-24)16-25-20(19-5-2-3-7-23(19)28-25)6-4-12-30-13-10-17(31)11-14-30/h8-9,15-17,27-28,31H,2-7,10-14H2,1H3,(H,29,32)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137574
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H35N5O3S/c1-27-35(33,34)18-9-10-24-21(16-18)22(26(32)29-24)17-25-20(19-6-3-4-8-23(19)28-25)7-5-11-31-14-12-30(2)13-15-31/h9-10,16-17,27-28H,3-8,11-15H2,1-2H3,(H,29,32)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137603
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-3-oxo-propyl]...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(=O)N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H33N5O4S/c1-27-36(34,35)17-7-9-23-20(15-17)21(26(33)29-23)16-24-19(18-5-3-4-6-22(18)28-24)8-10-25(32)31-13-11-30(2)12-14-31/h7,9,15-16,27-28H,3-6,8,10-14H2,1-2H3,(H,29,33)/b21-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137611
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c2CCCCc2[nH]c1\C=C1/C(=O)Nc2ccc(cc12)S(=O)(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C28H31ClN4O3S/c1-33(2)15-7-9-20-19-8-3-5-11-24(19)30-27(20)17-22-21-16-18(13-14-25(21)31-28(22)34)37(35,36)32-26-12-6-4-10-23(26)29/h4,6,10,12-14,16-17,30,32H,3,5,7-9,11,15H2,1-2H3,(H,31,34)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137595
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c(\C=C2/C(=O)Nc3ccc(cc23)S(C)(=O)=O)[nH]c2CCCCc12
Show InChI InChI=1S/C23H29N3O3S/c1-26(2)12-6-8-17-16-7-4-5-9-20(16)24-22(17)14-19-18-13-15(30(3,28)29)10-11-21(18)25-23(19)27/h10-11,13-14,24H,4-9,12H2,1-3H3,(H,25,27)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137584
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H31N3O3S/c1-4-31(29,30)16-11-12-22-19(14-16)20(24(28)26-22)15-23-18(9-7-13-27(2)3)17-8-5-6-10-21(17)25-23/h11-12,14-15,25H,4-10,13H2,1-3H3,(H,26,28)/b20-15-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137569
PNG
(3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137585
PNG
(5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137591
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C28H38N4O4S/c1-2-37(35,36)20-9-10-26-23(18-20)24(28(34)30-26)19-27-22(21-6-3-4-8-25(21)29-27)7-5-11-31-12-14-32(15-13-31)16-17-33/h9-10,18-19,29,33H,2-8,11-17H2,1H3,(H,30,34)/b24-19-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137583
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C27H37N5O4S/c1-28-37(35,36)19-8-9-25-22(17-19)23(27(34)30-25)18-26-21(20-5-2-3-7-24(20)29-26)6-4-10-31-11-13-32(14-12-31)15-16-33/h8-9,17-18,28-29,33H,2-7,10-16H2,1H3,(H,30,34)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137582
PNG
(CHEMBL292930 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)17-26(33)34/h8-9,15-16,28-29H,2-7,10-14,17H2,1H3,(H,30,35)(H,33,34)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137587
PNG
(3-[1-(3-Morpholin-4-ylmethyl-4,5,6,7-tetrahydro-1H...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N4O4S/c1-24-32(29,30)15-6-7-21-17(12-15)18(23(28)26-21)13-22-19(14-27-8-10-31-11-9-27)16-4-2-3-5-20(16)25-22/h6-7,12-13,24-25H,2-5,8-11,14H2,1H3,(H,26,28)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137589
PNG
(3-[1-{3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC3)C(C)=O)c2c1
Show InChI InChI=1S/C28H36N4O4S/c1-3-37(35,36)20-10-11-26-23(17-20)24(28(34)30-26)18-27-22(21-7-4-5-9-25(21)29-27)8-6-12-31-13-15-32(16-14-31)19(2)33/h10-11,17-18,29H,3-9,12-16H2,1-2H3,(H,30,34)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137584
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H31N3O3S/c1-4-31(29,30)16-11-12-22-19(14-16)20(24(28)26-22)15-23-18(9-7-13-27(2)3)17-8-5-6-10-21(17)25-23/h11-12,14-15,25H,4-10,13H2,1-3H3,(H,26,28)/b20-15-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137586
PNG
(3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(O)=O)c2c1
Show InChI InChI=1S/C22H24N2O5S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)24-19)12-20-15(8-10-21(25)26)14-5-3-4-6-18(14)23-20/h7,9,11-12,23H,2-6,8,10H2,1H3,(H,24,27)(H,25,26)/b17-12-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137578
PNG
(CHEMBL300853 | [4-(3-{2-[5-Ethanesulfonyl-2-oxo-1,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)18-27(33)34/h9-10,16-17,29H,2-8,11-15,18H2,1H3,(H,30,35)(H,33,34)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137591
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C28H38N4O4S/c1-2-37(35,36)20-9-10-26-23(18-20)24(28(34)30-26)19-27-22(21-6-3-4-8-25(21)29-27)7-5-11-31-12-14-32(15-13-31)16-17-33/h9-10,18-19,29,33H,2-8,11-17H2,1H3,(H,30,34)/b24-19-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137583
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C27H37N5O4S/c1-28-37(35,36)19-8-9-25-22(17-19)23(27(34)30-25)18-26-21(20-5-2-3-7-24(20)29-26)6-4-10-31-11-13-32(14-12-31)15-16-33/h8-9,17-18,28-29,33H,2-7,10-16H2,1H3,(H,30,34)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137578
PNG
(CHEMBL300853 | [4-(3-{2-[5-Ethanesulfonyl-2-oxo-1,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)18-27(33)34/h9-10,16-17,29H,2-8,11-15,18H2,1H3,(H,30,35)(H,33,34)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137582
PNG
(CHEMBL292930 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)17-26(33)34/h8-9,15-16,28-29H,2-7,10-14,17H2,1H3,(H,30,35)(H,33,34)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137578
PNG
(CHEMBL300853 | [4-(3-{2-[5-Ethanesulfonyl-2-oxo-1,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)18-27(33)34/h9-10,16-17,29H,2-8,11-15,18H2,1H3,(H,30,35)(H,33,34)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137609
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-acetyl)-piperazin-1-yl]-p...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC3)C(=O)CO)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)26(34)17-33/h8-9,15-16,28-29,33H,2-7,10-14,17H2,1H3,(H,30,35)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137581
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-hydroxy-piperidin-1...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C27H35N3O4S/c1-2-35(33,34)19-9-10-25-22(16-19)23(27(32)29-25)17-26-21(20-6-3-4-8-24(20)28-26)7-5-13-30-14-11-18(31)12-15-30/h9-10,16-18,28,31H,2-8,11-15H2,1H3,(H,29,32)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137607
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(=O)N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C27H34N4O4S/c1-3-36(34,35)18-8-10-24-21(16-18)22(27(33)29-24)17-25-20(19-6-4-5-7-23(19)28-25)9-11-26(32)31-14-12-30(2)13-15-31/h8,10,16-17,28H,3-7,9,11-15H2,1-2H3,(H,29,33)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137581
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-hydroxy-piperidin-1...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C27H35N3O4S/c1-2-35(33,34)19-9-10-25-22(16-19)23(27(32)29-25)17-26-21(20-6-3-4-8-24(20)28-26)7-5-13-30-14-11-18(31)12-15-30/h9-10,16-18,28,31H,2-8,11-15H2,1H3,(H,29,32)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137584
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H31N3O3S/c1-4-31(29,30)16-11-12-22-19(14-16)20(24(28)26-22)15-23-18(9-7-13-27(2)3)17-8-5-6-10-21(17)25-23/h11-12,14-15,25H,4-10,13H2,1-3H3,(H,26,28)/b20-15-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137570
PNG
(CHEMBL291759 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CCOC(=O)CN1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C29H39N5O5S/c1-3-39-28(35)19-34-15-13-33(14-16-34)12-6-8-22-21-7-4-5-9-25(21)31-27(22)18-24-23-17-20(40(37,38)30-2)10-11-26(23)32-29(24)36/h10-11,17-18,30-31H,3-9,12-16,19H2,1-2H3,(H,32,36)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137570
PNG
(CHEMBL291759 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CCOC(=O)CN1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C29H39N5O5S/c1-3-39-28(35)19-34-15-13-33(14-16-34)12-6-8-22-21-7-4-5-9-25(21)31-27(22)18-24-23-17-20(40(37,38)30-2)10-11-26(23)32-29(24)36/h10-11,17-18,30-31H,3-9,12-16,19H2,1-2H3,(H,32,36)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137591
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C28H38N4O4S/c1-2-37(35,36)20-9-10-26-23(18-20)24(28(34)30-26)19-27-22(21-6-3-4-8-25(21)29-27)7-5-11-31-12-14-32(15-13-31)16-17-33/h9-10,18-19,29,33H,2-8,11-17H2,1H3,(H,30,34)/b24-19-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137604
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCCCc12
Show InChI InChI=1S/C22H26FN3O/c1-26(2)11-5-7-16-15-6-3-4-8-19(15)24-21(16)13-18-17-12-14(23)9-10-20(17)25-22(18)27/h9-10,12-13,24H,3-8,11H2,1-2H3,(H,25,27)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137573
PNG
(3-{2-[5-Methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C21H24N4O4S/c1-23-30(28,29)12-6-8-18-15(10-12)16(21(27)25-18)11-19-14(7-9-20(22)26)13-4-2-3-5-17(13)24-19/h6,8,10-11,23-24H,2-5,7,9H2,1H3,(H2,22,26)(H,25,27)/b16-11-
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n/an/a 500n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137581
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-hydroxy-piperidin-1...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C27H35N3O4S/c1-2-35(33,34)19-9-10-25-22(16-19)23(27(32)29-25)17-26-21(20-6-3-4-8-24(20)28-26)7-5-13-30-14-11-18(31)12-15-30/h9-10,16-18,28,31H,2-8,11-15H2,1H3,(H,29,32)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137575
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)[nH]c2CCCCc12
Show InChI InChI=1S/C22H28N4O3S/c1-26(2)11-5-7-16-15-6-3-4-8-19(15)24-21(16)13-18-17-12-14(30(23,28)29)9-10-20(17)25-22(18)27/h9-10,12-13,24H,3-8,11H2,1-2H3,(H,25,27)(H2,23,28,29)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137570
PNG
(CHEMBL291759 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CCOC(=O)CN1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C29H39N5O5S/c1-3-39-28(35)19-34-15-13-33(14-16-34)12-6-8-22-21-7-4-5-9-25(21)31-27(22)18-24-23-17-20(40(37,38)30-2)10-11-26(23)32-29(24)36/h10-11,17-18,30-31H,3-9,12-16,19H2,1-2H3,(H,32,36)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137572
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C27H36N4O3S/c1-3-35(33,34)19-10-11-25-22(17-19)23(27(32)29-25)18-26-21(20-7-4-5-9-24(20)28-26)8-6-12-31-15-13-30(2)14-16-31/h10-11,17-18,28H,3-9,12-16H2,1-2H3,(H,29,32)/b23-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137583
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C27H37N5O4S/c1-28-37(35,36)19-8-9-25-22(17-19)23(27(34)30-25)18-26-21(20-5-2-3-7-24(20)29-26)6-4-10-31-11-13-32(14-12-31)15-16-33/h8-9,17-18,28-29,33H,2-7,10-16H2,1H3,(H,30,34)/b23-18-
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n/an/a 600n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137610
PNG
(5-Ethanesulfonyl-3-[1-(4,5,6,7-tetrahydro-1H-indol...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1
Show InChI InChI=1S/C19H20N2O3S/c1-2-25(23,24)14-7-8-18-15(11-14)16(19(22)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,2-6H2,1H3,(H,21,22)/b16-10-
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n/an/a 700n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137571
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H30N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h10-11,13-14,24-25H,4-9,12H2,1-3H3,(H,26,28)/b19-14-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137602
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c(\C=C2/C(=O)Nc3ccc(cc23)C(O)=O)[nH]c2CCCCc12
Show InChI InChI=1S/C23H27N3O3/c1-26(2)11-5-7-16-15-6-3-4-8-19(15)24-21(16)13-18-17-12-14(23(28)29)9-10-20(17)25-22(18)27/h9-10,12-13,24H,3-8,11H2,1-2H3,(H,25,27)(H,28,29)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137580
PNG
(3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahyd...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N4O4S/c1-26-34(31,32)17-8-9-23-20(15-17)21(25(30)28-23)16-24-19(18-5-2-3-7-22(18)27-24)6-4-10-29-11-13-33-14-12-29/h8-9,15-16,26-27H,2-7,10-14H2,1H3,(H,28,30)/b21-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137574
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H35N5O3S/c1-27-35(33,34)18-9-10-24-21(16-18)22(26(32)29-24)17-25-20(19-6-3-4-8-23(19)28-25)7-5-11-31-14-12-30(2)13-15-31/h9-10,16-17,27-28H,3-8,11-15H2,1-2H3,(H,29,32)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137580
PNG
(3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahyd...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N4O4S/c1-26-34(31,32)17-8-9-23-20(15-17)21(25(30)28-23)16-24-19(18-5-2-3-7-22(18)27-24)6-4-10-29-11-13-33-14-12-29/h8-9,15-16,26-27H,2-7,10-14H2,1H3,(H,28,30)/b21-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137581
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-hydroxy-piperidin-1...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C27H35N3O4S/c1-2-35(33,34)19-9-10-25-22(16-19)23(27(32)29-25)17-26-21(20-6-3-4-8-24(20)28-26)7-5-13-30-14-11-18(31)12-15-30/h9-10,16-18,28,31H,2-8,11-15H2,1H3,(H,29,32)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137585
PNG
(5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-
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n/an/a 800n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137581
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-hydroxy-piperidin-1...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C27H35N3O4S/c1-2-35(33,34)19-9-10-25-22(16-19)23(27(32)29-25)17-26-21(20-6-3-4-8-24(20)28-26)7-5-13-30-14-11-18(31)12-15-30/h9-10,16-18,28,31H,2-8,11-15H2,1H3,(H,29,32)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137612
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-propionyl-piperazin...)
Show SMILES CCC(=O)N1CCN(CCCc2c(\C=C3/C(=O)Nc4ccc(cc34)S(=O)(=O)CC)[nH]c3CCCCc23)CC1
Show InChI InChI=1S/C29H38N4O4S/c1-3-28(34)33-16-14-32(15-17-33)13-7-9-22-21-8-5-6-10-25(21)30-27(22)19-24-23-18-20(38(36,37)4-2)11-12-26(23)31-29(24)35/h11-12,18-19,30H,3-10,13-17H2,1-2H3,(H,31,35)/b24-19-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137574
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H35N5O3S/c1-27-35(33,34)18-9-10-24-21(16-18)22(26(32)29-24)17-25-20(19-6-3-4-8-23(19)28-25)7-5-11-31-14-12-30(2)13-15-31/h9-10,16-17,27-28H,3-8,11-15H2,1-2H3,(H,29,32)/b22-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137578
PNG
(CHEMBL300853 | [4-(3-{2-[5-Ethanesulfonyl-2-oxo-1,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)18-27(33)34/h9-10,16-17,29H,2-8,11-15,18H2,1H3,(H,30,35)(H,33,34)/b23-17-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137576
PNG
(3-[1-{3-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-4,5,...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C26H34N4O4S/c1-27-35(33,34)18-8-9-24-21(15-18)22(26(32)29-24)16-25-20(19-5-2-3-7-23(19)28-25)6-4-12-30-13-10-17(31)11-14-30/h8-9,15-17,27-28,31H,2-7,10-14H2,1H3,(H,29,32)/b22-16-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137570
PNG
(CHEMBL291759 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CCOC(=O)CN1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C29H39N5O5S/c1-3-39-28(35)19-34-15-13-33(14-16-34)12-6-8-22-21-7-4-5-9-25(21)31-27(22)18-24-23-17-20(40(37,38)30-2)10-11-26(23)32-29(24)36/h10-11,17-18,30-31H,3-9,12-16,19H2,1-2H3,(H,32,36)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137590
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H29N3O2/c1-26(2)12-6-8-17-16-7-4-5-9-20(16)24-22(17)14-19-18-13-15(28-3)10-11-21(18)25-23(19)27/h10-11,13-14,24H,4-9,12H2,1-3H3,(H,25,27)/b19-14-
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n/an/a 1.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137587
PNG
(3-[1-(3-Morpholin-4-ylmethyl-4,5,6,7-tetrahydro-1H...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N4O4S/c1-24-32(29,30)15-6-7-21-17(12-15)18(23(28)26-21)13-22-19(14-27-8-10-31-11-9-27)16-4-2-3-5-20(16)25-22/h6-7,12-13,24-25H,2-5,8-11,14H2,1H3,(H,26,28)/b18-13-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137605
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5-dimethyl-1H-p...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c(C)c(C)c3CCCN(C)C)c2c1
Show InChI InChI=1S/C21H28N4O3S/c1-13-14(2)23-20(16(13)7-6-10-25(4)5)12-18-17-11-15(29(27,28)22-3)8-9-19(17)24-21(18)26/h8-9,11-12,22-23H,6-7,10H2,1-5H3,(H,24,26)/b18-12-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137606
PNG
(CHEMBL294619 | methylamino (3Z)-3-({3-[3-(dimethyl...)
Show SMILES CNOC(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H30N4O3/c1-25-31-24(30)15-10-11-21-18(13-15)19(23(29)27-21)14-22-17(8-6-12-28(2)3)16-7-4-5-9-20(16)26-22/h10-11,13-14,25-26H,4-9,12H2,1-3H3,(H,27,29)/b19-14-
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n/an/a 1.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137571
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H30N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h10-11,13-14,24-25H,4-9,12H2,1-3H3,(H,26,28)/b19-14-
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n/an/a 1.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137591
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C28H38N4O4S/c1-2-37(35,36)20-9-10-26-23(18-20)24(28(34)30-26)19-27-22(21-6-3-4-8-25(21)29-27)7-5-11-31-12-14-32(15-13-31)16-17-33/h9-10,18-19,29,33H,2-8,11-17H2,1H3,(H,30,34)/b24-19-
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n/an/a 1.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137588
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c2CCCCc2[nH]c1\C=C1/C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C29H33FN4O3S/c1-34(2)15-5-7-23-22-6-3-4-8-26(22)32-28(23)17-25-24-16-21(13-14-27(24)33-29(25)35)38(36,37)31-18-19-9-11-20(30)12-10-19/h9-14,16-17,31-32H,3-8,15,18H2,1-2H3,(H,33,35)/b25-17-
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n/an/a 1.20E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137572
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C27H36N4O3S/c1-3-35(33,34)19-10-11-25-22(17-19)23(27(32)29-25)18-26-21(20-7-4-5-9-24(20)28-26)8-6-12-31-15-13-30(2)14-16-31/h10-11,17-18,28H,3-9,12-16H2,1-2H3,(H,29,32)/b23-18-
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n/an/a 1.20E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137574
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H35N5O3S/c1-27-35(33,34)18-9-10-24-21(16-18)22(26(32)29-24)17-25-20(19-6-3-4-8-23(19)28-25)7-5-11-31-14-12-30(2)13-15-31/h9-10,16-17,27-28H,3-8,11-15H2,1-2H3,(H,29,32)/b22-17-
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n/an/a 1.20E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50137585
PNG
(5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-
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n/an/a 1.40E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fyn tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50137571
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H30N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h10-11,13-14,24-25H,4-9,12H2,1-3H3,(H,26,28)/b19-14-
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n/an/a 1.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Lck tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137591
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C28H38N4O4S/c1-2-37(35,36)20-9-10-26-23(18-20)24(28(34)30-26)19-27-22(21-6-3-4-8-25(21)29-27)7-5-11-31-12-14-32(15-13-31)16-17-33/h9-10,18-19,29,33H,2-8,11-17H2,1H3,(H,30,34)/b24-19-
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n/an/a 1.70E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137580
PNG
(3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahyd...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N4O4S/c1-26-34(31,32)17-8-9-23-20(15-17)21(25(30)28-23)16-24-19(18-5-2-3-7-22(18)27-24)6-4-10-29-11-13-33-14-12-29/h8-9,15-16,26-27H,2-7,10-14H2,1H3,(H,28,30)/b21-16-
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n/an/a 1.70E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137598
PNG
(2-Oxo-3-[1-(4,5,6,7-tetrahydro-1H-indol-2-yl)-meth...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1
Show InChI InChI=1S/C18H19N3O3S/c1-19-25(23,24)13-6-7-17-14(10-13)15(18(22)21-17)9-12-8-11-4-2-3-5-16(11)20-12/h6-10,19-20H,2-5H2,1H3,(H,21,22)/b15-9-
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n/an/a 2.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137581
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-hydroxy-piperidin-1...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C27H35N3O4S/c1-2-35(33,34)19-9-10-25-22(16-19)23(27(32)29-25)17-26-21(20-6-3-4-8-24(20)28-26)7-5-13-30-14-11-18(31)12-15-30/h9-10,16-18,28,31H,2-8,11-15H2,1H3,(H,29,32)/b23-17-
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n/an/a 2.30E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137580
PNG
(3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahyd...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N4O4S/c1-26-34(31,32)17-8-9-23-20(15-17)21(25(30)28-23)16-24-19(18-5-2-3-7-22(18)27-24)6-4-10-29-11-13-33-14-12-29/h8-9,15-16,26-27H,2-7,10-14H2,1H3,(H,28,30)/b21-16-
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n/an/a 2.30E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137608
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c(\C=C2/C(=O)Nc3ccc(cc23)-c2ccccc2)[nH]c2CCCCc12
Show InChI InChI=1S/C28H31N3O/c1-31(2)16-8-12-22-21-11-6-7-13-25(21)29-27(22)18-24-23-17-20(19-9-4-3-5-10-19)14-15-26(23)30-28(24)32/h3-5,9-10,14-15,17-18,29H,6-8,11-13,16H2,1-2H3,(H,30,32)/b24-18-
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n/an/a 2.30E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137584
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H31N3O3S/c1-4-31(29,30)16-11-12-22-19(14-16)20(24(28)26-22)15-23-18(9-7-13-27(2)3)17-8-5-6-10-21(17)25-23/h11-12,14-15,25H,4-10,13H2,1-3H3,(H,26,28)/b20-15-
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n/an/a 2.50E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137599
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)N(C)C)[nH]c2CCCCc12
Show InChI InChI=1S/C24H32N4O3S/c1-27(2)13-7-9-18-17-8-5-6-10-21(17)25-23(18)15-20-19-14-16(32(30,31)28(3)4)11-12-22(19)26-24(20)29/h11-12,14-15,25H,5-10,13H2,1-4H3,(H,26,29)/b20-15-
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n/an/a 2.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137572
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C27H36N4O3S/c1-3-35(33,34)19-10-11-25-22(17-19)23(27(32)29-25)18-26-21(20-7-4-5-9-24(20)28-26)8-6-12-31-15-13-30(2)14-16-31/h10-11,17-18,28H,3-9,12-16H2,1-2H3,(H,29,32)/b23-18-
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n/an/a 2.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137584
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C24H31N3O3S/c1-4-31(29,30)16-11-12-22-19(14-16)20(24(28)26-22)15-23-18(9-7-13-27(2)3)17-8-5-6-10-21(17)25-23/h11-12,14-15,25H,4-10,13H2,1-3H3,(H,26,28)/b20-15-
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n/an/a 2.70E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137583
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C27H37N5O4S/c1-28-37(35,36)19-8-9-25-22(17-19)23(27(34)30-25)18-26-21(20-5-2-3-7-24(20)29-26)6-4-10-31-11-13-32(14-12-31)15-16-33/h8-9,17-18,28-29,33H,2-7,10-16H2,1H3,(H,30,34)/b23-18-
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n/an/a 3.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137597
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CN(C)CCCc1c(\C=C2/C(=O)Nc3ccccc23)[nH]c2CCCCc12
Show InChI InChI=1S/C22H27N3O/c1-25(2)13-7-10-16-15-8-3-5-11-19(15)23-21(16)14-18-17-9-4-6-12-20(17)24-22(18)26/h4,6,9,12,14,23H,3,5,7-8,10-11,13H2,1-2H3,(H,24,26)/b18-14-
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n/an/a 3.30E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137571
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C23H30N4O3S/c1-24-31(29,30)15-10-11-21-18(13-15)19(23(28)26-21)14-22-17(8-6-12-27(2)3)16-7-4-5-9-20(16)25-22/h10-11,13-14,24-25H,4-9,12H2,1-3H3,(H,26,28)/b19-14-
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n/an/a 3.30E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50137576
PNG
(3-[1-{3-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-4,5,...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C26H34N4O4S/c1-27-35(33,34)18-8-9-24-21(15-18)22(26(32)29-24)16-25-20(19-5-2-3-7-23(19)28-25)6-4-12-30-13-10-17(31)11-14-30/h8-9,15-17,27-28,31H,2-7,10-14H2,1H3,(H,29,32)/b22-16-
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n/an/a 3.40E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Fibroblast growth factor receptor 1


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137576
PNG
(3-[1-{3-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-4,5,...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C26H34N4O4S/c1-27-35(33,34)18-8-9-24-21(15-18)22(26(32)29-24)16-25-20(19-5-2-3-7-23(19)28-25)6-4-12-30-13-10-17(31)11-14-30/h8-9,15-17,27-28,31H,2-7,10-14H2,1H3,(H,29,32)/b22-16-
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n/an/a 4.70E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137585
PNG
(5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-
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n/an/a 5.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137569
PNG
(3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-
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n/an/a 5.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137583
PNG
(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C27H37N5O4S/c1-28-37(35,36)19-8-9-25-22(17-19)23(27(34)30-25)18-26-21(20-5-2-3-7-24(20)29-26)6-4-10-31-11-13-32(14-12-31)15-16-33/h8-9,17-18,28-29,33H,2-7,10-16H2,1H3,(H,30,34)/b23-18-
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n/an/a 5.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137573
PNG
(3-{2-[5-Methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C21H24N4O4S/c1-23-30(28,29)12-6-8-18-15(10-12)16(21(27)25-18)11-19-14(7-9-20(22)26)13-4-2-3-5-17(13)24-19/h6,8,10-11,23-24H,2-5,7,9H2,1H3,(H2,22,26)(H,25,27)/b16-11-
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n/an/a 6.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50137576
PNG
(3-[1-{3-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-4,5,...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCC(O)CC3)c2c1
Show InChI InChI=1S/C26H34N4O4S/c1-27-35(33,34)18-8-9-24-21(15-18)22(26(32)29-24)16-25-20(19-5-2-3-7-23(19)28-25)6-4-12-30-13-10-17(31)11-14-30/h8-9,15-17,27-28,31H,2-7,10-14H2,1H3,(H,29,32)/b22-16-
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n/an/a 7.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor 2


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137582
PNG
(CHEMBL292930 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)17-26(33)34/h8-9,15-16,28-29H,2-7,10-14,17H2,1H3,(H,30,35)(H,33,34)/b22-16-
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n/an/a 8.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137591
PNG
(5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1
Show InChI InChI=1S/C28H38N4O4S/c1-2-37(35,36)20-9-10-26-23(18-20)24(28(34)30-26)19-27-22(21-6-3-4-8-25(21)29-27)7-5-11-31-12-14-32(15-13-31)16-17-33/h9-10,18-19,29,33H,2-8,11-17H2,1H3,(H,30,34)/b24-19-
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n/an/a 9.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137596
PNG
(3-[1-[3-(3-Dimethylamino-propyl)-4,5,6,7-tetrahydr...)
Show SMILES CCS(=O)(=O)Cc1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN(C)C)c2c1
Show InChI InChI=1S/C25H33N3O3S/c1-4-32(30,31)16-17-11-12-23-20(14-17)21(25(29)27-23)15-24-19(9-7-13-28(2)3)18-8-5-6-10-22(18)26-24/h11-12,14-15,26H,4-10,13,16H2,1-3H3,(H,27,29)/b21-15-
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n/an/a 1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137569
PNG
(3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-
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n/an/a>1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137574
PNG
(3-[1-{3-[3-(4-Methyl-piperazin-1-yl)-propyl]-4,5,6...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C26H35N5O3S/c1-27-35(33,34)18-9-10-24-21(16-18)22(26(32)29-24)17-25-20(19-6-3-4-8-23(19)28-25)7-5-11-31-14-12-30(2)13-15-31/h9-10,16-17,27-28H,3-8,11-15H2,1-2H3,(H,29,32)/b22-17-
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n/an/a 1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137573
PNG
(3-{2-[5-Methylsulfamoyl-2-oxo-1,2-dihydro-indol-(3...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1
Show InChI InChI=1S/C21H24N4O4S/c1-23-30(28,29)12-6-8-18-15(10-12)16(21(27)25-18)11-19-14(7-9-20(22)26)13-4-2-3-5-17(13)24-19/h6,8,10-11,23-24H,2-5,7,9H2,1H3,(H2,22,26)(H,25,27)/b16-11-
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n/an/a>1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137582
PNG
(CHEMBL292930 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H35N5O5S/c1-28-38(36,37)18-8-9-24-21(15-18)22(27(35)30-24)16-25-20(19-5-2-3-7-23(19)29-25)6-4-10-31-11-13-32(14-12-31)17-26(33)34/h8-9,15-16,28-29H,2-7,10-14,17H2,1H3,(H,30,35)(H,33,34)/b22-16-
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n/an/a>1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50137578
PNG
(CHEMBL300853 | [4-(3-{2-[5-Ethanesulfonyl-2-oxo-1,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)18-27(33)34/h9-10,16-17,29H,2-8,11-15,18H2,1H3,(H,30,35)(H,33,34)/b23-17-
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n/an/a 1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Src protein tryrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137572
PNG
(5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(C)CC3)c2c1
Show InChI InChI=1S/C27H36N4O3S/c1-3-35(33,34)19-10-11-25-22(17-19)23(27(32)29-25)18-26-21(20-7-4-5-9-24(20)28-26)8-6-12-31-15-13-30(2)14-16-31/h10-11,17-18,28H,3-9,12-16H2,1-2H3,(H,29,32)/b23-18-
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n/an/a 1.10E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137578
PNG
(CHEMBL300853 | [4-(3-{2-[5-Ethanesulfonyl-2-oxo-1,...)
Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C28H36N4O5S/c1-2-38(36,37)19-9-10-25-22(16-19)23(28(35)30-25)17-26-21(20-6-3-4-8-24(20)29-26)7-5-11-31-12-14-32(15-13-31)18-27(33)34/h9-10,16-17,29H,2-8,11-15,18H2,1H3,(H,30,35)(H,33,34)/b23-17-
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n/an/a 1.30E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137580
PNG
(3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahyd...)
Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N4O4S/c1-26-34(31,32)17-8-9-23-20(15-17)21(25(30)28-23)16-24-19(18-5-2-3-7-22(18)27-24)6-4-10-29-11-13-33-14-12-29/h8-9,15-16,26-27H,2-7,10-14H2,1H3,(H,28,30)/b21-16-
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n/an/a 1.80E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50137570
PNG
(CHEMBL291759 | [4-(3-{2-[5-Methylsulfamoyl-2-oxo-1...)
Show SMILES CCOC(=O)CN1CCN(CCCc2c3CCCCc3[nH]c2\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NC)CC1
Show InChI InChI=1S/C29H39N5O5S/c1-3-39-28(35)19-34-15-13-33(14-16-34)12-6-8-22-21-7-4-5-9-25(21)31-27(22)18-24-23-17-20(40(37,38)30-2)10-11-26(23)32-29(24)36/h10-11,17-18,30-31H,3-9,12-16,19H2,1-2H3,(H,32,36)/b24-18-
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SUGEN, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta tyrosine kinase


Bioorg Med Chem Lett 14: 187-90 (2003)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%