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PubMed code 1573641

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50368604
PNG
(CHEMBL1907770)
Show SMILES [H]C12CN3C[C@]1(NC(=O)c1cc(Cl)c(N)cc1OC)C2CC3 |r|
Show InChI InChI=1S/C15H18ClN3O2/c1-21-13-5-12(17)11(16)4-8(13)14(20)18-15-7-19-3-2-9(15)10(15)6-19/h4-5,9-10H,2-3,6-7,17H2,1H3,(H,18,20)/t9?,10?,15-/m1/s1
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 0.230n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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 6.10n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50031475
PNG
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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 8n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005840
PNG
((endo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-8-11(17)10(16)7-9(14)15(20)18-12-4-6-19-5-2-3-13(12)19/h7-8,12-13H,2-6,17H2,1H3,(H,18,20)
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 14n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005840
PNG
((endo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-8-11(17)10(16)7-9(14)15(20)18-12-4-6-19-5-2-3-13(12)19/h7-8,12-13H,2-6,17H2,1H3,(H,18,20)
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 14n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005838
PNG
((exo) 4-Amino-5-chloro-2-ethoxy-N-(hexahydro-pyrro...)
Show SMILES CCOc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12
Show InChI InChI=1S/C17H24ClN3O2/c1-2-23-16-9-14(19)13(18)8-12(16)17(22)20-10-11-5-7-21-6-3-4-15(11)21/h8-9,11,15H,2-7,10,19H2,1H3,(H,20,22)
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 25n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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 30n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005841
PNG
((exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-y...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m1/s1
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 66n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005839
PNG
((endo) 4-Amino-5-chloro-2-ethoxy-N-(hexahydro-pyrr...)
Show SMILES CCOc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12
Show InChI InChI=1S/C16H22ClN3O2/c1-2-22-15-9-12(18)11(17)8-10(15)16(21)19-13-5-7-20-6-3-4-14(13)20/h8-9,13-14H,2-7,18H2,1H3,(H,19,21)
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 99n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005839
PNG
((endo) 4-Amino-5-chloro-2-ethoxy-N-(hexahydro-pyrr...)
Show SMILES CCOc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12
Show InChI InChI=1S/C16H22ClN3O2/c1-2-22-15-9-12(18)11(17)8-10(15)16(21)19-13-5-7-20-6-3-4-14(13)20/h8-9,13-14H,2-7,18H2,1H3,(H,19,21)
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 99n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005837
PNG
((endo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)
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 104n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005837
PNG
((endo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)
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 104n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM48320
PNG
(4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
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 113n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to dopamine receptor D2

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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 134n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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 152n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005842
PNG
((exo) N-(Hexahydro-pyrrolizin-1-yl)-benzamide | CH...)
Show SMILES O=C(NC1CCN2CCCC12)c1ccccc1
Show InChI InChI=1S/C14H18N2O/c17-14(11-5-2-1-3-6-11)15-12-8-10-16-9-4-7-13(12)16/h1-3,5-6,12-13H,4,7-10H2,(H,15,17)
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>200n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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 227n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]domperidone binding to dopamine receptor D2 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM48320
PNG
(4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
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 240n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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 390n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortices

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50031475
PNG
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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 415n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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 1.70E+3n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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 4.50E+3n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]rauwolscine binding to alpha-2 adrenergic receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50005834
PNG
(1-Isopropyl-3-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)CC2CC3CCC(C2)N3C)c1=O |TLB:13:14:21:17.18,THB:22:21:14.20.15:17.18|
Show InChI InChI=1S/C20H27N3O2/c1-13(2)22-17-6-4-5-7-18(17)23(20(22)25)19(24)12-14-10-15-8-9-16(11-14)21(15)3/h4-7,13-16H,8-12H2,1-3H3
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]rauwolscine binding to alpha-2 adrenergic receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50031475
PNG
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]5-HT binding to 5-hydroxytryptamine 1 receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50212465
PNG
(Renzapride)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 |TLB:12:13:20:18.17|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-3-5-19-4-2-9(13)8-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]rauwolscine binding to alpha-2 adrenergic receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]5-HT binding to 5-hydroxytryptamine 1 receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50031475
PNG
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]dihydroalprenolol prenolol binding to Beta adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50212465
PNG
(Renzapride)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 |TLB:12:13:20:18.17|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-3-5-19-4-2-9(13)8-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]dihydroalprenolol prenolol binding to Beta adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]5-HT binding to 5-hydroxytryptamine 1 receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50368604
PNG
(CHEMBL1907770)
Show SMILES [H]C12CN3C[C@]1(NC(=O)c1cc(Cl)c(N)cc1OC)C2CC3 |r|
Show InChI InChI=1S/C15H18ClN3O2/c1-21-13-5-12(17)11(16)4-8(13)14(20)18-15-7-19-3-2-9(15)10(15)6-19/h4-5,9-10H,2-3,6-7,17H2,1H3,(H,18,20)/t9?,10?,15-/m1/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]rauwolscine binding to alpha-2 adrenergic receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50005834
PNG
(1-Isopropyl-3-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)CC2CC3CCC(C2)N3C)c1=O |TLB:13:14:21:17.18,THB:22:21:14.20.15:17.18|
Show InChI InChI=1S/C20H27N3O2/c1-13(2)22-17-6-4-5-7-18(17)23(20(22)25)19(24)12-14-10-15-8-9-16(11-14)21(15)3/h4-7,13-16H,8-12H2,1-3H3
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]dihydroalprenolol prenolol binding to Beta adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]dihydroalprenolol prenolol binding to Beta adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50212465
PNG
(Renzapride)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 |TLB:12:13:20:18.17|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-3-5-19-4-2-9(13)8-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50005834
PNG
(1-Isopropyl-3-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)CC2CC3CCC(C2)N3C)c1=O |TLB:13:14:21:17.18,THB:22:21:14.20.15:17.18|
Show InChI InChI=1S/C20H27N3O2/c1-13(2)22-17-6-4-5-7-18(17)23(20(22)25)19(24)12-14-10-15-8-9-16(11-14)21(15)3/h4-7,13-16H,8-12H2,1-3H3
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]5-HT binding to 5-hydroxytryptamine 1 receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50005834
PNG
(1-Isopropyl-3-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)CC2CC3CCC(C2)N3C)c1=O |TLB:13:14:21:17.18,THB:22:21:14.20.15:17.18|
Show InChI InChI=1S/C20H27N3O2/c1-13(2)22-17-6-4-5-7-18(17)23(20(22)25)19(24)12-14-10-15-8-9-16(11-14)21(15)3/h4-7,13-16H,8-12H2,1-3H3
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50031475
PNG
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]domperidone binding to dopamine receptor D2 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50005834
PNG
(1-Isopropyl-3-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)CC2CC3CCC(C2)N3C)c1=O |TLB:13:14:21:17.18,THB:22:21:14.20.15:17.18|
Show InChI InChI=1S/C20H27N3O2/c1-13(2)22-17-6-4-5-7-18(17)23(20(22)25)19(24)12-14-10-15-8-9-16(11-14)21(15)3/h4-7,13-16H,8-12H2,1-3H3
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]domperidone binding to dopamine receptor D2 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50368604
PNG
(CHEMBL1907770)
Show SMILES [H]C12CN3C[C@]1(NC(=O)c1cc(Cl)c(N)cc1OC)C2CC3 |r|
Show InChI InChI=1S/C15H18ClN3O2/c1-21-13-5-12(17)11(16)4-8(13)14(20)18-15-7-19-3-2-9(15)10(15)6-19/h4-5,9-10H,2-3,6-7,17H2,1H3,(H,18,20)/t9?,10?,15-/m1/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50031475
PNG
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]rauwolscine binding to alpha-2 adrenergic receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50005834
PNG
(1-Isopropyl-3-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)CC2CC3CCC(C2)N3C)c1=O |TLB:13:14:21:17.18,THB:22:21:14.20.15:17.18|
Show InChI InChI=1S/C20H27N3O2/c1-13(2)22-17-6-4-5-7-18(17)23(20(22)25)19(24)12-14-10-15-8-9-16(11-14)21(15)3/h4-7,13-16H,8-12H2,1-3H3
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortices

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50212465
PNG
(Renzapride)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 |TLB:12:13:20:18.17|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-3-5-19-4-2-9(13)8-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortices

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50212465
PNG
(Renzapride)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 |TLB:12:13:20:18.17|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-3-5-19-4-2-9(13)8-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]5-HT binding to 5-hydroxytryptamine 1 receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50368604
PNG
(CHEMBL1907770)
Show SMILES [H]C12CN3C[C@]1(NC(=O)c1cc(Cl)c(N)cc1OC)C2CC3 |r|
Show InChI InChI=1S/C15H18ClN3O2/c1-21-13-5-12(17)11(16)4-8(13)14(20)18-15-7-19-3-2-9(15)10(15)6-19/h4-5,9-10H,2-3,6-7,17H2,1H3,(H,18,20)/t9?,10?,15-/m1/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50368604
PNG
(CHEMBL1907770)
Show SMILES [H]C12CN3C[C@]1(NC(=O)c1cc(Cl)c(N)cc1OC)C2CC3 |r|
Show InChI InChI=1S/C15H18ClN3O2/c1-21-13-5-12(17)11(16)4-8(13)14(20)18-15-7-19-3-2-9(15)10(15)6-19/h4-5,9-10H,2-3,6-7,17H2,1H3,(H,18,20)/t9?,10?,15-/m1/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50368604
PNG
(CHEMBL1907770)
Show SMILES [H]C12CN3C[C@]1(NC(=O)c1cc(Cl)c(N)cc1OC)C2CC3 |r|
Show InChI InChI=1S/C15H18ClN3O2/c1-21-13-5-12(17)11(16)4-8(13)14(20)18-15-7-19-3-2-9(15)10(15)6-19/h4-5,9-10H,2-3,6-7,17H2,1H3,(H,18,20)/t9?,10?,15-/m1/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]dihydroalprenolol prenolol binding to Beta adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50368604
PNG
(CHEMBL1907770)
Show SMILES [H]C12CN3C[C@]1(NC(=O)c1cc(Cl)c(N)cc1OC)C2CC3 |r|
Show InChI InChI=1S/C15H18ClN3O2/c1-21-13-5-12(17)11(16)4-8(13)14(20)18-15-7-19-3-2-9(15)10(15)6-19/h4-5,9-10H,2-3,6-7,17H2,1H3,(H,18,20)/t9?,10?,15-/m1/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]domperidone binding to dopamine receptor D2 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50031475
PNG
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]domperidone binding to dopamine receptor D2 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50005834
PNG
(1-Isopropyl-3-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)CC2CC3CCC(C2)N3C)c1=O |TLB:13:14:21:17.18,THB:22:21:14.20.15:17.18|
Show InChI InChI=1S/C20H27N3O2/c1-13(2)22-17-6-4-5-7-18(17)23(20(22)25)19(24)12-14-10-15-8-9-16(11-14)21(15)3/h4-7,13-16H,8-12H2,1-3H3
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50005834
PNG
(1-Isopropyl-3-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CC(C)n1c2ccccc2n(C(=O)CC2CC3CCC(C2)N3C)c1=O |TLB:13:14:21:17.18,THB:22:21:14.20.15:17.18|
Show InChI InChI=1S/C20H27N3O2/c1-13(2)22-17-6-4-5-7-18(17)23(20(22)25)19(24)12-14-10-15-8-9-16(11-14)21(15)3/h4-7,13-16H,8-12H2,1-3H3
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50212465
PNG
(Renzapride)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 |TLB:12:13:20:18.17|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-3-5-19-4-2-9(13)8-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50212465
PNG
(Renzapride)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 |TLB:12:13:20:18.17|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-3-5-19-4-2-9(13)8-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]domperidone binding to dopamine receptor D2 in rat striata

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50212465
PNG
(Renzapride)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 |TLB:12:13:20:18.17|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-3-5-19-4-2-9(13)8-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50368604
PNG
(CHEMBL1907770)
Show SMILES [H]C12CN3C[C@]1(NC(=O)c1cc(Cl)c(N)cc1OC)C2CC3 |r|
Show InChI InChI=1S/C15H18ClN3O2/c1-21-13-5-12(17)11(16)4-8(13)14(20)18-15-7-19-3-2-9(15)10(15)6-19/h4-5,9-10H,2-3,6-7,17H2,1H3,(H,18,20)/t9?,10?,15-/m1/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]5-HT binding to 5-hydroxytryptamine 1 receptor in rat cortex

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]dihydroalprenolol prenolol binding to Beta adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50031475
PNG
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)|
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50005833
PNG
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
The ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brain

J Med Chem 35: 1486-9 (1992)


BindingDB Entry DOI: 10.7270/Q2CC11B3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%