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PubMed code 15481971

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154439
PNG
(5,6-Dihydroxy-2-(3-hydroxy-phenyl)-pyrimidine-4-ca...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(O)c1
Show InChI InChI=1S/C11H8N2O5/c14-6-3-1-2-5(4-6)9-12-7(11(17)18)8(15)10(16)13-9/h1-4,14-15H,(H,17,18)(H,12,13,16)
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n/an/a 600n/an/an/an/an/an/a



Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154446
PNG
(5-Hydroxy-2-(3-hydroxy-phenyl)-1-methyl-6-oxo-1,6-...)
Show SMILES Cn1c(nc(C(O)=O)c(O)c1=O)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N2O5/c1-14-10(6-3-2-4-7(15)5-6)13-8(12(18)19)9(16)11(14)17/h2-5,15-16H,1H3,(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154444
PNG
(2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154442
PNG
(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50147498
PNG
(3-Hydroxy-4-oxo-4H-pyran-2,6-dicarboxylic acid 6-e...)
Show SMILES CCOC(=O)c1cc(=O)c(O)c(o1)C(O)=O
Show InChI InChI=1S/C9H8O7/c1-2-15-9(14)5-3-4(10)6(11)7(16-5)8(12)13/h3,11H,2H2,1H3,(H,12,13)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM33414
PNG
(CHEMBL440562 | pyrimidinol carboxylic acid, 6)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccccc1
Show InChI InChI=1S/C11H8N2O4/c14-8-7(11(16)17)12-9(13-10(8)15)6-4-2-1-3-5-6/h1-5,14H,(H,16,17)(H,12,13,15)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50115579
PNG
((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid | 2-...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1
Show InChI InChI=1S/C10H8O4/c11-8(6-9(12)10(13)14)7-4-2-1-3-5-7/h1-5H,6H2,(H,13,14)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154439
PNG
(5,6-Dihydroxy-2-(3-hydroxy-phenyl)-pyrimidine-4-ca...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(O)c1
Show InChI InChI=1S/C11H8N2O5/c14-6-3-1-2-5(4-6)9-12-7(11(17)18)8(15)10(16)13-9/h1-4,14-15H,(H,17,18)(H,12,13,16)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154446
PNG
(5-Hydroxy-2-(3-hydroxy-phenyl)-1-methyl-6-oxo-1,6-...)
Show SMILES Cn1c(nc(C(O)=O)c(O)c1=O)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N2O5/c1-14-10(6-3-2-4-7(15)5-6)13-8(12(18)19)9(16)11(14)17/h2-5,15-16H,1H3,(H,18,19)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154444
PNG
(2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50154442
PNG
(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HIV-RT is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154442
PNG
(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154441
PNG
(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Show SMILES COC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H9ClN2O4/c1-19-12(18)8-9(16)11(17)15-10(14-8)6-2-4-7(13)5-3-6/h2-5,16H,1H3,(H,14,15,17)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM33414
PNG
(CHEMBL440562 | pyrimidinol carboxylic acid, 6)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccccc1
Show InChI InChI=1S/C11H8N2O4/c14-8-7(11(16)17)12-9(13-10(8)15)6-4-2-1-3-5-6/h1-5,14H,(H,16,17)(H,12,13,15)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50154442
PNG
(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)
PDB
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HIV-integrase is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154445
PNG
(5-Hydroxy-2-(3-hydroxy-phenyl)-6-methoxy-pyrimidin...)
Show SMILES COc1nc(nc(C(O)=O)c1O)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N2O5/c1-19-11-9(16)8(12(17)18)13-10(14-11)6-3-2-4-7(15)5-6/h2-5,15-16H,1H3,(H,17,18)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50154444
PNG
(2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HIV-integrase is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154445
PNG
(5-Hydroxy-2-(3-hydroxy-phenyl)-6-methoxy-pyrimidin...)
Show SMILES COc1nc(nc(C(O)=O)c1O)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N2O5/c1-19-11-9(16)8(12(17)18)13-10(14-11)6-3-2-4-7(15)5-6/h2-5,15-16H,1H3,(H,17,18)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154443
PNG
(2-(4-Chloro-phenyl)-6-hydroxy-5-methoxy-pyrimidine...)
Show SMILES COc1c(nc([nH]c1=O)-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C12H9ClN2O4/c1-19-9-8(12(17)18)14-10(15-11(9)16)6-2-4-7(13)5-3-6/h2-5H,1H3,(H,17,18)(H,14,15,16)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154440
PNG
(2-(3-Hydroxy-phenyl)-pyrimidine-4,5-diol | CHEMBL1...)
Show SMILES Oc1cccc(c1)-c1ncc(O)c(=O)[nH]1
Show InChI InChI=1S/C10H8N2O3/c13-7-3-1-2-6(4-7)9-11-5-8(14)10(15)12-9/h1-5,13-14H,(H,11,12,15)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154440
PNG
(2-(3-Hydroxy-phenyl)-pyrimidine-4,5-diol | CHEMBL1...)
Show SMILES Oc1cccc(c1)-c1ncc(O)c(=O)[nH]1
Show InChI InChI=1S/C10H8N2O3/c13-7-3-1-2-6(4-7)9-11-5-8(14)10(15)12-9/h1-5,13-14H,(H,11,12,15)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50154439
PNG
(5,6-Dihydroxy-2-(3-hydroxy-phenyl)-pyrimidine-4-ca...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(O)c1
Show InChI InChI=1S/C11H8N2O5/c14-6-3-1-2-5(4-6)9-12-7(11(17)18)8(15)10(16)13-9/h1-4,14-15H,(H,17,18)(H,12,13,16)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HIV-integrase is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM33414
PNG
(CHEMBL440562 | pyrimidinol carboxylic acid, 6)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccccc1
Show InChI InChI=1S/C11H8N2O4/c14-8-7(11(16)17)12-9(13-10(8)15)6-4-2-1-3-5-6/h1-5,14H,(H,16,17)(H,12,13,15)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HIV-integrase is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154443
PNG
(2-(4-Chloro-phenyl)-6-hydroxy-5-methoxy-pyrimidine...)
Show SMILES COc1c(nc([nH]c1=O)-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C12H9ClN2O4/c1-19-9-8(12(17)18)14-10(15-11(9)16)6-2-4-7(13)5-3-6/h2-5H,1H3,(H,17,18)(H,14,15,16)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM33414
PNG
(CHEMBL440562 | pyrimidinol carboxylic acid, 6)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccccc1
Show InChI InChI=1S/C11H8N2O4/c14-8-7(11(16)17)12-9(13-10(8)15)6-4-2-1-3-5-6/h1-5,14H,(H,16,17)(H,12,13,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HIV-RT is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
DNA polymerase I


(Escherichia coli (strain K12))
BDBM33414
PNG
(CHEMBL440562 | pyrimidinol carboxylic acid, 6)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccccc1
Show InChI InChI=1S/C11H8N2O4/c14-8-7(11(16)17)12-9(13-10(8)15)6-4-2-1-3-5-6/h1-5,14H,(H,16,17)(H,12,13,15)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymerase


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
DNA polymerase I


(Escherichia coli (strain K12))
BDBM50154442
PNG
(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymerase


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
DNA polymerase I


(Escherichia coli (strain K12))
BDBM50154439
PNG
(5,6-Dihydroxy-2-(3-hydroxy-phenyl)-pyrimidine-4-ca...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(O)c1
Show InChI InChI=1S/C11H8N2O5/c14-6-3-1-2-5(4-6)9-12-7(11(17)18)8(15)10(16)13-9/h1-4,14-15H,(H,17,18)(H,12,13,16)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymerase


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
DNA polymerase I


(Escherichia coli (strain K12))
BDBM50154444
PNG
(2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymerase


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50154444
PNG
(2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HIV-RT is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50154439
PNG
(5,6-Dihydroxy-2-(3-hydroxy-phenyl)-pyrimidine-4-ca...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(O)c1
Show InChI InChI=1S/C11H8N2O5/c14-6-3-1-2-5(4-6)9-12-7(11(17)18)8(15)10(16)13-9/h1-4,14-15H,(H,17,18)(H,12,13,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HIV-RT is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50154441
PNG
(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Show SMILES COC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H9ClN2O4/c1-19-12(18)8-9(16)11(17)15-10(14-8)6-2-4-7(13)5-3-6/h2-5,16H,1H3,(H,14,15,17)
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Italy. Vinc

Curated by ChEMBL


Assay Description
Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined


J Med Chem 47: 5336-9 (2004)


Article DOI: 10.1021/jm0494669
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%