BindingDB logo
myBDB logout

PubMed code 15006389

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50085658
PNG
((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12 |r|
Show InChI InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 0.830n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141447
PNG
(CHEMBL279391 | N-[6-Cyclopentylamino-9-((2R,3R,4S,...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(NC(=O)CCc3ccccc3)nc12
Show InChI InChI=1S/C24H30N6O5/c31-12-16-19(33)20(34)23(35-16)30-13-25-18-21(26-15-8-4-5-9-15)28-24(29-22(18)30)27-17(32)11-10-14-6-2-1-3-7-14/h1-3,6-7,13,15-16,19-20,23,31,33-34H,4-5,8-12H2,(H2,26,27,28,29,32)/t16-,19-,20-,23-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 21n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141452
PNG
(3-Cyclopentyl-N-[6-cyclopentylamino-9-((2R,3R,4S,5...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(NC(=O)CCC3CCCC3)nc12
Show InChI InChI=1S/C23H34N6O5/c30-11-15-18(32)19(33)22(34-15)29-12-24-17-20(25-14-7-3-4-8-14)27-23(28-21(17)29)26-16(31)10-9-13-5-1-2-6-13/h12-15,18-19,22,30,32-33H,1-11H2,(H2,25,26,27,28,31)/t15-,18-,19-,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 32n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50085658
PNG
((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12 |r|
Show InChI InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 42n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141455
PNG
(CHEMBL285251 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dih...)
Show SMILES Nc1nc(NC(=O)\C=C\c2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H20N6O5/c20-16-13-17(25(9-21-13)18-15(29)14(28)11(8-26)30-18)24-19(23-16)22-12(27)7-6-10-4-2-1-3-5-10/h1-7,9,11,14-15,18,26,28-29H,8H2,(H3,20,22,23,24,27)/b7-6+/t11-,14-,15-,18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 71n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141453
PNG
(2-Cyclohexyl-N-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-h...)
Show SMILES CCNc1nc(NC(=O)CC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H30N6O5/c1-2-21-17-14-18(26(10-22-14)19-16(30)15(29)12(9-27)31-19)25-20(24-17)23-13(28)8-11-6-4-3-5-7-11/h10-12,15-16,19,27,29-30H,2-9H2,1H3,(H2,21,23,24,25,28)/t12-,15-,16-,19-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 181n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141453
PNG
(2-Cyclohexyl-N-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-h...)
Show SMILES CCNc1nc(NC(=O)CC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H30N6O5/c1-2-21-17-14-18(26(10-22-14)19-16(30)15(29)12(9-27)31-19)25-20(24-17)23-13(28)8-11-6-4-3-5-7-11/h10-12,15-16,19,27,29-30H,2-9H2,1H3,(H2,21,23,24,25,28)/t12-,15-,16-,19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 207n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141451
PNG
(CHEMBL36786 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CCC2CCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H26N6O5/c19-15-12-16(24(8-20-12)17-14(28)13(27)10(7-25)29-17)23-18(22-15)21-11(26)6-5-9-3-1-2-4-9/h8-10,13-14,17,25,27-28H,1-7H2,(H3,19,21,22,23,26)/t10-,13-,14-,17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 252n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141449
PNG
(CHEMBL36789 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H26N6O5/c19-15-12-16(24(8-20-12)17-14(28)13(27)10(7-25)29-17)23-18(22-15)21-11(26)6-9-4-2-1-3-5-9/h8-10,13-14,17,25,27-28H,1-7H2,(H3,19,21,22,23,26)/t10-,13-,14-,17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 342n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141456
PNG
(CHEMBL289982 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dih...)
Show SMILES Nc1nc(NC(=O)CCc2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H22N6O5/c20-16-13-17(25(9-21-13)18-15(29)14(28)11(8-26)30-18)24-19(23-16)22-12(27)7-6-10-4-2-1-3-5-10/h1-5,9,11,14-15,18,26,28-29H,6-8H2,(H3,20,22,23,24,27)/t11-,14-,15-,18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 432n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141450
PNG
(CHEMBL36320 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CCCC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H30N6O5/c21-17-14-18(26(10-22-14)19-16(30)15(29)12(9-27)31-19)25-20(24-17)23-13(28)8-4-7-11-5-2-1-3-6-11/h10-12,15-16,19,27,29-30H,1-9H2,(H3,21,23,24,25,28)/t12-,15-,16-,19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 733n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141455
PNG
(CHEMBL285251 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dih...)
Show SMILES Nc1nc(NC(=O)\C=C\c2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H20N6O5/c20-16-13-17(25(9-21-13)18-15(29)14(28)11(8-26)30-18)24-19(23-16)22-12(27)7-6-10-4-2-1-3-5-10/h1-7,9,11,14-15,18,26,28-29H,8H2,(H3,20,22,23,24,27)/b7-6+/t11-,14-,15-,18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 900n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141448
PNG
((2S,3S,4R,5R)-5-[6-Amino-2-(3-cyclopentyl-propiony...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NC(=O)CCC3CCCC3)nc12
Show InChI InChI=1S/C20H29N7O5/c1-2-22-18(31)15-13(29)14(30)19(32-15)27-9-23-12-16(21)25-20(26-17(12)27)24-11(28)8-7-10-5-3-4-6-10/h9-10,13-15,19,29-30H,2-8H2,1H3,(H,22,31)(H3,21,24,25,26,28)/t13-,14+,15-,19+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.01E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141451
PNG
(CHEMBL36786 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CCC2CCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H26N6O5/c19-15-12-16(24(8-20-12)17-14(28)13(27)10(7-25)29-17)23-18(22-15)21-11(26)6-5-9-3-1-2-4-9/h8-10,13-14,17,25,27-28H,1-7H2,(H3,19,21,22,23,26)/t10-,13-,14-,17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.04E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141450
PNG
(CHEMBL36320 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CCCC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H30N6O5/c21-17-14-18(26(10-22-14)19-16(30)15(29)12(9-27)31-19)25-20(24-17)23-13(28)8-4-7-11-5-2-1-3-6-11/h10-12,15-16,19,27,29-30H,1-9H2,(H3,21,23,24,25,28)/t12-,15-,16-,19-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.06E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141449
PNG
(CHEMBL36789 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H26N6O5/c19-15-12-16(24(8-20-12)17-14(28)13(27)10(7-25)29-17)23-18(22-15)21-11(26)6-9-4-2-1-3-5-9/h8-10,13-14,17,25,27-28H,1-7H2,(H3,19,21,22,23,26)/t10-,13-,14-,17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.23E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141447
PNG
(CHEMBL279391 | N-[6-Cyclopentylamino-9-((2R,3R,4S,...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(NC(=O)CCc3ccccc3)nc12
Show InChI InChI=1S/C24H30N6O5/c31-12-16-19(33)20(34)23(35-16)30-13-25-18-21(26-15-8-4-5-9-15)28-24(29-22(18)30)27-17(32)11-10-14-6-2-1-3-7-14/h1-3,6-7,13,15-16,19-20,23,31,33-34H,4-5,8-12H2,(H2,26,27,28,29,32)/t16-,19-,20-,23-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.25E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141452
PNG
(3-Cyclopentyl-N-[6-cyclopentylamino-9-((2R,3R,4S,5...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(NC(=O)CCC3CCCC3)nc12
Show InChI InChI=1S/C23H34N6O5/c30-11-15-18(32)19(33)22(34-15)29-12-24-17-20(25-14-7-3-4-8-14)27-23(28-21(17)29)26-16(31)10-9-13-5-1-2-6-13/h12-15,18-19,22,30,32-33H,1-11H2,(H2,25,26,27,28,31)/t15-,18-,19-,22-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.41E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141454
PNG
(CHEMBL288258 | Cyclohexanecarboxylic acid [6-amino...)
Show SMILES Nc1nc(NC(=O)C2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H24N6O5/c18-13-10-14(21-17(20-13)22-15(27)8-4-2-1-3-5-8)23(7-19-10)16-12(26)11(25)9(6-24)28-16/h7-9,11-12,16,24-26H,1-6H2,(H3,18,20,21,22,27)/t9-,11-,12-,16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.62E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141454
PNG
(CHEMBL288258 | Cyclohexanecarboxylic acid [6-amino...)
Show SMILES Nc1nc(NC(=O)C2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H24N6O5/c18-13-10-14(21-17(20-13)22-15(27)8-4-2-1-3-5-8)23(7-19-10)16-12(26)11(25)9(6-24)28-16/h7-9,11-12,16,24-26H,1-6H2,(H3,18,20,21,22,27)/t9-,11-,12-,16-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.78E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141450
PNG
(CHEMBL36320 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CCCC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H30N6O5/c21-17-14-18(26(10-22-14)19-16(30)15(29)12(9-27)31-19)25-20(24-17)23-13(28)8-4-7-11-5-2-1-3-6-11/h10-12,15-16,19,27,29-30H,1-9H2,(H3,21,23,24,25,28)/t12-,15-,16-,19-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.94E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141451
PNG
(CHEMBL36786 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CCC2CCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H26N6O5/c19-15-12-16(24(8-20-12)17-14(28)13(27)10(7-25)29-17)23-18(22-15)21-11(26)6-5-9-3-1-2-4-9/h8-10,13-14,17,25,27-28H,1-7H2,(H3,19,21,22,23,26)/t10-,13-,14-,17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.00E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141452
PNG
(3-Cyclopentyl-N-[6-cyclopentylamino-9-((2R,3R,4S,5...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(NC(=O)CCC3CCCC3)nc12
Show InChI InChI=1S/C23H34N6O5/c30-11-15-18(32)19(33)22(34-15)29-12-24-17-20(25-14-7-3-4-8-14)27-23(28-21(17)29)26-16(31)10-9-13-5-1-2-6-13/h12-15,18-19,22,30,32-33H,1-11H2,(H2,25,26,27,28,31)/t15-,18-,19-,22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.18E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50085658
PNG
((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12 |r|
Show InChI InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 2.27E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141449
PNG
(CHEMBL36789 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihy...)
Show SMILES Nc1nc(NC(=O)CC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H26N6O5/c19-15-12-16(24(8-20-12)17-14(28)13(27)10(7-25)29-17)23-18(22-15)21-11(26)6-9-4-2-1-3-5-9/h8-10,13-14,17,25,27-28H,1-7H2,(H3,19,21,22,23,26)/t10-,13-,14-,17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.41E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141456
PNG
(CHEMBL289982 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dih...)
Show SMILES Nc1nc(NC(=O)CCc2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H22N6O5/c20-16-13-17(25(9-21-13)18-15(29)14(28)11(8-26)30-18)24-19(23-16)22-12(27)7-6-10-4-2-1-3-5-10/h1-5,9,11,14-15,18,26,28-29H,6-8H2,(H3,20,22,23,24,27)/t11-,14-,15-,18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.71E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))		BDBM50141454
PNG
(CHEMBL288258 | Cyclohexanecarboxylic acid [6-amino...)
Show SMILES Nc1nc(NC(=O)C2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H24N6O5/c18-13-10-14(21-17(20-13)22-15(27)8-4-2-1-3-5-8)23(7-19-10)16-12(26)11(25)9(6-24)28-16/h7-9,11-12,16,24-26H,1-6H2,(H3,18,20,21,22,27)/t9-,11-,12-,16-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.76E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141455
PNG
(CHEMBL285251 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dih...)
Show SMILES Nc1nc(NC(=O)\C=C\c2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H20N6O5/c20-16-13-17(25(9-21-13)18-15(29)14(28)11(8-26)30-18)24-19(23-16)22-12(27)7-6-10-4-2-1-3-5-10/h1-7,9,11,14-15,18,26,28-29H,8H2,(H3,20,22,23,24,27)/b7-6+/t11-,14-,15-,18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.10E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141456
PNG
(CHEMBL289982 | N-[6-Amino-9-((2R,3R,4S,5R)-3,4-dih...)
Show SMILES Nc1nc(NC(=O)CCc2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H22N6O5/c20-16-13-17(25(9-21-13)18-15(29)14(28)11(8-26)30-18)24-19(23-16)22-12(27)7-6-10-4-2-1-3-5-10/h1-5,9,11,14-15,18,26,28-29H,6-8H2,(H3,20,22,23,24,27)/t11-,14-,15-,18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.57E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))		BDBM50141448
PNG
((2S,3S,4R,5R)-5-[6-Amino-2-(3-cyclopentyl-propiony...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NC(=O)CCC3CCCC3)nc12
Show InChI InChI=1S/C20H29N7O5/c1-2-22-18(31)15-13(29)14(30)19(32-15)27-9-23-12-16(21)25-20(26-17(12)27)24-11(28)8-7-10-5-3-4-6-10/h9-10,13-15,19,29-30H,2-8H2,1H3,(H,22,31)(H3,21,24,25,26,28)/t13-,14+,15-,19+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5.45E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141447
PNG
(CHEMBL279391 | N-[6-Cyclopentylamino-9-((2R,3R,4S,...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(NC(=O)CCc3ccccc3)nc12
Show InChI InChI=1S/C24H30N6O5/c31-12-16-19(33)20(34)23(35-16)30-13-25-18-21(26-15-8-4-5-9-15)28-24(29-22(18)30)27-17(32)11-10-14-6-2-1-3-7-14/h1-3,6-7,13,15-16,19-20,23,31,33-34H,4-5,8-12H2,(H2,26,27,28,29,32)/t16-,19-,20-,23-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5.66E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141453
PNG
(2-Cyclohexyl-N-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-h...)
Show SMILES CCNc1nc(NC(=O)CC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H30N6O5/c1-2-21-17-14-18(26(10-22-14)19-16(30)15(29)12(9-27)31-19)25-20(24-17)23-13(28)8-11-6-4-3-5-7-11/h10-12,15-16,19,27,29-30H,2-9H2,1H3,(H2,21,23,24,25,28)/t12-,15-,16-,19-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 7.75E+3n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))		BDBM50141448
PNG
((2S,3S,4R,5R)-5-[6-Amino-2-(3-cyclopentyl-propiony...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NC(=O)CCC3CCCC3)nc12
Show InChI InChI=1S/C20H29N7O5/c1-2-22-18(31)15-13(29)14(30)19(32-15)27-9-23-12-16(21)25-20(26-17(12)27)24-11(28)8-7-10-5-3-4-6-10/h9-10,13-15,19,29-30H,2-8H2,1H3,(H,22,31)(H3,21,24,25,26,28)/t13-,14+,15-,19+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.08E+4n/an/an/an/an/an/an/an/a



Inotek Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-NECA from human adenosine A2A receptor in stably transfected CHO cells

Bioorg Med Chem Lett 14: 1495-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.011
BindingDB Entry DOI: 10.7270/Q27H1J1D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%