Found 38 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20287
(2-[(4-tert-butylphenyl)methyl]-3-({[(3-fluoro-4-me...)Show SMILES CC(C)(C)C(=O)OCC(CNC(=S)NCc1ccc(NS(C)(=O)=O)c(F)c1)Cc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C28H40FN3O4S2/c1-27(2,3)22-11-8-19(9-12-22)14-21(18-36-25(33)28(4,5)6)17-31-26(37)30-16-20-10-13-24(23(29)15-20)32-38(7,34)35/h8-13,15,21,32H,14,16-18H2,1-7H3,(H2,30,31,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50130542
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H37N3O4S2/c1-18-7-8-21(13-19(18)2)14-22(17-33-24(30)26(3,4)5)16-28-25(34)27-15-20-9-11-23(12-10-20)29-35(6,31)32/h7-13,22,29H,14-17H2,1-6H3,(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Agonist effect on 45 [Ca2+] influx in vanilloid receptor expressing CHO cells relative to maximal capsaicin (300 nM) response, weak effect at 30 nM |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50130548
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1NS(C)(=O)=O Show InChI InChI=1S/C27H39N3O5S2/c1-18-8-9-20(12-19(18)2)13-22(17-35-25(31)27(3,4)5)16-29-26(36)28-15-21-10-11-23(24(14-21)34-6)30-37(7,32)33/h8-12,14,22,30H,13,15-17H2,1-7H3,(H2,28,29,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20293
(2-[(3,4-dimethylphenyl)methyl]-3-({[(3-fluoro-4-me...)Show SMILES Cc1ccc(CC(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H36FN3O4S2/c1-17-7-8-19(11-18(17)2)12-21(16-34-24(31)26(3,4)5)15-29-25(35)28-14-20-9-10-23(22(27)13-20)30-36(6,32)33/h7-11,13,21,30H,12,14-16H2,1-6H3,(H2,28,29,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20288
(2-[(4-tert-butylphenyl)methyl]-3-[1-(3-fluoro-4-me...)Show SMILES CC(C)(C)C(=O)OCC(CNC(=O)Cc1ccc(NS(C)(=O)=O)c(F)c1)Cc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C28H39FN2O5S/c1-27(2,3)22-11-8-19(9-12-22)14-21(18-36-26(33)28(4,5)6)17-30-25(32)16-20-10-13-24(23(29)15-20)31-37(7,34)35/h8-13,15,21,31H,14,16-18H2,1-7H3,(H,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20294
(2-[(3,4-dimethylphenyl)methyl]-3-[1-(3-fluoro-4-me...)Show SMILES Cc1ccc(CC(CNC(=O)Cc2ccc(NS(C)(=O)=O)c(F)c2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H35FN2O5S/c1-17-7-8-19(11-18(17)2)12-21(16-34-25(31)26(3,4)5)15-28-24(30)14-20-9-10-23(22(27)13-20)29-35(6,32)33/h7-11,13,21,29H,12,14-16H2,1-6H3,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144674
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(COC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1NS(C)(=O)=O Show InChI InChI=1S/C27H38N2O6S2/c1-18-8-9-20(12-19(18)2)13-22(17-34-25(30)27(3,4)5)15-28-26(36)35-16-21-10-11-23(24(14-21)33-6)29-37(7,31)32/h8-12,14,22,29H,13,15-17H2,1-7H3,(H,28,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 199 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144667
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)OCc2ccc(NS(C)(=O)=O)c(F)c2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H35FN2O5S2/c1-17-7-8-19(11-18(17)2)12-21(16-33-24(30)26(3,4)5)14-28-25(35)34-15-20-9-10-23(22(27)13-20)29-36(6,31)32/h7-11,13,21,29H,12,14-16H2,1-6H3,(H,28,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144665
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)C(C)(C)C)CN(O)C(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1C Show InChI InChI=1S/C26H36FN3O5S2/c1-17-7-8-19(11-18(17)2)12-21(16-35-24(31)26(3,4)5)15-30(32)25(36)28-14-20-9-10-23(22(27)13-20)29-37(6,33)34/h7-11,13,21,29,32H,12,14-16H2,1-6H3,(H,28,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 212 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144666
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)C(C)(C)C)CN(O)C(=S)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1C Show InChI InChI=1S/C26H36ClN3O5S2/c1-17-7-8-19(11-18(17)2)12-20(16-35-24(31)26(3,4)5)15-30(32)25(36)28-14-21-9-10-22(13-23(21)27)29-37(6,33)34/h7-11,13,20,29,32H,12,14-16H2,1-6H3,(H,28,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144669
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)OCc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H36N2O5S2/c1-18-7-8-21(13-19(18)2)14-22(17-32-24(29)26(3,4)5)15-27-25(34)33-16-20-9-11-23(12-10-20)28-35(6,30)31/h7-13,22,28H,14-17H2,1-6H3,(H,27,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 336 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144662
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(CNC(=S)N(O)CC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1NS(C)(=O)=O Show InChI InChI=1S/C27H39N3O6S2/c1-18-8-9-20(12-19(18)2)13-22(17-36-25(31)27(3,4)5)16-30(32)26(37)28-15-21-10-11-23(24(14-21)35-6)29-38(7,33)34/h8-12,14,22,29,32H,13,15-17H2,1-7H3,(H,28,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 396 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144668
(2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...)Show SMILES CC(C)(C)C(=O)OCC(CN(O)C(=S)NCc1ccc(NS(C)(=O)=O)c(F)c1)Cc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C28H40FN3O5S2/c1-27(2,3)22-11-8-19(9-12-22)14-21(18-37-25(33)28(4,5)6)17-32(34)26(38)30-16-20-10-13-24(23(29)15-20)31-39(7,35)36/h8-13,15,21,31,34H,14,16-18H2,1-7H3,(H,30,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 405 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144675
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(CC(=O)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1NS(C)(=O)=O Show InChI InChI=1S/C27H38N2O6S/c1-18-8-9-20(12-19(18)2)13-22(17-35-26(31)27(3,4)5)16-28-25(30)15-21-10-11-23(24(14-21)34-6)29-36(7,32)33/h8-12,14,22,29H,13,15-17H2,1-7H3,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144676
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)N(O)Cc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H37N3O5S2/c1-18-7-8-21(13-19(18)2)14-22(17-34-24(30)26(3,4)5)15-27-25(35)29(31)16-20-9-11-23(12-10-20)28-36(6,32)33/h7-13,22,28,31H,14-17H2,1-6H3,(H,27,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 481 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144671
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=O)Cc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H36N2O5S/c1-18-7-8-21(13-19(18)2)14-22(17-33-25(30)26(3,4)5)16-27-24(29)15-20-9-11-23(12-10-20)28-34(6,31)32/h7-13,22,28H,14-17H2,1-6H3,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144672
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)N(O)Cc2ccc(NS(C)(=O)=O)c(F)c2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H36FN3O5S2/c1-17-7-8-19(11-18(17)2)12-21(16-35-24(31)26(3,4)5)14-28-25(36)30(32)15-20-9-10-23(22(27)13-20)29-37(6,33)34/h7-11,13,21,29,32H,12,14-16H2,1-6H3,(H,28,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 546 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144673
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)C(C)(C)C)CN(O)C(=S)NCc2ccc(NS(C)(=O)=O)cc2F)cc1C Show InChI InChI=1S/C26H36FN3O5S2/c1-17-7-8-19(11-18(17)2)12-20(16-35-24(31)26(3,4)5)15-30(32)25(36)28-14-21-9-10-22(13-23(21)27)29-37(6,33)34/h7-11,13,20,29,32H,12,14-16H2,1-6H3,(H,28,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144663
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)C(C)(C)C)CN(O)C(=S)NCc2ccc(NS(C)(=O)=O)cc2)cc1C Show InChI InChI=1S/C26H37N3O5S2/c1-18-7-8-21(13-19(18)2)14-22(17-34-24(30)26(3,4)5)16-29(31)25(35)27-15-20-9-11-23(12-10-20)28-36(6,32)33/h7-13,22,28,31H,14-17H2,1-6H3,(H,27,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144664
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)Cc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H35NO6S/c1-18-7-8-21(13-19(18)2)14-22(17-33-25(29)26(3,4)5)16-32-24(28)15-20-9-11-23(12-10-20)27-34(6,30)31/h7-13,22,27H,14-17H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20293
(2-[(3,4-dimethylphenyl)methyl]-3-({[(3-fluoro-4-me...)Show SMILES Cc1ccc(CC(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H36FN3O4S2/c1-17-7-8-19(11-18(17)2)12-21(16-34-24(31)26(3,4)5)15-29-25(35)28-14-20-9-10-23(22(27)13-20)30-36(6,32)33/h7-11,13,21,30H,12,14-16H2,1-6H3,(H2,28,29,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20287
(2-[(4-tert-butylphenyl)methyl]-3-({[(3-fluoro-4-me...)Show SMILES CC(C)(C)C(=O)OCC(CNC(=S)NCc1ccc(NS(C)(=O)=O)c(F)c1)Cc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C28H40FN3O4S2/c1-27(2,3)22-11-8-19(9-12-22)14-21(18-36-25(33)28(4,5)6)17-31-26(37)30-16-20-10-13-24(23(29)15-20)32-38(7,34)35/h8-13,15,21,32H,14,16-18H2,1-7H3,(H2,30,31,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Agonist effect on 45 [Ca2+] influx in vanilloid receptor expressing CHO cells relative to maximal capsaicin (300 nM) response |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50130542
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H37N3O4S2/c1-18-7-8-21(13-19(18)2)14-22(17-33-24(30)26(3,4)5)16-28-25(34)27-15-20-9-11-23(12-10-20)29-35(6,31)32/h7-13,22,29H,14-17H2,1-6H3,(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144665
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)C(C)(C)C)CN(O)C(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1C Show InChI InChI=1S/C26H36FN3O5S2/c1-17-7-8-19(11-18(17)2)12-21(16-35-24(31)26(3,4)5)15-30(32)25(36)28-14-20-9-10-23(22(27)13-20)29-37(6,33)34/h7-11,13,21,29,32H,12,14-16H2,1-6H3,(H,28,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20294
(2-[(3,4-dimethylphenyl)methyl]-3-[1-(3-fluoro-4-me...)Show SMILES Cc1ccc(CC(CNC(=O)Cc2ccc(NS(C)(=O)=O)c(F)c2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H35FN2O5S/c1-17-7-8-19(11-18(17)2)12-21(16-34-25(31)26(3,4)5)15-28-24(30)14-20-9-10-23(22(27)13-20)29-35(6,32)33/h7-11,13,21,29H,12,14-16H2,1-6H3,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144667
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)OCc2ccc(NS(C)(=O)=O)c(F)c2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H35FN2O5S2/c1-17-7-8-19(11-18(17)2)12-21(16-33-24(30)26(3,4)5)14-28-25(35)34-15-20-9-10-23(22(27)13-20)29-36(6,31)32/h7-11,13,21,29H,12,14-16H2,1-6H3,(H,28,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144663
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)C(C)(C)C)CN(O)C(=S)NCc2ccc(NS(C)(=O)=O)cc2)cc1C Show InChI InChI=1S/C26H37N3O5S2/c1-18-7-8-21(13-19(18)2)14-22(17-34-24(30)26(3,4)5)16-29(31)25(35)27-15-20-9-11-23(12-10-20)28-36(6,32)33/h7-13,22,28,31H,14-17H2,1-6H3,(H,27,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 212 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144676
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)N(O)Cc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H37N3O5S2/c1-18-7-8-21(13-19(18)2)14-22(17-34-24(30)26(3,4)5)15-27-25(35)29(31)16-20-9-11-23(12-10-20)28-36(6,32)33/h7-13,22,28,31H,14-17H2,1-6H3,(H,27,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 331 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144669
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=S)OCc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H36N2O5S2/c1-18-7-8-21(13-19(18)2)14-22(17-32-24(29)26(3,4)5)15-27-25(34)33-16-20-9-11-23(12-10-20)28-35(6,30)31/h7-13,22,28H,14-17H2,1-6H3,(H,27,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20288
(2-[(4-tert-butylphenyl)methyl]-3-[1-(3-fluoro-4-me...)Show SMILES CC(C)(C)C(=O)OCC(CNC(=O)Cc1ccc(NS(C)(=O)=O)c(F)c1)Cc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C28H39FN2O5S/c1-27(2,3)22-11-8-19(9-12-22)14-21(18-36-26(33)28(4,5)6)17-30-25(32)16-20-10-13-24(23(29)15-20)31-37(7,34)35/h8-13,15,21,31H,14,16-18H2,1-7H3,(H,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144671
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(CNC(=O)Cc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H36N2O5S/c1-18-7-8-21(13-19(18)2)14-22(17-33-25(30)26(3,4)5)16-27-24(29)15-20-9-11-23(12-10-20)28-34(6,31)32/h7-13,22,28H,14-17H2,1-6H3,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144666
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)C(C)(C)C)CN(O)C(=S)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1C Show InChI InChI=1S/C26H36ClN3O5S2/c1-17-7-8-19(11-18(17)2)12-20(16-35-24(31)26(3,4)5)15-30(32)25(36)28-14-21-9-10-22(13-23(21)27)29-37(6,33)34/h7-11,13,20,29,32H,12,14-16H2,1-6H3,(H,28,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 757 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144664
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES Cc1ccc(CC(COC(=O)Cc2ccc(NS(C)(=O)=O)cc2)COC(=O)C(C)(C)C)cc1C Show InChI InChI=1S/C26H35NO6S/c1-18-7-8-21(13-19(18)2)14-22(17-33-25(29)26(3,4)5)16-32-24(28)15-20-9-11-23(12-10-20)27-34(6,30)31/h7-13,22,27H,14-17H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144668
(2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...)Show SMILES CC(C)(C)C(=O)OCC(CN(O)C(=S)NCc1ccc(NS(C)(=O)=O)c(F)c1)Cc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C28H40FN3O5S2/c1-27(2,3)22-11-8-19(9-12-22)14-21(18-37-25(33)28(4,5)6)17-32(34)26(38)30-16-20-10-13-24(23(29)15-20)31-39(7,35)36/h8-13,15,21,31,34H,14,16-18H2,1-7H3,(H,30,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid recptor expressing CHO cells |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144674
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(COC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1NS(C)(=O)=O Show InChI InChI=1S/C27H38N2O6S2/c1-18-8-9-20(12-19(18)2)13-22(17-34-25(30)27(3,4)5)15-28-26(36)35-16-21-10-11-23(24(14-21)33-6)29-37(7,31)32/h8-12,14,22,29H,13,15-17H2,1-7H3,(H,28,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 373 | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50130548
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1NS(C)(=O)=O Show InChI InChI=1S/C27H39N3O5S2/c1-18-8-9-20(12-19(18)2)13-22(17-35-25(31)27(3,4)5)16-29-26(36)28-15-21-10-11-23(24(14-21)34-6)30-37(7,32)33/h8-12,14,22,30H,13,15-17H2,1-7H3,(H2,28,29,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Agonist effect on 45 [Ca2+] influx in vanilloid receptor expressing CHO cells relative to maximal capsaicin (300 nM) response |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144675
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(CC(=O)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1NS(C)(=O)=O Show InChI InChI=1S/C27H38N2O6S/c1-18-8-9-20(12-19(18)2)13-22(17-35-26(31)27(3,4)5)16-28-25(30)15-21-10-11-23(24(14-21)34-6)29-36(7,32)33/h8-12,14,22,29H,13,15-17H2,1-7H3,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 244 | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Agonist effect on 45 [Ca2+] influx in vanilloid receptor expressing CHO cells relative to maximal capsaicin (300 nM) response |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50144662
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(CNC(=S)N(O)CC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1NS(C)(=O)=O Show InChI InChI=1S/C27H39N3O6S2/c1-18-8-9-20(12-19(18)2)13-22(17-36-25(31)27(3,4)5)16-30(32)26(37)28-15-21-10-11-23(24(14-21)35-6)29-38(7,33)34/h8-12,14,22,29,32H,13,15-17H2,1-7H3,(H,28,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 809 | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]-RTX displacement. |
Bioorg Med Chem Lett 14: 2291-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.002
BindingDB Entry DOI: 10.7270/Q2TT4QCG |
More data for this
Ligand-Target Pair | |
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