Found 15 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223948
(CHEMBL283443)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OC2Cc3ccccc3C2)c1)C(=O)NO Show InChI InChI=1S/C26H28N2O4/c1-31-23-7-6-21(12-24(23)32-22-10-16-4-2-3-5-17(16)11-22)26(15-27)13-19-8-18(25(29)28-30)9-20(19)14-26/h2-7,12,18-20,22,30H,8-11,13-14H2,1H3,(H,28,29)/t18-,19-,20+,26- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223945
(CHEMBL264369)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OC2Cc3ccccc3C2)c1)C(O)=O Show InChI InChI=1S/C26H27NO4/c1-30-23-7-6-21(12-24(23)31-22-10-16-4-2-3-5-17(16)11-22)26(15-27)13-19-8-18(25(28)29)9-20(19)14-26/h2-7,12,18-20,22H,8-11,13-14H2,1H3,(H,28,29)/t18-,19-,20+,26- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223953
(CHEMBL27107)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OC2CCCC2)c1)C(O)=O |r| Show InChI InChI=1S/C22H27NO4/c1-26-19-7-6-17(10-20(19)27-18-4-2-3-5-18)22(13-23)11-15-8-14(21(24)25)9-16(15)12-22/h6-7,10,14-16,18H,2-5,8-9,11-12H2,1H3,(H,24,25)/t14-,15-,16+,22- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223950
(CHEMBL280611)Show SMILES [H][C@@]1(C[C@@]2([H])C[C@](C[C@@]2([H])C1)(C#N)c1ccc(OC)c(OC2CCCC2)c1)C(=O)NO Show InChI InChI=1S/C22H28N2O4/c1-27-19-7-6-17(10-20(19)28-18-4-2-3-5-18)22(13-23)11-15-8-14(21(25)24-26)9-16(15)12-22/h6-7,10,14-16,18,26H,2-5,8-9,11-12H2,1H3,(H,24,25)/t14-,15-,16+,22- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50346088
((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N |r,wU:17.22,14.25,(4.79,2.97,;3.46,3.74,;2.12,2.97,;.79,3.74,;-.54,2.97,;-.54,1.43,;.79,.66,;2.12,1.43,;3.46,.66,;3.46,-.88,;4.7,-1.79,;4.23,-3.25,;2.69,-3.25,;2.21,-1.79,;-1.88,.66,;-3.42,.71,;-4.23,-.6,;-3.51,-1.96,;-1.97,-2.01,;-1.16,-.7,;-4.33,-3.26,;-3.6,-4.62,;-5.87,-3.21,;-1.77,2.19,;-1.66,3.73,)| Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223955
(CHEMBL24839)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OC(C)C)c1)C(=O)NO Show InChI InChI=1S/C20H26N2O4/c1-12(2)26-18-8-16(4-5-17(18)25-3)20(11-21)9-14-6-13(19(23)22-24)7-15(14)10-20/h4-5,8,12-15,24H,6-7,9-10H2,1-3H3,(H,22,23)/t13-,14-,15+,20- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223943
(CHEMBL27500)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OCC)c1)C(O)=O Show InChI InChI=1S/C19H23NO4/c1-3-24-17-8-15(4-5-16(17)23-2)19(11-20)9-13-6-12(18(21)22)7-14(13)10-19/h4-5,8,12-14H,3,6-7,9-10H2,1-2H3,(H,21,22)/t12-,13-,14+,19- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223944
(CHEMBL284867)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OCC2CC2)c1)C(=O)NO Show InChI InChI=1S/C21H26N2O4/c1-26-18-5-4-17(8-19(18)27-11-13-2-3-13)21(12-22)9-15-6-14(20(24)23-25)7-16(15)10-21/h4-5,8,13-16,25H,2-3,6-7,9-11H2,1H3,(H,23,24)/t14-,15-,16+,21- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223942
(CHEMBL27764)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OC)c1)C(=O)NO Show InChI InChI=1S/C18H22N2O4/c1-23-15-4-3-14(7-16(15)24-2)18(10-19)8-12-5-11(17(21)20-22)6-13(12)9-18/h3-4,7,11-13,22H,5-6,8-9H2,1-2H3,(H,20,21)/t11-,12-,13+,18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223947
(CHEMBL26767)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OC(C)C)c1)C(O)=O Show InChI InChI=1S/C20H25NO4/c1-12(2)25-18-8-16(4-5-17(18)24-3)20(11-21)9-14-6-13(19(22)23)7-15(14)10-20/h4-5,8,12-15H,6-7,9-10H2,1-3H3,(H,22,23)/t13-,14-,15+,20- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223946
(CHEMBL269289)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OCC2CC2)c1)C(O)=O Show InChI InChI=1S/C21H25NO4/c1-25-18-5-4-17(8-19(18)26-11-13-2-3-13)21(12-22)9-15-6-14(20(23)24)7-16(15)10-21/h4-5,8,13-16H,2-3,6-7,9-11H2,1H3,(H,23,24)/t14-,15-,16+,21- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223952
(CHEMBL27222)Show SMILES [H][C@]1(C[C@@]2([H])C[C@](C[C@@]2([H])C1)(C#N)c1ccc(OC)c(OC2CCCC2)c1)C(O)=O Show InChI InChI=1S/C22H27NO4/c1-26-19-7-6-17(10-20(19)27-18-4-2-3-5-18)22(13-23)11-15-8-14(21(24)25)9-16(15)12-22/h6-7,10,14-16,18H,2-5,8-9,11-12H2,1H3,(H,24,25)/t14-,15+,16-,22+ | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223949
(CHEMBL27724)Show SMILES [H][C@@]12C[C@@H](C[C@]1([H])C[C@@](C2)(C#N)c1ccc(OC)c(OC)c1)C(O)=O Show InChI InChI=1S/C18H21NO4/c1-22-15-4-3-14(7-16(15)23-2)18(10-19)8-12-5-11(17(20)21)6-13(12)9-18/h3-4,7,11-13H,5-6,8-9H2,1-2H3,(H,20,21)/t11-,12-,13+,18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223951
(CHEMBL26760)Show SMILES [H][C@@]1(C[C@@]2([H])C[C@@](C[C@@]2([H])C1)(C#N)c1ccc(OC)c(OC2CCCC2)c1)C(O)=O Show InChI InChI=1S/C22H27NO4/c1-26-19-7-6-17(10-20(19)27-18-4-2-3-5-18)22(13-23)11-15-8-14(21(24)25)9-16(15)12-22/h6-7,10,14-16,18H,2-5,8-9,11-12H2,1H3,(H,24,25)/t14-,15-,16+,22+ | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223954
(CHEMBL26993)Show SMILES [H][C@]1(C[C@@]2([H])C[C@@](C[C@@]2([H])C1)(C#N)c1ccc(OC)c(OC2CCCC2)c1)C(O)=O Show InChI InChI=1S/C22H27NO4/c1-26-19-7-6-17(10-20(19)27-18-4-2-3-5-18)22(13-23)11-15-8-14(21(24)25)9-16(15)12-22/h6-7,10,14-16,18H,2-5,8-9,11-12H2,1H3,(H,24,25)/t14-,15+,16-,22- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4 from U937 monocytic cells |
Bioorg Med Chem Lett 14: 1323-7 (2004)
BindingDB Entry DOI: 10.7270/Q2BR8VCM |
More data for this Ligand-Target Pair | |