Affinity Data by PubMed id=15214794

PubMed code 15214794

Found 20 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-lactamase TEM (Escherichia coli)	BDBM50149468 (CHEMBL263746 \| Sodium; (R)-6-[1-(5,6-dihydro-8H-im...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50149466 (CHEMBL124416 \| Sodium; (R)-6-[1-(5,6-dihydro-4H-py...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50149467 ((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Escherichia coli)	BDBM50149467 ((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class C (Amp-C) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Escherichia coli)	BDBM50149466 (CHEMBL124416 \| Sodium; (R)-6-[1-(5,6-dihydro-4H-py...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class C (Amp-C) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Enterobacter cloacae)	BDBM50149469 (CHEMBL331090 \| Sodium; (R)-7-oxo-6-[1-(5,6,7,8-tet...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Escherichia coli)	BDBM50149468 (CHEMBL263746 \| Sodium; (R)-6-[1-(5,6-dihydro-8H-im...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class C (Amp-C) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Escherichia coli)	BDBM50149469 (CHEMBL331090 \| Sodium; (R)-7-oxo-6-[1-(5,6,7,8-tet...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class C (Amp-C) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Enterobacter cloacae)	BDBM50149468 (CHEMBL263746 \| Sodium; (R)-6-[1-(5,6-dihydro-8H-im...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Metallo-beta-lactamase type 2 (Bacteroides fragilis)	BDBM50149466 (CHEMBL124416 \| Sodium; (R)-6-[1-(5,6-dihydro-4H-py...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class B (CCRA) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Enterobacter cloacae)	BDBM50149469 (CHEMBL331090 \| Sodium; (R)-7-oxo-6-[1-(5,6,7,8-tet...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Enterobacter cloacae)	BDBM50053173 ((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Enterobacter cloacae)	BDBM50149466 (CHEMBL124416 \| Sodium; (R)-6-[1-(5,6-dihydro-4H-py...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Metallo-beta-lactamase type 2 (Bacteroides fragilis)	BDBM50149468 (CHEMBL263746 \| Sodium; (R)-6-[1-(5,6-dihydro-8H-im...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class B (CCRA) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Escherichia coli)	BDBM50149467 ((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50053173 ((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Metallo-beta-lactamase type 2 (Bacteroides fragilis)	BDBM50149467 ((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class B (CCRA) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Metallo-beta-lactamase type 2 (Bacteroides fragilis)	BDBM50149469 (CHEMBL331090 \| Sodium; (R)-7-oxo-6-[1-(5,6,7,8-tet...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class B (CCRA) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase (Escherichia coli)	BDBM50053173 ((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class C (Amp-C) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Metallo-beta-lactamase type 2 (Bacteroides fragilis)	BDBM50053173 ((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class B (CCRA) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%