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PubMed code 15771455

Compile data set for download or QSAR
Found 110 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10885
PNG
((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Show SMILES CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
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 3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12140
PNG
(4-(N-(4-nitrophenyl)aminocarbonyl-hydrazinocarbony...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H13N5O6S/c15-26(24,25)12-7-1-9(2-8-12)13(20)17-18-14(21)16-10-3-5-11(6-4-10)19(22)23/h1-8H,(H,17,20)(H2,15,24,25)(H2,16,18,21)
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 3.20n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12140
PNG
(4-(N-(4-nitrophenyl)aminocarbonyl-hydrazinocarbony...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H13N5O6S/c15-26(24,25)12-7-1-9(2-8-12)13(20)17-18-14(21)16-10-3-5-11(6-4-10)19(22)23/h1-8H,(H,17,20)(H2,15,24,25)(H2,16,18,21)
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 5.10n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12151
PNG
(4-(N-(4-chlorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN4O6S2/c15-10-3-7-12(8-4-10)27(24,25)19-14(21)18-17-13(20)9-1-5-11(6-2-9)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 5.40n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12142
PNG
(4-(N-(4-biphenyl)aminocarbonyl-hydrazinocarbonyl)-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H18N4O4S/c21-29(27,28)18-12-8-16(9-13-18)19(25)23-24-20(26)22-17-10-6-15(7-11-17)14-4-2-1-3-5-14/h1-13H,(H,23,25)(H2,21,27,28)(H2,22,24,26)
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 5.40n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12149
PNG
(4-(N-(4-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-2-6-13(7-3-10)27(24,25)19-15(21)18-17-14(20)11-4-8-12(9-5-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 5.80n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12150
PNG
(N-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-4-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C14H13FN4O6S2/c15-10-3-7-12(8-4-10)27(24,25)19-14(21)18-17-13(20)9-1-5-11(6-2-9)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 6.20n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12144
PNG
(4-(N-(4-benzyloxyphenyl)aminocarbonyl-hydrazinocar...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H20N4O5S/c22-31(28,29)19-12-6-16(7-13-19)20(26)24-25-21(27)23-17-8-10-18(11-9-17)30-14-15-4-2-1-3-5-15/h1-13H,14H2,(H,24,26)(H2,22,28,29)(H2,23,25,27)
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 7n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12141
PNG
(4-(N-(4-bromophenyl)aminocarbonyl-hydrazinocarbony...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C14H13BrN4O4S/c15-10-3-5-11(6-4-10)17-14(21)19-18-13(20)9-1-7-12(8-2-9)24(16,22)23/h1-8H,(H,18,20)(H2,16,22,23)(H2,17,19,21)
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 7.30n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12137
PNG
(4-(N-(3,4-dichlorophenyl)aminocarbonyl-hydrazinoca...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H12Cl2N4O4S/c15-11-6-3-9(7-12(11)16)18-14(22)20-19-13(21)8-1-4-10(5-2-8)25(17,23)24/h1-7H,(H,19,21)(H2,17,23,24)(H2,18,20,22)
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 7.90n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12143
PNG
(4-(N-(4-phenoxyphenyl)aminocarbonyl-hydrazinocarbo...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H18N4O5S/c21-30(27,28)18-12-6-14(7-13-18)19(25)23-24-20(26)22-15-8-10-17(11-9-15)29-16-4-2-1-3-5-16/h1-13H,(H,23,25)(H2,21,27,28)(H2,22,24,26)
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 7.90n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10882
PNG
(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Show SMILES CCOc1ccc2nc(sc2c1)S(N)(=O)=O
Show InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
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 8n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12138
PNG
(4-(N-(4-acetylphenyl)aminocarbonyl-hydrazinocarbon...)
Show SMILES CC(=O)c1ccc(NC(=O)NNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C16H16N4O5S/c1-10(21)11-2-6-13(7-3-11)18-16(23)20-19-15(22)12-4-8-14(9-5-12)26(17,24)25/h2-9H,1H3,(H,19,22)(H2,17,24,25)(H2,18,20,23)
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 8.30n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12139
PNG
(4-(N-(4-ethyloxycarbonylphenyl)aminocarbonyl-hydra...)
Show SMILES CCOC(=O)c1ccc(NC(=O)NNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C17H18N4O6S/c1-2-27-16(23)12-3-7-13(8-4-12)19-17(24)21-20-15(22)11-5-9-14(10-6-11)28(18,25)26/h3-10H,2H2,1H3,(H,20,22)(H2,18,25,26)(H2,19,21,24)
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 8.5n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12141
PNG
(4-(N-(4-bromophenyl)aminocarbonyl-hydrazinocarbony...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C14H13BrN4O4S/c15-10-3-5-11(6-4-10)17-14(21)19-18-13(20)9-1-7-12(8-2-9)24(16,22)23/h1-8H,(H,18,20)(H2,16,22,23)(H2,17,19,21)
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 8.60n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10884
PNG
((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Show SMILES CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
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 9n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12139
PNG
(4-(N-(4-ethyloxycarbonylphenyl)aminocarbonyl-hydra...)
Show SMILES CCOC(=O)c1ccc(NC(=O)NNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C17H18N4O6S/c1-2-27-16(23)12-3-7-13(8-4-12)19-17(24)21-20-15(22)11-5-9-14(10-6-11)28(18,25)26/h3-10H,2H2,1H3,(H,20,22)(H2,18,25,26)(H2,19,21,24)
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 9n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12151
PNG
(4-(N-(4-chlorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN4O6S2/c15-10-3-7-12(8-4-10)27(24,25)19-14(21)18-17-13(20)9-1-5-11(6-2-9)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 9.10n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12150
PNG
(N-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-4-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C14H13FN4O6S2/c15-10-3-7-12(8-4-10)27(24,25)19-14(21)18-17-13(20)9-1-5-11(6-2-9)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 9.5n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12149
PNG
(4-(N-(4-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-2-6-13(7-3-10)27(24,25)19-15(21)18-17-14(20)11-4-8-12(9-5-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 9.80n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12142
PNG
(4-(N-(4-biphenyl)aminocarbonyl-hydrazinocarbonyl)-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H18N4O4S/c21-29(27,28)18-12-8-16(9-13-18)19(25)23-24-20(26)22-17-10-6-15(7-11-17)14-4-2-1-3-5-14/h1-13H,(H,23,25)(H2,21,27,28)(H2,22,24,26)
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 11n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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 12n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12137
PNG
(4-(N-(3,4-dichlorophenyl)aminocarbonyl-hydrazinoca...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H12Cl2N4O4S/c15-11-6-3-9(7-12(11)16)18-14(22)20-19-13(21)8-1-4-10(5-2-8)25(17,23)24/h1-7H,(H,19,21)(H2,17,23,24)(H2,18,20,22)
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 13n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12146
PNG
(2-[4-(aminosulfonyl)benzoyl]-N-9H-fluoren-9-ylhydr...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NC1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C21H18N4O4S/c22-30(28,29)14-11-9-13(10-12-14)20(26)24-25-21(27)23-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-12,19H,(H,24,26)(H2,22,28,29)(H2,23,25,27)
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 13n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10881
PNG
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Show SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O |w:3.2|
Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
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 14n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10890
PNG
(1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonam...)
Show SMILES NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2c(Cl)c[nH]c12
Show InChI InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
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 15n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12138
PNG
(4-(N-(4-acetylphenyl)aminocarbonyl-hydrazinocarbon...)
Show SMILES CC(=O)c1ccc(NC(=O)NNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C16H16N4O5S/c1-10(21)11-2-6-13(7-3-11)18-16(23)20-19-15(22)12-4-8-14(9-5-12)26(17,24)25/h2-9H,1H3,(H,19,22)(H2,17,24,25)(H2,18,20,23)
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 15n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12144
PNG
(4-(N-(4-benzyloxyphenyl)aminocarbonyl-hydrazinocar...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H20N4O5S/c22-31(28,29)19-12-6-16(7-13-19)20(26)24-25-21(27)23-17-8-10-18(11-9-17)30-14-15-4-2-1-3-5-15/h1-13H,14H2,(H,24,26)(H2,22,28,29)(H2,23,25,27)
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 15n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12143
PNG
(4-(N-(4-phenoxyphenyl)aminocarbonyl-hydrazinocarbo...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H18N4O5S/c21-30(27,28)18-12-6-14(7-13-18)19(25)23-24-20(26)22-15-8-10-17(11-9-15)29-16-4-2-1-3-5-16/h1-13H,(H,23,25)(H2,21,27,28)(H2,22,24,26)
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 18n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12145
PNG
(N-({[4-(adamantan-1-yl)phenyl]carbamoyl}amino)-4-s...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)C12CC3CC(CC(C3)C1)C2 |TLB:30:29:32:24.26.25,30:25:32:29.31.28,THB:28:29:24:26.32.27,28:27:24:29.31.30|
Show InChI InChI=1S/C24H28N4O4S/c25-33(31,32)21-7-1-18(2-8-21)22(29)27-28-23(30)26-20-5-3-19(4-6-20)24-12-15-9-16(13-24)11-17(10-15)14-24/h1-8,15-17H,9-14H2,(H,27,29)(H2,25,31,32)(H2,26,28,30)
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 24n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10890
PNG
(1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonam...)
Show SMILES NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2c(Cl)c[nH]c12
Show InChI InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
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 24n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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 25n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10882
PNG
(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Show SMILES CCOc1ccc2nc(sc2c1)S(N)(=O)=O
Show InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
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 25 -42.7n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12146
PNG
(2-[4-(aminosulfonyl)benzoyl]-N-9H-fluoren-9-ylhydr...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NC1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C21H18N4O4S/c22-30(28,29)14-11-9-13(10-12-14)20(26)24-25-21(27)23-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-12,19H,(H,24,26)(H2,22,28,29)(H2,23,25,27)
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 25n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10881
PNG
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Show SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O |w:3.2|
Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
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 27n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10890
PNG
(1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonam...)
Show SMILES NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2c(Cl)c[nH]c12
Show InChI InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
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 31 -42.1n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12148
PNG
(4-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-4-2-3-5-13(10)27(24,25)19-15(21)18-17-14(20)11-6-8-12(9-7-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 32n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10855
PNG
(2-aminobenzene-1-sulfonamide | CHEMBL6705 | US1017...)
Show SMILES Nc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C6H8N2O2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
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 33n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12145
PNG
(N-({[4-(adamantan-1-yl)phenyl]carbamoyl}amino)-4-s...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)C12CC3CC(CC(C3)C1)C2 |TLB:30:29:32:24.26.25,30:25:32:29.31.28,THB:28:29:24:26.32.27,28:27:24:29.31.30|
Show InChI InChI=1S/C24H28N4O4S/c25-33(31,32)21-7-1-18(2-8-21)22(29)27-28-23(30)26-20-5-3-19(4-6-20)24-12-15-9-16(13-24)11-17(10-15)14-24/h1-8,15-17H,9-14H2,(H,27,29)(H2,25,31,32)(H2,26,28,30)
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 33n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10882
PNG
(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Show SMILES CCOc1ccc2nc(sc2c1)S(N)(=O)=O
Show InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
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 34n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12147
PNG
(4-(N-phenylsulfonylaminocarbonyl-hydrazinocarbonyl...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O6S2/c15-25(21,22)11-8-6-10(7-9-11)13(19)16-17-14(20)18-26(23,24)12-4-2-1-3-5-12/h1-9H,(H,16,19)(H2,15,21,22)(H2,17,18,20)
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 35n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10885
PNG
((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Show SMILES CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
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 37n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10883
PNG
(4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 |...)
Show SMILES NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O
Show InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)
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 38n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10879
PNG
(2-Hydrazinobenzenesulfonamide | 2-hydrazinylbenzen...)
Show SMILES NNc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C6H9N3O2S/c7-9-5-3-1-2-4-6(5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11)
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 48n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10883
PNG
(4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 |...)
Show SMILES NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O
Show InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)
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 50n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10881
PNG
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Show SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O |w:3.2|
Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
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 50 -41.0n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12160
PNG
(3-fluoro-4-hydrazinylbenzene-1-sulfonamide | 4-Hyd...)
Show SMILES NNc1ccc(cc1F)S(N)(=O)=O
Show InChI InChI=1S/C6H8FN3O2S/c7-5-3-4(13(9,11)12)1-2-6(5)10-8/h1-3,10H,8H2,(H2,9,11,12)
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 51n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10884
PNG
((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Show SMILES CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
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 52n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12148
PNG
(4-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-4-2-3-5-13(10)27(24,25)19-15(21)18-17-14(20)11-6-8-12(9-7-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 54n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12157
PNG
(2-(N-(4-fluorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C14H13FN4O6S2/c15-9-5-7-10(8-6-9)27(24,25)19-14(21)18-17-13(20)11-3-1-2-4-12(11)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 64n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12147
PNG
(4-(N-phenylsulfonylaminocarbonyl-hydrazinocarbonyl...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O6S2/c15-25(21,22)11-8-6-10(7-9-11)13(19)16-17-14(20)18-26(23,24)12-4-2-1-3-5-12/h1-9H,(H,16,19)(H2,15,21,22)(H2,17,18,20)
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 67n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12156
PNG
(2-(N-(4-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-6-8-11(9-7-10)27(24,25)19-15(21)18-17-14(20)12-4-2-3-5-13(12)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 70n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12158
PNG
(2-(N-(4-chlorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN4O6S2/c15-9-5-7-10(8-6-9)27(24,25)19-14(21)18-17-13(20)11-3-1-2-4-12(11)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 72n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12161
PNG
(3-chloro-4-hydrazinylbenzene-1-sulfonamide | 4-Hyd...)
Show SMILES NNc1ccc(cc1Cl)S(N)(=O)=O
Show InChI InChI=1S/C6H8ClN3O2S/c7-5-3-4(13(9,11)12)1-2-6(5)10-8/h1-3,10H,8H2,(H2,9,11,12)
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 76n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12154
PNG
(N-{[(benzenesulfonyl)carbamoyl]amino}-2-sulfamoylb...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O6S2/c15-25(21,22)12-9-5-4-8-11(12)13(19)16-17-14(20)18-26(23,24)10-6-2-1-3-7-10/h1-9H,(H,16,19)(H2,15,21,22)(H2,17,18,20)
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 76n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10879
PNG
(2-Hydrazinobenzenesulfonamide | 2-hydrazinylbenzen...)
Show SMILES NNc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C6H9N3O2S/c7-9-5-3-1-2-4-6(5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11)
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 78n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12155
PNG
(2-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-6-2-4-8-12(10)27(24,25)19-15(21)18-17-14(20)11-7-3-5-9-13(11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 83n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10858
PNG
(4-hydrazinylbenzene-1-sulfonamide | CHEMBL7204 | a...)
Show SMILES NNc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C6H9N3O2S/c7-9-5-1-3-6(4-2-5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11)
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 83n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12156
PNG
(2-(N-(4-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-6-8-11(9-7-10)27(24,25)19-15(21)18-17-14(20)12-4-2-3-5-13(12)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 85n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12155
PNG
(2-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-6-2-4-8-12(10)27(24,25)19-15(21)18-17-14(20)11-7-3-5-9-13(11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 92n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12158
PNG
(2-(N-(4-chlorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN4O6S2/c15-9-5-7-10(8-6-9)27(24,25)19-14(21)18-17-13(20)11-3-1-2-4-12(11)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 94n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12157
PNG
(2-(N-(4-fluorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C14H13FN4O6S2/c15-9-5-7-10(8-6-9)27(24,25)19-14(21)18-17-13(20)11-3-1-2-4-12(11)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 97n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12154
PNG
(N-{[(benzenesulfonyl)carbamoyl]amino}-2-sulfamoylb...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O6S2/c15-25(21,22)12-9-5-4-8-11(12)13(19)16-17-14(20)18-26(23,24)10-6-2-1-3-7-10/h1-9H,(H,16,19)(H2,15,21,22)(H2,17,18,20)
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 107n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12136
PNG
(4-(hydrazinecarbonyl)benzene-1-sulfonamide | 4-Sul...)
Show SMILES NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C7H9N3O3S/c8-10-7(11)5-1-3-6(4-2-5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)
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 124n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12160
PNG
(3-fluoro-4-hydrazinylbenzene-1-sulfonamide | 4-Hyd...)
Show SMILES NNc1ccc(cc1F)S(N)(=O)=O
Show InChI InChI=1S/C6H8FN3O2S/c7-5-3-4(13(9,11)12)1-2-6(5)10-8/h1-3,10H,8H2,(H2,9,11,12)
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 136n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12161
PNG
(3-chloro-4-hydrazinylbenzene-1-sulfonamide | 4-Hyd...)
Show SMILES NNc1ccc(cc1Cl)S(N)(=O)=O
Show InChI InChI=1S/C6H8ClN3O2S/c7-5-3-4(13(9,11)12)1-2-6(5)10-8/h1-3,10H,8H2,(H2,9,11,12)
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 149n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12164
PNG
(2-acetohydrazidobenzene-1-sulfonamide | N-Acetyl-2...)
Show SMILES CC(=O)NNc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C8H11N3O3S/c1-6(12)10-11-7-4-2-3-5-8(7)15(9,13)14/h2-5,11H,1H3,(H,10,12)(H2,9,13,14)
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 175n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12136
PNG
(4-(hydrazinecarbonyl)benzene-1-sulfonamide | 4-Sul...)
Show SMILES NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C7H9N3O3S/c8-10-7(11)5-1-3-6(4-2-5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)
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 175n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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 250 -37.1n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM4703
PNG
(4-carboxybenzenesulfonamide 1 | 4-sulfamoylbenzoic...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C7H7NO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)(H2,8,11,12)
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 258n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12164
PNG
(2-acetohydrazidobenzene-1-sulfonamide | N-Acetyl-2...)
Show SMILES CC(=O)NNc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C8H11N3O3S/c1-6(12)10-11-7-4-2-3-5-8(7)15(9,13)14/h2-5,11H,1H3,(H,10,12)(H2,9,13,14)
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 264n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM10858
PNG
(4-hydrazinylbenzene-1-sulfonamide | CHEMBL7204 | a...)
Show SMILES NNc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C6H9N3O2S/c7-9-5-1-3-6(4-2-5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11)
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 265n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10855
PNG
(2-aminobenzene-1-sulfonamide | CHEMBL6705 | US1017...)
Show SMILES Nc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C6H8N2O2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
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 295n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12153
PNG
(2-(hydrazinecarbonyl)benzene-1-sulfonamide | hydra...)
Show SMILES NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C7H9N3O3S/c8-10-7(11)5-3-1-2-4-6(5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)
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 338n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM4703
PNG
(4-carboxybenzenesulfonamide 1 | 4-sulfamoylbenzoic...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C7H7NO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)(H2,8,11,12)
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 346n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM12152
PNG
(2-carboxymethylbenzenesulfonamide 5 | CHEMBL148680...)
Show SMILES COC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C8H9NO4S/c1-13-8(10)6-4-2-3-5-7(6)14(9,11)12/h2-5H,1H3,(H2,9,11,12)
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 420n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12153
PNG
(2-(hydrazinecarbonyl)benzene-1-sulfonamide | hydra...)
Show SMILES NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C7H9N3O3S/c8-10-7(11)5-3-1-2-4-6(5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)
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 547n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12151
PNG
(4-(N-(4-chlorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN4O6S2/c15-10-3-7-12(8-4-10)27(24,25)19-14(21)18-17-13(20)9-1-5-11(6-2-9)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 550n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12150
PNG
(N-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-4-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C14H13FN4O6S2/c15-10-3-7-12(8-4-10)27(24,25)19-14(21)18-17-13(20)9-1-5-11(6-2-9)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 600n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))		BDBM12152
PNG
(2-carboxymethylbenzenesulfonamide 5 | CHEMBL148680...)
Show SMILES COC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C8H9NO4S/c1-13-8(10)6-4-2-3-5-7(6)14(9,11)12/h2-5H,1H3,(H2,9,11,12)
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 680n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12149
PNG
(4-(N-(4-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-2-6-13(7-3-10)27(24,25)19-15(21)18-17-14(20)11-4-8-12(9-5-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 700n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12140
PNG
(4-(N-(4-nitrophenyl)aminocarbonyl-hydrazinocarbony...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H13N5O6S/c15-26(24,25)12-7-1-9(2-8-12)13(20)17-18-14(21)16-10-3-5-11(6-4-10)19(22)23/h1-8H,(H,17,20)(H2,15,24,25)(H2,16,18,21)
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 760 -34.3n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12148
PNG
(4-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-4-2-3-5-13(10)27(24,25)19-15(21)18-17-14(20)11-6-8-12(9-7-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 800n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12141
PNG
(4-(N-(4-bromophenyl)aminocarbonyl-hydrazinocarbony...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C14H13BrN4O4S/c15-10-3-5-11(6-4-10)17-14(21)19-18-13(20)9-1-7-12(8-2-9)24(16,22)23/h1-8H,(H,18,20)(H2,16,22,23)(H2,17,19,21)
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 865 -34.0n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12137
PNG
(4-(N-(3,4-dichlorophenyl)aminocarbonyl-hydrazinoca...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H12Cl2N4O4S/c15-11-6-3-9(7-12(11)16)18-14(22)20-19-13(21)8-1-4-10(5-2-8)25(17,23)24/h1-7H,(H,19,21)(H2,17,23,24)(H2,18,20,22)
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 1.15E+3 -33.3n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12142
PNG
(4-(N-(4-biphenyl)aminocarbonyl-hydrazinocarbonyl)-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H18N4O4S/c21-29(27,28)18-12-8-16(9-13-18)19(25)23-24-20(26)22-17-10-6-15(7-11-17)14-4-2-1-3-5-14/h1-13H,(H,23,25)(H2,21,27,28)(H2,22,24,26)
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 1.16E+3 -33.3n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12139
PNG
(4-(N-(4-ethyloxycarbonylphenyl)aminocarbonyl-hydra...)
Show SMILES CCOC(=O)c1ccc(NC(=O)NNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C17H18N4O6S/c1-2-27-16(23)12-3-7-13(8-4-12)19-17(24)21-20-15(22)11-5-9-14(10-6-11)28(18,25)26/h3-10H,2H2,1H3,(H,20,22)(H2,18,25,26)(H2,19,21,24)
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 1.20E+3 -33.2n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10883
PNG
(4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 |...)
Show SMILES NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O
Show InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)
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 1.20E+3 -33.2n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12147
PNG
(4-(N-phenylsulfonylaminocarbonyl-hydrazinocarbonyl...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O6S2/c15-25(21,22)11-8-6-10(7-9-11)13(19)16-17-14(20)18-26(23,24)12-4-2-1-3-5-12/h1-9H,(H,16,19)(H2,15,21,22)(H2,17,18,20)
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 1.25E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12144
PNG
(4-(N-(4-benzyloxyphenyl)aminocarbonyl-hydrazinocar...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H20N4O5S/c22-31(28,29)19-12-6-16(7-13-19)20(26)24-25-21(27)23-17-8-10-18(11-9-17)30-14-15-4-2-1-3-5-15/h1-13H,14H2,(H,24,26)(H2,22,28,29)(H2,23,25,27)
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 1.30E+3 -33.0n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12146
PNG
(2-[4-(aminosulfonyl)benzoyl]-N-9H-fluoren-9-ylhydr...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)NC1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C21H18N4O4S/c22-30(28,29)14-11-9-13(10-12-14)20(26)24-25-21(27)23-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-12,19H,(H,24,26)(H2,22,28,29)(H2,23,25,27)
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 1.36E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12143
PNG
(4-(N-(4-phenoxyphenyl)aminocarbonyl-hydrazinocarbo...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H18N4O5S/c21-30(27,28)18-12-6-14(7-13-18)19(25)23-24-20(26)22-15-8-10-17(11-9-15)29-16-4-2-1-3-5-16/h1-13H,(H,23,25)(H2,21,27,28)(H2,22,24,26)
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 1.45E+3 -32.8n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12138
PNG
(4-(N-(4-acetylphenyl)aminocarbonyl-hydrazinocarbon...)
Show SMILES CC(=O)c1ccc(NC(=O)NNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C16H16N4O5S/c1-10(21)11-2-6-13(7-3-11)18-16(23)20-19-15(22)12-4-8-14(9-5-12)26(17,24)25/h2-9H,1H3,(H,19,22)(H2,17,24,25)(H2,18,20,23)
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 1.45E+3 -32.8n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12145
PNG
(N-({[4-(adamantan-1-yl)phenyl]carbamoyl}amino)-4-s...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)Nc1ccc(cc1)C12CC3CC(CC(C3)C1)C2 |TLB:30:29:32:24.26.25,30:25:32:29.31.28,THB:28:29:24:26.32.27,28:27:24:29.31.30|
Show InChI InChI=1S/C24H28N4O4S/c25-33(31,32)21-7-1-18(2-8-21)22(29)27-28-23(30)26-20-5-3-19(4-6-20)24-12-15-9-16(13-24)11-17(10-15)14-24/h1-8,15-17H,9-14H2,(H,27,29)(H2,25,31,32)(H2,26,28,30)
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 2.40E+3 -31.5n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12161
PNG
(3-chloro-4-hydrazinylbenzene-1-sulfonamide | 4-Hyd...)
Show SMILES NNc1ccc(cc1Cl)S(N)(=O)=O
Show InChI InChI=1S/C6H8ClN3O2S/c7-5-3-4(13(9,11)12)1-2-6(5)10-8/h1-3,10H,8H2,(H2,9,11,12)
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 2.80E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12136
PNG
(4-(hydrazinecarbonyl)benzene-1-sulfonamide | 4-Sul...)
Show SMILES NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C7H9N3O3S/c8-10-7(11)5-1-3-6(4-2-5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)
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 2.95E+3 -31.0n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12160
PNG
(3-fluoro-4-hydrazinylbenzene-1-sulfonamide | 4-Hyd...)
Show SMILES NNc1ccc(cc1F)S(N)(=O)=O
Show InChI InChI=1S/C6H8FN3O2S/c7-5-3-4(13(9,11)12)1-2-6(5)10-8/h1-3,10H,8H2,(H2,9,11,12)
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 3.30E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM4703
PNG
(4-carboxybenzenesulfonamide 1 | 4-sulfamoylbenzoic...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C7H7NO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)(H2,8,11,12)
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 3.40E+3 -30.7n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12156
PNG
(2-(N-(4-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-6-8-11(9-7-10)27(24,25)19-15(21)18-17-14(20)12-4-2-3-5-13(12)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 3.40E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12158
PNG
(2-(N-(4-chlorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN4O6S2/c15-9-5-7-10(8-6-9)27(24,25)19-14(21)18-17-13(20)11-3-1-2-4-12(11)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 3.60E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10858
PNG
(4-hydrazinylbenzene-1-sulfonamide | CHEMBL7204 | a...)
Show SMILES NNc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C6H9N3O2S/c7-9-5-1-3-6(4-2-5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11)
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 3.90E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12155
PNG
(2-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-6-2-4-8-12(10)27(24,25)19-15(21)18-17-14(20)11-7-3-5-9-13(11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 4.70E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12154
PNG
(N-{[(benzenesulfonyl)carbamoyl]amino}-2-sulfamoylb...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O6S2/c15-25(21,22)12-9-5-4-8-11(12)13(19)16-17-14(20)18-26(23,24)10-6-2-1-3-7-10/h1-9H,(H,16,19)(H2,15,21,22)(H2,17,18,20)
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 4.80E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12157
PNG
(2-(N-(4-fluorophenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES NS(=O)(=O)c1ccccc1C(=O)NNC(=O)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C14H13FN4O6S2/c15-9-5-7-10(8-6-9)27(24,25)19-14(21)18-17-13(20)11-3-1-2-4-12(11)26(16,22)23/h1-8H,(H,17,20)(H2,16,22,23)(H2,18,19,21)
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 4.90E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12153
PNG
(2-(hydrazinecarbonyl)benzene-1-sulfonamide | hydra...)
Show SMILES NNC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C7H9N3O3S/c8-10-7(11)5-3-1-2-4-6(5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)
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 2.45E+4n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12152
PNG
(2-carboxymethylbenzenesulfonamide 5 | CHEMBL148680...)
Show SMILES COC(=O)c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C8H9NO4S/c1-13-8(10)6-4-2-3-5-7(6)14(9,11)12/h2-5H,1H3,(H2,9,11,12)
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 3.58E+4n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10879
PNG
(2-Hydrazinobenzenesulfonamide | 2-hydrazinylbenzen...)
Show SMILES NNc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C6H9N3O2S/c7-9-5-3-1-2-4-6(5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11)
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 3.60E+4n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10855
PNG
(2-aminobenzene-1-sulfonamide | CHEMBL6705 | US1017...)
Show SMILES Nc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C6H8N2O2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
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 4.54E+4n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM12164
PNG
(2-acetohydrazidobenzene-1-sulfonamide | N-Acetyl-2...)
Show SMILES CC(=O)NNc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C8H11N3O3S/c1-6(12)10-11-7-4-2-3-5-8(7)15(9,13)14/h2-5,11H,1H3,(H,10,12)(H2,9,13,14)
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 4.83E+4n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))		BDBM10884
PNG
((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Show SMILES CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
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 5.00E+4 -24.1n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...

J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%