Found 79 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162143
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-m-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-5-4-6-18(13-16)28-25(29)27-17-7-9-19(10-8-17)32-22-11-12-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162144
(1-(4-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20ClN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-12-11-21(19)32-18-9-7-17(8-10-18)28-24(29)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162167
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-ph...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-22-14-19-20(15-23(22)30-2)25-13-12-21(19)31-18-10-8-17(9-11-18)27-24(28)26-16-6-4-3-5-7-16/h3-15H,1-2H3,(H2,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162154
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)Show SMILES COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C25H23N3O5/c1-30-22-7-5-4-6-19(22)28-25(29)27-16-8-10-17(11-9-16)33-21-12-13-26-20-15-24(32-3)23(31-2)14-18(20)21/h4-15H,1-3H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162169
(1-(2,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-19(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-20-11-14(25)3-8-18(20)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162166
(1-[2-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-18(16(25)10-14)29-24(31)30-19-5-3-13(26)9-17(19)27/h3-12H,1-2H3,(H2,29,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162168
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-12-11-21(19)32-18-9-7-17(8-10-18)28-24(29)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162142
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-17-20(14-23(22)31-2)26-12-11-21(17)32-16-9-7-15(8-10-16)27-24(29)28-19-6-4-3-5-18(19)25/h3-14H,1-2H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162155
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-p-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-4-6-17(7-5-16)27-25(29)28-18-8-10-19(11-9-18)32-22-12-13-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162156
(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162148
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162145
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1 Show InChI InChI=1S/C25H23N3O5/c1-30-19-6-4-5-17(13-19)28-25(29)27-16-7-9-18(10-8-16)33-22-11-12-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162160
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162152
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C25H23N3O5/c1-30-18-8-4-16(5-9-18)27-25(29)28-17-6-10-19(11-7-17)33-22-12-13-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162158
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(c4)[N+]([O-])=O)cc3)c2cc1OC Show InChI InChI=1S/C24H20N4O6/c1-32-22-13-19-20(14-23(22)33-2)25-11-10-21(19)34-18-8-6-15(7-9-18)26-24(29)27-16-4-3-5-17(12-16)28(30)31/h3-14H,1-2H3,(H2,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162140
(1-(3,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-3-14(4-7-16)28-24(30)29-15-5-8-18(25)19(26)11-15/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162162
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162171
(1-(3-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H20ClN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162156
(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162170
(1-(2,6-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162163
(1-(3,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-19-20(13-23(22)32-2)27-8-7-21(19)33-18-5-3-16(4-6-18)28-24(30)29-17-10-14(25)9-15(26)11-17/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162145
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1 Show InChI InChI=1S/C25H23N3O5/c1-30-19-6-4-5-17(13-19)28-25(29)27-16-7-9-18(10-8-16)33-22-11-12-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162152
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C25H23N3O5/c1-30-18-8-4-16(5-9-18)27-25(29)28-17-6-10-19(11-7-17)33-22-12-13-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
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UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162157
(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C24H22N4O5/c1-30-17-8-4-15(5-9-17)27-24(29)28-16-6-10-18(11-7-16)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162150
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-o-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4C)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-6-4-5-7-20(16)28-25(29)27-17-8-10-18(11-9-17)32-22-12-13-26-21-15-24(31-3)23(30-2)14-19(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162139
(1-[3-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3Cl)c2cc1OC Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-16(21)25)29-24(31)30-18-5-3-13(26)9-17(18)27/h3-12H,1-2H3,(H2,29,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162166
(1-[2-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-18(16(25)10-14)29-24(31)30-19-5-3-13(26)9-17(19)27/h3-12H,1-2H3,(H2,29,30,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162143
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-m-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-5-4-6-18(13-16)28-25(29)27-17-7-9-19(10-8-17)32-22-11-12-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162148
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
KEGG
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Similars
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162170
(1-(2,6-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162167
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-ph...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-22-14-19-20(15-23(22)30-2)25-13-12-21(19)31-18-10-8-17(9-11-18)27-24(28)26-16-6-4-3-5-7-16/h3-15H,1-2H3,(H2,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162150
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-o-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4C)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-6-4-5-7-20(16)28-25(29)27-17-8-10-18(11-9-17)32-22-12-13-26-21-15-24(31-3)23(30-2)14-19(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
KEGG
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PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162157
(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C24H22N4O5/c1-30-17-8-4-15(5-9-17)27-24(29)28-16-6-10-18(11-7-16)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29) | PDB
KEGG
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PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162141
(1-(3,4-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(Cl)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-3-14(4-7-16)28-24(30)29-15-5-8-18(25)19(26)11-15/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162142
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-17-20(14-23(22)31-2)26-12-11-21(17)32-16-9-7-15(8-10-16)27-24(29)28-19-6-4-3-5-18(19)25/h3-14H,1-2H3,(H2,27,28,29) | PDB
KEGG
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PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 in cell-free assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162169
(1-(2,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-19(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-20-11-14(25)3-8-18(20)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
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PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162165
(1-(2,4-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4Cl)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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UniChem
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| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162153
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(cc4)[N+]([O-])=O)cc3)c2cc1OC Show InChI InChI=1S/C24H20N4O6/c1-32-22-13-19-20(14-23(22)33-2)25-12-11-21(19)34-18-9-5-16(6-10-18)27-24(29)26-15-3-7-17(8-4-15)28(30)31/h3-14H,1-2H3,(H2,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162168
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-12-11-21(19)32-18-9-7-17(8-10-18)28-24(29)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,29) | PDB
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| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162154
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)Show SMILES COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C25H23N3O5/c1-30-22-7-5-4-6-19(22)28-25(29)27-16-8-10-17(11-9-16)33-21-12-13-26-20-15-24(32-3)23(31-2)14-18(20)21/h4-15H,1-3H3,(H2,27,28,29) | PDB
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| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162159
(1-[4-(6,7-Dimethoxy-quinolin-4-ylsulfanyl)-phenyl]...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Sc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C25H23N3O4S/c1-30-18-8-4-16(5-9-18)27-25(29)28-17-6-10-19(11-7-17)33-24-12-13-26-21-15-23(32-3)22(31-2)14-20(21)24/h4-15H,1-3H3,(H2,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162172
(1-(2,5-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(Cl)ccc4Cl)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-22-12-17-19(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-20-11-14(25)3-8-18(20)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162162
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29) | PDB
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| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162140
(1-(3,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-3-14(4-7-16)28-24(30)29-15-5-8-18(25)19(26)11-15/h3-13H,1-2H3,(H2,28,29,30) | PDB
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| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162146
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4[N+]([O-])=O)cc3)c2cc1OC Show InChI InChI=1S/C24H20N4O6/c1-32-22-13-17-19(14-23(22)33-2)25-12-11-21(17)34-16-9-7-15(8-10-16)26-24(29)27-18-5-3-4-6-20(18)28(30)31/h3-14H,1-2H3,(H2,26,27,29) | PDB
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| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162138
(1-(3,5-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(Cl)cc(Cl)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-22-12-19-20(13-23(22)32-2)27-8-7-21(19)33-18-5-3-16(4-6-18)28-24(30)29-17-10-14(25)9-15(26)11-17/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162151
(1-(2,6-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
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| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162144
(1-(4-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20ClN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-12-11-21(19)32-18-9-7-17(8-10-18)28-24(29)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,29) | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162163
(1-(3,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-19-20(13-23(22)32-2)27-8-7-21(19)33-18-5-3-16(4-6-18)28-24(30)29-17-10-14(25)9-15(26)11-17/h3-13H,1-2H3,(H2,28,29,30) | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162139
(1-[3-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3Cl)c2cc1OC Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-16(21)25)29-24(31)30-18-5-3-13(26)9-17(18)27/h3-12H,1-2H3,(H2,29,30,31) | PDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162159
(1-[4-(6,7-Dimethoxy-quinolin-4-ylsulfanyl)-phenyl]...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Sc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C25H23N3O4S/c1-30-18-8-4-16(5-9-18)27-25(29)28-17-6-10-19(11-7-17)33-24-12-13-26-21-15-23(32-3)22(31-2)14-20(21)24/h4-15H,1-3H3,(H2,27,28,29) | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162160
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
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PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162153
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(cc4)[N+]([O-])=O)cc3)c2cc1OC Show InChI InChI=1S/C24H20N4O6/c1-32-22-13-19-20(14-23(22)33-2)25-12-11-21(19)34-18-9-5-16(6-10-18)27-24(29)26-15-3-7-17(8-4-15)28(30)31/h3-14H,1-2H3,(H2,26,27,29) | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162158
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(c4)[N+]([O-])=O)cc3)c2cc1OC Show InChI InChI=1S/C24H20N4O6/c1-32-22-13-19-20(14-23(22)33-2)25-11-10-21(19)34-18-8-6-15(7-9-18)26-24(29)27-16-4-3-5-17(12-16)28(30)31/h3-14H,1-2H3,(H2,26,27,29) | PDB
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PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162146
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4[N+]([O-])=O)cc3)c2cc1OC Show InChI InChI=1S/C24H20N4O6/c1-32-22-13-17-19(14-23(22)33-2)25-12-11-21(17)34-16-9-7-15(8-10-16)26-24(29)27-18-5-3-4-6-20(18)28(30)31/h3-14H,1-2H3,(H2,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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UniChem
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PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162137
(1-[4-(6,7-Dimethoxy-quinolin-4-ylamino)-phenyl]-3-...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Nc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C25H24N4O4/c1-31-19-10-8-18(9-11-19)29-25(30)28-17-6-4-16(5-7-17)27-21-12-13-26-22-15-24(33-3)23(32-2)14-20(21)22/h4-15H,1-3H3,(H,26,27)(H2,28,29,30) | PDB
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PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162161
(1-(2,3-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4Cl)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162171
(1-(3-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H20ClN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29) | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162161
(1-(2,3-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4Cl)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
NCI pathway
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PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162155
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-p-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-4-6-17(7-5-16)27-25(29)28-18-8-10-19(11-9-18)32-22-12-13-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
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| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162165
(1-(2,4-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4Cl)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162151
(1-(2,6-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
MMDB
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UniChem
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PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
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PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of proto-oncogene tyrosine-protein kinase kit in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162172
(1-(2,5-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(Cl)ccc4Cl)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-22-12-17-19(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-20-11-14(25)3-8-18(20)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
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PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162149
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O3S/c1-29-22-13-19-20(14-23(22)30-2)26-12-11-21(19)31-18-9-7-17(8-10-18)28-24(32)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,32) | PDB
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162164
(1-(4-Fluorophenyl)-2-cyano-3-{4-[(6,7-dimethoxy-4-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(NC#N)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C25H22FN5O3/c1-32-23-13-20-21(14-24(23)33-2)28-12-11-22(20)34-19-9-7-18(8-10-19)31-25(29-15-27)30-17-5-3-16(26)4-6-17/h3-14,25,29-31H,1-2H3 | PDB
MMDB
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PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162141
(1-(3,4-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(Cl)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-3-14(4-7-16)28-24(30)29-15-5-8-18(25)19(26)11-15/h3-13H,1-2H3,(H2,28,29,30) | PDB
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| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
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| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162138
(1-(3,5-Dichloro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(Cl)cc(Cl)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19Cl2N3O4/c1-31-22-12-19-20(13-23(22)32-2)27-8-7-21(19)33-18-5-3-16(4-6-18)28-24(30)29-17-10-14(25)9-15(26)11-17/h3-13H,1-2H3,(H2,28,29,30) | PDB
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| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162137
(1-[4-(6,7-Dimethoxy-quinolin-4-ylamino)-phenyl]-3-...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Nc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C25H24N4O4/c1-31-19-10-8-18(9-11-19)29-25(30)28-17-6-4-16(5-7-17)27-21-12-13-26-22-15-24(33-3)23(32-2)14-20(21)22/h4-15H,1-3H3,(H,26,27)(H2,28,29,30) | PDB
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| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162149
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O3S/c1-29-22-13-19-20(14-23(22)30-2)26-12-11-21(19)31-18-9-7-17(8-10-18)28-24(32)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,32) | PDB
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| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
MMDB
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| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of fibroblast growth factor receptor 2 in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162164
(1-(4-Fluorophenyl)-2-cyano-3-{4-[(6,7-dimethoxy-4-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(NC#N)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C25H22FN5O3/c1-32-23-13-20-21(14-24(23)33-2)28-12-11-22(20)34-19-9-7-18(8-10-19)31-25(29-15-27)30-17-5-3-16(26)4-6-17/h3-14,25,29-31H,1-2H3 | PDB
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| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor in cell-free assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of mitogen activated protein kinase in cell-free assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB
MMDB
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CHEMBL
MCE
PC cid
PC sid
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of hepatocyte growth factor receptor in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this
Ligand-Target Pair | |
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