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PubMed code 15566302

Compile data set for download or QSAR
Found 101 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156861
PNG
(2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-6-fluor...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccc(Cl)s2)c2cc(F)ccc12
Show InChI InChI=1S/C27H26ClFN2O3S/c28-26-8-6-20(35-26)16-31-17-23(21-7-5-19(29)15-24(21)31)18-9-11-30(12-10-18)13-14-34-25-4-2-1-3-22(25)27(32)33/h1-8,15,17-18H,9-14,16H2,(H,32,33)
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n/an/a 28n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156893
PNG
(2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperid...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C27H34N2O5/c1-3-33-16-15-29-19-24(22-6-4-5-7-25(22)29)20-10-12-28(13-11-20)14-17-34-26-18-21(32-2)8-9-23(26)27(30)31/h4-9,18-20H,3,10-17H2,1-2H3,(H,30,31)
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n/an/a 34n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156886
PNG
(2-{2-[4-(6-fluoro-1-furan-2-ylmethyl-1H-indol-3-yl...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccco2)c2cc(F)ccc12
Show InChI InChI=1S/C27H27FN2O4/c28-20-7-8-22-24(18-30(25(22)16-20)17-21-4-3-14-33-21)19-9-11-29(12-10-19)13-15-34-26-6-2-1-5-23(26)27(31)32/h1-8,14,16,18-19H,9-13,15,17H2,(H,31,32)
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n/an/a 37n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156876
PNG
(2-{2-[4-(6-fluoro-1-furan-3-ylmethyl-1H-indol-3-yl...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccoc2)c2cc(F)ccc12
Show InChI InChI=1S/C27H27FN2O4/c28-21-5-6-22-24(17-30(25(22)15-21)16-19-9-13-33-18-19)20-7-10-29(11-8-20)12-14-34-26-4-2-1-3-23(26)27(31)32/h1-6,9,13,15,17-18,20H,7-8,10-12,14,16H2,(H,31,32)
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n/an/a 42n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156879
PNG
(2-{2-[4-(1-butyl-6-fluoro-1H-indol-3-yl)piperidin-...)
Show SMILES CCCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C26H31FN2O3/c1-2-3-12-29-18-23(21-9-8-20(27)17-24(21)29)19-10-13-28(14-11-19)15-16-32-25-7-5-4-6-22(25)26(30)31/h4-9,17-19H,2-3,10-16H2,1H3,(H,30,31)
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n/an/a 47n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156857
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-6-fluoro-1H-indol-3-yl)...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C26H31FN2O4/c1-2-32-15-14-29-18-23(21-8-7-20(27)17-24(21)29)19-9-11-28(12-10-19)13-16-33-25-6-4-3-5-22(25)26(30)31/h3-8,17-19H,2,9-16H2,1H3,(H,30,31)
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n/an/a 76n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156860
PNG
(2-(2-(4-(7-bromo-1-(2-ethoxyethyl)-1H-indol-3-yl)p...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cccc(Br)c12
Show InChI InChI=1S/C26H31BrN2O4/c1-2-32-16-15-29-18-22(20-7-5-8-23(27)25(20)29)19-10-12-28(13-11-19)14-17-33-24-9-4-3-6-21(24)26(30)31/h3-9,18-19H,2,10-17H2,1H3,(H,30,31)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156853
PNG
(2-(2-(4-(1-(2-methoxyethyl)-1H-indol-3-yl)piperidi...)
Show SMILES COCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O4/c1-30-16-15-27-18-22(20-6-2-4-8-23(20)27)19-10-12-26(13-11-19)14-17-31-24-9-5-3-7-21(24)25(28)29/h2-9,18-19H,10-17H2,1H3,(H,28,29)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156867
PNG
(2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperid...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-17-16-28-19-23(21-7-3-5-9-24(21)28)20-11-13-27(14-12-20)15-18-32-25-10-6-4-8-22(25)26(29)30/h3-10,19-20H,2,11-18H2,1H3,(H,29,30)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156887
PNG
(3-[4-(1-furan-2-ylmethyl-1H-indol-3-yl)piperidin-1...)
Show SMILES OC(=O)c1cccc(CN2CCC(CC2)c2cn(Cc3ccco3)c3ccccc23)c1
Show InChI InChI=1S/C26H26N2O3/c29-26(30)21-6-3-5-19(15-21)16-27-12-10-20(11-13-27)24-18-28(17-22-7-4-14-31-22)25-9-2-1-8-23(24)25/h1-9,14-15,18,20H,10-13,16-17H2,(H,29,30)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156884
PNG
(3-[4-(1-thiophen-2-ylmethyl-1H-indol-3-yl)piperidi...)
Show SMILES OC(=O)c1cccc(CN2CCC(CC2)c2cn(Cc3cccs3)c3ccccc23)c1
Show InChI InChI=1S/C26H26N2O2S/c29-26(30)21-6-3-5-19(15-21)16-27-12-10-20(11-13-27)24-18-28(17-22-7-4-14-31-22)25-9-2-1-8-23(24)25/h1-9,14-15,18,20H,10-13,16-17H2,(H,29,30)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156866
PNG
(5-[4-(6-fluoro-1-thiophen-2-ylmethyl-1H-indol-3-yl...)
Show SMILES COc1ccc(CN2CCC(CC2)c2cn(Cc3cccs3)c3cc(F)ccc23)cc1C(O)=O
Show InChI InChI=1S/C27H27FN2O3S/c1-33-26-7-4-18(13-23(26)27(31)32)15-29-10-8-19(9-11-29)24-17-30(16-21-3-2-12-34-21)25-14-20(28)5-6-22(24)25/h2-7,12-14,17,19H,8-11,15-16H2,1H3,(H,31,32)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156877
PNG
(5-[4-(6-fluoro-1-furan-3-ylmethyl-1H-indol-3-yl)pi...)
Show SMILES COc1ccc(CN2CCC(CC2)c2cn(Cc3ccoc3)c3cc(F)ccc23)cc1C(O)=O
Show InChI InChI=1S/C27H27FN2O4/c1-33-26-5-2-18(12-23(26)27(31)32)14-29-9-6-20(7-10-29)24-16-30(15-19-8-11-34-17-19)25-13-21(28)3-4-22(24)25/h2-5,8,11-13,16-17,20H,6-7,9-10,14-15H2,1H3,(H,31,32)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156850
PNG
(2-{2-[4-(1-allyl-1H-indol-3-yl)piperidin-1-yl]etho...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC=C)c2ccccc12
Show InChI InChI=1S/C25H28N2O3/c1-2-13-27-18-22(20-7-3-5-9-23(20)27)19-11-14-26(15-12-19)16-17-30-24-10-6-4-8-21(24)25(28)29/h2-10,18-19H,1,11-17H2,(H,28,29)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156865
PNG
(2-(2-(4-(1-(furan-2-ylmethyl)-1H-indol-3-yl)piperi...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccco2)c2ccccc12
Show InChI InChI=1S/C27H28N2O4/c30-27(31)23-8-2-4-10-26(23)33-17-15-28-13-11-20(12-14-28)24-19-29(18-21-6-5-16-32-21)25-9-3-1-7-22(24)25/h1-10,16,19-20H,11-15,17-18H2,(H,30,31)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156892
PNG
(2-(2-(4-(1-(thiophen-2-ylmethyl)-1H-indol-3-yl)pip...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2cccs2)c2ccccc12
Show InChI InChI=1S/C27H28N2O3S/c30-27(31)23-8-2-4-10-26(23)32-16-15-28-13-11-20(12-14-28)24-19-29(18-21-6-5-17-33-21)25-9-3-1-7-22(24)25/h1-10,17,19-20H,11-16,18H2,(H,30,31)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156900
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-5-fluoro-1H-indol-3-yl)...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cc(F)ccc12
Show InChI InChI=1S/C26H31FN2O4/c1-2-32-15-14-29-18-23(22-17-20(27)7-8-24(22)29)19-9-11-28(12-10-19)13-16-33-25-6-4-3-5-21(25)26(30)31/h3-8,17-19H,2,9-16H2,1H3,(H,30,31)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156897
PNG
(3-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccsc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C24H30N2O4S/c1-2-29-14-13-26-17-20(19-5-3-4-6-21(19)26)18-7-10-25(11-8-18)12-15-30-22-9-16-31-23(22)24(27)28/h3-6,9,16-18H,2,7-8,10-15H2,1H3,(H,27,28)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156880
PNG
(3-{4-[1-(5-Chloro-thiophen-2-ylmethyl)-1H-indol-3-...)
Show SMILES OC(=O)c1cccc(CN2CCC(CC2)c2cn(Cc3ccc(Cl)s3)c3ccccc23)c1
Show InChI InChI=1S/C26H25ClN2O2S/c27-25-9-8-21(32-25)16-29-17-23(22-6-1-2-7-24(22)29)19-10-12-28(13-11-19)15-18-4-3-5-20(14-18)26(30)31/h1-9,14,17,19H,10-13,15-16H2,(H,30,31)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156882
PNG
(2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-1H-indo...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccc(Cl)s2)c2ccccc12
Show InChI InChI=1S/C27H27ClN2O3S/c28-26-10-9-20(34-26)17-30-18-23(21-5-1-3-7-24(21)30)19-11-13-29(14-12-19)15-16-33-25-8-4-2-6-22(25)27(31)32/h1-10,18-19H,11-17H2,(H,31,32)
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n/an/a 120n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156899
PNG
(2-{2-[4-(1-cyclopropylmethyl-6-fluoro-1H-indol-3-y...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC2CC2)c2cc(F)ccc12
Show InChI InChI=1S/C26H29FN2O3/c27-20-7-8-21-23(17-29(24(21)15-20)16-18-5-6-18)19-9-11-28(12-10-19)13-14-32-25-4-2-1-3-22(25)26(30)31/h1-4,7-8,15,17-19H,5-6,9-14,16H2,(H,30,31)
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n/an/a 121n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156855
PNG
(3-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3cccc(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-16-15-28-19-24(23-8-3-4-9-25(23)28)20-10-12-27(13-11-20)14-17-32-22-7-5-6-21(18-22)26(29)30/h3-9,18-20H,2,10-17H2,1H3,(H,29,30)
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n/an/a 123n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156872
PNG
(2-methoxy-5-[4-(1-thiophen-2-ylmethyl-1H-indol-3-y...)
Show SMILES COc1ccc(CN2CCC(CC2)c2cn(Cc3cccs3)c3ccccc23)cc1C(O)=O
Show InChI InChI=1S/C27H28N2O3S/c1-32-26-9-8-19(15-23(26)27(30)31)16-28-12-10-20(11-13-28)24-18-29(17-21-5-4-14-33-21)25-7-3-2-6-22(24)25/h2-9,14-15,18,20H,10-13,16-17H2,1H3,(H,30,31)
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n/an/a 125n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156873
PNG
(2-{2-[4-(1-Butyl-1H-indol-3-yl)-piperidin-1-yl]-et...)
Show SMILES CCCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O3/c1-2-3-14-28-19-23(21-8-4-6-10-24(21)28)20-12-15-27(16-13-20)17-18-31-25-11-7-5-9-22(25)26(29)30/h4-11,19-20H,2-3,12-18H2,1H3,(H,29,30)
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n/an/a 127n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156891
PNG
(2-(3-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidi...)
Show SMILES CCOCCn1cc(C2CCN(Cc3cccc(OCC(O)=O)c3)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-15-14-28-18-24(23-8-3-4-9-25(23)28)21-10-12-27(13-11-21)17-20-6-5-7-22(16-20)32-19-26(29)30/h3-9,16,18,21H,2,10-15,17,19H2,1H3,(H,29,30)
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n/an/a 130n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156863
PNG
(2-(2-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl...)
Show SMILES COCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H29FN2O4/c1-31-14-13-28-17-22(20-7-6-19(26)16-23(20)28)18-8-10-27(11-9-18)12-15-32-24-5-3-2-4-21(24)25(29)30/h2-7,16-18H,8-15H2,1H3,(H,29,30)
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n/an/a 140n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156869
PNG
(2-{2-[4-(1-cyclopropylmethyl-1H-indol-3-yl)piperid...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC2CC2)c2ccccc12
Show InChI InChI=1S/C26H30N2O3/c29-26(30)22-6-2-4-8-25(22)31-16-15-27-13-11-20(12-14-27)23-18-28(17-19-9-10-19)24-7-3-1-5-21(23)24/h1-8,18-20H,9-17H2,(H,29,30)
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n/an/a 140n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156898
PNG
(5-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperidin-...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccc(OC)c(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-3-32-15-14-28-18-23(21-6-4-5-7-24(21)28)20-10-12-27(13-11-20)17-19-8-9-25(31-2)22(16-19)26(29)30/h4-9,16,18,20H,3,10-15,17H2,1-2H3,(H,29,30)
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n/an/a 145n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156855
PNG
(3-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3cccc(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-16-15-28-19-24(23-8-3-4-9-25(23)28)20-10-12-27(13-11-20)14-17-32-22-7-5-6-21(18-22)26(29)30/h3-9,18-20H,2,10-17H2,1H3,(H,29,30)
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n/an/a 145n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156874
PNG
(5-{4-[1-(5-chlorothiophen-2-ylmethyl)-6-fluoro-1H-...)
Show SMILES COc1ccc(CN2CCC(CC2)c2cn(Cc3ccc(Cl)s3)c3cc(F)ccc23)cc1C(O)=O
Show InChI InChI=1S/C27H26ClFN2O3S/c1-34-25-6-2-17(12-22(25)27(32)33)14-30-10-8-18(9-11-30)23-16-31(15-20-4-7-26(28)35-20)24-13-19(29)3-5-21(23)24/h2-7,12-13,16,18H,8-11,14-15H2,1H3,(H,32,33)
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n/an/a 150n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156858
PNG
(3-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl]pi...)
Show SMILES COCCn1cc(C2CCN(Cc3cccc(c3)C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C24H27FN2O3/c1-30-12-11-27-16-22(21-6-5-20(25)14-23(21)27)18-7-9-26(10-8-18)15-17-3-2-4-19(13-17)24(28)29/h2-6,13-14,16,18H,7-12,15H2,1H3,(H,28,29)
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n/an/a 150n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156859
PNG
(2-(2-(4-(5-bromo-1-(2-ethoxyethyl)-1H-indol-3-yl)p...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cc(Br)ccc12
Show InChI InChI=1S/C26H31BrN2O4/c1-2-32-15-14-29-18-23(22-17-20(27)7-8-24(22)29)19-9-11-28(12-10-19)13-16-33-25-6-4-3-5-21(25)26(30)31/h3-8,17-19H,2,9-16H2,1H3,(H,30,31)
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n/an/a 150n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156894
PNG
(4-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccc(cc3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-17-16-28-19-24(23-5-3-4-6-25(23)28)20-11-13-27(14-12-20)15-18-32-22-9-7-21(8-10-22)26(29)30/h3-10,19-20H,2,11-18H2,1H3,(H,29,30)
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n/an/a 150n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156883
PNG
(2-(2-{4-[1-(2-ethoxyethyl)-5-methoxy-1H-indol-3-yl...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cc(OC)ccc12
Show InChI InChI=1S/C27H34N2O5/c1-3-33-16-15-29-19-24(23-18-21(32-2)8-9-25(23)29)20-10-12-28(13-11-20)14-17-34-26-7-5-4-6-22(26)27(30)31/h4-9,18-20H,3,10-17H2,1-2H3,(H,30,31)
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n/an/a 155n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156881
PNG
(2-(2-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidi...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccccc3OCC(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-16-15-28-18-23(22-8-4-5-9-24(22)28)20-11-13-27(14-12-20)17-21-7-3-6-10-25(21)32-19-26(29)30/h3-10,18,20H,2,11-17,19H2,1H3,(H,29,30)
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n/an/a 196n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156871
PNG
(3-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperidin-...)
Show SMILES CCOCCn1cc(C2CCN(Cc3cccc(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O3/c1-2-30-15-14-27-18-23(22-8-3-4-9-24(22)27)20-10-12-26(13-11-20)17-19-6-5-7-21(16-19)25(28)29/h3-9,16,18,20H,2,10-15,17H2,1H3,(H,28,29)
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n/an/a 218n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156890
PNG
(5-acetyl-2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccc(cc3C(O)=O)C(C)=O)CC2)c2ccccc12
Show InChI InChI=1S/C28H34N2O5/c1-3-34-16-15-30-19-25(23-6-4-5-7-26(23)30)21-10-12-29(13-11-21)14-17-35-27-9-8-22(20(2)31)18-24(27)28(32)33/h4-9,18-19,21H,3,10-17H2,1-2H3,(H,32,33)
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n/an/a 219n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156856
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccc(C)cc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C27H34N2O4/c1-3-32-16-15-29-19-24(22-6-4-5-7-25(22)29)21-10-12-28(13-11-21)14-17-33-26-9-8-20(2)18-23(26)27(30)31/h4-9,18-19,21H,3,10-17H2,1-2H3,(H,30,31)
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n/an/a 221n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156878
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3c(Br)cc(Br)cc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H30Br2N2O4/c1-2-33-13-12-30-17-22(20-5-3-4-6-24(20)30)18-7-9-29(10-8-18)11-14-34-25-21(26(31)32)15-19(27)16-23(25)28/h3-6,15-18H,2,7-14H2,1H3,(H,31,32)
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n/an/a 225n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156856
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccc(C)cc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C27H34N2O4/c1-3-32-16-15-29-19-24(22-6-4-5-7-25(22)29)21-10-12-28(13-11-21)14-17-33-26-9-8-20(2)18-23(26)27(30)31/h4-9,18-19,21H,3,10-17H2,1-2H3,(H,30,31)
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n/an/a 225n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156885
PNG
(5-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl]pi...)
Show SMILES COCCn1cc(C2CCN(Cc3ccc(OC)c(c3)C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H29FN2O4/c1-31-12-11-28-16-22(20-5-4-19(26)14-23(20)28)18-7-9-27(10-8-18)15-17-3-6-24(32-2)21(13-17)25(29)30/h3-6,13-14,16,18H,7-12,15H2,1-2H3,(H,29,30)
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n/an/a 245n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156857
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-6-fluoro-1H-indol-3-yl)...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C26H31FN2O4/c1-2-32-15-14-29-18-23(21-8-7-20(27)17-24(21)29)19-9-11-28(12-10-19)13-16-33-25-6-4-3-5-22(25)26(30)31/h3-8,17-19H,2,9-16H2,1H3,(H,30,31)
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n/an/a 260n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156889
PNG
(5-{4-[1-(2-ethoxyethyl)-1H-indol-3-yl]piperidin-1-...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccc(F)c(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H29FN2O3/c1-2-31-14-13-28-17-22(20-5-3-4-6-24(20)28)19-9-11-27(12-10-19)16-18-7-8-23(26)21(15-18)25(29)30/h3-8,15,17,19H,2,9-14,16H2,1H3,(H,29,30)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156851
PNG
(2-(4-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidi...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccc(OCC(O)=O)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-16-15-28-18-24(23-5-3-4-6-25(23)28)21-11-13-27(14-12-21)17-20-7-9-22(10-8-20)32-19-26(29)30/h3-10,18,21H,2,11-17,19H2,1H3,(H,29,30)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156854
PNG
(2-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin-1...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O3/c1-2-30-16-15-27-18-23(22-9-5-6-10-24(22)27)19-11-13-26(14-12-19)17-20-7-3-4-8-21(20)25(28)29/h3-10,18-19H,2,11-17H2,1H3,(H,28,29)
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n/an/a 330n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156862
PNG
(4-bromo-3-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)pip...)
Show SMILES CCOCCn1cc(C2CCN(Cc3cc(ccc3Br)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H29BrN2O3/c1-2-31-14-13-28-17-22(21-5-3-4-6-24(21)28)18-9-11-27(12-10-18)16-20-15-19(25(29)30)7-8-23(20)26/h3-8,15,17-18H,2,9-14,16H2,1H3,(H,29,30)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156870
PNG
(2-(2-{4-[1-(2-[1,3]dioxolan-2-yl-ethyl)-1H-indol-3...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CCC2OCCO2)c2ccccc12
Show InChI InChI=1S/C27H32N2O5/c30-27(31)22-6-2-4-8-25(22)32-16-15-28-12-9-20(10-13-28)23-19-29(14-11-26-33-17-18-34-26)24-7-3-1-5-21(23)24/h1-8,19-20,26H,9-18H2,(H,30,31)
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n/an/a 354n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156864
PNG
(2-(2-(4-(1-(2-(1,4-dioxan-2-yl)ethyl)-1H-indol-3-y...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CCC2COCCO2)c2ccccc12
Show InChI InChI=1S/C28H34N2O5/c31-28(32)24-6-2-4-8-27(24)35-16-15-29-12-9-21(10-13-29)25-19-30(26-7-3-1-5-23(25)26)14-11-22-20-33-17-18-34-22/h1-8,19,21-22H,9-18,20H2,(H,31,32)
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n/an/a 390n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156896
PNG
(2-methoxy-5-{4-[1-(2-methoxyethyl)-1H-indol-3-yl]p...)
Show SMILES COCCn1cc(C2CCN(Cc3ccc(OC)c(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O4/c1-30-14-13-27-17-22(20-5-3-4-6-23(20)27)19-9-11-26(12-10-19)16-18-7-8-24(31-2)21(15-18)25(28)29/h3-8,15,17,19H,9-14,16H2,1-2H3,(H,28,29)
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n/an/a 470n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156875
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3cccc(F)c3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H31FN2O4/c1-2-32-16-15-29-18-21(20-6-3-4-8-23(20)29)19-10-12-28(13-11-19)14-17-33-24-9-5-7-22(27)25(24)26(30)31/h3-9,18-19H,2,10-17H2,1H3,(H,30,31)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156868
PNG
(3-{4-[1-(2-ethoxyethyl)-5-methoxy-1H-indol-3-yl]pi...)
Show SMILES CCOCCn1cc(C2CCN(Cc3cccc(c3)C(O)=O)CC2)c2cc(OC)ccc12
Show InChI InChI=1S/C26H32N2O4/c1-3-32-14-13-28-18-24(23-16-22(31-2)7-8-25(23)28)20-9-11-27(12-10-20)17-19-5-4-6-21(15-19)26(29)30/h4-8,15-16,18,20H,3,9-14,17H2,1-2H3,(H,29,30)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156888
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-7-methyl-1H-indol-3-yl)...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cccc(C)c12
Show InChI InChI=1S/C27H34N2O4/c1-3-32-17-16-29-19-24(22-9-6-7-20(2)26(22)29)21-11-13-28(14-12-21)15-18-33-25-10-5-4-8-23(25)27(30)31/h4-10,19,21H,3,11-18H2,1-2H3,(H,30,31)
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n/an/a 500n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156878
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3c(Br)cc(Br)cc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H30Br2N2O4/c1-2-33-13-12-30-17-22(20-5-3-4-6-24(20)30)18-7-9-29(10-8-18)11-14-34-25-21(26(31)32)15-19(27)16-23(25)28/h3-6,15-18H,2,7-14H2,1H3,(H,31,32)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156895
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-6-(trifluoromethyl)-1H-...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C27H31F3N2O4/c1-2-35-15-14-32-18-23(21-8-7-20(17-24(21)32)27(28,29)30)19-9-11-31(12-10-19)13-16-36-25-6-4-3-5-22(25)26(33)34/h3-8,17-19H,2,9-16H2,1H3,(H,33,34)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156900
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-5-fluoro-1H-indol-3-yl)...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cc(F)ccc12
Show InChI InChI=1S/C26H31FN2O4/c1-2-32-15-14-29-18-23(22-17-20(27)7-8-24(22)29)19-9-11-28(12-10-19)13-16-33-25-6-4-3-5-21(25)26(30)31/h3-8,17-19H,2,9-16H2,1H3,(H,30,31)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156892
PNG
(2-(2-(4-(1-(thiophen-2-ylmethyl)-1H-indol-3-yl)pip...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2cccs2)c2ccccc12
Show InChI InChI=1S/C27H28N2O3S/c30-27(31)23-8-2-4-10-26(23)32-16-15-28-13-11-20(12-14-28)24-19-29(18-21-6-5-17-33-21)25-9-3-1-7-22(24)25/h1-10,17,19-20H,11-16,18H2,(H,30,31)
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n/an/a 500n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156852
PNG
(2-(2-(4-(1-(2-(pyridin-2-yl)ethyl)-1H-indol-3-yl)p...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CCc2ccccn2)c2ccccc12
Show InChI InChI=1S/C29H31N3O3/c33-29(34)25-9-2-4-11-28(25)35-20-19-31-16-12-22(13-17-31)26-21-32(27-10-3-1-8-24(26)27)18-14-23-7-5-6-15-30-23/h1-11,15,21-22H,12-14,16-20H2,(H,33,34)
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n/an/a 570n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156887
PNG
(3-[4-(1-furan-2-ylmethyl-1H-indol-3-yl)piperidin-1...)
Show SMILES OC(=O)c1cccc(CN2CCC(CC2)c2cn(Cc3ccco3)c3ccccc23)c1
Show InChI InChI=1S/C26H26N2O3/c29-26(30)21-6-3-5-19(15-21)16-27-12-10-20(11-13-27)24-18-28(17-22-7-4-14-31-22)25-9-2-1-8-23(24)25/h1-9,14-15,18,20H,10-13,16-17H2,(H,29,30)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156894
PNG
(4-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccc(cc3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-17-16-28-19-24(23-5-3-4-6-25(23)28)20-11-13-27(14-12-20)15-18-32-22-9-7-21(8-10-22)26(29)30/h3-10,19-20H,2,11-18H2,1H3,(H,29,30)
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n/an/a 691n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156893
PNG
(2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperid...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C27H34N2O5/c1-3-33-16-15-29-19-24(22-6-4-5-7-25(22)29)20-10-12-28(13-11-20)14-17-34-26-18-21(32-2)8-9-23(26)27(30)31/h4-9,18-20H,3,10-17H2,1-2H3,(H,30,31)
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n/an/a 779n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156875
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3cccc(F)c3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H31FN2O4/c1-2-32-16-15-29-18-21(20-6-3-4-8-23(20)29)19-10-12-28(13-11-19)14-17-33-24-9-5-7-22(27)25(24)26(30)31/h3-9,18-19H,2,10-17H2,1H3,(H,30,31)
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n/an/a 850n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156886
PNG
(2-{2-[4-(6-fluoro-1-furan-2-ylmethyl-1H-indol-3-yl...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccco2)c2cc(F)ccc12
Show InChI InChI=1S/C27H27FN2O4/c28-20-7-8-22-24(18-30(25(22)16-20)17-21-4-3-14-33-21)19-9-11-29(12-10-19)13-15-34-26-6-2-1-5-23(26)27(31)32/h1-8,14,16,18-19H,9-13,15,17H2,(H,31,32)
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n/an/a 870n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156876
PNG
(2-{2-[4-(6-fluoro-1-furan-3-ylmethyl-1H-indol-3-yl...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccoc2)c2cc(F)ccc12
Show InChI InChI=1S/C27H27FN2O4/c28-21-5-6-22-24(17-30(25(22)15-21)16-19-9-13-33-18-19)20-7-10-29(11-8-20)12-14-34-26-4-2-1-3-23(26)27(31)32/h1-6,9,13,15,17-18,20H,7-8,10-12,14,16H2,(H,31,32)
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n/an/a 880n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156890
PNG
(5-acetyl-2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccc(cc3C(O)=O)C(C)=O)CC2)c2ccccc12
Show InChI InChI=1S/C28H34N2O5/c1-3-34-16-15-30-19-25(23-6-4-5-7-26(23)30)21-10-12-29(13-11-21)14-17-35-27-9-8-22(20(2)31)18-24(27)28(32)33/h4-9,18-19,21H,3,10-17H2,1-2H3,(H,32,33)
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n/an/a 950n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156861
PNG
(2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-6-fluor...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccc(Cl)s2)c2cc(F)ccc12
Show InChI InChI=1S/C27H26ClFN2O3S/c28-26-8-6-20(35-26)16-31-17-23(21-7-5-19(29)15-24(21)31)18-9-11-30(12-10-18)13-14-34-25-4-2-1-3-22(25)27(32)33/h1-8,15,17-18H,9-14,16H2,(H,32,33)
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n/an/a 1.03E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156863
PNG
(2-(2-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl...)
Show SMILES COCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H29FN2O4/c1-31-14-13-28-17-22(20-7-6-19(26)16-23(20)28)18-8-10-27(11-9-18)12-15-32-24-5-3-2-4-21(24)25(29)30/h2-7,16-18H,8-15H2,1H3,(H,29,30)
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n/an/a 1.19E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156884
PNG
(3-[4-(1-thiophen-2-ylmethyl-1H-indol-3-yl)piperidi...)
Show SMILES OC(=O)c1cccc(CN2CCC(CC2)c2cn(Cc3cccs3)c3ccccc23)c1
Show InChI InChI=1S/C26H26N2O2S/c29-26(30)21-6-3-5-19(15-21)16-27-12-10-20(11-13-27)24-18-28(17-22-7-4-14-31-22)25-9-2-1-8-23(24)25/h1-9,14-15,18,20H,10-13,16-17H2,(H,29,30)
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n/an/a 1.33E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156860
PNG
(2-(2-(4-(7-bromo-1-(2-ethoxyethyl)-1H-indol-3-yl)p...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cccc(Br)c12
Show InChI InChI=1S/C26H31BrN2O4/c1-2-32-16-15-29-18-22(20-7-5-8-23(27)25(20)29)19-10-12-28(13-11-19)14-17-33-24-9-4-3-6-21(24)26(30)31/h3-9,18-19H,2,10-17H2,1H3,(H,30,31)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156859
PNG
(2-(2-(4-(5-bromo-1-(2-ethoxyethyl)-1H-indol-3-yl)p...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cc(Br)ccc12
Show InChI InChI=1S/C26H31BrN2O4/c1-2-32-15-14-29-18-23(22-17-20(27)7-8-24(22)29)19-9-11-28(12-10-19)13-16-33-25-6-4-3-5-21(25)26(30)31/h3-8,17-19H,2,9-16H2,1H3,(H,30,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156877
PNG
(5-[4-(6-fluoro-1-furan-3-ylmethyl-1H-indol-3-yl)pi...)
Show SMILES COc1ccc(CN2CCC(CC2)c2cn(Cc3ccoc3)c3cc(F)ccc23)cc1C(O)=O
Show InChI InChI=1S/C27H27FN2O4/c1-33-26-5-2-18(12-23(26)27(31)32)14-29-9-6-20(7-10-29)24-16-30(15-19-8-11-34-17-19)25-13-21(28)3-4-22(24)25/h2-5,8,11-13,16-17,20H,6-7,9-10,14-15H2,1H3,(H,31,32)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156871
PNG
(3-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperidin-...)
Show SMILES CCOCCn1cc(C2CCN(Cc3cccc(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O3/c1-2-30-15-14-27-18-23(22-8-3-4-9-24(22)27)20-10-12-26(13-11-20)17-19-6-5-7-21(16-19)25(28)29/h3-9,16,18,20H,2,10-15,17H2,1H3,(H,28,29)
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n/an/a 1.77E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156882
PNG
(2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-1H-indo...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccc(Cl)s2)c2ccccc12
Show InChI InChI=1S/C27H27ClN2O3S/c28-26-10-9-20(34-26)17-30-18-23(21-5-1-3-7-24(21)30)19-11-13-29(14-12-19)15-16-33-25-8-4-2-6-22(25)27(31)32/h1-10,18-19H,11-17H2,(H,31,32)
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n/an/a 1.86E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156891
PNG
(2-(3-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidi...)
Show SMILES CCOCCn1cc(C2CCN(Cc3cccc(OCC(O)=O)c3)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-15-14-28-18-24(23-8-3-4-9-25(23)28)21-10-12-27(13-11-21)17-20-6-5-7-22(16-20)32-19-26(29)30/h3-9,16,18,21H,2,10-15,17,19H2,1H3,(H,29,30)
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n/an/a 1.92E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156881
PNG
(2-(2-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidi...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccccc3OCC(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-16-15-28-18-23(22-8-4-5-9-24(22)28)20-11-13-27(14-12-20)17-21-7-3-6-10-25(21)32-19-26(29)30/h3-10,18,20H,2,11-17,19H2,1H3,(H,29,30)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156864
PNG
(2-(2-(4-(1-(2-(1,4-dioxan-2-yl)ethyl)-1H-indol-3-y...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CCC2COCCO2)c2ccccc12
Show InChI InChI=1S/C28H34N2O5/c31-28(32)24-6-2-4-8-27(24)35-16-15-29-12-9-21(10-13-29)25-19-30(26-7-3-1-5-23(25)26)14-11-22-20-33-17-18-34-22/h1-8,19,21-22H,9-18,20H2,(H,31,32)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156879
PNG
(2-{2-[4-(1-butyl-6-fluoro-1H-indol-3-yl)piperidin-...)
Show SMILES CCCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C26H31FN2O3/c1-2-3-12-29-18-23(21-9-8-20(27)17-24(21)29)19-10-13-28(14-11-19)15-16-32-25-7-5-4-6-22(25)26(30)31/h4-9,17-19H,2-3,10-16H2,1H3,(H,30,31)
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n/an/a 2.15E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156895
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-6-(trifluoromethyl)-1H-...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C27H31F3N2O4/c1-2-35-15-14-32-18-23(21-8-7-20(17-24(21)32)27(28,29)30)19-9-11-31(12-10-19)13-16-36-25-6-4-3-5-22(25)26(33)34/h3-8,17-19H,2,9-16H2,1H3,(H,33,34)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156852
PNG
(2-(2-(4-(1-(2-(pyridin-2-yl)ethyl)-1H-indol-3-yl)p...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CCc2ccccn2)c2ccccc12
Show InChI InChI=1S/C29H31N3O3/c33-29(34)25-9-2-4-11-28(25)35-20-19-31-16-12-22(13-17-31)26-21-32(27-10-3-1-8-24(26)27)18-14-23-7-5-6-15-30-23/h1-11,15,21-22H,12-14,16-20H2,(H,33,34)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156866
PNG
(5-[4-(6-fluoro-1-thiophen-2-ylmethyl-1H-indol-3-yl...)
Show SMILES COc1ccc(CN2CCC(CC2)c2cn(Cc3cccs3)c3cc(F)ccc23)cc1C(O)=O
Show InChI InChI=1S/C27H27FN2O3S/c1-33-26-7-4-18(13-23(26)27(31)32)15-29-10-8-19(9-11-29)24-17-30(16-21-3-2-12-34-21)25-14-20(28)5-6-22(24)25/h2-7,12-14,17,19H,8-11,15-16H2,1H3,(H,31,32)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156854
PNG
(2-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin-1...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O3/c1-2-30-16-15-27-18-23(22-9-5-6-10-24(22)27)19-11-13-26(14-12-19)17-20-7-3-4-8-21(20)25(28)29/h3-10,18-19H,2,11-17H2,1H3,(H,28,29)
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n/an/a 3.05E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156874
PNG
(5-{4-[1-(5-chlorothiophen-2-ylmethyl)-6-fluoro-1H-...)
Show SMILES COc1ccc(CN2CCC(CC2)c2cn(Cc3ccc(Cl)s3)c3cc(F)ccc23)cc1C(O)=O
Show InChI InChI=1S/C27H26ClFN2O3S/c1-34-25-6-2-17(12-22(25)27(32)33)14-30-10-8-18(9-11-30)23-16-31(15-20-4-7-26(28)35-20)24-13-19(29)3-5-21(23)24/h2-7,12-13,16,18H,8-11,14-15H2,1H3,(H,32,33)
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n/an/a 3.06E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156888
PNG
(2-(2-(4-(1-(2-ethoxyethyl)-7-methyl-1H-indol-3-yl)...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cccc(C)c12
Show InChI InChI=1S/C27H34N2O4/c1-3-32-17-16-29-19-24(22-9-6-7-20(2)26(22)29)21-11-13-28(14-12-21)15-18-33-25-10-5-4-8-23(25)27(30)31/h4-10,19,21H,3,11-18H2,1-2H3,(H,30,31)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156872
PNG
(2-methoxy-5-[4-(1-thiophen-2-ylmethyl-1H-indol-3-y...)
Show SMILES COc1ccc(CN2CCC(CC2)c2cn(Cc3cccs3)c3ccccc23)cc1C(O)=O
Show InChI InChI=1S/C27H28N2O3S/c1-32-26-9-8-19(15-23(26)27(30)31)16-28-12-10-20(11-13-28)24-18-29(17-21-5-4-14-33-21)25-7-3-2-6-22(24)25/h2-9,14-15,18,20H,10-13,16-17H2,1H3,(H,30,31)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156867
PNG
(2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperid...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-17-16-28-19-23(21-7-3-5-9-24(21)28)20-11-13-27(14-12-20)15-18-32-25-10-6-4-8-22(25)26(29)30/h3-10,19-20H,2,11-18H2,1H3,(H,29,30)
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n/an/a 3.27E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156858
PNG
(3-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl]pi...)
Show SMILES COCCn1cc(C2CCN(Cc3cccc(c3)C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C24H27FN2O3/c1-30-12-11-27-16-22(21-6-5-20(25)14-23(21)27)18-7-9-26(10-8-18)15-17-3-2-4-19(13-17)24(28)29/h2-6,13-14,16,18H,7-12,15H2,1H3,(H,28,29)
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n/an/a 3.85E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156851
PNG
(2-(4-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidi...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccc(OCC(O)=O)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-2-31-16-15-28-18-24(23-5-3-4-6-25(23)28)21-11-13-27(14-12-21)17-20-7-9-22(10-8-20)32-19-26(29)30/h3-10,18,21H,2,11-17,19H2,1H3,(H,29,30)
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n/an/a 3.98E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156870
PNG
(2-(2-{4-[1-(2-[1,3]dioxolan-2-yl-ethyl)-1H-indol-3...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CCC2OCCO2)c2ccccc12
Show InChI InChI=1S/C27H32N2O5/c30-27(31)22-6-2-4-8-25(22)32-16-15-28-12-9-20(10-13-28)23-19-29(14-11-26-33-17-18-34-26)24-7-3-1-5-21(23)24/h1-8,19-20,26H,9-18H2,(H,30,31)
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n/an/a 4.52E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156898
PNG
(5-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperidin-...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccc(OC)c(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O4/c1-3-32-15-14-28-18-23(21-6-4-5-7-24(21)28)20-10-12-27(13-11-20)17-19-8-9-25(31-2)22(16-19)26(29)30/h4-9,16,18,20H,3,10-15,17H2,1-2H3,(H,29,30)
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n/an/a 5.35E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156862
PNG
(4-bromo-3-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)pip...)
Show SMILES CCOCCn1cc(C2CCN(Cc3cc(ccc3Br)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H29BrN2O3/c1-2-31-14-13-28-17-22(21-5-3-4-6-24(21)28)18-9-11-27(12-10-18)16-20-15-19(25(29)30)7-8-23(20)26/h3-8,15,17-18H,2,9-14,16H2,1H3,(H,29,30)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156889
PNG
(5-{4-[1-(2-ethoxyethyl)-1H-indol-3-yl]piperidin-1-...)
Show SMILES CCOCCn1cc(C2CCN(Cc3ccc(F)c(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H29FN2O3/c1-2-31-14-13-28-17-22(20-5-3-4-6-24(20)28)19-9-11-27(12-10-19)16-18-7-8-23(26)21(15-18)25(29)30/h3-8,15,17,19H,2,9-14,16H2,1H3,(H,29,30)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156883
PNG
(2-(2-{4-[1-(2-ethoxyethyl)-5-methoxy-1H-indol-3-yl...)
Show SMILES CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2cc(OC)ccc12
Show InChI InChI=1S/C27H34N2O5/c1-3-33-16-15-29-19-24(23-18-21(32-2)8-9-25(23)29)20-10-12-28(13-11-20)14-17-34-26-7-5-4-6-22(26)27(30)31/h4-9,18-20H,3,10-17H2,1-2H3,(H,30,31)
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n/an/a 6.70E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156873
PNG
(2-{2-[4-(1-Butyl-1H-indol-3-yl)-piperidin-1-yl]-et...)
Show SMILES CCCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N2O3/c1-2-3-14-28-19-23(21-8-4-6-10-24(21)28)20-12-15-27(16-13-20)17-18-31-25-11-7-5-9-22(25)26(29)30/h4-11,19-20H,2-3,12-18H2,1H3,(H,29,30)
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n/an/a 9.11E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156850
PNG
(2-{2-[4-(1-allyl-1H-indol-3-yl)piperidin-1-yl]etho...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC=C)c2ccccc12
Show InChI InChI=1S/C25H28N2O3/c1-2-13-27-18-22(20-7-3-5-9-23(20)27)19-11-14-26(15-12-19)16-17-30-24-10-6-4-8-21(24)25(28)29/h2-10,18-19H,1,11-17H2,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156853
PNG
(2-(2-(4-(1-(2-methoxyethyl)-1H-indol-3-yl)piperidi...)
Show SMILES COCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O4/c1-30-16-15-27-18-22(20-6-2-4-8-23(20)27)19-10-12-26(13-11-19)14-17-31-24-9-5-3-7-21(24)25(28)29/h2-9,18-19H,10-17H2,1H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156885
PNG
(5-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl]pi...)
Show SMILES COCCn1cc(C2CCN(Cc3ccc(OC)c(c3)C(O)=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H29FN2O4/c1-31-12-11-28-16-22(20-5-4-19(26)14-23(20)28)18-7-9-27(10-8-18)15-17-3-6-24(32-2)21(13-17)25(29)30/h3-6,13-14,16,18H,7-12,15H2,1-2H3,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156896
PNG
(2-methoxy-5-{4-[1-(2-methoxyethyl)-1H-indol-3-yl]p...)
Show SMILES COCCn1cc(C2CCN(Cc3ccc(OC)c(c3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O4/c1-30-14-13-27-17-22(20-5-3-4-6-23(20)27)19-9-11-26(12-10-19)16-18-7-8-24(31-2)21(15-18)25(28)29/h3-8,15,17,19H,9-14,16H2,1-2H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156869
PNG
(2-{2-[4-(1-cyclopropylmethyl-1H-indol-3-yl)piperid...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC2CC2)c2ccccc12
Show InChI InChI=1S/C26H30N2O3/c29-26(30)22-6-2-4-8-25(22)31-16-15-27-13-11-20(12-14-27)23-18-28(17-19-9-10-19)24-7-3-1-5-21(23)24/h1-8,18-20H,9-17H2,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156880
PNG
(3-{4-[1-(5-Chloro-thiophen-2-ylmethyl)-1H-indol-3-...)
Show SMILES OC(=O)c1cccc(CN2CCC(CC2)c2cn(Cc3ccc(Cl)s3)c3ccccc23)c1
Show InChI InChI=1S/C26H25ClN2O2S/c27-25-9-8-21(32-25)16-29-17-23(22-6-1-2-7-24(22)29)19-10-12-28(13-11-19)15-18-4-3-5-20(14-18)26(30)31/h1-9,14,17,19H,10-13,15-16H2,(H,30,31)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156899
PNG
(2-{2-[4-(1-cyclopropylmethyl-6-fluoro-1H-indol-3-y...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC2CC2)c2cc(F)ccc12
Show InChI InChI=1S/C26H29FN2O3/c27-20-7-8-21-23(17-29(24(21)15-20)16-18-5-6-18)19-9-11-28(12-10-19)13-14-32-25-4-2-1-3-22(25)26(30)31/h1-4,7-8,15,17-19H,5-6,9-14,16H2,(H,30,31)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156868
PNG
(3-{4-[1-(2-ethoxyethyl)-5-methoxy-1H-indol-3-yl]pi...)
Show SMILES CCOCCn1cc(C2CCN(Cc3cccc(c3)C(O)=O)CC2)c2cc(OC)ccc12
Show InChI InChI=1S/C26H32N2O4/c1-3-32-14-13-28-18-24(23-16-22(31-2)7-8-25(23)28)20-9-11-27(12-10-20)17-19-5-4-6-21(15-19)26(29)30/h4-8,15-16,18,20H,3,9-14,17H2,1-2H3,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156865
PNG
(2-(2-(4-(1-(furan-2-ylmethyl)-1H-indol-3-yl)piperi...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccco2)c2ccccc12
Show InChI InChI=1S/C27H28N2O4/c30-27(31)23-8-2-4-10-26(23)33-17-15-28-13-11-20(12-14-28)24-19-29(18-21-6-5-16-32-21)25-9-3-1-7-22(24)25/h1-10,16,19-20H,11-15,17-18H2,(H,30,31)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%