BindingDB logo
myBDB logout

PubMed code 15012994

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15459
PNG
(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Show SMILES C[C@H](Nc1cc(ccn1)-c1c(nc(C2CCNCC2)n1C)-c1cccc(c1)C(F)(F)F)c1ccccc1 |r|
Show InChI InChI=1S/C29H30F3N5/c1-19(20-7-4-3-5-8-20)35-25-18-23(13-16-34-25)27-26(22-9-6-10-24(17-22)29(30,31)32)36-28(37(27)2)21-11-14-33-15-12-21/h3-10,13,16-19,21,33H,11-12,14-15H2,1-2H3,(H,34,35)/t19-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15448
PNG
(1,3-diethyl-5-[3-(3-methylphenyl)-1H-pyrazol-4-yl]...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1c[nH]nc1-c1cccc(C)c1
Show InChI InChI=1S/C21H22N4O/c1-4-24-18-10-9-15(12-19(18)25(5-2)21(24)26)17-13-22-23-20(17)16-8-6-7-14(3)11-16/h6-13H,4-5H2,1-3H3,(H,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15442
PNG
(1,3-diethyl-5-[3-(4-fluoro-3-methylphenyl)-1H-pyra...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1c[nH]nc1-c1ccc(F)c(C)c1
Show InChI InChI=1S/C21H21FN4O/c1-4-25-18-9-7-14(11-19(18)26(5-2)21(25)27)16-12-23-24-20(16)15-6-8-17(22)13(3)10-15/h6-12H,4-5H2,1-3H3,(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM13336
PNG
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15458
PNG
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Show SMILES COc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN5O/c1-26-19-22-11-8-16(24-19)18-17(13-2-4-14(20)5-3-13)23-12-25(18)15-6-9-21-10-7-15/h2-5,8,11-12,15,21H,6-7,9-10H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15419
PNG
(1,3-diethyl-5-[4-(3-methylphenyl)-1H-imidazol-5-yl...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nc[nH]c1-c1cccc(C)c1
Show InChI InChI=1S/C21H22N4O/c1-4-24-17-10-9-16(12-18(17)25(5-2)21(24)26)20-19(22-13-23-20)15-8-6-7-14(3)11-15/h6-13H,4-5H2,1-3H3,(H,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 50n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15457
PNG
(2-(4-fluorophenyl)-4-methoxy-3-(pyridin-4-yl)-1H-p...)
Show SMILES COc1cc(N)nc2[nH]c(c(-c3ccncc3)c12)-c1ccc(F)cc1
Show InChI InChI=1S/C19H15FN4O/c1-25-14-10-15(21)23-19-17(14)16(11-6-8-22-9-7-11)18(24-19)12-2-4-13(20)5-3-12/h2-10H,1H3,(H3,21,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15443
PNG
(1,3-diethyl-5-{3-[3-(trifluoromethyl)phenyl]-1H-py...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1c[nH]nc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O/c1-3-27-17-9-8-13(11-18(17)28(4-2)20(27)29)16-12-25-26-19(16)14-6-5-7-15(10-14)21(22,23)24/h5-12H,3-4H2,1-2H3,(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15438
PNG
(1,3-diethyl-5-[4-(3-methylphenyl)-2-(pyridin-3-yl)...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nc([nH]c1-c1cccc(C)c1)-c1cccnc1
Show InChI InChI=1S/C26H25N5O/c1-4-30-21-12-11-19(15-22(21)31(5-2)26(30)32)24-23(18-9-6-8-17(3)14-18)28-25(29-24)20-10-7-13-27-16-20/h6-16H,4-5H2,1-3H3,(H,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15439
PNG
(1,3-diethyl-5-[4-(3-methylphenyl)-2-(piperidin-4-y...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nc([nH]c1-c1cccc(C)c1)C1CCNCC1
Show InChI InChI=1S/C26H31N5O/c1-4-30-21-10-9-20(16-22(21)31(5-2)26(30)32)24-23(19-8-6-7-17(3)15-19)28-25(29-24)18-11-13-27-14-12-18/h6-10,15-16,18,27H,4-5,11-14H2,1-3H3,(H,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15461
PNG
(1,3-diethyl-5-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H28FN5O/c1-3-29-21-10-7-18(15-22(21)30(4-2)25(29)32)24-23(17-5-8-19(26)9-6-17)28-16-31(24)20-11-13-27-14-12-20/h5-10,15-16,20,27H,3-4,11-14H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15418
PNG
(1,3-dimethyl-5-[4-(3-methylphenyl)-1H-imidazol-5-y...)
Show SMILES Cc1cccc(c1)-c1[nH]cnc1-c1ccc2n(C)c(=O)n(C)c2c1
Show InChI InChI=1S/C19H18N4O/c1-12-5-4-6-13(9-12)17-18(21-11-20-17)14-7-8-15-16(10-14)23(3)19(24)22(15)2/h4-11H,1-3H3,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15421
PNG
(1,3-diethyl-5-[4-(4-fluorophenyl)-1H-imidazol-5-yl...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nc[nH]c1-c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-3-24-16-10-7-14(11-17(16)25(4-2)20(24)26)19-18(22-12-23-19)13-5-8-15(21)9-6-13/h5-12H,3-4H2,1-2H3,(H,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 100n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15420
PNG
(5-[4-(4-fluorophenyl)-1H-imidazol-5-yl]-1,3-dimeth...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc[nH]c1-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN4O/c1-22-14-8-5-12(9-15(14)23(2)18(22)24)17-16(20-10-21-17)11-3-6-13(19)7-4-11/h3-10H,1-2H3,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 140n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15432
PNG
(1,3-dimethyl-5-[4-(3-methylphenyl)-2-(thiophen-2-y...)
Show SMILES Cc1cccc(c1)-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1
Show InChI InChI=1S/C23H20N4OS/c1-14-6-4-7-15(12-14)20-21(25-22(24-20)19-8-5-11-29-19)16-9-10-17-18(13-16)27(3)23(28)26(17)2/h4-13H,1-3H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 140n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15417
PNG
(1,3-diethyl-5-(4-phenyl-1H-imidazol-5-yl)-2,3-dihy...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nc[nH]c1-c1ccccc1
Show InChI InChI=1S/C20H20N4O/c1-3-23-16-11-10-15(12-17(16)24(4-2)20(23)25)19-18(21-13-22-19)14-8-6-5-7-9-14/h5-13H,3-4H2,1-2H3,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 140n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15446
PNG
(1,3-diethyl-5-(3-phenyl-1H-pyrazol-4-yl)-2,3-dihyd...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1c[nH]nc1-c1ccccc1
Show InChI InChI=1S/C20H20N4O/c1-3-23-17-11-10-15(12-18(17)24(4-2)20(23)25)16-13-21-22-19(16)14-8-6-5-7-9-14/h5-13H,3-4H2,1-2H3,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15444
PNG
(1,3-dimethyl-5-(3-phenyl-1H-pyrazol-4-yl)-2,3-dihy...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1c[nH]nc1-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-21-15-9-8-13(10-16(15)22(2)18(21)23)14-11-19-20-17(14)12-6-4-3-5-7-12/h3-11H,1-2H3,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15437
PNG
(1,3-dimethyl-5-[4-(3-methylphenyl)-2-(pyridin-3-yl...)
Show SMILES Cc1cccc(c1)-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccnc1
Show InChI InChI=1S/C24H21N5O/c1-15-6-4-7-16(12-15)21-22(27-23(26-21)18-8-5-11-25-14-18)17-9-10-19-20(13-17)29(3)24(30)28(19)2/h4-14H,1-3H3,(H,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15460
PNG
(5-[6-amino-2-(3-methylphenyl)-1H-pyrrolo[2,3-b]pyr...)
Show SMILES Cc1cccc(c1)-c1[nH]c2nc(N)ccc2c1-c1ccc2n(C)c(=O)n(C)c2c1
Show InChI InChI=1S/C23H21N5O/c1-13-5-4-6-15(11-13)21-20(16-8-10-19(24)25-22(16)26-21)14-7-9-17-18(12-14)28(3)23(29)27(17)2/h4-12H,1-3H3,(H3,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15422
PNG
(1,3-dimethyl-5-[4-phenyl-2-(thiophen-2-yl)-1H-imid...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccccc1)-c1cccs1
Show InChI InChI=1S/C22H18N4OS/c1-25-16-11-10-15(13-17(16)26(2)22(25)27)20-19(14-7-4-3-5-8-14)23-21(24-20)18-9-6-12-28-18/h3-13H,1-2H3,(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 260n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15425
PNG
(5-[4-(4-fluorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccc(F)cc1)-c1cccs1
Show InChI InChI=1S/C22H17FN4OS/c1-26-16-10-7-14(12-17(16)27(2)22(26)28)20-19(13-5-8-15(23)9-6-13)24-21(25-20)18-4-3-11-29-18/h3-12H,1-2H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 270n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15416
PNG
(1,3-dimethyl-5-(4-phenyl-1H-imidazol-5-yl)-2,3-dih...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc[nH]c1-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-21-14-9-8-13(10-15(14)22(2)18(21)23)17-16(19-11-20-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 290n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15423
PNG
(5-[4-(2-fluorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccccc1F)-c1cccs1
Show InChI InChI=1S/C22H17FN4OS/c1-26-16-10-9-13(12-17(16)27(2)22(26)28)19-20(14-6-3-4-7-15(14)23)25-21(24-19)18-8-5-11-29-18/h3-12H,1-2H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 370n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15427
PNG
(5-[4-(3-chlorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1cccc(Cl)c1)-c1cccs1
Show InChI InChI=1S/C22H17ClN4OS/c1-26-16-9-8-14(12-17(16)27(2)22(26)28)20-19(13-5-3-6-15(23)11-13)24-21(25-20)18-7-4-10-29-18/h3-12H,1-2H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 380n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15424
PNG
(5-[4-(3-fluorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1cccc(F)c1)-c1cccs1
Show InChI InChI=1S/C22H17FN4OS/c1-26-16-9-8-14(12-17(16)27(2)22(26)28)20-19(13-5-3-6-15(23)11-13)24-21(25-20)18-7-4-10-29-18/h3-12H,1-2H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 390n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15434
PNG
(5-[4-(3-ethylphenyl)-2-(thiophen-2-yl)-1H-imidazol...)
Show SMILES CCc1cccc(c1)-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1
Show InChI InChI=1S/C24H22N4OS/c1-4-15-7-5-8-16(13-15)21-22(26-23(25-21)20-9-6-12-30-20)17-10-11-18-19(14-17)28(3)24(29)27(18)2/h5-14H,4H2,1-3H3,(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 500n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15426
PNG
(5-[4-(2-chlorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccccc1Cl)-c1cccs1
Show InChI InChI=1S/C22H17ClN4OS/c1-26-16-10-9-13(12-17(16)27(2)22(26)28)19-20(14-6-3-4-7-15(14)23)25-21(24-19)18-8-5-11-29-18/h3-12H,1-2H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 540n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15428
PNG
(5-[4-(4-chlorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccc(Cl)cc1)-c1cccs1
Show InChI InChI=1S/C22H17ClN4OS/c1-26-16-10-7-14(12-17(16)27(2)22(26)28)20-19(13-5-8-15(23)9-6-13)24-21(25-20)18-4-3-11-29-18/h3-12H,1-2H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 680n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15447
PNG
(1,3-diethyl-5-(4-phenyl-1H-pyrazol-3-yl)-2,3-dihyd...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1n[nH]cc1-c1ccccc1
Show InChI InChI=1S/C20H20N4O/c1-3-23-17-11-10-15(12-18(17)24(4-2)20(23)25)19-16(13-21-22-19)14-8-6-5-7-9-14/h5-13H,3-4H2,1-2H3,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 680n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15455
PNG
(1,3-diethyl-5-[1-(3-methylphenyl)-1H-pyrazol-5-yl]...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1ccnn1-c1cccc(C)c1
Show InChI InChI=1S/C21H22N4O/c1-4-23-19-10-9-16(14-20(19)24(5-2)21(23)26)18-11-12-22-25(18)17-8-6-7-15(3)13-17/h6-14H,4-5H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 690n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15449
PNG
(1,3-diethyl-5-[4-(3-methylphenyl)-1H-pyrazol-3-yl]...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1n[nH]cc1-c1cccc(C)c1
Show InChI InChI=1S/C21H22N4O/c1-4-24-18-10-9-16(12-19(18)25(5-2)21(24)26)20-17(13-22-23-20)15-8-6-7-14(3)11-15/h6-13H,4-5H2,1-3H3,(H,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 730n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15451
PNG
(1,3-diethyl-5-[4-(3-methylphenyl)-1,3-oxazol-5-yl]...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1ocnc1-c1cccc(C)c1
Show InChI InChI=1S/C21H21N3O2/c1-4-23-17-10-9-16(12-18(17)24(5-2)21(23)25)20-19(22-13-26-20)15-8-6-7-14(3)11-15/h6-13H,4-5H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15452
PNG
(1,3-diethyl-5-[5-(4-fluoro-3-methylphenyl)-1H-1,2,...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-n1nnnc1-c1ccc(F)c(C)c1
Show InChI InChI=1S/C19H19FN6O/c1-4-24-16-9-7-14(11-17(16)25(5-2)19(24)27)26-18(21-22-23-26)13-6-8-15(20)12(3)10-13/h6-11H,4-5H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15441
PNG
(1,3-diethyl-5-[2-(3-methylphenyl)-5-(pyridin-3-yl)...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1cc([nH]c1-c1cccc(C)c1)-c1cccnc1
Show InChI InChI=1S/C27H26N4O/c1-4-30-24-12-11-19(15-25(24)31(5-2)27(30)32)22-16-23(21-10-7-13-28-17-21)29-26(22)20-9-6-8-18(3)14-20/h6-17,29H,4-5H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15453
PNG
(1,3-diethyl-5-[1-(4-fluoro-3-methylphenyl)-1H-1,2,...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nnnn1-c1ccc(F)c(C)c1
Show InChI InChI=1S/C19H19FN6O/c1-4-24-16-9-6-13(11-17(16)25(5-2)19(24)27)18-21-22-23-26(18)14-7-8-15(20)12(3)10-14/h6-11H,4-5H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15456
PNG
(1,3-diethyl-5-[2-(3-methylphenyl)pyridin-3-yl]-2,3...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1cccnc1-c1cccc(C)c1
Show InChI InChI=1S/C23H23N3O/c1-4-25-20-12-11-17(15-21(20)26(5-2)23(25)27)19-10-7-13-24-22(19)18-9-6-8-16(3)14-18/h6-15H,4-5H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15415
PNG
(1,3-diethyl-5-(1H-imidazol-5-yl)-2,3-dihydro-1H-1,...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1c[nH]cn1
Show InChI InChI=1S/C14H16N4O/c1-3-17-12-6-5-10(11-8-15-9-16-11)7-13(12)18(4-2)14(17)19/h5-9H,3-4H2,1-2H3,(H,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15462
PNG
(1,3-diethyl-5-[1-methyl-4-(3-methylphenyl)-2-(pipe...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1c(nc(C2CCNCC2)n1C)-c1cccc(C)c1
Show InChI InChI=1S/C27H33N5O/c1-5-31-22-11-10-21(17-23(22)32(6-2)27(31)33)25-24(20-9-7-8-18(3)16-20)29-26(30(25)4)19-12-14-28-15-13-19/h7-11,16-17,19,28H,5-6,12-15H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.25E+3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15430
PNG
(1,3-dimethyl-5-[2-(thiophen-2-yl)-4-[3-(trifluorom...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1cccc(c1)C(F)(F)F)-c1cccs1
Show InChI InChI=1S/C23H17F3N4OS/c1-29-16-9-8-14(12-17(16)30(2)22(29)31)20-19(27-21(28-20)18-7-4-10-32-18)13-5-3-6-15(11-13)23(24,25)26/h3-12H,1-2H3,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.50E+3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15433
PNG
(1,3-dimethyl-5-[4-(4-methylphenyl)-2-(thiophen-2-y...)
Show SMILES Cc1ccc(cc1)-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1
Show InChI InChI=1S/C23H20N4OS/c1-14-6-8-15(9-7-14)20-21(25-22(24-20)19-5-4-12-29-19)16-10-11-17-18(13-16)27(3)23(28)26(17)2/h4-13H,1-3H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.80E+3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15445
PNG
(1,3-dimethyl-5-(4-phenyl-1H-pyrazol-3-yl)-2,3-dihy...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1n[nH]cc1-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-21-15-9-8-13(10-16(15)22(2)18(21)23)17-14(11-19-20-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15440
PNG
(5-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccc(F)cc1)-c1ccc(cc1)S(C)=O
Show InChI InChI=1S/C25H21FN4O2S/c1-29-20-13-8-17(14-21(20)30(2)25(29)31)23-22(15-4-9-18(26)10-5-15)27-24(28-23)16-6-11-19(12-7-16)33(3)32/h4-14H,1-3H3,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15431
PNG
(1,3-dimethyl-5-[4-(2-methylphenyl)-2-(thiophen-2-y...)
Show SMILES Cc1ccccc1-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1
Show InChI InChI=1S/C23H20N4OS/c1-14-7-4-5-8-16(14)21-20(24-22(25-21)19-9-6-12-29-19)15-10-11-17-18(13-15)27(3)23(28)26(17)2/h4-13H,1-3H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.20E+3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15435
PNG
(5-[4-(4-ethylphenyl)-2-(thiophen-2-yl)-1H-imidazol...)
Show SMILES CCc1ccc(cc1)-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1
Show InChI InChI=1S/C24H22N4OS/c1-4-15-7-9-16(10-8-15)21-22(26-23(25-21)20-6-5-13-30-20)17-11-12-18-19(14-17)28(3)24(29)27(18)2/h5-14H,4H2,1-3H3,(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 8.00E+3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15450
PNG
(1,3-dimethyl-5-[3-(3-methylphenyl)-4H-1,2,4-triazo...)
Show SMILES Cc1cccc(c1)-c1nncn1-c1ccc2n(C)c(=O)n(C)c2c1
Show InChI InChI=1S/C18H17N5O/c1-12-5-4-6-13(9-12)17-20-19-11-23(17)14-7-8-15-16(10-14)22(3)18(24)21(15)2/h4-11H,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15454
PNG
(1,3-dimethyl-5-[1-(3-methylphenyl)-1H-imidazol-5-y...)
Show SMILES Cc1cccc(c1)-n1cncc1-c1ccc2n(C)c(=O)n(C)c2c1
Show InChI InChI=1S/C19H18N4O/c1-13-5-4-6-15(9-13)23-12-20-11-18(23)14-7-8-16-17(10-14)22(3)19(24)21(16)2/h4-12H,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.44E+4n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15429
PNG
(1,3-dimethyl-5-[2-(thiophen-2-yl)-4-[3-(trifluorom...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1cccc(OC(F)(F)F)c1)-c1cccs1
Show InChI InChI=1S/C23H17F3N4O2S/c1-29-16-9-8-14(12-17(16)30(2)22(29)31)20-19(27-21(28-20)18-7-4-10-33-18)13-5-3-6-15(11-13)32-23(24,25)26/h3-12H,1-2H3,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.58E+4n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM15436
PNG
(1,3-dimethyl-5-{4-[3-(propan-2-yl)phenyl]-2-(thiop...)
Show SMILES CC(C)c1cccc(c1)-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1
Show InChI InChI=1S/C25H24N4OS/c1-15(2)16-7-5-8-17(13-16)22-23(27-24(26-22)21-9-6-12-31-21)18-10-11-19-20(14-18)29(4)25(30)28(19)3/h5-15H,1-4H3,(H,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>3.20E+4n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...

Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%