Found 68 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141020
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(I)cc2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O)C(N)=O Show InChI InChI=1S/C51H68IN13O10S2/c1-26(66)39(42(54)68)63-49(75)41-51(3,4)77-76-25-38(62-43(69)33(53)21-28-11-6-5-7-12-28)47(73)60-36(22-29-16-18-31(52)19-17-29)45(71)61-37(23-30-24-58-34-14-9-8-13-32(30)34)46(72)59-35(15-10-20-57-50(55)56)44(70)64-40(27(2)67)48(74)65-41/h5-9,11-14,16-19,24,26-27,33,35-41,58,66-67H,10,15,20-23,25,53H2,1-4H3,(H2,54,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74)(H4,55,56,57)/t26-,27-,33-,35+,36+,37+,38+,39+,40-,41+/m1/s1 | PDB
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibition of 1 nM alpha melanocortin stimulating hormone (MSH) from frog skin |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141037
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O Show InChI InChI=1S/C58H72N14O9S2/c1-32(73)47(49(60)74)71-56(81)48-58(2,3)83-82-31-46(70-50(75)39(59)25-33-15-6-4-7-16-33)55(80)67-43(26-34-17-8-5-9-18-34)52(77)69-44(27-35-29-64-40-21-12-10-19-37(35)40)53(78)66-42(23-14-24-63-57(61)62)51(76)68-45(54(79)72-48)28-36-30-65-41-22-13-11-20-38(36)41/h4-13,15-22,29-30,32,39,42-48,64-65,73H,14,23-28,31,59H2,1-3H3,(H2,60,74)(H,66,78)(H,67,80)(H,68,76)(H,69,77)(H,70,75)(H,71,81)(H,72,79)(H4,61,62,63)/t32-,39-,42+,43+,44+,45-,46+,47+,48+/m1/s1 | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibition of 1 nM alpha melanocortin stimulating hormone (MSH) from frog skin |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141025
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]([C@@H](C)O)C(=O)N1)C(N)=O Show InChI InChI=1S/C49H64IN13O10S2/c1-25(64)39(41(52)66)62-47(72)38-24-75-74-23-37(60-42(67)32(51)19-27-9-4-3-5-10-27)46(71)58-35(20-28-14-16-30(50)17-15-28)44(69)59-36(21-29-22-56-33-12-7-6-11-31(29)33)45(70)57-34(13-8-18-55-49(53)54)43(68)63-40(26(2)65)48(73)61-38/h3-7,9-12,14-17,22,25-26,32,34-40,56,64-65H,8,13,18-21,23-24,51H2,1-2H3,(H2,52,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,73)(H,62,72)(H,63,68)(H4,53,54,55)/t25-,26-,32-,34+,35-,36+,37+,38-,39+,40-/m1/s1 | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibition of 1 nM alpha melanocortin stimulating hormone (MSH) from frog skin |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141039
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]([C@@H](C)O)C(=O)N1)C(N)=O Show InChI InChI=1S/C49H65N13O11S2/c1-25(63)39(41(51)66)61-47(72)38-24-75-74-23-37(59-42(67)32(50)19-27-9-4-3-5-10-27)46(71)57-35(20-28-14-16-30(65)17-15-28)44(69)58-36(21-29-22-55-33-12-7-6-11-31(29)33)45(70)56-34(13-8-18-54-49(52)53)43(68)62-40(26(2)64)48(73)60-38/h3-7,9-12,14-17,22,25-26,32,34-40,55,63-65H,8,13,18-21,23-24,50H2,1-2H3,(H2,51,66)(H,56,70)(H,57,71)(H,58,69)(H,59,67)(H,60,73)(H,61,72)(H,62,68)(H4,52,53,54)/t25-,26-,32-,34+,35+,36+,37+,38-,39+,40-/m1/s1 | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibition of 1 nM alpha melanocortin stimulating hormone (MSH) from frog skin |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141036
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O Show InChI InChI=1S/C50H67N13O11S2/c1-26(65)39(41(52)67)62-48(74)40-50(2,3)76-75-25-38(61-42(68)32(51)20-27-10-5-4-6-11-27)47(73)58-35(21-28-15-17-30(66)18-16-28)44(70)59-36(22-29-23-56-33-13-8-7-12-31(29)33)45(71)57-34(14-9-19-55-49(53)54)43(69)60-37(24-64)46(72)63-40/h4-8,10-13,15-18,23,26,32,34-40,56,64-66H,9,14,19-22,24-25,51H2,1-3H3,(H2,52,67)(H,57,71)(H,58,73)(H,59,70)(H,60,69)(H,61,68)(H,62,74)(H,63,72)(H4,53,54,55)/t26-,32-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibition of 1 nM alpha melanocortin stimulating hormone (MSH) from frog skin |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141042
((2R,3S)-2-{[(3S,6R,9S,14R,17S)-14-[(2S)-2-amino-3-...)Show SMILES [H][C@@]12Cc3ccccc3CN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCN=C(N)N)NC2=O)C(=O)N[C@H]([C@H](C)O)C(N)=O)NC(=O)[C@@H](N)Cc1ccccc1 |wU:28.62,13.15,70.76,46.51,wD:60.65,23.72,32.35,61.68,1.0,(10.8,.31,;9.63,-1.14,;9.63,.4,;8.29,1.16,;8.29,2.72,;6.95,3.49,;5.62,2.72,;5.62,1.16,;6.95,.4,;6.95,-1.14,;8.29,-1.91,;7.25,-3.06,;5.97,-2.21,;6.64,-4.46,;5.15,-4.06,;4.05,-2.97,;4.29,-1.43,;2.91,-.73,;1.82,-1.82,;2.52,-3.21,;6.47,-5.99,;6.8,-7.51,;5.34,-8.04,;7.55,-8.83,;8.71,-9.86,;10.12,-10.49,;11.65,-10.65,;13.14,-10.34,;14.49,-9.56,;15.52,-8.42,;16.15,-7.01,;17.64,-7.41,;16.31,-5.48,;17.85,-5.4,;18.69,-6.69,;20.22,-6.78,;20.62,-8.27,;19.33,-9.11,;19.08,-10.62,;17.65,-11.18,;16.45,-10.2,;16.7,-8.69,;18.13,-8.13,;15.99,-3.97,;15.22,-2.64,;16.4,-1.66,;14.08,-1.61,;14.91,-.31,;16.45,-.4,;17.29,.9,;18.83,.82,;19.67,2.11,;21.2,2.03,;18.97,3.49,;12.67,-.98,;11.13,-.82,;11.05,.71,;14.47,-11.09,;13.14,-11.85,;15.8,-11.88,;15.78,-13.42,;17.3,-13.62,;18.24,-12.45,;17.89,-15.01,;14.84,-14.59,;15.42,-15.98,;13.31,-14.38,;6.37,-9.81,;6.6,-11.33,;8.04,-11.89,;5.4,-12.31,;5.64,-13.82,;3.97,-11.75,;3.73,-10.23,;4.92,-9.25,;4.67,-7.73,;3.25,-7.18,;2.05,-8.15,;2.29,-9.67,)| Show InChI InChI=1S/C52H65N15O9S2/c1-28(68)43(44(54)69)66-49(74)41-26-78-77-25-40(64-45(70)35(53)18-29-10-3-2-4-11-29)48(73)63-39(21-33-23-57-27-60-33)51(76)67-24-31-13-6-5-12-30(31)20-42(67)50(75)61-37(16-9-17-58-52(55)56)46(71)62-38(47(72)65-41)19-32-22-59-36-15-8-7-14-34(32)36/h2-8,10-15,22-23,27-28,35,37-43,59,68H,9,16-21,24-26,53H2,1H3,(H2,54,69)(H,57,60)(H,61,75)(H,62,71)(H,63,73)(H,64,70)(H,65,72)(H,66,74)(H4,55,56,58)/t28-,35-,37-,38+,39-,40-,41+,42?,43+/m0/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibition of 1 nM alpha melanocortin stimulating hormone (MSH) from frog skin |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141024
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O |wU:7.6,36.38,50.54,25.27,wD:3.3,62.74,11.11,72.78,1.1,(15.11,-14.87,;16.5,-14.15,;17.78,-14.99,;16.57,-12.62,;15.27,-11.78,;13.9,-12.48,;13.83,-14.01,;12.62,-11.64,;13.25,-10.25,;13.4,-8.71,;14.95,-8.63,;13.08,-7.2,;14.52,-6.65,;14.91,-5.17,;14.43,-3.7,;15.67,-2.78,;16.92,-3.68,;18.41,-3.36,;19.46,-4.5,;18.99,-5.96,;17.48,-6.29,;16.45,-5.15,;12.32,-5.87,;11.17,-4.84,;12.01,-3.54,;9.76,-4.22,;10.17,-2.73,;11.64,-2.33,;12.04,-.85,;13.54,-.44,;13.94,1.04,;15.41,1.44,;12.85,2.13,;8.24,-4.06,;6.73,-4.37,;6.17,-2.94,;5.4,-5.14,;4.42,-3.94,;4.98,-2.51,;4.14,-1.22,;5.1,-.02,;6.55,-.57,;7.92,.13,;9.21,-.71,;9.13,-2.24,;7.76,-2.95,;6.47,-2.12,;4.36,-6.29,;3.73,-7.69,;2.26,-7.29,;3.58,-9.22,;2.05,-9.31,;1.19,-8.01,;1.89,-6.64,;1.05,-5.35,;-.48,-5.43,;-1.32,-4.15,;-1.18,-6.8,;-.34,-8.1,;3.89,-10.73,;4.66,-12.06,;3.47,-13.03,;5.8,-13.08,;7.22,-13.71,;8.75,-13.87,;10.26,-13.56,;11.59,-12.78,;11.83,-14.32,;13.03,-13.34,;4.96,-14.39,;5.68,-15.76,;7.21,-15.83,;4.84,-17.04,;5.54,-18.41,;3.29,-16.97,;2.59,-15.6,;1.05,-15.52,;.36,-14.13,;1.19,-12.85,;2.73,-12.94,;3.43,-14.31,;17.94,-11.92,;19.23,-12.76,;18.02,-10.38,)| Show InChI InChI=1S/C58H72N14O10S2/c1-31(73)47(49(60)75)71-56(82)48-58(2,3)84-83-30-46(70-50(76)39(59)24-32-12-5-4-6-13-32)55(81)67-43(25-33-19-21-36(74)22-20-33)52(78)69-44(26-34-28-64-40-16-9-7-14-37(34)40)53(79)66-42(18-11-23-63-57(61)62)51(77)68-45(54(80)72-48)27-35-29-65-41-17-10-8-15-38(35)41/h4-10,12-17,19-22,28-29,31,39,42-48,64-65,73-74H,11,18,23-27,30,59H2,1-3H3,(H2,60,75)(H,66,79)(H,67,81)(H,68,77)(H,69,78)(H,70,76)(H,71,82)(H,72,80)(H4,61,62,63)/t31-,39-,42+,43+,44+,45-,46+,47+,48?/m1/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibition of 1 nM alpha melanocortin stimulating hormone (MSH) from frog skin |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141032
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O Show InChI InChI=1S/C58H72N14O9S2/c1-32(73)47(49(60)74)71-56(81)48-58(2,3)83-82-31-46(70-50(75)39(59)25-33-15-6-4-7-16-33)55(80)67-43(26-34-17-8-5-9-18-34)52(77)69-44(27-35-29-64-40-21-12-10-19-37(35)40)53(78)66-42(23-14-24-63-57(61)62)51(76)68-45(54(79)72-48)28-36-30-65-41-22-13-11-20-38(36)41/h4-13,15-22,29-30,32,39,42-48,64-65,73H,14,23-28,31,59H2,1-3H3,(H2,60,74)(H,66,78)(H,67,80)(H,68,76)(H,69,77)(H,70,75)(H,71,81)(H,72,79)(H4,61,62,63)/t32-,39-,42+,43+,44+,45+,46+,47+,48+/m1/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibition of 1 nM alpha melanocortin stimulating hormone (MSH) from frog skin |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50017181
(CHEMBL441738)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 | KEGG
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PubMed
| n/a | n/a | n/a | n/a | 0.0460 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141034
((2S,3R)-2-{[(4S,7R,10S,13R,16S,19R)-19-[(2R)-2-ami...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ncc[nH]2)C(=O)N[C@H](Cc2cccc3ccccc23)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H67N15O9S2/c1-30(71)46(47(57)72)70-54(79)44-29-81-80-28-43(68-48(73)37(56)23-31-11-3-2-4-12-31)53(78)67-42(26-45-60-21-22-61-45)52(77)66-40(24-33-15-9-14-32-13-5-6-16-35(32)33)50(75)64-39(19-10-20-62-55(58)59)49(74)65-41(51(76)69-44)25-34-27-63-38-18-8-7-17-36(34)38/h2-9,11-18,21-22,27,30,37,39-44,46,63,71H,10,19-20,23-26,28-29,56H2,1H3,(H2,57,72)(H,60,61)(H,64,75)(H,65,74)(H,66,77)(H,67,78)(H,68,73)(H,69,76)(H,70,79)(H4,58,59,62)/t30-,37-,39+,40-,41-,42+,43+,44-,46+/m1/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50141023
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37-,38-,39-,40+,41-,42+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141028
(1N-(1-carbamoyl-2-hydroxypropyl)-16-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-29(68)43(44(54)69)67-47(72)38-18-20-77-78-27-42(66-45(70)35(53)21-30-11-4-2-5-12-30)51(76)65-41(24-33-26-57-28-60-33)50(75)63-39(22-31-13-6-3-7-14-31)48(73)61-37(17-10-19-58-52(55)56)46(71)64-40(49(74)62-38)23-32-25-59-36-16-9-8-15-34(32)36/h2-9,11-16,25-26,28-29,35,37-43,59,68H,10,17-24,27,53H2,1H3,(H2,54,69)(H,57,60)(H,61,73)(H,62,74)(H,63,75)(H,64,71)(H,65,76)(H,66,70)(H,67,72)(H4,55,56,58)/t29-,35+,37+,38-,39-,40-,41+,42+,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 75 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141029
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc(C)[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-28(68)43(44(54)69)67-51(76)42-27-78-77-26-41(65-45(70)35(53)20-30-12-5-3-6-13-30)50(75)64-40(23-33-25-58-29(2)60-33)49(74)62-38(21-31-14-7-4-8-15-31)47(72)61-37(18-11-19-57-52(55)56)46(71)63-39(48(73)66-42)22-32-24-59-36-17-10-9-16-34(32)36/h3-10,12-17,24-25,28,35,37-43,59,68H,11,18-23,26-27,53H2,1-2H3,(H2,54,69)(H,58,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,57)/t28-,35+,37+,38-,39-,40+,41+,42-,43+/m1/s1 | KEGG
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UniChem
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PubMed
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141019
(CHEMBL411400 | H-D-Phe-c[Cys-His-D-Phe-Arg-Trp-Pen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O Show InChI InChI=1S/C53H69N15O9S2/c1-29(69)42(44(55)70)67-51(77)43-53(2,3)79-78-27-41(66-45(71)35(54)21-30-13-6-4-7-14-30)50(76)65-40(24-33-26-58-28-61-33)48(74)63-38(22-31-15-8-5-9-16-31)47(73)62-37(19-12-20-59-52(56)57)46(72)64-39(49(75)68-43)23-32-25-60-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,60,69H,12,19-24,27,54H2,1-3H3,(H2,55,70)(H,58,61)(H,62,73)(H,63,74)(H,64,72)(H,65,76)(H,66,71)(H,67,77)(H,68,75)(H4,56,57,59)/t29-,35-,37+,38-,39-,40-,41+,42+,43+/m1/s1 | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141030
(1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C50H63N13O9S2/c1-29(64)43(44(53)66)62-49(71)41-27-74-73-26-40(60-45(67)35(52)19-30-11-4-2-5-12-30)48(70)58-38(22-33-24-54-28-56-33)47(69)59-39(20-31-13-6-3-7-14-31)50(72)63(18-10-17-51)25-42(65)57-37(46(68)61-41)21-32-23-55-36-16-9-8-15-34(32)36/h2-9,11-16,23-24,28-29,35,37-41,43,55,64H,10,17-22,25-27,51-52H2,1H3,(H2,53,66)(H,54,56)(H,57,65)(H,58,70)(H,59,69)(H,60,67)(H,61,68)(H,62,71)/t29-,35-,37-,38+,39+,40+,41-,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141027
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H64ClN15O9S2/c1-27(68)42(43(54)69)67-50(76)41-25-78-77-24-40(65-44(70)34(53)18-28-8-3-2-4-9-28)49(75)64-39(21-32-23-57-26-60-32)48(74)62-37(19-29-13-15-31(52)16-14-29)46(72)61-36(12-7-17-58-51(55)56)45(71)63-38(47(73)66-41)20-30-22-59-35-11-6-5-10-33(30)35/h2-6,8-11,13-16,22-23,26-27,34,36-42,59,68H,7,12,17-21,24-25,53H2,1H3,(H2,54,69)(H,57,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,58)/t27-,34+,36-,37-,38+,39-,40-,41+,42+/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141028
(1N-(1-carbamoyl-2-hydroxypropyl)-16-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-29(68)43(44(54)69)67-47(72)38-18-20-77-78-27-42(66-45(70)35(53)21-30-11-4-2-5-12-30)51(76)65-41(24-33-26-57-28-60-33)50(75)63-39(22-31-13-6-3-7-14-31)48(73)61-37(17-10-19-58-52(55)56)46(71)64-40(49(74)62-38)23-32-25-59-36-16-9-8-15-34(32)36/h2-9,11-16,25-26,28-29,35,37-43,59,68H,10,17-24,27,53H2,1H3,(H2,54,69)(H,57,60)(H,61,73)(H,62,74)(H,63,75)(H,64,71)(H,65,76)(H,66,70)(H,67,72)(H4,55,56,58)/t29-,35+,37+,38-,39-,40-,41+,42+,43+/m1/s1 | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141034
((2S,3R)-2-{[(4S,7R,10S,13R,16S,19R)-19-[(2R)-2-ami...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ncc[nH]2)C(=O)N[C@H](Cc2cccc3ccccc23)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H67N15O9S2/c1-30(71)46(47(57)72)70-54(79)44-29-81-80-28-43(68-48(73)37(56)23-31-11-3-2-4-12-31)53(78)67-42(26-45-60-21-22-61-45)52(77)66-40(24-33-15-9-14-32-13-5-6-16-35(32)33)50(75)64-39(19-10-20-62-55(58)59)49(74)65-41(51(76)69-44)25-34-27-63-38-18-8-7-17-36(34)38/h2-9,11-18,21-22,27,30,37,39-44,46,63,71H,10,19-20,23-26,28-29,56H2,1H3,(H2,57,72)(H,60,61)(H,64,75)(H,65,74)(H,66,77)(H,67,78)(H,68,73)(H,69,76)(H,70,79)(H4,58,59,62)/t30-,37-,39+,40-,41-,42+,43+,44-,46+/m1/s1 | PDB
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UniChem
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PubMed
| n/a | n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141023
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37-,38-,39-,40+,41-,42+/m1/s1 | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141019
(CHEMBL411400 | H-D-Phe-c[Cys-His-D-Phe-Arg-Trp-Pen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O Show InChI InChI=1S/C53H69N15O9S2/c1-29(69)42(44(55)70)67-51(77)43-53(2,3)79-78-27-41(66-45(71)35(54)21-30-13-6-4-7-14-30)50(76)65-40(24-33-26-58-28-61-33)48(74)63-38(22-31-15-8-5-9-16-31)47(73)62-37(19-12-20-59-52(56)57)46(72)64-39(49(75)68-43)23-32-25-60-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,60,69H,12,19-24,27,54H2,1-3H3,(H2,55,70)(H,58,61)(H,62,73)(H,63,74)(H,64,72)(H,65,76)(H,66,71)(H,67,77)(H,68,75)(H4,56,57,59)/t29-,35-,37+,38-,39-,40-,41+,42+,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141027
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H64ClN15O9S2/c1-27(68)42(43(54)69)67-50(76)41-25-78-77-24-40(65-44(70)34(53)18-28-8-3-2-4-9-28)49(75)64-39(21-32-23-57-26-60-32)48(74)62-37(19-29-13-15-31(52)16-14-29)46(72)61-36(12-7-17-58-51(55)56)45(71)63-38(47(73)66-41)20-30-22-59-35-11-6-5-10-33(30)35/h2-6,8-11,13-16,22-23,26-27,34,36-42,59,68H,7,12,17-21,24-25,53H2,1H3,(H2,54,69)(H,57,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,58)/t27-,34+,36-,37-,38+,39-,40-,41+,42+/m0/s1 | PDB
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University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141026
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37+,38-,39+,40+,41-,42+/m1/s1 | KEGG
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| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141030
(1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C50H63N13O9S2/c1-29(64)43(44(53)66)62-49(71)41-27-74-73-26-40(60-45(67)35(52)19-30-11-4-2-5-12-30)48(70)58-38(22-33-24-54-28-56-33)47(69)59-39(20-31-13-6-3-7-14-31)50(72)63(18-10-17-51)25-42(65)57-37(46(68)61-41)21-32-23-55-36-16-9-8-15-34(32)36/h2-9,11-16,23-24,28-29,35,37-41,43,55,64H,10,17-22,25-27,51-52H2,1H3,(H2,53,66)(H,54,56)(H,57,65)(H,58,70)(H,59,69)(H,60,67)(H,61,68)(H,62,71)/t29-,35-,37-,38+,39+,40+,41-,43+/m1/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141029
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc(C)[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-28(68)43(44(54)69)67-51(76)42-27-78-77-26-41(65-45(70)35(53)20-30-12-5-3-6-13-30)50(75)64-40(23-33-25-58-29(2)60-33)49(74)62-38(21-31-14-7-4-8-15-31)47(72)61-37(18-11-19-57-52(55)56)46(71)63-39(48(73)66-42)22-32-24-59-36-17-10-9-16-34(32)36/h3-10,12-17,24-25,28,35,37-43,59,68H,11,18-23,26-27,53H2,1-2H3,(H2,54,69)(H,58,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,57)/t28-,35+,37+,38-,39-,40+,41+,42-,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141026
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37+,38-,39+,40+,41-,42+/m1/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50141028
(1N-(1-carbamoyl-2-hydroxypropyl)-16-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-29(68)43(44(54)69)67-47(72)38-18-20-77-78-27-42(66-45(70)35(53)21-30-11-4-2-5-12-30)51(76)65-41(24-33-26-57-28-60-33)50(75)63-39(22-31-13-6-3-7-14-31)48(73)61-37(17-10-19-58-52(55)56)46(71)64-40(49(74)62-38)23-32-25-59-36-16-9-8-15-34(32)36/h2-9,11-16,25-26,28-29,35,37-43,59,68H,10,17-24,27,53H2,1H3,(H2,54,69)(H,57,60)(H,61,73)(H,62,74)(H,63,75)(H,64,71)(H,65,76)(H,66,70)(H,67,72)(H4,55,56,58)/t29-,35+,37+,38-,39-,40-,41+,42+,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 51 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50017181
(CHEMBL441738)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 0.0640 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141026
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37+,38-,39+,40+,41-,42+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141041
(CHEMBL407098 | H-D-Phe-c[Hcy-His-D-Phe-Arg-Trp-Cys...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1CSSCC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ncc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-29(68)43(44(54)69)67-51(76)41-28-78-77-22-18-37(61-45(70)34(53)23-30-11-4-2-5-12-30)47(72)65-40(26-42-57-20-21-58-42)50(75)63-38(24-31-13-6-3-7-14-31)48(73)62-36(17-10-19-59-52(55)56)46(71)64-39(49(74)66-41)25-32-27-60-35-16-9-8-15-33(32)35/h2-9,11-16,20-21,27,29,34,36-41,43,60,68H,10,17-19,22-26,28,53H2,1H3,(H2,54,69)(H,57,58)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H,66,74)(H,67,76)(H4,55,56,59)/t29-,34-,36+,37+,38-,39-,40+,41+,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50141026
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37+,38-,39+,40+,41-,42+/m1/s1 | PDB
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PubMed
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141021
(1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC(C)(C)[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N13O9S2/c1-29(66)42(44(55)67)64-50(73)41-27-75-76-52(2,3)43(65-45(68)35(54)21-30-13-6-4-7-14-30)51(74)62-40(24-33-26-56-28-58-33)49(72)60-38(22-31-15-8-5-9-16-31)47(70)59-37(19-12-20-53)46(69)61-39(48(71)63-41)23-32-25-57-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,57,66H,12,19-24,27,53-54H2,1-3H3,(H2,55,67)(H,56,58)(H,59,70)(H,60,72)(H,61,69)(H,62,74)(H,63,71)(H,64,73)(H,65,68)/t29-,35-,37?,38+,39-,40+,41-,42+,43-/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 59 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141033
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2cccc3ccccc23)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H67N15O9S2/c1-30(71)46(47(57)72)70-54(79)45-28-81-80-27-44(68-48(73)38(56)21-31-11-3-2-4-12-31)53(78)67-43(24-35-26-60-29-63-35)52(77)66-41(22-33-15-9-14-32-13-5-6-16-36(32)33)50(75)64-40(19-10-20-61-55(58)59)49(74)65-42(51(76)69-45)23-34-25-62-39-18-8-7-17-37(34)39/h2-9,11-18,25-26,29-30,38,40-46,62,71H,10,19-24,27-28,56H2,1H3,(H2,57,72)(H,60,63)(H,64,75)(H,65,74)(H,66,77)(H,67,78)(H,68,73)(H,69,76)(H,70,79)(H4,58,59,61)/t30-,38-,40+,41+,42-,43+,44+,45+,46+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141023
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37-,38-,39-,40+,41-,42+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141029
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc(C)[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-28(68)43(44(54)69)67-51(76)42-27-78-77-26-41(65-45(70)35(53)20-30-12-5-3-6-13-30)50(75)64-40(23-33-25-58-29(2)60-33)49(74)62-38(21-31-14-7-4-8-15-31)47(72)61-37(18-11-19-57-52(55)56)46(71)63-39(48(73)66-42)22-32-24-59-36-17-10-9-16-34(32)36/h3-10,12-17,24-25,28,35,37-43,59,68H,11,18-23,26-27,53H2,1-2H3,(H2,54,69)(H,58,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,57)/t28-,35+,37+,38-,39-,40+,41+,42-,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141018
(1N-(1-carbamoyl-2-hydroxypropyl)-7-[3-amino(imino)...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H72N16O10/c1-31(72)46(47(57)74)71-50(77)39-19-10-11-21-61-45(73)27-44(67-48(75)37(56)23-32-13-4-2-5-14-32)54(81)70-43(26-35-29-60-30-64-35)53(80)68-41(24-33-15-6-3-7-16-33)51(78)66-40(20-12-22-62-55(58)59)49(76)69-42(52(79)65-39)25-34-28-63-38-18-9-8-17-36(34)38/h2-9,13-18,28-31,37,39-44,46,63,72H,10-12,19-27,56H2,1H3,(H2,57,74)(H,60,64)(H,61,73)(H,65,79)(H,66,78)(H,67,75)(H,68,80)(H,69,76)(H,70,81)(H,71,77)(H4,58,59,62)/t31-,37+,39-,40+,41-,42-,43+,44+,46+/m1/s1 | KEGG
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| n/a | n/a | n/a | n/a | 0.0470 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141022
(1N-(1-carbamoyl-2-hydroxypropyl)-7-[3-amino(imino)...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc(C)[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C57H76N16O10/c1-32(74)48(49(59)76)73-53(80)41-20-11-12-24-62-47(75)23-22-43(67-50(77)39(58)26-34-14-5-3-6-15-34)52(79)72-46(29-37-31-64-33(2)66-37)56(83)70-44(27-35-16-7-4-8-17-35)54(81)69-42(21-13-25-63-57(60)61)51(78)71-45(55(82)68-41)28-36-30-65-40-19-10-9-18-38(36)40/h3-10,14-19,30-32,39,41-46,48,65,74H,11-13,20-29,58H2,1-2H3,(H2,59,76)(H,62,75)(H,64,66)(H,67,77)(H,68,82)(H,69,81)(H,70,83)(H,71,78)(H,72,79)(H,73,80)(H4,60,61,63)/t32-,39-,41-,42+,43+,44+,45-,46+,48+/m1/s1 | PDB
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University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141028
(1N-(1-carbamoyl-2-hydroxypropyl)-16-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-29(68)43(44(54)69)67-47(72)38-18-20-77-78-27-42(66-45(70)35(53)21-30-11-4-2-5-12-30)51(76)65-41(24-33-26-57-28-60-33)50(75)63-39(22-31-13-6-3-7-14-31)48(73)61-37(17-10-19-58-52(55)56)46(71)64-40(49(74)62-38)23-32-25-59-36-16-9-8-15-34(32)36/h2-9,11-16,25-26,28-29,35,37-43,59,68H,10,17-24,27,53H2,1H3,(H2,54,69)(H,57,60)(H,61,73)(H,62,74)(H,63,75)(H,64,71)(H,65,76)(H,66,70)(H,67,72)(H4,55,56,58)/t29-,35+,37+,38-,39-,40-,41+,42+,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50029747
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O Show InChI InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141034
((2S,3R)-2-{[(4S,7R,10S,13R,16S,19R)-19-[(2R)-2-ami...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ncc[nH]2)C(=O)N[C@H](Cc2cccc3ccccc23)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H67N15O9S2/c1-30(71)46(47(57)72)70-54(79)44-29-81-80-28-43(68-48(73)37(56)23-31-11-3-2-4-12-31)53(78)67-42(26-45-60-21-22-61-45)52(77)66-40(24-33-15-9-14-32-13-5-6-16-35(32)33)50(75)64-39(19-10-20-62-55(58)59)49(74)65-41(51(76)69-44)25-34-27-63-38-18-8-7-17-36(34)38/h2-9,11-18,21-22,27,30,37,39-44,46,63,71H,10,19-20,23-26,28-29,56H2,1H3,(H2,57,72)(H,60,61)(H,64,75)(H,65,74)(H,66,77)(H,67,78)(H,68,73)(H,69,76)(H,70,79)(H4,58,59,62)/t30-,37-,39+,40-,41-,42+,43+,44-,46+/m1/s1 | KEGG
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| n/a | n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50017181
(CHEMBL441738)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 | PDB
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PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141019
(CHEMBL411400 | H-D-Phe-c[Cys-His-D-Phe-Arg-Trp-Pen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O Show InChI InChI=1S/C53H69N15O9S2/c1-29(69)42(44(55)70)67-51(77)43-53(2,3)79-78-27-41(66-45(71)35(54)21-30-13-6-4-7-14-30)50(76)65-40(24-33-26-58-28-61-33)48(74)63-38(22-31-15-8-5-9-16-31)47(73)62-37(19-12-20-59-52(56)57)46(72)64-39(49(75)68-43)23-32-25-60-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,60,69H,12,19-24,27,54H2,1-3H3,(H2,55,70)(H,58,61)(H,62,73)(H,63,74)(H,64,72)(H,65,76)(H,66,71)(H,67,77)(H,68,75)(H4,56,57,59)/t29-,35-,37+,38-,39-,40-,41+,42+,43+/m1/s1 | UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141023
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37-,38-,39-,40+,41-,42+/m1/s1 | KEGG
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UniChem
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PubMed
| n/a | n/a | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141018
(1N-(1-carbamoyl-2-hydroxypropyl)-7-[3-amino(imino)...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H72N16O10/c1-31(72)46(47(57)74)71-50(77)39-19-10-11-21-61-45(73)27-44(67-48(75)37(56)23-32-13-4-2-5-14-32)54(81)70-43(26-35-29-60-30-64-35)53(80)68-41(24-33-15-6-3-7-16-33)51(78)66-40(20-12-22-62-55(58)59)49(76)69-42(52(79)65-39)25-34-28-63-38-18-9-8-17-36(34)38/h2-9,13-18,28-31,37,39-44,46,63,72H,10-12,19-27,56H2,1H3,(H2,57,74)(H,60,64)(H,61,73)(H,65,79)(H,66,78)(H,67,75)(H,68,80)(H,69,76)(H,70,81)(H,71,77)(H4,58,59,62)/t31-,37+,39-,40+,41-,42-,43+,44+,46+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141026
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37+,38-,39+,40+,41-,42+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141035
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34+,36+,37-,38-,39+,40+,41-,42+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50141019
(CHEMBL411400 | H-D-Phe-c[Cys-His-D-Phe-Arg-Trp-Pen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O Show InChI InChI=1S/C53H69N15O9S2/c1-29(69)42(44(55)70)67-51(77)43-53(2,3)79-78-27-41(66-45(71)35(54)21-30-13-6-4-7-14-30)50(76)65-40(24-33-26-58-28-61-33)48(74)63-38(22-31-15-8-5-9-16-31)47(73)62-37(19-12-20-59-52(56)57)46(72)64-39(49(75)68-43)23-32-25-60-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,60,69H,12,19-24,27,54H2,1-3H3,(H2,55,70)(H,58,61)(H,62,73)(H,63,74)(H,64,72)(H,65,76)(H,66,71)(H,67,77)(H,68,75)(H4,56,57,59)/t29-,35-,37+,38-,39-,40-,41+,42+,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141035
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34+,36+,37-,38-,39+,40+,41-,42+/m1/s1 | KEGG
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PC sid
UniChem
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PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141030
(1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C50H63N13O9S2/c1-29(64)43(44(53)66)62-49(71)41-27-74-73-26-40(60-45(67)35(52)19-30-11-4-2-5-12-30)48(70)58-38(22-33-24-54-28-56-33)47(69)59-39(20-31-13-6-3-7-14-31)50(72)63(18-10-17-51)25-42(65)57-37(46(68)61-41)21-32-23-55-36-16-9-8-15-34(32)36/h2-9,11-16,23-24,28-29,35,37-41,43,55,64H,10,17-22,25-27,51-52H2,1H3,(H2,53,66)(H,54,56)(H,57,65)(H,58,70)(H,59,69)(H,60,67)(H,61,68)(H,62,71)/t29-,35-,37-,38+,39+,40+,41-,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 660 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141027
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H64ClN15O9S2/c1-27(68)42(43(54)69)67-50(76)41-25-78-77-24-40(65-44(70)34(53)18-28-8-3-2-4-9-28)49(75)64-39(21-32-23-57-26-60-32)48(74)62-37(19-29-13-15-31(52)16-14-29)46(72)61-36(12-7-17-58-51(55)56)45(71)63-38(47(73)66-41)20-30-22-59-35-11-6-5-10-33(30)35/h2-6,8-11,13-16,22-23,26-27,34,36-42,59,68H,7,12,17-21,24-25,53H2,1H3,(H2,54,69)(H,57,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,58)/t27-,34+,36-,37-,38+,39-,40-,41+,42+/m0/s1 | KEGG
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UniChem
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| n/a | n/a | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50017181
(CHEMBL441738)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 | PDB
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PubMed
| n/a | n/a | n/a | n/a | 0.290 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50141018
(1N-(1-carbamoyl-2-hydroxypropyl)-7-[3-amino(imino)...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H72N16O10/c1-31(72)46(47(57)74)71-50(77)39-19-10-11-21-61-45(73)27-44(67-48(75)37(56)23-32-13-4-2-5-14-32)54(81)70-43(26-35-29-60-30-64-35)53(80)68-41(24-33-15-6-3-7-16-33)51(78)66-40(20-12-22-62-55(58)59)49(76)69-42(52(79)65-39)25-34-28-63-38-18-9-8-17-36(34)38/h2-9,13-18,28-31,37,39-44,46,63,72H,10-12,19-27,56H2,1H3,(H2,57,74)(H,60,64)(H,61,73)(H,65,79)(H,66,78)(H,67,75)(H,68,80)(H,69,76)(H,70,81)(H,71,77)(H4,58,59,62)/t31-,37+,39-,40+,41-,42-,43+,44+,46+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.380 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141030
(1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C50H63N13O9S2/c1-29(64)43(44(53)66)62-49(71)41-27-74-73-26-40(60-45(67)35(52)19-30-11-4-2-5-12-30)48(70)58-38(22-33-24-54-28-56-33)47(69)59-39(20-31-13-6-3-7-14-31)50(72)63(18-10-17-51)25-42(65)57-37(46(68)61-41)21-32-23-55-36-16-9-8-15-34(32)36/h2-9,11-16,23-24,28-29,35,37-41,43,55,64H,10,17-22,25-27,51-52H2,1H3,(H2,53,66)(H,54,56)(H,57,65)(H,58,70)(H,59,69)(H,60,67)(H,61,68)(H,62,71)/t29-,35-,37-,38+,39+,40+,41-,43+/m1/s1 | KEGG
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UniChem
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PubMed
| n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141031
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H64FN15O9S2/c1-27(68)42(43(54)69)67-50(76)41-25-78-77-24-40(65-44(70)34(53)18-28-8-3-2-4-9-28)49(75)64-39(21-32-23-57-26-60-32)48(74)62-37(19-29-13-15-31(52)16-14-29)46(72)61-36(12-7-17-58-51(55)56)45(71)63-38(47(73)66-41)20-30-22-59-35-11-6-5-10-33(30)35/h2-6,8-11,13-16,22-23,26-27,34,36-42,59,68H,7,12,17-21,24-25,53H2,1H3,(H2,54,69)(H,57,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,58)/t27-,34-,36+,37+,38-,39+,40+,41+,42+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141029
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc(C)[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-28(68)43(44(54)69)67-51(76)42-27-78-77-26-41(65-45(70)35(53)20-30-12-5-3-6-13-30)50(75)64-40(23-33-25-58-29(2)60-33)49(74)62-38(21-31-14-7-4-8-15-31)47(72)61-37(18-11-19-57-52(55)56)46(71)63-39(48(73)66-42)22-32-24-59-36-17-10-9-16-34(32)36/h3-10,12-17,24-25,28,35,37-43,59,68H,11,18-23,26-27,53H2,1-2H3,(H2,54,69)(H,58,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,57)/t28-,35+,37+,38-,39-,40+,41+,42-,43+/m1/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 0.550 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141018
(1N-(1-carbamoyl-2-hydroxypropyl)-7-[3-amino(imino)...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H72N16O10/c1-31(72)46(47(57)74)71-50(77)39-19-10-11-21-61-45(73)27-44(67-48(75)37(56)23-32-13-4-2-5-14-32)54(81)70-43(26-35-29-60-30-64-35)53(80)68-41(24-33-15-6-3-7-16-33)51(78)66-40(20-12-22-62-55(58)59)49(76)69-42(52(79)65-39)25-34-28-63-38-18-9-8-17-36(34)38/h2-9,13-18,28-31,37,39-44,46,63,72H,10-12,19-27,56H2,1H3,(H2,57,74)(H,60,64)(H,61,73)(H,65,79)(H,66,78)(H,67,75)(H,68,80)(H,69,76)(H,70,81)(H,71,77)(H4,58,59,62)/t31-,37+,39-,40+,41-,42-,43+,44+,46+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50141027
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H64ClN15O9S2/c1-27(68)42(43(54)69)67-50(76)41-25-78-77-24-40(65-44(70)34(53)18-28-8-3-2-4-9-28)49(75)64-39(21-32-23-57-26-60-32)48(74)62-37(19-29-13-15-31(52)16-14-29)46(72)61-36(12-7-17-58-51(55)56)45(71)63-38(47(73)66-41)20-30-22-59-35-11-6-5-10-33(30)35/h2-6,8-11,13-16,22-23,26-27,34,36-42,59,68H,7,12,17-21,24-25,53H2,1H3,(H2,54,69)(H,57,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,58)/t27-,34+,36-,37-,38+,39-,40-,41+,42+/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141021
(1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC(C)(C)[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N13O9S2/c1-29(66)42(44(55)67)64-50(73)41-27-75-76-52(2,3)43(65-45(68)35(54)21-30-13-6-4-7-14-30)51(74)62-40(24-33-26-56-28-58-33)49(72)60-38(22-31-15-8-5-9-16-31)47(70)59-37(19-12-20-53)46(69)61-39(48(71)63-41)23-32-25-57-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,57,66H,12,19-24,27,53-54H2,1-3H3,(H2,55,67)(H,56,58)(H,59,70)(H,60,72)(H,61,69)(H,62,74)(H,63,71)(H,64,73)(H,65,68)/t29-,35-,37?,38+,39-,40+,41-,42+,43-/m1/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 59 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141034
((2S,3R)-2-{[(4S,7R,10S,13R,16S,19R)-19-[(2R)-2-ami...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ncc[nH]2)C(=O)N[C@H](Cc2cccc3ccccc23)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H67N15O9S2/c1-30(71)46(47(57)72)70-54(79)44-29-81-80-28-43(68-48(73)37(56)23-31-11-3-2-4-12-31)53(78)67-42(26-45-60-21-22-61-45)52(77)66-40(24-33-15-9-14-32-13-5-6-16-35(32)33)50(75)64-39(19-10-20-62-55(58)59)49(74)65-41(51(76)69-44)25-34-27-63-38-18-8-7-17-36(34)38/h2-9,11-18,21-22,27,30,37,39-44,46,63,71H,10,19-20,23-26,28-29,56H2,1H3,(H2,57,72)(H,60,61)(H,64,75)(H,65,74)(H,66,77)(H,67,78)(H,68,73)(H,69,76)(H,70,79)(H4,58,59,62)/t30-,37-,39+,40-,41-,42+,43+,44-,46+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50141030
(1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C50H63N13O9S2/c1-29(64)43(44(53)66)62-49(71)41-27-74-73-26-40(60-45(67)35(52)19-30-11-4-2-5-12-30)48(70)58-38(22-33-24-54-28-56-33)47(69)59-39(20-31-13-6-3-7-14-31)50(72)63(18-10-17-51)25-42(65)57-37(46(68)61-41)21-32-23-55-36-16-9-8-15-34(32)36/h2-9,11-16,23-24,28-29,35,37-41,43,55,64H,10,17-22,25-27,51-52H2,1H3,(H2,53,66)(H,54,56)(H,57,65)(H,58,70)(H,59,69)(H,60,67)(H,61,68)(H,62,71)/t29-,35-,37-,38+,39+,40+,41-,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50141029
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc(C)[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-28(68)43(44(54)69)67-51(76)42-27-78-77-26-41(65-45(70)35(53)20-30-12-5-3-6-13-30)50(75)64-40(23-33-25-58-29(2)60-33)49(74)62-38(21-31-14-7-4-8-15-31)47(72)61-37(18-11-19-57-52(55)56)46(71)63-39(48(73)66-42)22-32-24-59-36-17-10-9-16-34(32)36/h3-10,12-17,24-25,28,35,37-43,59,68H,11,18-23,26-27,53H2,1-2H3,(H2,54,69)(H,58,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,57)/t28-,35+,37+,38-,39-,40+,41+,42-,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 8.90 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141035
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34+,36+,37-,38-,39+,40+,41-,42+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.00000300 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141028
(1N-(1-carbamoyl-2-hydroxypropyl)-16-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N15O9S2/c1-29(68)43(44(54)69)67-47(72)38-18-20-77-78-27-42(66-45(70)35(53)21-30-11-4-2-5-12-30)51(76)65-41(24-33-26-57-28-60-33)50(75)63-39(22-31-13-6-3-7-14-31)48(73)61-37(17-10-19-58-52(55)56)46(71)64-40(49(74)62-38)23-32-25-59-36-16-9-8-15-34(32)36/h2-9,11-16,25-26,28-29,35,37-43,59,68H,10,17-24,27,53H2,1H3,(H2,54,69)(H,57,60)(H,61,73)(H,62,74)(H,63,75)(H,64,71)(H,65,76)(H,66,70)(H,67,72)(H4,55,56,58)/t29-,35+,37+,38-,39-,40-,41+,42+,43+/m1/s1 | UniProtKB/SwissProt
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50141019
(CHEMBL411400 | H-D-Phe-c[Cys-His-D-Phe-Arg-Trp-Pen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O Show InChI InChI=1S/C53H69N15O9S2/c1-29(69)42(44(55)70)67-51(77)43-53(2,3)79-78-27-41(66-45(71)35(54)21-30-13-6-4-7-14-30)50(76)65-40(24-33-26-58-28-61-33)48(74)63-38(22-31-15-8-5-9-16-31)47(73)62-37(19-12-20-59-52(56)57)46(72)64-39(49(75)68-43)23-32-25-60-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,60,69H,12,19-24,27,54H2,1-3H3,(H2,55,70)(H,58,61)(H,62,73)(H,63,74)(H,64,72)(H,65,76)(H,66,71)(H,67,77)(H,68,75)(H4,56,57,59)/t29-,35-,37+,38-,39-,40-,41+,42+,43+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50252861
(CHEMBL507214 | H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin. |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141018
(1N-(1-carbamoyl-2-hydroxypropyl)-7-[3-amino(imino)...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C55H72N16O10/c1-31(72)46(47(57)74)71-50(77)39-19-10-11-21-61-45(73)27-44(67-48(75)37(56)23-32-13-4-2-5-14-32)54(81)70-43(26-35-29-60-30-64-35)53(80)68-41(24-33-15-6-3-7-16-33)51(78)66-40(20-12-22-62-55(58)59)49(76)69-42(52(79)65-39)25-34-28-63-38-18-9-8-17-36(34)38/h2-9,13-18,28-31,37,39-44,46,63,72H,10-12,19-27,56H2,1H3,(H2,57,74)(H,60,64)(H,61,73)(H,65,79)(H,66,78)(H,67,75)(H,68,80)(H,69,76)(H,70,81)(H,71,77)(H4,58,59,62)/t31-,37+,39-,40+,41-,42-,43+,44+,46+/m1/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 0.0740 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Rattus norvegicus) | BDBM50141023
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37-,38-,39-,40+,41-,42+/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50141027
(1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino...)Show SMILES C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C51H64ClN15O9S2/c1-27(68)42(43(54)69)67-50(76)41-25-78-77-24-40(65-44(70)34(53)18-28-8-3-2-4-9-28)49(75)64-39(21-32-23-57-26-60-32)48(74)62-37(19-29-13-15-31(52)16-14-29)46(72)61-36(12-7-17-58-51(55)56)45(71)63-38(47(73)66-41)20-30-22-59-35-11-6-5-10-33(30)35/h2-6,8-11,13-16,22-23,26-27,34,36-42,59,68H,7,12,17-21,24-25,53H2,1H3,(H2,54,69)(H,57,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,58)/t27-,34+,36-,37-,38+,39-,40-,41+,42+/m0/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximum agonist response for mouse melanocortin 5 receptor (MC5R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50141021
(1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phen...)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC(C)(C)[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O Show InChI InChI=1S/C52H67N13O9S2/c1-29(66)42(44(55)67)64-50(73)41-27-75-76-52(2,3)43(65-45(68)35(54)21-30-13-6-4-7-14-30)51(74)62-40(24-33-26-56-28-58-33)49(72)60-38(22-31-15-8-5-9-16-31)47(70)59-37(19-12-20-53)46(69)61-39(48(71)63-41)23-32-25-57-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,57,66H,12,19-24,27,53-54H2,1-3H3,(H2,55,67)(H,56,58)(H,59,70)(H,60,72)(H,61,69)(H,62,74)(H,63,71)(H,64,73)(H,65,68)/t29-,35-,37?,38+,39-,40+,41-,42+,43-/m1/s1 | KEGG
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PubMed
| n/a | n/a | n/a | n/a | 59 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Maximal agonist response of mouse melanocortin 1 receptor (MC1R) |
J Med Chem 47: 1514-26 (2004)
Article DOI: 10.1021/jm030452x
BindingDB Entry DOI: 10.7270/Q2XP75PK |
More data for this
Ligand-Target Pair | |
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