Affinity Data by PubMed id=15225713

PubMed code 15225713

Found 36 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149792 (5-(2-Methyl-thiazol-4-ylethynyl)-[3,3'']bipyridiny...) Show SMILES Cc1nc(cs1)C#Cc1cncc(c1)-c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149801 (2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine \| ...) Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149805 (2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyr...) Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50122759 (2-Methyl-4-phenylethynyl-thiazole \| CHEMBL63042) Show SMILES Cc1nc(cs1)C#Cc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149802 (2-Methyl-4-m-tolylethynyl-thiazole \| 2-methyl-4-(m...) Show SMILES Cc1nc(cs1)C#Cc1cccc(C)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50122758 (2-methyl-4-(pyridin-3-ylethynyl)thiazole \| 3-(2-(2...) Show SMILES Cc1nc(cs1)C#Cc1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149800 (5-(2-Methyl-thiazol-4-ylethynyl)-[3,4'']bipyridiny...) Show SMILES Cc1nc(cs1)C#Cc1cncc(c1)-c1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149796 (5-(2-Methyl-thiazol-4-ylethynyl)-[2,2'']bipyridiny...) Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149798 (3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene \| ...) Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149795 (5-(2-Methyl-thiazol-4-ylethynyl)-[2,4'']bipyridiny...) Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149794 (5''-(2-Methyl-thiazol-4-ylethynyl)-[2,3'']bipyridi...) Show SMILES Cc1nc(cs1)C#Cc1cncc(c1)-c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149793 (3-(2-Methyl-thiazol-4-ylethynyl)-5-phenyl-pyridine...) Show SMILES Cc1nc(cs1)C#Cc1cncc(c1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149799 (4-Biphenyl-4-ylethynyl-2-methyl-thiazole \| CHEMBL1...) Show SMILES Cc1nc(cs1)C#Cc1ccc(cc1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149797 (2-Methyl-4-o-tolylethynyl-thiazole \| CHEMBL181915) Show SMILES Cc1nc(cs1)C#Cc1ccccc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50122757 (2-(2-Methyl-thiazol-4-ylethynyl)-pyridine \| CHEMBL...) Show SMILES Cc1nc(cs1)C#Cc1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	54	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149804 (4-Biphenyl-2-ylethynyl-2-methyl-thiazole \| CHEMBL1...) Show SMILES Cc1nc(cs1)C#Cc1ccccc1-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	145	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50122763 (4-(2-Methyl-thiazol-4-ylethynyl)-pyridine \| CHEMBL...) Show SMILES Cc1nc(cs1)C#Cc1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	218	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50149803 (2-Methyl-4-p-tolylethynyl-thiazole \| CHEMBL185813) Show SMILES Cc1nc(cs1)C#Cc1ccc(C)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	638	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149801 (2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine \| ...) Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149793 (3-(2-Methyl-thiazol-4-ylethynyl)-5-phenyl-pyridine...) Show SMILES Cc1nc(cs1)C#Cc1cncc(c1)-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149802 (2-Methyl-4-m-tolylethynyl-thiazole \| 2-methyl-4-(m...) Show SMILES Cc1nc(cs1)C#Cc1cccc(C)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149805 (2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyr...) Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1cccnc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149792 (5-(2-Methyl-thiazol-4-ylethynyl)-[3,3'']bipyridiny...) Show SMILES Cc1nc(cs1)C#Cc1cncc(c1)-c1cccnc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149796 (5-(2-Methyl-thiazol-4-ylethynyl)-[2,2'']bipyridiny...) Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50122759 (2-Methyl-4-phenylethynyl-thiazole \| CHEMBL63042) Show SMILES Cc1nc(cs1)C#Cc1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50122758 (2-methyl-4-(pyridin-3-ylethynyl)thiazole \| 3-(2-(2...) Show SMILES Cc1nc(cs1)C#Cc1cccnc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149797 (2-Methyl-4-o-tolylethynyl-thiazole \| CHEMBL181915) Show SMILES Cc1nc(cs1)C#Cc1ccccc1C Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149800 (5-(2-Methyl-thiazol-4-ylethynyl)-[3,4'']bipyridiny...) Show SMILES Cc1nc(cs1)C#Cc1cncc(c1)-c1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149794 (5''-(2-Methyl-thiazol-4-ylethynyl)-[2,3'']bipyridi...) Show SMILES Cc1nc(cs1)C#Cc1cncc(c1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149799 (4-Biphenyl-4-ylethynyl-2-methyl-thiazole \| CHEMBL1...) Show SMILES Cc1nc(cs1)C#Cc1ccc(cc1)-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149795 (5-(2-Methyl-thiazol-4-ylethynyl)-[2,4'']bipyridiny...) Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149798 (3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene \| ...) Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50122757 (2-(2-Methyl-thiazol-4-ylethynyl)-pyridine \| CHEMBL...) Show SMILES Cc1nc(cs1)C#Cc1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50122763 (4-(2-Methyl-thiazol-4-ylethynyl)-pyridine \| CHEMBL...) Show SMILES Cc1nc(cs1)C#Cc1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149804 (4-Biphenyl-2-ylethynyl-2-methyl-thiazole \| CHEMBL1...) Show SMILES Cc1nc(cs1)C#Cc1ccccc1-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	423	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50149803 (2-Methyl-4-p-tolylethynyl-thiazole \| CHEMBL185813) Show SMILES Cc1nc(cs1)C#Cc1ccc(C)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	845	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist				Bioorg Med Chem Lett 14: 3993-6 (2004) Article DOI: 10.1016/j.bmcl.2004.05.037 BindingDB Entry DOI: 10.7270/Q2T43SKQ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%