Affinity Data by PubMed id=15566281

PubMed code 15566281

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM16046 (3-{[(5-aminopentyl)carbamoyl]methoxy}-5-{[(1R)-1-(...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	4.5	22
Merck Research Laboratories					Assay Description The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...				J Med Chem 47: 6117-9 (2004) Article DOI: 10.1021/jm049388p BindingDB Entry DOI: 10.7270/Q21C1V47
Merck Research Laboratories					More data for this Ligand-Target Pair				3D Structure (crystal)
Beta-secretase 1 (Homo sapiens (Human))	BDBM16044 (3-{[(5-aminopentyl)carbamoyl]methoxy}-5-{[(1R)-1-p...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	4.5	22
Merck Research Laboratories					Assay Description The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...				J Med Chem 47: 6117-9 (2004) Article DOI: 10.1021/jm049388p BindingDB Entry DOI: 10.7270/Q21C1V47
Merck Research Laboratories					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16043 (3-{[(5-aminopentyl)carbamoyl]methoxy}-5-(2-cyanoph...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	4.5	22
Merck Research Laboratories					Assay Description The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...				J Med Chem 47: 6117-9 (2004) Article DOI: 10.1021/jm049388p BindingDB Entry DOI: 10.7270/Q21C1V47
Merck Research Laboratories					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16042 (5-{[(5-aminopentyl)carbamoyl]methoxy}-3-N-[(1R)-1-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	4.5	22
Merck Research Laboratories					Assay Description The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...				J Med Chem 47: 6117-9 (2004) Article DOI: 10.1021/jm049388p BindingDB Entry DOI: 10.7270/Q21C1V47
Merck Research Laboratories					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16045 (3-{[(5-aminopentyl)carbamoyl]methoxy}-5-{[(1S)-1-p...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	4.5	22
Merck Research Laboratories					Assay Description The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...				J Med Chem 47: 6117-9 (2004) Article DOI: 10.1021/jm049388p BindingDB Entry DOI: 10.7270/Q21C1V47
Merck Research Laboratories					More data for this Ligand-Target Pair

* indicates data uncertainty>20%