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PubMed code 15149704

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium sensing receptor


(Rattus norvegicus)
BDBM50147700
PNG
((1H-Indol-2-ylmethyl)-(1-naphthalen-1-yl-ethyl)-am...)
Show SMILES CC(NCc1cc2ccccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1S/C21H20N2/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18/h2-13,15,22-23H,14H2,1H3
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.30E+3n/an/an/an/a



UPR 2301 Centre National de la Recherche Scientifique

Curated by ChEMBL


Assay Description
Ability to stimulate [3H]inositol phosphates accumulation in CHO cells expressing rat Calcium sensing receptor (CaSR) at 2 mM [Ca2+]


Bioorg Med Chem Lett 14: 3345-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.056
More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50404271
PNG
(CHEMBL2092942)
Show SMILES C[C@@H](NCc1cc2ccccc2[nH]1)c1cccc2ccccc12 |r|
Show InChI InChI=1S/C21H20N2/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18/h2-13,15,22-23H,14H2,1H3/t15-/m1/s1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



UPR 2301 Centre National de la Recherche Scientifique

Curated by ChEMBL


Assay Description
Ability to stimulate [3H]inositol phosphates accumulation in CHO cells expressing rat Calcium sensing receptor (CaSR) at 2 mM [Ca2+]


Bioorg Med Chem Lett 14: 3345-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.056
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50404271
PNG
(CHEMBL2092942)
Show SMILES C[C@@H](NCc1cc2ccccc2[nH]1)c1cccc2ccccc12 |r|
Show InChI InChI=1S/C21H20N2/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18/h2-13,15,22-23H,14H2,1H3/t15-/m1/s1
PDB

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 310n/an/an/an/a



UPR 2301 Centre National de la Recherche Scientifique

Curated by ChEMBL


Assay Description
Ability to stimulate [3H]inositol phosphates accumulation in HEK293 cells expressing the human calcium sensing receptor (CaSR) at 2 mM [Ca2+]


Bioorg Med Chem Lett 14: 3345-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.056
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%