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PubMed code 15225695

Compile data set for download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8574
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 19 | N-[6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1cccnc1)C1CC1
Show InChI InChI=1S/C15H12N4O2/c20-14(9-3-4-9)19-13-11-6-12(10-2-1-5-16-7-10)21-15(11)18-8-17-13/h1-2,5-9H,3-4H2,(H,17,18,19,20)
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n/an/a 5n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8579
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 24 | N-[6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1cccnc1)C1CCCC1
Show InChI InChI=1S/C17H16N4O2/c22-16(11-4-1-2-5-11)21-15-13-8-14(12-6-3-7-18-9-12)23-17(13)20-10-19-15/h3,6-11H,1-2,4-5H2,(H,19,20,21,22)
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n/an/a 5n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8575
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C18H17N3O2/c22-17(13-8-4-5-9-13)21-16-14-10-15(12-6-2-1-3-7-12)23-18(14)20-11-19-16/h1-3,6-7,10-11,13H,4-5,8-9H2,(H,19,20,21,22)
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n/an/a 23n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8563
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 8 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C19H19N3O3/c1-24-14-8-6-12(7-9-14)16-10-15-17(20-11-21-19(15)25-16)22-18(23)13-4-2-3-5-13/h6-11,13H,2-5H2,1H3,(H,20,21,22,23)
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n/an/a 32n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8558
PNG
(6-(4-methoxyphenyl)-5-(pyridin-3-yl)furo[2,3-d]pyr...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1cccnc1
Show InChI InChI=1S/C18H14N4O2/c1-23-13-6-4-11(5-7-13)16-14(12-3-2-8-20-9-12)15-17(19)21-10-22-18(15)24-16/h2-10H,1H3,(H2,19,21,22)
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n/an/a 81n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8561
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 6 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C(C)C)ncnc2o1
Show InChI InChI=1S/C17H17N3O3/c1-10(2)16(21)20-15-13-8-14(23-17(13)19-9-18-15)11-4-6-12(22-3)7-5-11/h4-10H,1-3H3,(H,18,19,20,21)
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n/an/a 132n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8570
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 15 | N-{6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C16H13N3O2/c20-15(11-6-7-11)19-14-12-8-13(10-4-2-1-3-5-10)21-16(12)18-9-17-14/h1-5,8-9,11H,6-7H2,(H,17,18,19,20)
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n/an/a 174n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8578
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 23 | N-[6-...)
Show SMILES Fc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H16FN3O2/c19-13-7-5-11(6-8-13)15-9-14-16(20-10-21-18(14)24-15)22-17(23)12-3-1-2-4-12/h5-10,12H,1-4H2,(H,20,21,22,23)
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n/an/a 219n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8577
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 22 | N-[6-...)
Show SMILES Cc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C19H19N3O2/c1-12-6-8-13(9-7-12)16-10-15-17(20-11-21-19(15)24-16)22-18(23)14-4-2-3-5-14/h6-11,14H,2-5H2,1H3,(H,20,21,22,23)
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n/an/a 240n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8562
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 7 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C17H15N3O3/c1-22-12-6-4-10(5-7-12)14-8-13-15(18-9-19-17(13)23-14)20-16(21)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,18,19,20,21)
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n/an/a 316n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8564
PNG
(2-cyclopentyl-N-[6-(4-methoxyphenyl)furo[2,3-d]pyr...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)CC3CCCC3)ncnc2o1
Show InChI InChI=1S/C20H21N3O3/c1-25-15-8-6-14(7-9-15)17-11-16-19(21-12-22-20(16)26-17)23-18(24)10-13-4-2-3-5-13/h6-9,11-13H,2-5,10H2,1H3,(H,21,22,23,24)
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n/an/a 324n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8559
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 4 | N-[6-(...)
Show SMILES CCCCCC(=O)Nc1ncnc2oc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C19H21N3O3/c1-3-4-5-6-17(23)22-18-15-11-16(25-19(15)21-12-20-18)13-7-9-14(24-2)10-8-13/h7-12H,3-6H2,1-2H3,(H,20,21,22,23)
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n/an/a 437n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8574
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 19 | N-[6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1cccnc1)C1CC1
Show InChI InChI=1S/C15H12N4O2/c20-14(9-3-4-9)19-13-11-6-12(10-2-1-5-16-7-10)21-15(11)18-8-17-13/h1-2,5-9H,3-4H2,(H,17,18,19,20)
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n/an/a 447n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8579
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 24 | N-[6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1cccnc1)C1CCCC1
Show InChI InChI=1S/C17H16N4O2/c22-16(11-4-1-2-5-11)21-15-13-8-14(12-6-3-7-18-9-12)23-17(13)20-10-19-15/h3,6-11H,1-2,4-5H2,(H,19,20,21,22)
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Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8560
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 5 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)CCSC)ncnc2o1
Show InChI InChI=1S/C17H17N3O3S/c1-22-12-5-3-11(4-6-12)14-9-13-16(18-10-19-17(13)23-14)20-15(21)7-8-24-2/h3-6,9-10H,7-8H2,1-2H3,(H,18,19,20,21)
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n/an/a 537n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8576
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 21 | N-[6-...)
Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H16ClN3O2/c19-13-7-5-11(6-8-13)15-9-14-16(20-10-21-18(14)24-15)22-17(23)12-3-1-2-4-12/h5-10,12H,1-4H2,(H,20,21,22,23)
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n/an/a 550n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8573
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 18 | N-[6-...)
Show SMILES Fc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C16H12FN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)
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n/an/a 575n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8572
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 17 | N-[6-...)
Show SMILES Cc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C17H15N3O2/c1-10-2-4-11(5-3-10)14-8-13-15(18-9-19-17(13)22-14)20-16(21)12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,18,19,20,21)
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n/an/a 617n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8572
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 17 | N-[6-...)
Show SMILES Cc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C17H15N3O2/c1-10-2-4-11(5-3-10)14-8-13-15(18-9-19-17(13)22-14)20-16(21)12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,18,19,20,21)
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n/an/a 631n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8570
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 15 | N-{6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C16H13N3O2/c20-15(11-6-7-11)19-14-12-8-13(10-4-2-1-3-5-10)21-16(12)18-9-17-14/h1-5,8-9,11H,6-7H2,(H,17,18,19,20)
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n/an/a 832n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8571
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 16 | N-[6-...)
Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)
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n/an/a 1.00E+3n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8563
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 8 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C19H19N3O3/c1-24-14-8-6-12(7-9-14)16-10-15-17(20-11-21-19(15)25-16)22-18(23)13-4-2-3-5-13/h6-11,13H,2-5H2,1H3,(H,20,21,22,23)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8565
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 10 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CCCCC3)ncnc2o1
Show InChI InChI=1S/C20H21N3O3/c1-25-15-9-7-13(8-10-15)17-11-16-18(21-12-22-20(16)26-17)23-19(24)14-5-3-2-4-6-14/h7-12,14H,2-6H2,1H3,(H,21,22,23,24)
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n/an/a 1.82E+3n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8567
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 12 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)N3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H18N4O3/c1-24-13-6-4-12(5-7-13)15-10-14-16(19-11-20-17(14)25-15)21-18(23)22-8-2-3-9-22/h4-7,10-11H,2-3,8-9H2,1H3,(H,19,20,21,23)
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n/an/a 1.95E+3n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8573
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 18 | N-[6-...)
Show SMILES Fc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C16H12FN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)
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n/an/a 2.04E+3n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8571
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 16 | N-[6-...)
Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)
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n/an/a 2.04E+3n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8569
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 14 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3ccco3)ncnc2o1
Show InChI InChI=1S/C18H13N3O4/c1-23-12-6-4-11(5-7-12)15-9-13-16(19-10-20-18(13)25-15)21-17(22)14-3-2-8-24-14/h2-10H,1H3,(H,19,20,21,22)
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n/an/a 2.40E+3n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8574
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 19 | N-[6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1cccnc1)C1CC1
Show InChI InChI=1S/C15H12N4O2/c20-14(9-3-4-9)19-13-11-6-12(10-2-1-5-16-7-10)21-15(11)18-8-17-13/h1-2,5-9H,3-4H2,(H,17,18,19,20)
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n/an/a 3.24E+3n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8562
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 7 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C17H15N3O3/c1-22-12-6-4-10(5-7-12)14-8-13-15(18-9-19-17(13)23-14)20-16(21)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,18,19,20,21)
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n/an/a 3.55E+3n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8567
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 12 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)N3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H18N4O3/c1-24-13-6-4-12(5-7-13)15-10-14-16(19-11-20-17(14)25-15)21-18(23)22-8-2-3-9-22/h4-7,10-11H,2-3,8-9H2,1H3,(H,19,20,21,23)
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n/an/a 1.23E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8578
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 23 | N-[6-...)
Show SMILES Fc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H16FN3O2/c19-13-7-5-11(6-8-13)15-9-14-16(20-10-21-18(14)24-15)22-17(23)12-3-1-2-4-12/h5-10,12H,1-4H2,(H,20,21,22,23)
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n/an/a>1.90E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8564
PNG
(2-cyclopentyl-N-[6-(4-methoxyphenyl)furo[2,3-d]pyr...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)CC3CCCC3)ncnc2o1
Show InChI InChI=1S/C20H21N3O3/c1-25-15-8-6-14(7-9-15)17-11-16-19(21-12-22-20(16)26-17)23-18(24)10-13-4-2-3-5-13/h6-9,11-13H,2-5,10H2,1H3,(H,21,22,23,24)
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n/an/a>1.90E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8573
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 18 | N-[6-...)
Show SMILES Fc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C16H12FN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)
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n/an/a>1.90E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8559
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 4 | N-[6-(...)
Show SMILES CCCCCC(=O)Nc1ncnc2oc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C19H21N3O3/c1-3-4-5-6-17(23)22-18-15-11-16(25-19(15)21-12-20-18)13-7-9-14(24-2)10-8-13/h7-12H,3-6H2,1-2H3,(H,20,21,22,23)
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n/an/a>1.90E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8563
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 8 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C19H19N3O3/c1-24-14-8-6-12(7-9-14)16-10-15-17(20-11-21-19(15)25-16)22-18(23)13-4-2-3-5-13/h6-11,13H,2-5H2,1H3,(H,20,21,22,23)
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n/an/a>1.90E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8578
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 23 | N-[6-...)
Show SMILES Fc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H16FN3O2/c19-13-7-5-11(6-8-13)15-9-14-16(20-10-21-18(14)24-15)22-17(23)12-3-1-2-4-12/h5-10,12H,1-4H2,(H,20,21,22,23)
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n/an/a>1.90E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8575
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C18H17N3O2/c22-17(13-8-4-5-9-13)21-16-14-10-15(12-6-2-1-3-7-12)23-18(14)20-11-19-16/h1-3,6-7,10-11,13H,4-5,8-9H2,(H,19,20,21,22)
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n/an/a>1.90E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8576
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 21 | N-[6-...)
Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H16ClN3O2/c19-13-7-5-11(6-8-13)15-9-14-16(20-10-21-18(14)24-15)22-17(23)12-3-1-2-4-12/h5-10,12H,1-4H2,(H,20,21,22,23)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8571
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 16 | N-[6-...)
Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8560
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 5 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)CCSC)ncnc2o1
Show InChI InChI=1S/C17H17N3O3S/c1-22-12-5-3-11(4-6-12)14-9-13-16(18-10-19-17(13)23-14)20-15(21)7-8-24-2/h3-6,9-10H,7-8H2,1-2H3,(H,18,19,20,21)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8577
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 22 | N-[6-...)
Show SMILES Cc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C19H19N3O2/c1-12-6-8-13(9-7-12)16-10-15-17(20-11-21-19(15)24-16)22-18(23)14-4-2-3-5-14/h6-11,14H,2-5H2,1H3,(H,20,21,22,23)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8562
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 7 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C17H15N3O3/c1-22-12-6-4-10(5-7-12)14-8-13-15(18-9-19-17(13)23-14)20-16(21)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,18,19,20,21)
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Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8565
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 10 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CCCCC3)ncnc2o1
Show InChI InChI=1S/C20H21N3O3/c1-25-15-9-7-13(8-10-15)17-11-16-18(21-12-22-20(16)26-17)23-19(24)14-5-3-2-4-6-14/h7-12,14H,2-6H2,1H3,(H,21,22,23,24)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8566
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 11 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)N3CCOCC3)ncnc2o1
Show InChI InChI=1S/C18H18N4O4/c1-24-13-4-2-12(3-5-13)15-10-14-16(19-11-20-17(14)26-15)21-18(23)22-6-8-25-9-7-22/h2-5,10-11H,6-9H2,1H3,(H,19,20,21,23)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8576
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 21 | N-[6-...)
Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H16ClN3O2/c19-13-7-5-11(6-8-13)15-9-14-16(20-10-21-18(14)24-15)22-17(23)12-3-1-2-4-12/h5-10,12H,1-4H2,(H,20,21,22,23)
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Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8569
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 14 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3ccco3)ncnc2o1
Show InChI InChI=1S/C18H13N3O4/c1-23-12-6-4-11(5-7-12)15-9-13-16(19-10-20-18(13)25-15)21-17(22)14-3-2-8-24-14/h2-10H,1H3,(H,19,20,21,22)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8577
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 22 | N-[6-...)
Show SMILES Cc1ccc(cc1)-c1cc2c(NC(=O)C3CCCC3)ncnc2o1
Show InChI InChI=1S/C19H19N3O2/c1-12-6-8-13(9-7-12)16-10-15-17(20-11-21-19(15)24-16)22-18(23)14-4-2-3-5-14/h6-11,14H,2-5H2,1H3,(H,20,21,22,23)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8561
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 6 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C(C)C)ncnc2o1
Show InChI InChI=1S/C17H17N3O3/c1-10(2)16(21)20-15-13-8-14(23-17(13)19-9-18-15)11-4-6-12(22-3)7-5-11/h4-10H,1-3H3,(H,18,19,20,21)
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n/an/a>2.10E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8572
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 17 | N-[6-...)
Show SMILES Cc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C17H15N3O2/c1-10-2-4-11(5-3-10)14-8-13-15(18-9-19-17(13)22-14)20-16(21)12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,18,19,20,21)
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n/an/a>2.10E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8567
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 12 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)N3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H18N4O3/c1-24-13-6-4-12(5-7-13)15-10-14-16(19-11-20-17(14)25-15)21-18(23)22-8-2-3-9-22/h4-7,10-11H,2-3,8-9H2,1H3,(H,19,20,21,23)
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n/an/a>2.10E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8570
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 15 | N-{6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C16H13N3O2/c20-15(11-6-7-11)19-14-12-8-13(10-4-2-1-3-5-10)21-16(12)18-9-17-14/h1-5,8-9,11H,6-7H2,(H,17,18,19,20)
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n/an/a>2.10E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM8568
PNG
(3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidi...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1
Show InChI InChI=1S/C20H14FN3O3/c1-26-15-7-5-12(6-8-15)17-10-16-18(22-11-23-20(16)27-17)24-19(25)13-3-2-4-14(21)9-13/h2-11H,1H3,(H,22,23,24,25)
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n/an/a>2.10E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8568
PNG
(3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidi...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1
Show InChI InChI=1S/C20H14FN3O3/c1-26-15-7-5-12(6-8-15)17-10-16-18(22-11-23-20(16)27-17)24-19(25)13-3-2-4-14(21)9-13/h2-11H,1H3,(H,22,23,24,25)
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n/an/a 2.19E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8575
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C18H17N3O2/c22-17(13-8-4-5-9-13)21-16-14-10-15(12-6-2-1-3-7-12)23-18(14)20-11-19-16/h1-3,6-7,10-11,13H,4-5,8-9H2,(H,19,20,21,22)
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n/an/a>2.30E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8579
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 24 | N-[6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1cccnc1)C1CCCC1
Show InChI InChI=1S/C17H16N4O2/c22-16(11-4-1-2-5-11)21-15-13-8-14(12-6-3-7-18-9-12)23-17(13)20-10-19-15/h3,6-11H,1-2,4-5H2,(H,19,20,21,22)
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n/an/a>2.40E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8566
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 11 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)N3CCOCC3)ncnc2o1
Show InChI InChI=1S/C18H18N4O4/c1-24-13-4-2-12(3-5-13)15-10-14-16(19-11-20-17(14)26-15)21-18(23)22-6-8-25-9-7-22/h2-5,10-11H,6-9H2,1H3,(H,19,20,21,23)
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n/an/a>3.40E+4n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM8568
PNG
(3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidi...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1
Show InChI InChI=1S/C20H14FN3O3/c1-26-15-7-5-12(6-8-15)17-10-16-18(22-11-23-20(16)27-17)24-19(25)13-3-2-4-14(21)9-13/h2-11H,1H3,(H,22,23,24,25)
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n/an/a>3.50E+4n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8560
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 5 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)CCSC)ncnc2o1
Show InChI InChI=1S/C17H17N3O3S/c1-22-12-5-3-11(4-6-12)14-9-13-16(18-10-19-17(13)23-14)20-15(21)7-8-24-2/h3-6,9-10H,7-8H2,1-2H3,(H,18,19,20,21)
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n/an/a>4.70E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8565
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 10 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CCCCC3)ncnc2o1
Show InChI InChI=1S/C20H21N3O3/c1-25-15-9-7-13(8-10-15)17-11-16-18(21-12-22-20(16)26-17)23-19(24)14-5-3-2-4-6-14/h7-12,14H,2-6H2,1H3,(H,21,22,23,24)
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n/an/a>4.80E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8564
PNG
(2-cyclopentyl-N-[6-(4-methoxyphenyl)furo[2,3-d]pyr...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)CC3CCCC3)ncnc2o1
Show InChI InChI=1S/C20H21N3O3/c1-25-15-8-6-14(7-9-15)17-11-16-19(21-12-22-20(16)26-17)23-18(24)10-13-4-2-3-5-13/h6-9,11-13H,2-5,10H2,1H3,(H,21,22,23,24)
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n/an/a>4.80E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8561
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 6 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C(C)C)ncnc2o1
Show InChI InChI=1S/C17H17N3O3/c1-10(2)16(21)20-15-13-8-14(23-17(13)19-9-18-15)11-4-6-12(22-3)7-5-11/h4-10H,1-3H3,(H,18,19,20,21)
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n/an/a>4.80E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8559
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 4 | N-[6-(...)
Show SMILES CCCCCC(=O)Nc1ncnc2oc(cc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C19H21N3O3/c1-3-4-5-6-17(23)22-18-15-11-16(25-19(15)21-12-20-18)13-7-9-14(24-2)10-8-13/h7-12H,3-6H2,1-2H3,(H,20,21,22,23)
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n/an/a>4.80E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8569
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 14 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3ccco3)ncnc2o1
Show InChI InChI=1S/C18H13N3O4/c1-23-12-6-4-11(5-7-12)15-9-13-16(19-10-20-18(13)25-15)21-17(22)14-3-2-8-24-14/h2-10H,1H3,(H,19,20,21,22)
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n/an/a>4.80E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM8566
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 11 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)N3CCOCC3)ncnc2o1
Show InChI InChI=1S/C18H18N4O4/c1-24-13-4-2-12(3-5-13)15-10-14-16(19-11-20-17(14)26-15)21-18(23)22-6-8-25-9-7-22/h2-5,10-11H,6-9H2,1H3,(H,19,20,21,23)
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n/an/a>4.80E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%