BindingDB logo
myBDB logout

PubMed code 15163203

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148073
PNG
(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:10:9:22:33.6.7|
Show InChI InChI=1S/C30H37NO3/c1-33-26-11-5-10-24-19-27-30(34-18-6-9-22-7-3-2-4-8-22)15-14-25(32)20-29(30,28(24)26)16-17-31(27)21-23-12-13-23/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 340n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148076
PNG
(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Show SMILES Oc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:9:8:21:32.5.6|
Show InChI InChI=1S/C29H35NO3/c31-24-13-14-29(33-17-5-8-21-6-2-1-3-7-21)26-18-23-9-4-10-25(32)27(23)28(29,19-24)15-16-30(26)20-22-11-12-22/h1-4,6-7,9-10,22,26,32H,5,8,11-20H2/t26-,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 400n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148072
PNG
(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Show SMILES O=C1CC[C@@]2(OCCCc3ccccc3)[C@H]3Cc4cccc5OC1C2(CCN3CC1CC1)c45 |TLB:28:27:4:32.17.16|
Show InChI InChI=1S/C29H33NO3/c31-23-13-14-29(32-17-5-8-20-6-2-1-3-7-20)25-18-22-9-4-10-24-26(22)28(29,27(23)33-24)15-16-30(25)19-21-11-12-21/h1-4,6-7,9-10,21,25,27H,5,8,11-19H2/t25-,27?,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 840n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148076
PNG
(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Show SMILES Oc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:9:8:21:32.5.6|
Show InChI InChI=1S/C29H35NO3/c31-24-13-14-29(33-17-5-8-21-6-2-1-3-7-21)26-18-23-9-4-10-25(32)27(23)28(29,19-24)15-16-30(26)20-22-11-12-22/h1-4,6-7,9-10,22,26,32H,5,8,11-20H2/t26-,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5.06E+3n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148076
PNG
(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Show SMILES Oc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:9:8:21:32.5.6|
Show InChI InChI=1S/C29H35NO3/c31-24-13-14-29(33-17-5-8-21-6-2-1-3-7-21)26-18-23-9-4-10-25(32)27(23)28(29,19-24)15-16-30(26)20-22-11-12-22/h1-4,6-7,9-10,22,26,32H,5,8,11-20H2/t26-,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5.84E+3n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148073
PNG
(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:10:9:22:33.6.7|
Show InChI InChI=1S/C30H37NO3/c1-33-26-11-5-10-24-19-27-30(34-18-6-9-22-7-3-2-4-8-22)15-14-25(32)20-29(30,28(24)26)16-17-31(27)21-23-12-13-23/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 7.36E+3n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148071
PNG
((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12 |r|
Show InChI InChI=1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 1.06E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148074
PNG
(3-benzyloxy-17-cyclopropylmethyl-10-methoxy-(1R,9R...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OCc3ccccc3)c12 |TLB:12:11:2:31.18.17|
Show InChI InChI=1S/C28H33NO3/c1-31-28-13-12-23(30)17-27(28)14-15-29(18-20-10-11-20)25(28)16-22-8-5-9-24(26(22)27)32-19-21-6-3-2-4-7-21/h2-9,20,25H,10-19H2,1H3/t25-,27?,28-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.16E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148070
PNG
(3-butoxy-17-cyclopropylmethyl-10-methoxy-(1R,9R,10...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:13:12:25:28.9.10|
Show InChI InChI=1S/C25H35NO3/c1-3-4-14-29-21-7-5-6-19-15-22-25(28-2)11-10-20(27)16-24(25,23(19)21)12-13-26(22)17-18-8-9-18/h5-7,18,22H,3-4,8-17H2,1-2H3/t22-,24?,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.38E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148079
PNG
(3-butoxy-17-cyclopropylmethyl-10-(3-phenylpropoxy)...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:13:12:25:36.9.10|
Show InChI InChI=1S/C33H43NO3/c1-2-3-20-36-29-13-7-12-27-22-30-33(37-21-8-11-25-9-5-4-6-10-25)17-16-28(35)23-32(33,31(27)29)18-19-34(30)24-26-14-15-26/h4-7,9-10,12-13,26,30H,2-3,8,11,14-24H2,1H3/t30-,32?,33-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.49E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148073
PNG
(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:10:9:22:33.6.7|
Show InChI InChI=1S/C30H37NO3/c1-33-26-11-5-10-24-19-27-30(34-18-6-9-22-7-3-2-4-8-22)15-14-25(32)20-29(30,28(24)26)16-17-31(27)21-23-12-13-23/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.69E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148072
PNG
(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Show SMILES O=C1CC[C@@]2(OCCCc3ccccc3)[C@H]3Cc4cccc5OC1C2(CCN3CC1CC1)c45 |TLB:28:27:4:32.17.16|
Show InChI InChI=1S/C29H33NO3/c31-23-13-14-29(32-17-5-8-20-6-2-1-3-7-20)25-18-22-9-4-10-24-26(22)28(29,27(23)33-24)15-16-30(25)19-21-11-12-21/h1-4,6-7,9-10,21,25,27H,5,8,11-19H2/t25-,27?,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.28E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148078
PNG
(17-cyclopropylmethyl-10-methoxy-13-oxo-(1R,9R,10S)...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OC(=O)\C=C\c3ccccc3)c12 |TLB:12:11:2:34.18.17|
Show InChI InChI=1S/C30H33NO4/c1-34-30-15-14-24(32)19-29(30)16-17-31(20-22-10-11-22)26(30)18-23-8-5-9-25(28(23)29)35-27(33)13-12-21-6-3-2-4-7-21/h2-9,12-13,22,26H,10-11,14-20H2,1H3/b13-12+/t26-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.79E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148075
PNG
(17-cyclopropylmethyl-10-methoxy-3-(3-phenylpropoxy...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OCCCc3ccccc3)c12 |TLB:12:11:2:33.18.17|
Show InChI InChI=1S/C30H37NO3/c1-33-30-15-14-25(32)20-29(30)16-17-31(21-23-12-13-23)27(30)19-24-10-5-11-26(28(24)29)34-18-6-9-22-7-3-2-4-8-22/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.33E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148077
PNG
(17-cyclopropylmethyl-3-hexyloxy-10-methoxy-(1R,9R,...)
Show SMILES CCCCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:15:14:27:30.11.12|
Show InChI InChI=1S/C27H39NO3/c1-3-4-5-6-16-31-23-9-7-8-21-17-24-27(30-2)13-12-22(29)18-26(27,25(21)23)14-15-28(24)19-20-10-11-20/h7-9,20,24H,3-6,10-19H2,1-2H3/t24-,26?,27-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.49E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148072
PNG
(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Show SMILES O=C1CC[C@@]2(OCCCc3ccccc3)[C@H]3Cc4cccc5OC1C2(CCN3CC1CC1)c45 |TLB:28:27:4:32.17.16|
Show InChI InChI=1S/C29H33NO3/c31-23-13-14-29(32-17-5-8-20-6-2-1-3-7-20)25-18-22-9-4-10-24-26(22)28(29,27(23)33-24)15-16-30(25)19-21-11-12-21/h1-4,6-7,9-10,21,25,27H,5,8,11-19H2/t25-,27?,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.62E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148074
PNG
(3-benzyloxy-17-cyclopropylmethyl-10-methoxy-(1R,9R...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OCc3ccccc3)c12 |TLB:12:11:2:31.18.17|
Show InChI InChI=1S/C28H33NO3/c1-31-28-13-12-23(30)17-27(28)14-15-29(18-20-10-11-20)25(28)16-22-8-5-9-24(26(22)27)32-19-21-6-3-2-4-7-21/h2-9,20,25H,10-19H2,1H3/t25-,27?,28-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5.68E+4n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148071
PNG
((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12 |r|
Show InChI InChI=1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 1.09E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148079
PNG
(3-butoxy-17-cyclopropylmethyl-10-(3-phenylpropoxy)...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:13:12:25:36.9.10|
Show InChI InChI=1S/C33H43NO3/c1-2-3-20-36-29-13-7-12-27-22-30-33(37-21-8-11-25-9-5-4-6-10-25)17-16-28(35)23-32(33,31(27)29)18-19-34(30)24-26-14-15-26/h4-7,9-10,12-13,26,30H,2-3,8,11,14-24H2,1H3/t30-,32?,33-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.50E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148075
PNG
(17-cyclopropylmethyl-10-methoxy-3-(3-phenylpropoxy...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OCCCc3ccccc3)c12 |TLB:12:11:2:33.18.17|
Show InChI InChI=1S/C30H37NO3/c1-33-30-15-14-25(32)20-29(30)16-17-31(21-23-12-13-23)27(30)19-24-10-5-11-26(28(24)29)34-18-6-9-22-7-3-2-4-8-22/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.08E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148074
PNG
(3-benzyloxy-17-cyclopropylmethyl-10-methoxy-(1R,9R...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OCc3ccccc3)c12 |TLB:12:11:2:31.18.17|
Show InChI InChI=1S/C28H33NO3/c1-31-28-13-12-23(30)17-27(28)14-15-29(18-20-10-11-20)25(28)16-22-8-5-9-24(26(22)27)32-19-21-6-3-2-4-7-21/h2-9,20,25H,10-19H2,1H3/t25-,27?,28-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.13E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148079
PNG
(3-butoxy-17-cyclopropylmethyl-10-(3-phenylpropoxy)...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:13:12:25:36.9.10|
Show InChI InChI=1S/C33H43NO3/c1-2-3-20-36-29-13-7-12-27-22-30-33(37-21-8-11-25-9-5-4-6-10-25)17-16-28(35)23-32(33,31(27)29)18-19-34(30)24-26-14-15-26/h4-7,9-10,12-13,26,30H,2-3,8,11,14-24H2,1H3/t30-,32?,33-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.32E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148070
PNG
(3-butoxy-17-cyclopropylmethyl-10-methoxy-(1R,9R,10...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:13:12:25:28.9.10|
Show InChI InChI=1S/C25H35NO3/c1-3-4-14-29-21-7-5-6-19-15-22-25(28-2)11-10-20(27)16-24(25,23(19)21)12-13-26(22)17-18-8-9-18/h5-7,18,22H,3-4,8-17H2,1-2H3/t22-,24?,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.61E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148078
PNG
(17-cyclopropylmethyl-10-methoxy-13-oxo-(1R,9R,10S)...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OC(=O)\C=C\c3ccccc3)c12 |TLB:12:11:2:34.18.17|
Show InChI InChI=1S/C30H33NO4/c1-34-30-15-14-24(32)19-29(30)16-17-31(20-22-10-11-22)26(30)18-23-8-5-9-25(28(23)29)35-27(33)13-12-21-6-3-2-4-7-21/h2-9,12-13,22,26H,10-11,14-20H2,1H3/b13-12+/t26-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
 3.59E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148071
PNG
((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12 |r|
Show InChI InChI=1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 4.14E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148077
PNG
(17-cyclopropylmethyl-3-hexyloxy-10-methoxy-(1R,9R,...)
Show SMILES CCCCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:15:14:27:30.11.12|
Show InChI InChI=1S/C27H39NO3/c1-3-4-5-6-16-31-23-9-7-8-21-17-24-27(30-2)13-12-22(29)18-26(27,25(21)23)14-15-28(24)19-20-10-11-20/h7-9,20,24H,3-6,10-19H2,1-2H3/t24-,26?,27-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.41E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148070
PNG
(3-butoxy-17-cyclopropylmethyl-10-methoxy-(1R,9R,10...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:13:12:25:28.9.10|
Show InChI InChI=1S/C25H35NO3/c1-3-4-14-29-21-7-5-6-19-15-22-25(28-2)11-10-20(27)16-24(25,23(19)21)12-13-26(22)17-18-8-9-18/h5-7,18,22H,3-4,8-17H2,1-2H3/t22-,24?,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 7.65E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148078
PNG
(17-cyclopropylmethyl-10-methoxy-13-oxo-(1R,9R,10S)...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OC(=O)\C=C\c3ccccc3)c12 |TLB:12:11:2:34.18.17|
Show InChI InChI=1S/C30H33NO4/c1-34-30-15-14-24(32)19-29(30)16-17-31(20-22-10-11-22)26(30)18-23-8-5-9-25(28(23)29)35-27(33)13-12-21-6-3-2-4-7-21/h2-9,12-13,22,26H,10-11,14-20H2,1H3/b13-12+/t26-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
 8.41E+5n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148077
PNG
(17-cyclopropylmethyl-3-hexyloxy-10-methoxy-(1R,9R,...)
Show SMILES CCCCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:15:14:27:30.11.12|
Show InChI InChI=1S/C27H39NO3/c1-3-4-5-6-16-31-23-9-7-8-21-17-24-27(30-2)13-12-22(29)18-26(27,25(21)23)14-15-28(24)19-20-10-11-20/h7-9,20,24H,3-6,10-19H2,1-2H3/t24-,26?,27-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.17E+6n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50148075
PNG
(17-cyclopropylmethyl-10-methoxy-3-(3-phenylpropoxy...)
Show SMILES CO[C@@]12CCC(=O)CC11CCN(CC3CC3)[C@@H]2Cc2cccc(OCCCc3ccccc3)c12 |TLB:12:11:2:33.18.17|
Show InChI InChI=1S/C30H37NO3/c1-33-30-15-14-25(32)20-29(30)16-17-31(21-23-12-13-23)27(30)19-24-10-5-11-26(28(24)29)34-18-6-9-22-7-3-2-4-8-22/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.41E+6n/an/an/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM50148070
PNG
(3-butoxy-17-cyclopropylmethyl-10-methoxy-(1R,9R,10...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:13:12:25:28.9.10|
Show InChI InChI=1S/C25H35NO3/c1-3-4-14-29-21-7-5-6-19-15-22-25(28-2)11-10-20(27)16-24(25,23(19)21)12-13-26(22)17-18-8-9-18/h5-7,18,22H,3-4,8-17H2,1-2H3/t22-,24?,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50148071
PNG
((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12 |r|
Show InChI InChI=1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22-/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 20n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM50148072
PNG
(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Show SMILES O=C1CC[C@@]2(OCCCc3ccccc3)[C@H]3Cc4cccc5OC1C2(CCN3CC1CC1)c45 |TLB:28:27:4:32.17.16|
Show InChI InChI=1S/C29H33NO3/c31-23-13-14-29(32-17-5-8-20-6-2-1-3-7-20)25-18-22-9-4-10-24-26(22)28(29,27(23)33-24)15-16-30(25)19-21-11-12-21/h1-4,6-7,9-10,21,25,27H,5,8,11-19H2/t25-,27?,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50148076
PNG
(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Show SMILES Oc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:9:8:21:32.5.6|
Show InChI InChI=1S/C29H35NO3/c31-24-13-14-29(33-17-5-8-21-6-2-1-3-7-21)26-18-23-9-4-10-25(32)27(23)28(29,19-24)15-16-30(26)20-22-11-12-22/h1-4,6-7,9-10,22,26,32H,5,8,11-20H2/t26-,28?,29-/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.5n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50148073
PNG
(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:10:9:22:33.6.7|
Show InChI InChI=1S/C30H37NO3/c1-33-26-11-5-10-24-19-27-30(34-18-6-9-22-7-3-2-4-8-22)15-14-25(32)20-29(30,28(24)26)16-17-31(27)21-23-12-13-23/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 21n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM50148071
PNG
((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12 |r|
Show InChI InChI=1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 117n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM50148076
PNG
(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Show SMILES Oc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:9:8:21:32.5.6|
Show InChI InChI=1S/C29H35NO3/c31-24-13-14-29(33-17-5-8-21-6-2-1-3-7-21)26-18-23-9-4-10-25(32)27(23)28(29,19-24)15-16-30(26)20-22-11-12-22/h1-4,6-7,9-10,22,26,32H,5,8,11-20H2/t26-,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.5n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50148071
PNG
((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12 |r|
Show InChI InChI=1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 1.11E+3n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM50148073
PNG
(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:10:9:22:33.6.7|
Show InChI InChI=1S/C30H37NO3/c1-33-26-11-5-10-24-19-27-30(34-18-6-9-22-7-3-2-4-8-22)15-14-25(32)20-29(30,28(24)26)16-17-31(27)21-23-12-13-23/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50148072
PNG
(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Show SMILES O=C1CC[C@@]2(OCCCc3ccccc3)[C@H]3Cc4cccc5OC1C2(CCN3CC1CC1)c45 |TLB:28:27:4:32.17.16|
Show InChI InChI=1S/C29H33NO3/c31-23-13-14-29(32-17-5-8-20-6-2-1-3-7-20)25-18-22-9-4-10-24-26(22)28(29,27(23)33-24)15-16-30(25)19-21-11-12-21/h1-4,6-7,9-10,21,25,27H,5,8,11-19H2/t25-,27?,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 87n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50148072
PNG
(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Show SMILES O=C1CC[C@@]2(OCCCc3ccccc3)[C@H]3Cc4cccc5OC1C2(CCN3CC1CC1)c45 |TLB:28:27:4:32.17.16|
Show InChI InChI=1S/C29H33NO3/c31-23-13-14-29(32-17-5-8-20-6-2-1-3-7-20)25-18-22-9-4-10-24-26(22)28(29,27(23)33-24)15-16-30(25)19-21-11-12-21/h1-4,6-7,9-10,21,25,27H,5,8,11-19H2/t25-,27?,28?,29-/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 9.80n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50148076
PNG
(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Show SMILES Oc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:9:8:21:32.5.6|
Show InChI InChI=1S/C29H35NO3/c31-24-13-14-29(33-17-5-8-21-6-2-1-3-7-21)26-18-23-9-4-10-25(32)27(23)28(29,19-24)15-16-30(26)20-22-11-12-22/h1-4,6-7,9-10,22,26,32H,5,8,11-20H2/t26-,28?,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 7.90n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50148073
PNG
(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Show SMILES COc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12 |TLB:10:9:22:33.6.7|
Show InChI InChI=1S/C30H37NO3/c1-33-26-11-5-10-24-19-27-30(34-18-6-9-22-7-3-2-4-8-22)15-14-25(32)20-29(30,28(24)26)16-17-31(27)21-23-12-13-23/h2-5,7-8,10-11,23,27H,6,9,12-21H2,1H3/t27-,29?,30-/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50148070
PNG
(3-butoxy-17-cyclopropylmethyl-10-methoxy-(1R,9R,10...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:13:12:25:28.9.10|
Show InChI InChI=1S/C25H35NO3/c1-3-4-14-29-21-7-5-6-19-15-22-25(28-2)11-10-20(27)16-24(25,23(19)21)12-13-26(22)17-18-8-9-18/h5-7,18,22H,3-4,8-17H2,1-2H3/t22-,24?,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.61E+3n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50148070
PNG
(3-butoxy-17-cyclopropylmethyl-10-methoxy-(1R,9R,10...)
Show SMILES CCCCOc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OC)c12 |TLB:13:12:25:28.9.10|
Show InChI InChI=1S/C25H35NO3/c1-3-4-14-29-21-7-5-6-19-15-22-25(28-2)11-10-20(27)16-24(25,23(19)21)12-13-26(22)17-18-8-9-18/h5-7,18,22H,3-4,8-17H2,1-2H3/t22-,24?,25-/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...

J Med Chem 47: 3242-7 (2004)


Article DOI: 10.1021/jm031126k
BindingDB Entry DOI: 10.7270/Q2TD9WT4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%