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PubMed code 15696596

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84516
PNG
(Sulindac analogue, 13)
Show SMILES CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13FO2S/c1-10-14(6-11-4-5-21-9-11)13-3-2-12(18)7-16(13)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 600n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM84518
PNG
(Sulindac analogue, 15)
Show SMILES CCC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccoc1 |c:2|
Show InChI InChI=1S/C18H15FO3/c1-2-13-15(7-11-5-6-22-10-11)14-4-3-12(19)8-16(14)17(13)9-18(20)21/h3-8,10H,2,9H2,1H3,(H,20,21)/b15-7-
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n/an/a 900n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84522
PNG
(Sulindac analogue, 19)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13BrO2S/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 1.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84518
PNG
(Sulindac analogue, 15)
Show SMILES CCC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccoc1 |c:2|
Show InChI InChI=1S/C18H15FO3/c1-2-13-15(7-11-5-6-22-10-11)14-4-3-12(19)8-16(14)17(13)9-18(20)21/h3-8,10H,2,9H2,1H3,(H,20,21)/b15-7-
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n/an/a 1.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84521
PNG
(Sulindac analogue, 18)
Show SMILES CC1=C(CC(O)=O)c2cc(Br)ccc2\C1=C/c1ccccc1 |c:1|
Show InChI InChI=1S/C19H15BrO2/c1-12-16(9-13-5-3-2-4-6-13)15-8-7-14(20)10-18(15)17(12)11-19(21)22/h2-10H,11H2,1H3,(H,21,22)/b16-9-
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n/an/a 1.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84519
PNG
(Sulindac analogue, 16)
Show SMILES CCC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(OCc2ccccc2)cc1 |c:2|
Show InChI InChI=1S/C27H23FO3/c1-2-22-24(23-13-10-20(28)15-25(23)26(22)16-27(29)30)14-18-8-11-21(12-9-18)31-17-19-6-4-3-5-7-19/h3-15H,2,16-17H2,1H3,(H,29,30)/b24-14-
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n/an/a 2.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM84522
PNG
(Sulindac analogue, 19)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13BrO2S/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 3.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84524
PNG
(Sulindac analogue, 21)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13BrO3/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 3.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM84518
PNG
(Sulindac analogue, 15)
Show SMILES CCC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccoc1 |c:2|
Show InChI InChI=1S/C18H15FO3/c1-2-13-15(7-11-5-6-22-10-11)14-4-3-12(19)8-16(14)17(13)9-18(20)21/h3-8,10H,2,9H2,1H3,(H,20,21)/b15-7-
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n/an/a 3.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM84522
PNG
(Sulindac analogue, 19)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13BrO2S/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 4.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM84522
PNG
(Sulindac analogue, 19)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13BrO2S/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 4.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84520
PNG
(Sulindac analogue, 17)
Show SMILES CC1=C(CC(O)=O)c2cc(Cl)ccc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13ClO3/c1-10-14(6-11-4-5-21-9-11)13-3-2-12(18)7-16(13)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 5.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84515
PNG
(Sulindac analogue, 12)
Show SMILES CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1cccs1 |c:1|
Show InChI InChI=1S/C17H13FO2S/c1-10-14(8-12-3-2-6-21-12)13-5-4-11(18)7-16(13)15(10)9-17(19)20/h2-8H,9H2,1H3,(H,19,20)/b14-8-
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n/an/a 5.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84526
PNG
(Sulindac analogue, 23)
Show SMILES CCC1=C(CC(O)=O)c2cc(\C=C\C(=O)OC(C)(C)C)ccc2\C1=C/c1ccsc1 |c:2|
Show InChI InChI=1S/C25H26O4S/c1-5-18-20(13-17-10-11-30-15-17)19-8-6-16(7-9-24(28)29-25(2,3)4)12-21(19)22(18)14-23(26)27/h6-13,15H,5,14H2,1-4H3,(H,26,27)/b9-7+,20-13-
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Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM84518
PNG
(Sulindac analogue, 15)
Show SMILES CCC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccoc1 |c:2|
Show InChI InChI=1S/C18H15FO3/c1-2-13-15(7-11-5-6-22-10-11)14-4-3-12(19)8-16(14)17(13)9-18(20)21/h3-8,10H,2,9H2,1H3,(H,20,21)/b15-7-
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Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84527
PNG
(Sulindac analogue, 24)
Show SMILES CCC1=C(CC(O)=O)c2cc(ccc2\C1=C/c1ccsc1)C#Cc1ccccc1 |c:2|
Show InChI InChI=1S/C26H20O2S/c1-2-21-23(15-20-12-13-29-17-20)22-11-10-19(9-8-18-6-4-3-5-7-18)14-24(22)25(21)16-26(27)28/h3-7,10-15,17H,2,16H2,1H3,(H,27,28)/b23-15-
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Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84513
PNG
(Sulindac analogue, 10)
Show SMILES CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(F)c(F)c1 |c:1|
Show InChI InChI=1S/C19H13F3O2/c1-10-14(6-11-2-5-17(21)18(22)7-11)13-4-3-12(20)8-16(13)15(10)9-19(23)24/h2-8H,9H2,1H3,(H,23,24)/b14-6-
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Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM84520
PNG
(Sulindac analogue, 17)
Show SMILES CC1=C(CC(O)=O)c2cc(Cl)ccc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13ClO3/c1-10-14(6-11-4-5-21-9-11)13-3-2-12(18)7-16(13)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 7.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84525
PNG
(Sulindac analogue, 22)
Show SMILES CC1=C(CC(O)=O)c2cc(I)ccc2\C1=C/c1cccc(OCc2ccccc2)c1 |c:1|
Show InChI InChI=1S/C26H21IO3/c1-17-23(22-11-10-20(27)14-25(22)24(17)15-26(28)29)13-19-8-5-9-21(12-19)30-16-18-6-3-2-4-7-18/h2-14H,15-16H2,1H3,(H,28,29)/b23-13-
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n/an/a 7.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM84520
PNG
(Sulindac analogue, 17)
Show SMILES CC1=C(CC(O)=O)c2cc(Cl)ccc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13ClO3/c1-10-14(6-11-4-5-21-9-11)13-3-2-12(18)7-16(13)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 8.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM84517
PNG
(Sulindac analogue, 14)
Show SMILES CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13FO3/c1-10-14(6-11-4-5-21-9-11)13-3-2-12(18)7-16(13)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 8.00E+3n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84514
PNG
(Sulindac analogue, 11)
Show SMILES CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1cccc(OCc2ccccc2)c1 |c:1|
Show InChI InChI=1S/C26H21FO3/c1-17-23(22-11-10-20(27)14-25(22)24(17)15-26(28)29)13-19-8-5-9-21(12-19)30-16-18-6-3-2-4-7-18/h2-14H,15-16H2,1H3,(H,28,29)/b23-13-
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n/an/a 1.10E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM84523
PNG
(Sulindac analogue, 20)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C\c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13BrO2S/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6+
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n/an/a 1.10E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM84522
PNG
(Sulindac analogue, 19)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13BrO2S/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 1.20E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM84524
PNG
(Sulindac analogue, 21)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13BrO3/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 1.30E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM84520
PNG
(Sulindac analogue, 17)
Show SMILES CC1=C(CC(O)=O)c2cc(Cl)ccc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13ClO3/c1-10-14(6-11-4-5-21-9-11)13-3-2-12(18)7-16(13)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 1.40E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM84516
PNG
(Sulindac analogue, 13)
Show SMILES CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13FO2S/c1-10-14(6-11-4-5-21-9-11)13-3-2-12(18)7-16(13)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 1.40E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM84516
PNG
(Sulindac analogue, 13)
Show SMILES CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13FO2S/c1-10-14(6-11-4-5-21-9-11)13-3-2-12(18)7-16(13)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 1.50E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM84524
PNG
(Sulindac analogue, 21)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13BrO3/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 1.50E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM84524
PNG
(Sulindac analogue, 21)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13BrO3/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 2.20E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM84522
PNG
(Sulindac analogue, 19)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13BrO2S/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 2.30E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM84524
PNG
(Sulindac analogue, 21)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C/c1ccoc1 |c:1|
Show InChI InChI=1S/C17H13BrO3/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6-
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n/an/a 2.40E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM84523
PNG
(Sulindac analogue, 20)
Show SMILES CC1=C(CC(O)=O)c2ccc(Br)cc2\C1=C\c1ccsc1 |c:1|
Show InChI InChI=1S/C17H13BrO2S/c1-10-14(6-11-4-5-21-9-11)16-7-12(18)2-3-13(16)15(10)8-17(19)20/h2-7,9H,8H2,1H3,(H,19,20)/b14-6+
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n/an/a 7.10E+4n/an/an/an/an/an/a



Max-Planck-Institut für Molekulare Physiologie



Assay Description
The kinase-catalyzed phosphorylation of poly(Glu4-Tyr) in the presence of varying concentrations of inhibitor was determined. The kinase were employ...

Chembiochem 6: 527-31 (2005)


Article DOI: 10.1002/cbic.200400192
BindingDB Entry DOI: 10.7270/Q2KP80PS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%