Affinity Data by PubMed id=15115382

PubMed code 15115382

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50145689 (CHEMBL80844 \| [1-[(S)-2-((R)-2-Benzyloxycarbonylam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Urokinase-type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50145688 (CHEMBL311067 \| benzyl (R)-1-((S)-1-(1-(diphenoxyph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Urokinase-type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50145690 (CHEMBL80977 \| {1-[(S)-2-((R)-2-Benzyloxycarbonylam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Urokinase-type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50145688 (CHEMBL311067 \| benzyl (R)-1-((S)-1-(1-(diphenoxyph...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against thrombin				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50145687 (CHEMBL80680 \| [(S)-[(S)-2-((R)-2-Benzyloxycarbonyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Urokinase-type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50145693 (CHEMBL430813 \| [[(S)-2-((R)-2-Benzyloxycarbonylami...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Urokinase-type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50145691 (CHEMBL310235 \| {1-[(S)-2-((R)-2-Benzyloxycarbonyla...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Urokinase-type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50145692 (CHEMBL421318 \| [[(S)-2-((R)-2-Benzyloxycarbonylami...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Urokinase-type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50145688 (CHEMBL311067 \| benzyl (R)-1-((S)-1-(1-(diphenoxyph...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against plasmin				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50145689 (CHEMBL80844 \| [1-[(S)-2-((R)-2-Benzyloxycarbonylam...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Tissue type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50145689 (CHEMBL80844 \| [1-[(S)-2-((R)-2-Benzyloxycarbonylam...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against plasmin				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50145689 (CHEMBL80844 \| [1-[(S)-2-((R)-2-Benzyloxycarbonylam...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against thrombin				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50145687 (CHEMBL80680 \| [(S)-[(S)-2-((R)-2-Benzyloxycarbonyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against plasmin				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50145688 (CHEMBL311067 \| benzyl (R)-1-((S)-1-(1-(diphenoxyph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Coagulation factor Xa				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50145689 (CHEMBL80844 \| [1-[(S)-2-((R)-2-Benzyloxycarbonylam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Coagulation factor Xa				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM16173 (3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...) Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.07E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against Urokinase-type plasminogen activator				J Med Chem 47: 2411-3 (2004) Article DOI: 10.1021/jm0499209 BindingDB Entry DOI: 10.7270/Q2348JTB
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%