BindingDB logo
myBDB logout

PubMed code 15837294

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5815
PNG
(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C27H19F4N5O3/c1-38-18-9-4-15(5-10-18)23-21(22-24(32)33-13-34-25(22)39-23)14-2-7-17(8-3-14)35-26(37)36-20-12-16(27(29,30)31)6-11-19(20)28/h2-13H,1H3,(H2,32,33,34)(H2,35,36,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 2n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5815
PNG
(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C27H19F4N5O3/c1-38-18-9-4-15(5-10-18)23-21(22-24(32)33-13-34-25(22)39-23)14-2-7-17(8-3-14)35-26(37)36-20-12-16(27(29,30)31)6-11-19(20)28/h2-13H,1H3,(H2,32,33,34)(H2,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
MMDB
PDB
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5825
PNG
(3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidi...)
Show SMILES CN(c1ccc(NC(=O)Nc2ccccc2)cc1)c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1
Show InChI InChI=1S/C24H23N7O3S/c1-31(20-12-10-18(11-13-20)29-24(32)28-17-6-3-2-4-7-17)22-14-15-26-23(30-22)27-19-8-5-9-21(16-19)35(25,33)34/h2-16H,1H3,(H2,25,33,34)(H,26,27,30)(H2,28,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5819
PNG
(3-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]amino}p...)
Show SMILES CN(c1ccc(NC(=O)Nc2ccccc2)cc1)c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1
Show InChI InChI=1S/C26H26N6O3S/c1-32(23-13-11-21(12-14-23)30-26(33)29-20-8-4-3-5-9-20)24-15-16-27-25(31-24)28-22-10-6-7-19(17-22)18-36(2,34)35/h3-17H,18H2,1-2H3,(H,27,28,31)(H2,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5816
PNG
(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C26H20ClN5O3/c1-34-20-12-4-16(5-13-20)23-21(22-24(28)29-14-30-25(22)35-23)15-2-8-18(9-3-15)31-26(33)32-19-10-6-17(27)7-11-19/h2-14H,1H3,(H2,28,29,30)(H2,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5814
PNG
(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C26H21N5O3/c1-33-20-13-9-17(10-14-20)23-21(22-24(27)28-15-29-25(22)34-23)16-7-11-19(12-8-16)31-26(32)30-18-5-3-2-4-6-18/h2-15H,1H3,(H2,27,28,29)(H2,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 28n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5810
PNG
(N-{3-[4-amino-5-(4-phenylphenyl)furo[2,3-d]pyrimid...)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1oc2ncnc(N)c2c1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H20N4O3S/c1-33(30,31)29-20-9-5-8-19(14-20)23-21(22-24(26)27-15-28-25(22)32-23)18-12-10-17(11-13-18)16-6-3-2-4-7-16/h2-15,29H,1H3,(H2,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 36n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5818
PNG
(furo[2,3-d]pyrimidine deriv. 7n | {4-[4-amino-6-(4...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(N)=O)cc1
Show InChI InChI=1S/C20H17N5O3/c1-27-14-8-4-12(5-9-14)17-15(16-18(21)23-10-24-19(16)28-17)11-2-6-13(7-3-11)25-20(22)26/h2-10H,1H3,(H2,21,23,24)(H3,22,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 58n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5817
PNG
(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)NC2CCCCC2)cc1
Show InChI InChI=1S/C26H27N5O3/c1-33-20-13-9-17(10-14-20)23-21(22-24(27)28-15-29-25(22)34-23)16-7-11-19(12-8-16)31-26(32)30-18-5-3-2-4-6-18/h7-15,18H,2-6H2,1H3,(H2,27,28,29)(H2,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 59n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5814
PNG
(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C26H21N5O3/c1-33-20-13-9-17(10-14-20)23-21(22-24(27)28-15-29-25(22)34-23)16-7-11-19(12-8-16)31-26(32)30-18-5-3-2-4-6-18/h2-15H,1H3,(H2,27,28,29)(H2,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 62n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5808
PNG
(N-{3-[4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1c(oc2ncnc(N)c12)-c1cccc(NS(C)(=O)=O)c1
Show InChI InChI=1S/C20H18N4O4S/c1-27-15-8-6-12(7-9-15)16-17-19(21)22-11-23-20(17)28-18(16)13-4-3-5-14(10-13)24-29(2,25)26/h3-11,24H,1-2H3,(H2,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 65n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5821
PNG
(phenyl N-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]...)
Show SMILES CN(c1ccc(NC(=O)Oc2ccccc2)cc1)c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1
Show InChI InChI=1S/C26H25N5O4S/c1-31(22-13-11-20(12-14-22)29-26(32)35-23-9-4-3-5-10-23)24-15-16-27-25(30-24)28-21-8-6-7-19(17-21)18-36(2,33)34/h3-17H,18H2,1-2H3,(H,29,32)(H,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 95n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5822
PNG
(3-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]amino}p...)
Show SMILES CN(c1ccc(NC(=S)Nc2ccccc2)cc1)c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1
Show InChI InChI=1S/C26H26N6O2S2/c1-32(23-13-11-21(12-14-23)30-26(35)29-20-8-4-3-5-9-20)24-15-16-27-25(31-24)28-22-10-6-7-19(17-22)18-36(2,33)34/h3-17H,18H2,1-2H3,(H,27,28,31)(H2,29,30,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 117n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5820
PNG
(N-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]amino}p...)
Show SMILES CN(c1ccc(NC(=O)Cc2ccccc2)cc1)c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1
Show InChI InChI=1S/C27H27N5O3S/c1-32(24-13-11-22(12-14-24)29-26(33)18-20-7-4-3-5-8-20)25-15-16-28-27(31-25)30-23-10-6-9-21(17-23)19-36(2,34)35/h3-17H,18-19H2,1-2H3,(H,29,33)(H,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 176n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5806
PNG
(3-[4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin...)
Show SMILES COc1ccc(cc1)-c1c(oc2ncnc(N)c12)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C20H16N4O3/c1-26-14-7-5-11(6-8-14)15-16-18(21)23-10-24-20(16)27-17(15)12-3-2-4-13(9-12)19(22)25/h2-10H,1H3,(H2,22,25)(H2,21,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 180n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5817
PNG
(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)NC2CCCCC2)cc1
Show InChI InChI=1S/C26H27N5O3/c1-33-20-13-9-17(10-14-20)23-21(22-24(27)28-15-29-25(22)34-23)16-7-11-19(12-8-16)31-26(32)30-18-5-3-2-4-6-18/h7-15,18H,2-6H2,1H3,(H2,27,28,29)(H2,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 186n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5810
PNG
(N-{3-[4-amino-5-(4-phenylphenyl)furo[2,3-d]pyrimid...)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1oc2ncnc(N)c2c1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H20N4O3S/c1-33(30,31)29-20-9-5-8-19(14-20)23-21(22-24(26)27-15-28-25(22)32-23)18-12-10-17(11-13-18)16-6-3-2-4-7-16/h2-15,29H,1H3,(H2,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 190n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5823
PNG
(N-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]amino}p...)
Show SMILES CN(c1ccc(NS(=O)(=O)Cc2ccccc2)cc1)c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1
Show InChI InChI=1S/C26H27N5O4S2/c1-31(24-13-11-22(12-14-24)30-37(34,35)19-20-7-4-3-5-8-20)25-15-16-27-26(29-25)28-23-10-6-9-21(17-23)18-36(2,32)33/h3-17,30H,18-19H2,1-2H3,(H,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 269n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5818
PNG
(furo[2,3-d]pyrimidine deriv. 7n | {4-[4-amino-6-(4...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(N)=O)cc1
Show InChI InChI=1S/C20H17N5O3/c1-27-14-8-4-12(5-9-14)17-15(16-18(21)23-10-24-19(16)28-17)11-2-6-13(7-3-11)25-20(22)26/h2-10H,1H3,(H2,21,23,24)(H3,22,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 275n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5808
PNG
(N-{3-[4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1c(oc2ncnc(N)c12)-c1cccc(NS(C)(=O)=O)c1
Show InChI InChI=1S/C20H18N4O4S/c1-27-15-8-6-12(7-9-15)16-17-19(21)22-11-23-20(17)28-18(16)13-4-3-5-14(10-13)24-29(2,25)26/h3-11,24H,1-2H3,(H2,21,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 300n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5824
PNG
(1-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]amino}p...)
Show SMILES CN(c1ccc(cc1)N=C(N)Nc1ccccc1)c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1 |w:8.8|
Show InChI InChI=1S/C26H27N7O2S/c1-33(23-13-11-21(12-14-23)30-25(27)29-20-8-4-3-5-9-20)24-15-16-28-26(32-24)31-22-10-6-7-19(17-22)18-36(2,34)35/h3-17H,18H2,1-2H3,(H3,27,29,30)(H,28,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 324n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5809
PNG
(5-[4-(dimethylamino)phenyl]-6-(4-methoxyphenyl)fur...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C21H20N4O2/c1-25(2)15-8-4-13(5-9-15)17-18-20(22)23-12-24-21(18)27-19(17)14-6-10-16(26-3)11-7-14/h4-12H,1-3H3,(H2,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 350n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5812
PNG
(N-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NC(=O)c2cccc(F)c2)cc1
Show InChI InChI=1S/C26H19FN4O3/c1-33-20-11-7-16(8-12-20)23-21(22-24(28)29-14-30-26(22)34-23)15-5-9-19(10-6-15)31-25(32)17-3-2-4-18(27)13-17/h2-14H,1H3,(H,31,32)(H2,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 501n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5806
PNG
(3-[4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin...)
Show SMILES COc1ccc(cc1)-c1c(oc2ncnc(N)c12)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C20H16N4O3/c1-26-14-7-5-11(6-8-14)15-16-18(21)23-10-24-20(16)27-17(15)12-3-2-4-13(9-12)19(22)25/h2-10H,1H3,(H2,22,25)(H2,21,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 540n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5809
PNG
(5-[4-(dimethylamino)phenyl]-6-(4-methoxyphenyl)fur...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C21H20N4O2/c1-25(2)15-8-4-13(5-9-15)17-18-20(22)23-12-24-21(18)27-19(17)14-6-10-16(26-3)11-7-14/h4-12H,1-3H3,(H2,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 600n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5813
PNG
(N-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(NS(=O)(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C25H19ClN4O4S/c1-33-19-11-7-16(8-12-19)23-21(22-24(27)28-14-29-25(22)34-23)15-5-9-18(10-6-15)30-35(31,32)20-4-2-3-17(26)13-20/h2-14,30H,1H3,(H2,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 851n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5802
PNG
(5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-ami...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(OC)cc1
Show InChI InChI=1S/C20H17N3O3/c1-24-14-7-3-12(4-8-14)16-17-19(21)22-11-23-20(17)26-18(16)13-5-9-15(25-2)10-6-13/h3-11H,1-2H3,(H2,21,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+3n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5802
PNG
(5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-ami...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1ccc(OC)cc1
Show InChI InChI=1S/C20H17N3O3/c1-24-14-7-3-12(4-8-14)16-17-19(21)22-11-23-20(17)26-18(16)13-5-9-15(25-2)10-6-13/h3-11H,1-2H3,(H2,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.12E+3n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5807
PNG
(3-[4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin...)
Show SMILES COc1ccc(cc1)-c1c(oc2ncnc(N)c12)-c1cccc(c1)C(=O)N(C)C
Show InChI InChI=1S/C22H20N4O3/c1-26(2)22(27)15-6-4-5-14(11-15)19-17(13-7-9-16(28-3)10-8-13)18-20(23)24-12-25-21(18)29-19/h4-12H,1-3H3,(H2,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.48E+3n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5805
PNG
(6-(3,4-dichlorophenyl)-5-(4-methoxyphenyl)furo[2,3...)
Show SMILES COc1ccc(cc1)-c1c(oc2ncnc(N)c12)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2N3O2/c1-25-12-5-2-10(3-6-12)15-16-18(22)23-9-24-19(16)26-17(15)11-4-7-13(20)14(21)8-11/h2-9H,1H3,(H2,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.78E+3n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5803
PNG
(5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | ...)
Show SMILES COc1ccc(cc1)-c1coc2ncnc(N)c12
Show InChI InChI=1S/C13H11N3O2/c1-17-9-4-2-8(3-5-9)10-6-18-13-11(10)12(14)15-7-16-13/h2-7H,1H3,(H2,14,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5804
PNG
(6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | ...)
Show SMILES COc1ccc(cc1)-c1cc2c(N)ncnc2o1
Show InChI InChI=1S/C13H11N3O2/c1-17-9-4-2-8(3-5-9)11-6-10-12(14)15-7-16-13(10)18-11/h2-7H,1H3,(H2,14,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a>1.70E+4n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5811
PNG
(N-{3-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(N)c2c1-c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C21H18N4O3/c1-12(26)25-15-5-3-4-14(10-15)17-18-20(22)23-11-24-21(18)28-19(17)13-6-8-16(27-2)9-7-13/h3-11H,1-2H3,(H,25,26)(H2,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5804
PNG
(6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | ...)
Show SMILES COc1ccc(cc1)-c1cc2c(N)ncnc2o1
Show InChI InChI=1S/C13H11N3O2/c1-17-9-4-2-8(3-5-9)11-6-10-12(14)15-7-16-13(10)18-11/h2-7H,1H3,(H2,14,15,16)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM5803
PNG
(5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | ...)
Show SMILES COc1ccc(cc1)-c1coc2ncnc(N)c12
Show InChI InChI=1S/C13H11N3O2/c1-17-9-4-2-8(3-5-9)10-6-18-13-11(10)12(14)15-7-16-13/h2-7H,1H3,(H2,14,15,16)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5805
PNG
(6-(3,4-dichlorophenyl)-5-(4-methoxyphenyl)furo[2,3...)
Show SMILES COc1ccc(cc1)-c1c(oc2ncnc(N)c12)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2N3O2/c1-25-12-5-2-10(3-6-12)15-16-18(22)23-9-24-19(16)26-17(15)11-4-7-13(20)14(21)8-11/h2-9H,1H3,(H2,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...

Bioorg Med Chem Lett 15: 2203-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.034
BindingDB Entry DOI: 10.7270/Q2QC01P9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%