Affinity Data by PubMed id=15615514

PubMed code 15615514

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4552 (4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6071 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{4-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6442 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{3-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6441 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-[4-(morp...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6084 (7-[(2,4-dichlorophenyl)amino]-2-{4-[(4-methylpiper...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6439 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-phenylth...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6447 (7-(2,4-dichlorophenoxy)-2-{4-[(4-methylpiperazin-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6445 (4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-[4-(morp...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6438 (7-[(2,4-dichloro-5-methoxyphenyl)amino]thieno[3,2-...) Show SMILES COc1cc(Nc2c(cnc3ccsc23)C#N)c(Cl)cc1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6443 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{2-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6444 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-3-[4-(morp...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	37
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				J Med Chem 47: 6666-8 (2004) Article DOI: 10.1021/jm049237m BindingDB Entry DOI: 10.7270/Q2CV4FXN
Wyeth Research					More data for this Ligand-Target Pair

* indicates data uncertainty>20%