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PubMed code 14695830

Compile data set for download or QSAR
Found 111 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50135800
PNG
((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Show SMILES Oc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H27NO/c22-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-21(19)13-14-4-5-14/h6-7,12,14,17,19,22H,1-5,8-11,13H2/t17-,19+,20+/m0/s1
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 0.0340n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50135800
PNG
((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Show SMILES Oc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H27NO/c22-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-21(19)13-14-4-5-14/h6-7,12,14,17,19,22H,1-5,8-11,13H2/t17-,19+,20+/m0/s1
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 0.0600n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137996
PNG
(3-Carboxamido-N-cyclopropylmethylmorphinan | CHEMB...)
Show SMILES NC(=O)c1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C21H28N2O/c22-20(24)16-7-6-15-12-19-17-3-1-2-8-21(17,18(15)11-16)9-10-23(19)13-14-4-5-14/h6-7,11,14,17,19H,1-5,8-10,12-13H2,(H2,22,24)/t17-,19+,21+/m0/s1
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 0.0600n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138007
PNG
(3-Carboxamido-N-methylmorphinan | CHEMBL297292)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)C(N)=O
Show InChI InChI=1S/C18H24N2O/c1-20-9-8-18-7-3-2-4-14(18)16(20)11-12-5-6-13(17(19)21)10-15(12)18/h5-6,10,14,16H,2-4,7-9,11H2,1H3,(H2,19,21)/t14-,16+,18+/m0/s1
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 0.0700n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50135808
PNG
((-)-3-Hydroxy-N-cyclobutylmethylmorphinan S(+)-Man...)
Show SMILES Oc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1 |r,TLB:16:15:4.21.5:7|
Show InChI InChI=1S/C21H29NO/c23-17-8-7-16-12-20-18-6-1-2-9-21(18,19(16)13-17)10-11-22(20)14-15-4-3-5-15/h7-8,13,15,18,20,23H,1-6,9-12,14H2/t18-,20+,21+/m0/s1
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 0.0800n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137994
PNG
(3-Carboxamido-N-cyclobutylmethylmorphinan | CHEMBL...)
Show SMILES NC(=O)c1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H30N2O/c23-21(25)17-8-7-16-13-20-18-6-1-2-9-22(18,19(16)12-17)10-11-24(20)14-15-4-3-5-15/h7-8,12,15,18,20H,1-6,9-11,13-14H2,(H2,23,25)/t18-,20+,22+/m0/s1
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 0.0900n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137994
PNG
(3-Carboxamido-N-cyclobutylmethylmorphinan | CHEMBL...)
Show SMILES NC(=O)c1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H30N2O/c23-21(25)17-8-7-16-13-20-18-6-1-2-9-22(18,19(16)12-17)10-11-24(20)14-15-4-3-5-15/h7-8,12,15,18,20H,1-6,9-11,13-14H2,(H2,23,25)/t18-,20+,22+/m0/s1
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 0.100n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137996
PNG
(3-Carboxamido-N-cyclopropylmethylmorphinan | CHEMB...)
Show SMILES NC(=O)c1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C21H28N2O/c22-20(24)16-7-6-15-12-19-17-3-1-2-8-21(17,18(15)11-16)9-10-23(19)13-14-4-5-14/h6-7,11,14,17,19H,1-5,8-10,12-13H2,(H2,22,24)/t17-,19+,21+/m0/s1
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 0.180n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137997
PNG
(3-Amino-N-cyclopropylmethylmorphinan | 3-aminocycl...)
Show SMILES Nc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H28N2/c21-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-22(19)13-14-4-5-14/h6-7,12,14,17,19H,1-5,8-11,13,21H2/t17-,19+,20+/m0/s1
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 0.180n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137989
PNG
(3-Hydroxy-10-keto-N-(tetrahydrofuran-2-yl)methylmo...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3C[C@@H]3CCCO3)c2c1
Show InChI InChI=1S/C21H27NO3/c23-14-6-7-16-18(12-14)21-8-2-1-5-17(21)19(20(16)24)22(10-9-21)13-15-4-3-11-25-15/h6-7,12,15,17,19,23H,1-5,8-11,13H2/t15-,17-,19-,21+/m0/s1
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 0.180n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017233
PNG
(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r,TLB:0:1:12.18.11:9|
Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
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 0.210n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50135808
PNG
((-)-3-Hydroxy-N-cyclobutylmethylmorphinan S(+)-Man...)
Show SMILES Oc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1 |r,TLB:16:15:4.21.5:7|
Show InChI InChI=1S/C21H29NO/c23-17-8-7-16-12-20-18-6-1-2-9-21(18,19(16)13-17)10-11-22(20)14-15-4-3-5-15/h7-8,13,15,18,20,23H,1-6,9-12,14H2/t18-,20+,21+/m0/s1
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 0.230n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137989
PNG
(3-Hydroxy-10-keto-N-(tetrahydrofuran-2-yl)methylmo...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3C[C@@H]3CCCO3)c2c1
Show InChI InChI=1S/C21H27NO3/c23-14-6-7-16-18(12-14)21-8-2-1-5-17(21)19(20(16)24)22(10-9-21)13-15-4-3-11-25-15/h6-7,12,15,17,19,23H,1-5,8-11,13H2/t15-,17-,19-,21+/m0/s1
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 0.380n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137990
PNG
(3-Hydroxy-10-keto-N-cyclobutylmethylmorphinan | CH...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H27NO2/c23-15-7-8-16-18(12-15)21-9-2-1-6-17(21)19(20(16)24)22(11-10-21)13-14-4-3-5-14/h7-8,12,14,17,19,23H,1-6,9-11,13H2/t17-,19-,21+/m0/s1
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 0.480n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50000091
PNG
((6S,11R)-3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-...)
Show SMILES CC[C@]12CCN(CC3CC3)C([C@@H]1C)C(=O)c1ccc(O)cc21 |TLB:6:5:13.21.15:11,14:13:11:5.3.4,THB:20:21:11:5.3.4|
Show InChI InChI=1S/C19H25NO2/c1-3-19-8-9-20(11-13-4-5-13)17(12(19)2)18(22)15-7-6-14(21)10-16(15)19/h6-7,10,12-13,17,21H,3-5,8-9,11H2,1-2H3/t12-,17?,19-/m0/s1
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 0.620n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138011
PNG
(3-Hydroxy-10-keto-N-(2-phenylethyl)morphinan | CHE...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCc3ccccc3)c2c1
Show InChI InChI=1S/C24H27NO2/c26-18-9-10-19-21(16-18)24-12-5-4-8-20(24)22(23(19)27)25(15-13-24)14-11-17-6-2-1-3-7-17/h1-3,6-7,9-10,16,20,22,26H,4-5,8,11-15H2/t20-,22-,24+/m0/s1
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 0.630n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50000091
PNG
((6S,11R)-3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-...)
Show SMILES CC[C@]12CCN(CC3CC3)C([C@@H]1C)C(=O)c1ccc(O)cc21 |TLB:6:5:13.21.15:11,14:13:11:5.3.4,THB:20:21:11:5.3.4|
Show InChI InChI=1S/C19H25NO2/c1-3-19-8-9-20(11-13-4-5-13)17(12(19)2)18(22)15-7-6-14(21)10-16(15)19/h6-7,10,12-13,17,21H,3-5,8-9,11H2,1-2H3/t12-,17?,19-/m0/s1
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 0.780n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137989
PNG
(3-Hydroxy-10-keto-N-(tetrahydrofuran-2-yl)methylmo...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3C[C@@H]3CCCO3)c2c1
Show InChI InChI=1S/C21H27NO3/c23-14-6-7-16-18(12-14)21-8-2-1-5-17(21)19(20(16)24)22(10-9-21)13-15-4-3-11-25-15/h6-7,12,15,17,19,23H,1-5,8-11,13H2/t15-,17-,19-,21+/m0/s1
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 1n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137996
PNG
(3-Carboxamido-N-cyclopropylmethylmorphinan | CHEMB...)
Show SMILES NC(=O)c1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C21H28N2O/c22-20(24)16-7-6-15-12-19-17-3-1-2-8-21(17,18(15)11-16)9-10-23(19)13-14-4-5-14/h6-7,11,14,17,19H,1-5,8-10,12-13H2,(H2,22,24)/t17-,19+,21+/m0/s1
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 1n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137997
PNG
(3-Amino-N-cyclopropylmethylmorphinan | 3-aminocycl...)
Show SMILES Nc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H28N2/c21-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-22(19)13-14-4-5-14/h6-7,12,14,17,19H,1-5,8-11,13,21H2/t17-,19+,20+/m0/s1
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 1.30n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138014
PNG
(3-Amino-N-cyclobutylmethylmorphinan | 3-aminobutor...)
Show SMILES Nc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H30N2/c22-17-8-7-16-12-20-18-6-1-2-9-21(18,19(16)13-17)10-11-23(20)14-15-4-3-5-15/h7-8,13,15,18,20H,1-6,9-12,14,22H2/t18-,20+,21+/m0/s1
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 1.80n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50135800
PNG
((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Show SMILES Oc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H27NO/c22-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-21(19)13-14-4-5-14/h6-7,12,14,17,19,22H,1-5,8-11,13H2/t17-,19+,20+/m0/s1
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 1.90n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017233
PNG
(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r,TLB:0:1:12.18.11:9|
Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
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 2.30n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137986
PNG
(3-Hydroxy-10-keto-N-(3-fluoropropyl)morphinan | CH...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCCF)c2c1
Show InChI InChI=1S/C19H24FNO2/c20-9-3-10-21-11-8-19-7-2-1-4-15(19)17(21)18(23)14-6-5-13(22)12-16(14)19/h5-6,12,15,17,22H,1-4,7-11H2/t15-,17-,19+/m0/s1
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 2.5n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138013
PNG
(3-Carboxamido-10-keto-N-cyclobutylmethylmorphinan ...)
Show SMILES NC(=O)c1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H28N2O2/c23-21(26)15-7-8-16-18(12-15)22-9-2-1-6-17(22)19(20(16)25)24(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H2,23,26)/t17-,19-,22+/m0/s1
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 2.5n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138013
PNG
(3-Carboxamido-10-keto-N-cyclobutylmethylmorphinan ...)
Show SMILES NC(=O)c1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H28N2O2/c23-21(26)15-7-8-16-18(12-15)22-9-2-1-6-17(22)19(20(16)25)24(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H2,23,26)/t17-,19-,22+/m0/s1
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 2.70n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137990
PNG
(3-Hydroxy-10-keto-N-cyclobutylmethylmorphinan | CH...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H27NO2/c23-15-7-8-16-18(12-15)21-9-2-1-6-17(21)19(20(16)24)22(11-10-21)13-14-4-3-5-14/h7-8,12,14,17,19,23H,1-6,9-11,13H2/t17-,19-,21+/m0/s1
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 3.30n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50000091
PNG
((6S,11R)-3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-...)
Show SMILES CC[C@]12CCN(CC3CC3)C([C@@H]1C)C(=O)c1ccc(O)cc21 |TLB:6:5:13.21.15:11,14:13:11:5.3.4,THB:20:21:11:5.3.4|
Show InChI InChI=1S/C19H25NO2/c1-3-19-8-9-20(11-13-4-5-13)17(12(19)2)18(22)15-7-6-14(21)10-16(15)19/h6-7,10,12-13,17,21H,3-5,8-9,11H2,1-2H3/t12-,17?,19-/m0/s1
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 3.40n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138014
PNG
(3-Amino-N-cyclobutylmethylmorphinan | 3-aminobutor...)
Show SMILES Nc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H30N2/c22-17-8-7-16-12-20-18-6-1-2-9-21(18,19(16)13-17)10-11-23(20)14-15-4-3-5-15/h7-8,13,15,18,20H,1-6,9-12,14,22H2/t18-,20+,21+/m0/s1
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 3.70n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138007
PNG
(3-Carboxamido-N-methylmorphinan | CHEMBL297292)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)C(N)=O
Show InChI InChI=1S/C18H24N2O/c1-20-9-8-18-7-3-2-4-14(18)16(20)11-12-5-6-13(17(19)21)10-15(12)18/h5-6,10,14,16H,2-4,7-9,11H2,1H3,(H2,19,21)/t14-,16+,18+/m0/s1
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 3.90n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137994
PNG
(3-Carboxamido-N-cyclobutylmethylmorphinan | CHEMBL...)
Show SMILES NC(=O)c1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H30N2O/c23-21(25)17-8-7-16-13-20-18-6-1-2-9-22(18,19(16)12-17)10-11-24(20)14-15-4-3-5-15/h7-8,12,15,18,20H,1-6,9-11,13-14H2,(H2,23,25)/t18-,20+,22+/m0/s1
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 4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017233
PNG
(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r,TLB:0:1:12.18.11:9|
Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
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 4.20n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137998
PNG
(3-Benzylamino-10-keto-N-cyclobutylmethylmorphinan ...)
Show SMILES O=C(Nc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1)c1ccccc1
Show InChI InChI=1S/C28H32N2O2/c31-26-22-13-12-21(29-27(32)20-9-2-1-3-10-20)17-24(22)28-14-5-4-11-23(28)25(26)30(16-15-28)18-19-7-6-8-19/h1-3,9-10,12-13,17,19,23,25H,4-8,11,14-16,18H2,(H,29,32)/t23-,25-,28+/m0/s1
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 4.40n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138008
PNG
(3-Amino-10-keto-N-cyclobutylmethylmorphinan | CHEM...)
Show SMILES Nc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H28N2O/c22-15-7-8-16-18(12-15)21-9-2-1-6-17(21)19(20(16)24)23(11-10-21)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13,22H2/t17-,19-,21+/m0/s1
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 4.70n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50135808
PNG
((-)-3-Hydroxy-N-cyclobutylmethylmorphinan S(+)-Man...)
Show SMILES Oc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1 |r,TLB:16:15:4.21.5:7|
Show InChI InChI=1S/C21H29NO/c23-17-8-7-16-12-20-18-6-1-2-9-21(18,19(16)13-17)10-11-22(20)14-15-4-3-5-15/h7-8,13,15,18,20,23H,1-6,9-12,14H2/t18-,20+,21+/m0/s1
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 5.90n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138001
PNG
(3-Cyano-N-cyclobutylmethylmorphinan | CHEMBL48157)
Show SMILES N#Cc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H28N2/c23-14-17-7-8-18-13-21-19-6-1-2-9-22(19,20(18)12-17)10-11-24(21)15-16-4-3-5-16/h7-8,12,16,19,21H,1-6,9-11,13,15H2/t19-,21+,22+/m0/s1
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 6n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138002
PNG
(3-Hydroxy-10-keto-N-(3,3-dimethylallyl)morphinan |...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6][C@]23[#6]-[#6]-[#6]-[#6]-[#6@H]2-[#6@H]-1-[#6](=O)-c1ccc(-[#8])cc31
Show InChI InChI=1S/C21H27NO2/c1-14(2)8-11-22-12-10-21-9-4-3-5-17(21)19(22)20(24)16-7-6-15(23)13-18(16)21/h6-8,13,17,19,23H,3-5,9-12H2,1-2H3/t17-,19-,21+/m0/s1
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 7.40n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138011
PNG
(3-Hydroxy-10-keto-N-(2-phenylethyl)morphinan | CHE...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCc3ccccc3)c2c1
Show InChI InChI=1S/C24H27NO2/c26-18-9-10-19-21(16-18)24-12-5-4-8-20(24)22(23(19)27)25(15-13-24)14-11-17-6-2-1-3-7-17/h1-3,6-7,9-10,16,20,22,26H,4-5,8,11-15H2/t20-,22-,24+/m0/s1
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 7.70n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137998
PNG
(3-Benzylamino-10-keto-N-cyclobutylmethylmorphinan ...)
Show SMILES O=C(Nc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1)c1ccccc1
Show InChI InChI=1S/C28H32N2O2/c31-26-22-13-12-21(29-27(32)20-9-2-1-3-10-20)17-24(22)28-14-5-4-11-23(28)25(26)30(16-15-28)18-19-7-6-8-19/h1-3,9-10,12-13,17,19,23,25H,4-8,11,14-16,18H2,(H,29,32)/t23-,25-,28+/m0/s1
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 7.70n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138010
PNG
(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(N)cc31
Show InChI InChI=1S/C17H24N2/c1-19-9-8-17-7-3-2-4-14(17)16(19)10-12-5-6-13(18)11-15(12)17/h5-6,11,14,16H,2-4,7-10,18H2,1H3/t14-,16+,17+/m0/s1
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 7.90n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138016
PNG
(3-Aminomethyl-N-cyclobutylmethylmorphinan | CHEMBL...)
Show SMILES NCc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H32N2/c23-14-17-7-8-18-13-21-19-6-1-2-9-22(19,20(18)12-17)10-11-24(21)15-16-4-3-5-16/h7-8,12,16,19,21H,1-6,9-11,13-15,23H2/t19-,21+,22+/m0/s1
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 8.5n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138016
PNG
(3-Aminomethyl-N-cyclobutylmethylmorphinan | CHEMBL...)
Show SMILES NCc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H32N2/c23-14-17-7-8-18-13-21-19-6-1-2-9-22(19,20(18)12-17)10-11-24(21)15-16-4-3-5-16/h7-8,12,16,19,21H,1-6,9-11,13-15,23H2/t19-,21+,22+/m0/s1
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 8.60n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138011
PNG
(3-Hydroxy-10-keto-N-(2-phenylethyl)morphinan | CHE...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCc3ccccc3)c2c1
Show InChI InChI=1S/C24H27NO2/c26-18-9-10-19-21(16-18)24-12-5-4-8-20(24)22(23(19)27)25(15-13-24)14-11-17-6-2-1-3-7-17/h1-3,6-7,9-10,16,20,22,26H,4-5,8,11-15H2/t20-,22-,24+/m0/s1
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 9.70n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138007
PNG
(3-Carboxamido-N-methylmorphinan | CHEMBL297292)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)C(N)=O
Show InChI InChI=1S/C18H24N2O/c1-20-9-8-18-7-3-2-4-14(18)16(20)11-12-5-6-13(17(19)21)10-15(12)18/h5-6,10,14,16H,2-4,7-9,11H2,1H3,(H2,19,21)/t14-,16+,18+/m0/s1
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 13n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138012
PNG
(3-Methoxy normorphinan | CHEMBL297467)
Show SMILES COc1ccc2C(=O)[C@H]3NCC[C@@]4(CCCC[C@@H]34)c2c1
Show InChI InChI=1S/C17H21NO2/c1-20-11-5-6-12-14(10-11)17-7-3-2-4-13(17)15(16(12)19)18-9-8-17/h5-6,10,13,15,18H,2-4,7-9H2,1H3/t13-,15-,17+/m0/s1
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 16n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137992
PNG
(3-Hydroxy-10-keto-N-(2-methoxyethyl)morphinan | CH...)
Show SMILES COCCN1CC[C@]23CCCC[C@H]2[C@H]1C(=O)c1ccc(O)cc31
Show InChI InChI=1S/C19H25NO3/c1-23-11-10-20-9-8-19-7-3-2-4-15(19)17(20)18(22)14-6-5-13(21)12-16(14)19/h5-6,12,15,17,21H,2-4,7-11H2,1H3/t15-,17-,19+/m0/s1
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 17n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138002
PNG
(3-Hydroxy-10-keto-N-(3,3-dimethylallyl)morphinan |...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6][C@]23[#6]-[#6]-[#6]-[#6]-[#6@H]2-[#6@H]-1-[#6](=O)-c1ccc(-[#8])cc31
Show InChI InChI=1S/C21H27NO2/c1-14(2)8-11-22-12-10-21-9-4-3-5-17(21)19(22)20(24)16-7-6-15(23)13-18(16)21/h6-8,13,17,19,23H,3-5,9-12H2,1-2H3/t17-,19-,21+/m0/s1
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 19n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138006
PNG
(3-hydroxy-normorphinan | CHEMBL48936)
Show SMILES Oc1ccc2C(=O)[C@H]3NCC[C@@]4(CCCC[C@@H]34)c2c1
Show InChI InChI=1S/C16H19NO2/c18-10-4-5-11-13(9-10)16-6-2-1-3-12(16)14(15(11)19)17-8-7-16/h4-5,9,12,14,17-18H,1-3,6-8H2/t12-,14-,16+/m0/s1
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 20n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137986
PNG
(3-Hydroxy-10-keto-N-(3-fluoropropyl)morphinan | CH...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCCF)c2c1
Show InChI InChI=1S/C19H24FNO2/c20-9-3-10-21-11-8-19-7-2-1-4-15(19)17(21)18(23)14-6-5-13(22)12-16(14)19/h5-6,12,15,17,22H,1-4,7-11H2/t15-,17-,19+/m0/s1
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 20n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137999
PNG
(3-Cyano-N-methylmorphinan | CHEMBL296304)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)C#N
Show InChI InChI=1S/C18H22N2/c1-20-9-8-18-7-3-2-4-15(18)17(20)11-14-6-5-13(12-19)10-16(14)18/h5-6,10,15,17H,2-4,7-9,11H2,1H3/t15-,17+,18+/m0/s1
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 20n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137988
PNG
(3-Hydroxy-10-keto-N-methylmorphinan | CHEMBL432120)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1C(=O)c1ccc(O)cc31
Show InChI InChI=1S/C17H21NO2/c1-18-9-8-17-7-3-2-4-13(17)15(18)16(20)12-6-5-11(19)10-14(12)17/h5-6,10,13,15,19H,2-4,7-9H2,1H3/t13-,15-,17+/m0/s1
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 21n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138008
PNG
(3-Amino-10-keto-N-cyclobutylmethylmorphinan | CHEM...)
Show SMILES Nc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H28N2O/c22-15-7-8-16-18(12-15)21-9-2-1-6-17(21)19(20(16)24)23(11-10-21)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13,22H2/t17-,19-,21+/m0/s1
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 23n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138004
PNG
(3-Hydroxy-10-keto-N-cyclopropylmethylmorphinan | C...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H25NO2/c22-14-6-7-15-17(11-14)20-8-2-1-3-16(20)18(19(15)23)21(10-9-20)12-13-4-5-13/h6-7,11,13,16,18,22H,1-5,8-10,12H2/t16-,18-,20+/m0/s1
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 24n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138006
PNG
(3-hydroxy-normorphinan | CHEMBL48936)
Show SMILES Oc1ccc2C(=O)[C@H]3NCC[C@@]4(CCCC[C@@H]34)c2c1
Show InChI InChI=1S/C16H19NO2/c18-10-4-5-11-13(9-10)16-6-2-1-3-12(16)14(15(11)19)17-8-7-16/h4-5,9,12,14,17-18H,1-3,6-8H2/t12-,14-,16+/m0/s1
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 25n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138005
PNG
(3-Carboxyl-10-keto-N-cyclobutylmethyl morphinan | ...)
Show SMILES OC(=O)c1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H27NO3/c24-20-16-8-7-15(21(25)26)12-18(16)22-9-2-1-6-17(22)19(20)23(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H,25,26)/t17-,19-,22+/m0/s1
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 28n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138001
PNG
(3-Cyano-N-cyclobutylmethylmorphinan | CHEMBL48157)
Show SMILES N#Cc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H28N2/c23-14-17-7-8-18-13-21-19-6-1-2-9-22(19,20(18)12-17)10-11-24(21)15-16-4-3-5-16/h7-8,12,16,19,21H,1-6,9-11,13,15H2/t19-,21+,22+/m0/s1
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 37n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137988
PNG
(3-Hydroxy-10-keto-N-methylmorphinan | CHEMBL432120)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1C(=O)c1ccc(O)cc31
Show InChI InChI=1S/C17H21NO2/c1-18-9-8-17-7-3-2-4-13(17)15(18)16(20)12-6-5-11(19)10-14(12)17/h5-6,10,13,15,19H,2-4,7-9H2,1H3/t13-,15-,17+/m0/s1
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 47n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138013
PNG
(3-Carboxamido-10-keto-N-cyclobutylmethylmorphinan ...)
Show SMILES NC(=O)c1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H28N2O2/c23-21(26)15-7-8-16-18(12-15)22-9-2-1-6-17(22)19(20(16)25)24(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H2,23,26)/t17-,19-,22+/m0/s1
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 50n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138005
PNG
(3-Carboxyl-10-keto-N-cyclobutylmethyl morphinan | ...)
Show SMILES OC(=O)c1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H27NO3/c24-20-16-8-7-15(21(25)26)12-18(16)22-9-2-1-6-17(22)19(20)23(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H,25,26)/t17-,19-,22+/m0/s1
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 59n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138003
PNG
(3-Hydroxy-10-keto-N-propargylmorphinan | CHEMBL298...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC#C)c2c1
Show InChI InChI=1S/C19H21NO2/c1-2-10-20-11-9-19-8-4-3-5-15(19)17(20)18(22)14-7-6-13(21)12-16(14)19/h1,6-7,12,15,17,21H,3-5,8-11H2/t15-,17-,19+/m0/s1
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 60n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138000
PNG
(3-Aminomethyl-N-methylmorphinan | CHEMBL49318)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(CN)cc31
Show InChI InChI=1S/C18H26N2/c1-20-9-8-18-7-3-2-4-15(18)17(20)11-14-6-5-13(12-19)10-16(14)18/h5-6,10,15,17H,2-4,7-9,11-12,19H2,1H3/t15-,17+,18+/m0/s1
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 66n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137992
PNG
(3-Hydroxy-10-keto-N-(2-methoxyethyl)morphinan | CH...)
Show SMILES COCCN1CC[C@]23CCCC[C@H]2[C@H]1C(=O)c1ccc(O)cc31
Show InChI InChI=1S/C19H25NO3/c1-23-11-10-20-9-8-19-7-3-2-4-15(19)17(20)18(22)14-6-5-13(21)12-16(14)19/h5-6,12,15,17,21H,2-4,7-11H2,1H3/t15-,17-,19+/m0/s1
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 90n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138012
PNG
(3-Methoxy normorphinan | CHEMBL297467)
Show SMILES COc1ccc2C(=O)[C@H]3NCC[C@@]4(CCCC[C@@H]34)c2c1
Show InChI InChI=1S/C17H21NO2/c1-20-11-5-6-12-14(10-11)17-7-3-2-4-13(17)15(16(12)19)18-9-8-17/h5-6,10,13,15,18H,2-4,7-9H2,1H3/t13-,15-,17+/m0/s1
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 110n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138010
PNG
(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(N)cc31
Show InChI InChI=1S/C17H24N2/c1-19-9-8-17-7-3-2-4-14(17)16(19)10-12-5-6-13(18)11-15(12)17/h5-6,11,14,16H,2-4,7-10,18H2,1H3/t14-,16+,17+/m0/s1
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 110n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138000
PNG
(3-Aminomethyl-N-methylmorphinan | CHEMBL49318)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(CN)cc31
Show InChI InChI=1S/C18H26N2/c1-20-9-8-18-7-3-2-4-15(18)17(20)11-14-6-5-13(12-19)10-16(14)18/h5-6,10,15,17H,2-4,7-9,11-12,19H2,1H3/t15-,17+,18+/m0/s1
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 120n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138004
PNG
(3-Hydroxy-10-keto-N-cyclopropylmethylmorphinan | C...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H25NO2/c22-14-6-7-15-17(11-14)20-8-2-1-3-16(20)18(19(15)23)21(10-9-20)12-13-4-5-13/h6-7,11,13,16,18,22H,1-5,8-10,12H2/t16-,18-,20+/m0/s1
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 150n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137997
PNG
(3-Amino-N-cyclopropylmethylmorphinan | 3-aminocycl...)
Show SMILES Nc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H28N2/c21-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-22(19)13-14-4-5-14/h6-7,12,14,17,19H,1-5,8-11,13,21H2/t17-,19+,20+/m0/s1
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 150n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138014
PNG
(3-Amino-N-cyclobutylmethylmorphinan | 3-aminobutor...)
Show SMILES Nc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H30N2/c22-17-8-7-16-12-20-18-6-1-2-9-21(18,19(16)13-17)10-11-23(20)14-15-4-3-5-15/h7-8,13,15,18,20H,1-6,9-12,14,22H2/t18-,20+,21+/m0/s1
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 180n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138003
PNG
(3-Hydroxy-10-keto-N-propargylmorphinan | CHEMBL298...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC#C)c2c1
Show InChI InChI=1S/C19H21NO2/c1-2-10-20-11-9-19-8-4-3-5-15(19)17(20)18(22)14-7-6-13(21)12-16(14)19/h1,6-7,12,15,17,21H,3-5,8-11H2/t15-,17-,19+/m0/s1
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 190n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137999
PNG
(3-Cyano-N-methylmorphinan | CHEMBL296304)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)C#N
Show InChI InChI=1S/C18H22N2/c1-20-9-8-18-7-3-2-4-15(18)17(20)11-14-6-5-13(12-19)10-16(14)18/h5-6,10,15,17H,2-4,7-9,11H2,1H3/t15-,17+,18+/m0/s1
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 200n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137987
PNG
(3-Tetrazolo-10-keto-N-cyclobutylmethylmorphinan | ...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(ccc12)-c1nnn[nH]1
Show InChI InChI=1S/C22H27N5O/c28-20-16-8-7-15(21-23-25-26-24-21)12-18(16)22-9-2-1-6-17(22)19(20)27(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H,23,24,25,26)/t17-,19-,22+/m0/s1
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 230n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138004
PNG
(3-Hydroxy-10-keto-N-cyclopropylmethylmorphinan | C...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H25NO2/c22-14-6-7-15-17(11-14)20-8-2-1-3-16(20)18(19(15)23)21(10-9-20)12-13-4-5-13/h6-7,11,13,16,18,22H,1-5,8-10,12H2/t16-,18-,20+/m0/s1
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 240n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138015
PNG
(3-Hydroxy-10-keto-N-(2-fluoroethyl)morphinan | CHE...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCF)c2c1
Show InChI InChI=1S/C18H22FNO2/c19-8-10-20-9-7-18-6-2-1-3-14(18)16(20)17(22)13-5-4-12(21)11-15(13)18/h4-5,11,14,16,21H,1-3,6-10H2/t14-,16-,18+/m0/s1
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 250n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137990
PNG
(3-Hydroxy-10-keto-N-cyclobutylmethylmorphinan | CH...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H27NO2/c23-15-7-8-16-18(12-15)21-9-2-1-6-17(21)19(20(16)24)22(11-10-21)13-14-4-3-5-14/h7-8,12,14,17,19,23H,1-6,9-11,13H2/t17-,19-,21+/m0/s1
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 260n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137995
PNG
(3-O-Cyclobutylmethyl-10-keto-N-cyclobutylmethylmor...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(OCC3CCC3)ccc12
Show InChI InChI=1S/C26H35NO2/c28-25-21-11-10-20(29-17-19-7-4-8-19)15-23(21)26-12-2-1-9-22(26)24(25)27(14-13-26)16-18-5-3-6-18/h10-11,15,18-19,22,24H,1-9,12-14,16-17H2/t22-,24-,26+/m0/s1
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 290n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137987
PNG
(3-Tetrazolo-10-keto-N-cyclobutylmethylmorphinan | ...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(ccc12)-c1nnn[nH]1
Show InChI InChI=1S/C22H27N5O/c28-20-16-8-7-15(21-23-25-26-24-21)12-18(16)22-9-2-1-6-17(22)19(20)27(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H,23,24,25,26)/t17-,19-,22+/m0/s1
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 360n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137998
PNG
(3-Benzylamino-10-keto-N-cyclobutylmethylmorphinan ...)
Show SMILES O=C(Nc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1)c1ccccc1
Show InChI InChI=1S/C28H32N2O2/c31-26-22-13-12-21(29-27(32)20-9-2-1-3-10-20)17-24(22)28-14-5-4-11-23(28)25(26)30(16-15-28)18-19-7-6-8-19/h1-3,9-10,12-13,17,19,23,25H,4-8,11,14-16,18H2,(H,29,32)/t23-,25-,28+/m0/s1
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 380n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137993
PNG
(3-(1'H-Tetrazol-5'-yl)-N-methylmorphinan | CHEMBL2...)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)-c1nnn[nH]1
Show InChI InChI=1S/C18H23N5/c1-23-9-8-18-7-3-2-4-14(18)16(23)11-12-5-6-13(10-15(12)18)17-19-21-22-20-17/h5-6,10,14,16H,2-4,7-9,11H2,1H3,(H,19,20,21,22)/t14-,16+,18+/m0/s1
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 380n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137993
PNG
(3-(1'H-Tetrazol-5'-yl)-N-methylmorphinan | CHEMBL2...)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)-c1nnn[nH]1
Show InChI InChI=1S/C18H23N5/c1-23-9-8-18-7-3-2-4-14(18)16(23)11-12-5-6-13(10-15(12)18)17-19-21-22-20-17/h5-6,10,14,16H,2-4,7-9,11H2,1H3,(H,19,20,21,22)/t14-,16+,18+/m0/s1
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 380n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138012
PNG
(3-Methoxy normorphinan | CHEMBL297467)
Show SMILES COc1ccc2C(=O)[C@H]3NCC[C@@]4(CCCC[C@@H]34)c2c1
Show InChI InChI=1S/C17H21NO2/c1-20-11-5-6-12-14(10-11)17-7-3-2-4-13(17)15(16(12)19)18-9-8-17/h5-6,10,13,15,18H,2-4,7-9H2,1H3/t13-,15-,17+/m0/s1
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 390n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138017
PNG
(3-Cyano-10-keto-N-cyclobutylmethylmorphinan | CHEM...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(ccc12)C#N
Show InChI InChI=1S/C22H26N2O/c23-13-16-7-8-17-19(12-16)22-9-2-1-6-18(22)20(21(17)25)24(11-10-22)14-15-4-3-5-15/h7-8,12,15,18,20H,1-6,9-11,14H2/t18-,20-,22+/m0/s1
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 400n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138016
PNG
(3-Aminomethyl-N-cyclobutylmethylmorphinan | CHEMBL...)
Show SMILES NCc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H32N2/c23-14-17-7-8-18-13-21-19-6-1-2-9-22(19,20(18)12-17)10-11-24(21)15-16-4-3-5-16/h7-8,12,16,19,21H,1-6,9-11,13-15,23H2/t19-,21+,22+/m0/s1
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 410n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50137991
PNG
(3-O-Propargyl-10-keto-N-propargylmorphinan | CHEMB...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC#C)c2cc(OCC#C)ccc12
Show InChI InChI=1S/C22H23NO2/c1-3-12-23-13-11-22-10-6-5-7-18(22)20(23)21(24)17-9-8-16(15-19(17)22)25-14-4-2/h1-2,8-9,15,18,20H,5-7,10-14H2/t18-,20-,22+/m0/s1
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 500n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138015
PNG
(3-Hydroxy-10-keto-N-(2-fluoroethyl)morphinan | CHE...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCF)c2c1
Show InChI InChI=1S/C18H22FNO2/c19-8-10-20-9-7-18-6-2-1-3-14(18)16(20)17(22)13-5-4-12(21)11-15(13)18/h4-5,11,14,16,21H,1-3,6-10H2/t14-,16-,18+/m0/s1
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 560n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138008
PNG
(3-Amino-10-keto-N-cyclobutylmethylmorphinan | CHEM...)
Show SMILES Nc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C21H28N2O/c22-15-7-8-16-18(12-15)21-9-2-1-6-17(21)19(20(16)24)23(11-10-21)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13,22H2/t17-,19-,21+/m0/s1
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 600n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137986
PNG
(3-Hydroxy-10-keto-N-(3-fluoropropyl)morphinan | CH...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCCF)c2c1
Show InChI InChI=1S/C19H24FNO2/c20-9-3-10-21-11-8-19-7-2-1-4-15(19)17(21)18(23)14-6-5-13(22)12-16(14)19/h5-6,12,15,17,22H,1-4,7-11H2/t15-,17-,19+/m0/s1
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 690n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137991
PNG
(3-O-Propargyl-10-keto-N-propargylmorphinan | CHEMB...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC#C)c2cc(OCC#C)ccc12
Show InChI InChI=1S/C22H23NO2/c1-3-12-23-13-11-22-10-6-5-7-18(22)20(23)21(24)17-9-8-16(15-19(17)22)25-14-4-2/h1-2,8-9,15,18,20H,5-7,10-14H2/t18-,20-,22+/m0/s1
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 710n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138009
PNG
(3-Hydroxy-10-keto-N-(2-naphthylmethyl)morphinan | ...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3Cc3ccc4ccccc4c3)c2c1
Show InChI InChI=1S/C27H27NO2/c29-21-10-11-22-24(16-21)27-12-4-3-7-23(27)25(26(22)30)28(14-13-27)17-18-8-9-19-5-1-2-6-20(19)15-18/h1-2,5-6,8-11,15-16,23,25,29H,3-4,7,12-14,17H2/t23-,25-,27+/m0/s1
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 780n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50137995
PNG
(3-O-Cyclobutylmethyl-10-keto-N-cyclobutylmethylmor...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(OCC3CCC3)ccc12
Show InChI InChI=1S/C26H35NO2/c28-25-21-11-10-20(29-17-19-7-4-8-19)15-23(21)26-12-2-1-9-22(26)24(25)27(14-13-26)16-18-5-3-6-18/h10-11,15,18-19,22,24H,1-9,12-14,16-17H2/t22-,24-,26+/m0/s1
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 800n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138005
PNG
(3-Carboxyl-10-keto-N-cyclobutylmethyl morphinan | ...)
Show SMILES OC(=O)c1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H27NO3/c24-20-16-8-7-15(21(25)26)12-18(16)22-9-2-1-6-17(22)19(20)23(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H,25,26)/t17-,19-,22+/m0/s1
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 800n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50138018
PNG
(3-(1'H-Tetrazol-5'-yl)-N-cyclobutylmethylmorphinan...)
Show SMILES C(C1CCC1)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)-c1nnn[nH]1
Show InChI InChI=1S/C22H29N5/c1-2-9-22-10-11-27(14-15-4-3-5-15)20(18(22)6-1)13-16-7-8-17(12-19(16)22)21-23-25-26-24-21/h7-8,12,15,18,20H,1-6,9-11,13-14H2,(H,23,24,25,26)/t18-,20+,22+/m0/s1
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 850n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137999
PNG
(3-Cyano-N-methylmorphinan | CHEMBL296304)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)C#N
Show InChI InChI=1S/C18H22N2/c1-20-9-8-18-7-3-2-4-15(18)17(20)11-14-6-5-13(12-19)10-16(14)18/h5-6,10,15,17H,2-4,7-9,11H2,1H3/t15-,17+,18+/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138002
PNG
(3-Hydroxy-10-keto-N-(3,3-dimethylallyl)morphinan |...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6][C@]23[#6]-[#6]-[#6]-[#6]-[#6@H]2-[#6@H]-1-[#6](=O)-c1ccc(-[#8])cc31
Show InChI InChI=1S/C21H27NO2/c1-14(2)8-11-22-12-10-21-9-4-3-5-17(21)19(22)20(24)16-7-6-15(23)13-18(16)21/h6-8,13,17,19,23H,3-5,9-12H2,1-2H3/t17-,19-,21+/m0/s1
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 1.10E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138018
PNG
(3-(1'H-Tetrazol-5'-yl)-N-cyclobutylmethylmorphinan...)
Show SMILES C(C1CCC1)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)-c1nnn[nH]1
Show InChI InChI=1S/C22H29N5/c1-2-9-22-10-11-27(14-15-4-3-5-15)20(18(22)6-1)13-16-7-8-17(12-19(16)22)21-23-25-26-24-21/h7-8,12,15,18,20H,1-6,9-11,13-14H2,(H,23,24,25,26)/t18-,20+,22+/m0/s1
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 1.10E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137988
PNG
(3-Hydroxy-10-keto-N-methylmorphinan | CHEMBL432120)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1C(=O)c1ccc(O)cc31
Show InChI InChI=1S/C17H21NO2/c1-18-9-8-17-7-3-2-4-13(17)15(18)16(20)12-6-5-11(19)10-14(12)17/h5-6,10,13,15,19H,2-4,7-9H2,1H3/t13-,15-,17+/m0/s1
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 1.20E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138010
PNG
(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(N)cc31
Show InChI InChI=1S/C17H24N2/c1-19-9-8-17-7-3-2-4-14(17)16(19)10-12-5-6-13(18)11-15(12)17/h5-6,11,14,16H,2-4,7-10,18H2,1H3/t14-,16+,17+/m0/s1
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 1.50E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137987
PNG
(3-Tetrazolo-10-keto-N-cyclobutylmethylmorphinan | ...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(ccc12)-c1nnn[nH]1
Show InChI InChI=1S/C22H27N5O/c28-20-16-8-7-15(21-23-25-26-24-21)12-18(16)22-9-2-1-6-17(22)19(20)27(11-10-22)13-14-4-3-5-14/h7-8,12,14,17,19H,1-6,9-11,13H2,(H,23,24,25,26)/t17-,19-,22+/m0/s1
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 1.80E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138001
PNG
(3-Cyano-N-cyclobutylmethylmorphinan | CHEMBL48157)
Show SMILES N#Cc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Show InChI InChI=1S/C22H28N2/c23-14-17-7-8-18-13-21-19-6-1-2-9-22(19,20(18)12-17)10-11-24(21)15-16-4-3-5-16/h7-8,12,16,19,21H,1-6,9-11,13,15H2/t19-,21+,22+/m0/s1
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 1.90E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138017
PNG
(3-Cyano-10-keto-N-cyclobutylmethylmorphinan | CHEM...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(ccc12)C#N
Show InChI InChI=1S/C22H26N2O/c23-13-16-7-8-17-19(12-16)22-9-2-1-6-18(22)20(21(17)25)24(11-10-22)14-15-4-3-5-15/h7-8,12,15,18,20H,1-6,9-11,14H2/t18-,20-,22+/m0/s1
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 2.20E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50138009
PNG
(3-Hydroxy-10-keto-N-(2-naphthylmethyl)morphinan | ...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3Cc3ccc4ccccc4c3)c2c1
Show InChI InChI=1S/C27H27NO2/c29-21-10-11-22-24(16-21)27-12-4-3-7-23(27)25(26(22)30)28(14-13-27)17-18-8-9-19-5-1-2-6-20(19)15-18/h1-2,5-6,8-11,15-16,23,25,29H,3-4,7,12-14,17H2/t23-,25-,27+/m0/s1
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 2.20E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138003
PNG
(3-Hydroxy-10-keto-N-propargylmorphinan | CHEMBL298...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC#C)c2c1
Show InChI InChI=1S/C19H21NO2/c1-2-10-20-11-9-19-8-4-3-5-15(19)17(20)18(22)14-7-6-13(21)12-16(14)19/h1,6-7,12,15,17,21H,3-5,8-11H2/t15-,17-,19+/m0/s1
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 2.30E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138000
PNG
(3-Aminomethyl-N-methylmorphinan | CHEMBL49318)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(CN)cc31
Show InChI InChI=1S/C18H26N2/c1-20-9-8-18-7-3-2-4-15(18)17(20)11-14-6-5-13(12-19)10-16(14)18/h5-6,10,15,17H,2-4,7-9,11-12,19H2,1H3/t15-,17+,18+/m0/s1
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 2.50E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138015
PNG
(3-Hydroxy-10-keto-N-(2-fluoroethyl)morphinan | CHE...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3CCF)c2c1
Show InChI InChI=1S/C18H22FNO2/c19-8-10-20-9-7-18-6-2-1-3-14(18)16(20)17(22)13-5-4-12(21)11-15(13)18/h4-5,11,14,16,21H,1-3,6-10H2/t14-,16-,18+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137992
PNG
(3-Hydroxy-10-keto-N-(2-methoxyethyl)morphinan | CH...)
Show SMILES COCCN1CC[C@]23CCCC[C@H]2[C@H]1C(=O)c1ccc(O)cc31
Show InChI InChI=1S/C19H25NO3/c1-23-11-10-20-9-8-19-7-3-2-4-15(19)17(20)18(22)14-6-5-13(21)12-16(14)19/h5-6,12,15,17,21H,2-4,7-11H2,1H3/t15-,17-,19+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137995
PNG
(3-O-Cyclobutylmethyl-10-keto-N-cyclobutylmethylmor...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(OCC3CCC3)ccc12
Show InChI InChI=1S/C26H35NO2/c28-25-21-11-10-20(29-17-19-7-4-8-19)15-23(21)26-12-2-1-9-22(26)24(25)27(14-13-26)16-18-5-3-6-18/h10-11,15,18-19,22,24H,1-9,12-14,16-17H2/t22-,24-,26+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137991
PNG
(3-O-Propargyl-10-keto-N-propargylmorphinan | CHEMB...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC#C)c2cc(OCC#C)ccc12
Show InChI InChI=1S/C22H23NO2/c1-3-12-23-13-11-22-10-6-5-7-18(22)20(23)21(24)17-9-8-16(15-19(17)22)25-14-4-2/h1-2,8-9,15,18,20H,5-7,10-14H2/t18-,20-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50137993
PNG
(3-(1'H-Tetrazol-5'-yl)-N-methylmorphinan | CHEMBL2...)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)-c1nnn[nH]1
Show InChI InChI=1S/C18H23N5/c1-23-9-8-18-7-3-2-4-14(18)16(23)11-12-5-6-13(10-15(12)18)17-19-21-22-20-17/h5-6,10,14,16H,2-4,7-9,11H2,1H3,(H,19,20,21,22)/t14-,16+,18+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138006
PNG
(3-hydroxy-normorphinan | CHEMBL48936)
Show SMILES Oc1ccc2C(=O)[C@H]3NCC[C@@]4(CCCC[C@@H]34)c2c1
Show InChI InChI=1S/C16H19NO2/c18-10-4-5-11-13(9-10)16-6-2-1-3-12(16)14(15(11)19)17-8-7-16/h4-5,9,12,14,17-18H,1-3,6-8H2/t12-,14-,16+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138017
PNG
(3-Cyano-10-keto-N-cyclobutylmethylmorphinan | CHEM...)
Show SMILES O=C1[C@@H]2[C@@H]3CCCC[C@]3(CCN2CC2CCC2)c2cc(ccc12)C#N
Show InChI InChI=1S/C22H26N2O/c23-13-16-7-8-17-19(12-16)22-9-2-1-6-18(22)20(21(17)25)24(11-10-22)14-15-4-3-5-15/h7-8,12,15,18,20H,1-6,9-11,14H2/t18-,20-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138018
PNG
(3-(1'H-Tetrazol-5'-yl)-N-cyclobutylmethylmorphinan...)
Show SMILES C(C1CCC1)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(cc31)-c1nnn[nH]1
Show InChI InChI=1S/C22H29N5/c1-2-9-22-10-11-27(14-15-4-3-5-15)20(18(22)6-1)13-16-7-8-17(12-19(16)22)21-23-25-26-24-21/h7-8,12,15,18,20H,1-6,9-11,13-14H2,(H,23,24,25,26)/t18-,20+,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50138009
PNG
(3-Hydroxy-10-keto-N-(2-naphthylmethyl)morphinan | ...)
Show SMILES Oc1ccc2C(=O)[C@@H]3[C@@H]4CCCC[C@]4(CCN3Cc3ccc4ccccc4c3)c2c1
Show InChI InChI=1S/C27H27NO2/c29-21-10-11-22-24(16-21)27-12-4-3-7-23(27)25(26(22)30)28(14-13-27)17-18-8-9-19-5-1-2-6-20(19)15-18/h1-2,5-6,8-11,15-16,23,25,29H,3-4,7,12-14,17H2/t23-,25-,27+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes.

J Med Chem 47: 165-74 (2003)


Article DOI: 10.1021/jm0304156
BindingDB Entry DOI: 10.7270/Q2KD1XB2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%