Affinity Data by PubMed id=15080999

PubMed code 15080999

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6558 (3-quinolinecarbonitrile deriv. 26 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6551 (3-quinolinecarbonitrile deriv. 19 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6550 (3-quinolinecarbonitrile deriv. 18 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6559 (3-quinolinecarbonitrile deriv. 28 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6557 (3-quinolinecarbonitrile deriv. 25 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6555 (3-quinolinecarbonitrile deriv. 23 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6552 (3-quinolinecarbonitrile deriv. 20 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6553 (3-quinolinecarbonitrile deriv. 21 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6556 (3-quinolinecarbonitrile deriv. 24 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6554 (3-quinolinecarbonitrile deriv. 22 \| 4-[(2,4-dichlo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 14: 2155-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.035 BindingDB Entry DOI: 10.7270/Q2R49P0H
Wyeth Research					More data for this Ligand-Target Pair

* indicates data uncertainty>20%