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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 2.20 | -49.4 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Vertex | Assay Description Assays were performed for the Itk enzyme containing residues 357-620, and an Itk enzyme containing the catalytic kinase domain and the TH and SH2 dom... | J Biol Chem 279: 18727-32 (2004) Article DOI: 10.1074/jbc.M400031200 BindingDB Entry DOI: 10.7270/Q2ZK5F0F | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | <10 | <-45.7 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Vertex | Assay Description Assays were performed for the Itk enzyme containing residues 357-620, and an Itk enzyme containing the catalytic kinase domain and the TH and SH2 dom... | J Biol Chem 279: 18727-32 (2004) Article DOI: 10.1074/jbc.M400031200 BindingDB Entry DOI: 10.7270/Q2ZK5F0F | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
