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PubMed code 15908206

Compile data set for download or QSAR
Found 164 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11225
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1 |r|
Show InChI InChI=1S/C23H26FN7O2/c1-30(2)22(32)19(20(25)23(33)31-11-10-18(24)13-31)15-8-6-14(7-9-15)16-4-3-5-17(12-16)21-26-28-29-27-21/h3-9,12,18-20H,10-11,13,25H2,1-2H3,(H,26,27,28,29)/p+1/t18-,19-,20-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11218
PNG
((2S,3S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC[C@H]1C#N)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-13-3-4-19(28)14-25)17-7-5-15(6-8-17)16-9-11-18(24)12-10-16/h5-12,19-21H,3-4,13,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11193
PNG
((1S,2S)-1-carboxy-1-[4-(4-fluorophenyl)phenyl]-3-[...)
Show SMILES [NH3+][C@@H]([C@@H](C(O)=O)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H20F2N2O3/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(20(26)27)18(23)19(25)24-10-9-16(22)11-24/h1-8,16-18H,9-11,23H2,(H,26,27)/p+1/t16-,17-,18-/m0/s1
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n/an/a 6.60n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11213
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26FN3O2/c1-25(2)21(27)19(20(24)22(28)26-13-3-4-14-26)17-7-5-15(6-8-17)16-9-11-18(23)12-10-16/h5-12,19-20H,3-4,13-14,24H2,1-2H3/p+1/t19-,20-/m0/s1
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n/an/a 7.5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11216
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCSC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O2S/c1-24(2)20(26)18(19(23)21(27)25-11-12-28-13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11207
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C24H27F2N3O2/c25-19-9-7-17(8-10-19)16-3-5-18(6-4-16)21(23(30)28-12-1-2-13-28)22(27)24(31)29-14-11-20(26)15-29/h3-10,20-22H,1-2,11-15,27H2/p+1/t20-,21-,22-/m0/s1
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n/an/a 9.20n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11203
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)Nc1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C21H21F2N7O2/c22-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(31)25-21-26-28-29-27-21)18(24)20(32)30-10-9-16(23)11-30/h1-8,16-18H,9-11,24H2,(H2,25,26,27,28,29,31)/p+1/t16-,17-,18-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11140
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-26(2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19-,20-/m0/s1
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n/an/a 12n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11221
PNG
((1S,2S)-1-[4-(2,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-8-7-15(23)11-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11211
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-(3-fluoroazetidin-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H23F2N3O2/c1-25(2)20(27)18(19(24)21(28)26-11-17(23)12-26)15-5-3-13(4-6-15)14-7-9-16(22)10-8-14/h3-10,17-19H,11-12,24H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11227
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccnc1 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-11-9-17(22)13-26)15-7-5-14(6-8-15)16-4-3-10-24-12-16/h3-8,10,12,17-19H,9,11,13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11204
PNG
((1S,2S)-1-[ethyl(methyl)carbamoyl]-1-[4-(4-fluorop...)
Show SMILES CCN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H27F2N3O2/c1-3-27(2)22(29)20(21(26)23(30)28-13-12-19(25)14-28)17-6-4-15(5-7-17)16-8-10-18(24)11-9-16/h4-11,19-21H,3,12-14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11228
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccncc1 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-12-9-17(22)13-26)16-5-3-14(4-6-16)15-7-10-24-11-8-15/h3-8,10-11,17-19H,9,12-13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11226
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O |r|
Show InChI InChI=1S/C23H28FN3O4S/c1-26(2)22(28)20(21(25)23(29)27-12-11-18(24)14-27)16-9-7-15(8-10-16)17-5-4-6-19(13-17)32(3,30)31/h4-10,13,18,20-21H,11-12,14,25H2,1-3H3/p+1/t18-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11222
PNG
((1S,2S)-1-[4-(3,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(23)12-28)14-5-3-13(4-6-14)15-7-8-17(24)18(25)11-15/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11215
PNG
((2S,3S)-1-(3,3-difluoropyrrolidin-1-yl)-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)20(29)18(19(26)21(30)28-12-11-22(24,25)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-19H,11-13,26H2,1-2H3/p+1/t18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11212
PNG
((2S,3S)-1-(3,3-difluoroazetidin-1-yl)-3-(dimethylc...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H22F3N3O2/c1-26(2)19(28)17(18(25)20(29)27-11-21(23,24)12-27)15-5-3-13(4-6-15)14-7-9-16(22)10-8-14/h3-10,17-18H,11-12,25H2,1-2H3/p+1/t17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11214
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-26(2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19+,20+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11196
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CNC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H23F2N3O2/c1-25-20(27)18(19(24)21(28)26-11-10-17(23)12-26)15-4-2-13(3-5-15)14-6-8-16(22)9-7-14/h2-9,17-19H,10-12,24H2,1H3,(H,25,27)/p+1/t17-,18-,19-/m0/s1
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n/an/a 37n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11224
PNG
((1S,2S)-1-[4-(3-cyanophenyl)phenyl]-1-(dimethylcar...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-11-10-19(24)14-28)17-8-6-16(7-9-17)18-5-3-4-15(12-18)13-25/h3-9,12,19-21H,10-11,14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11206
PNG
((2S,3S)-4-(azetidin-1-yl)-3-[4-(4-fluorophenyl)phe...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C23H25F2N3O2/c24-18-8-6-16(7-9-18)15-2-4-17(5-3-15)20(22(29)27-11-1-12-27)21(26)23(30)28-13-10-19(25)14-28/h2-9,19-21H,1,10-14,26H2/p+1/t19-,20-,21-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11208
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CON(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O3/c1-26(30-2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19-,20-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11223
PNG
((1S,2S)-1-[4-(2,5-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cc(F)ccc1F |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-11-15(23)7-8-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 56n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11205
PNG
((1S,2S)-1-(diethylcarbamoyl)-1-[4-(4-fluorophenyl)...)
Show SMILES CCN(CC)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H29F2N3O2/c1-3-28(4-2)23(30)21(22(27)24(31)29-14-13-20(26)15-29)18-7-5-16(6-8-18)17-9-11-19(25)12-10-17/h5-12,20-22H,3-4,13-15,27H2,1-2H3/p+1/t20-,21-,22-/m0/s1
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n/an/a 59n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11189
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H22F2N2O/c1-13(19(23)20(25)24-11-10-18(22)12-24)14-2-4-15(5-3-14)16-6-8-17(21)9-7-16/h2-9,13,18-19H,10-12,23H2,1H3/p+1/t13-,18-,19-/m0/s1
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n/an/a 64n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11209
PNG
((1S,2S)-1-(N',N'-dimethylhydrazinecarbonyl)-1-[4-(...)
Show SMILES CN(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26F2N4O2/c1-27(2)26-21(29)19(20(25)22(30)28-12-11-18(24)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11201
PNG
((1S,2S)-1-(cyclopropylcarbamoyl)-1-[4-(4-fluorophe...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)NC1CC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C23H25F2N3O2/c24-17-7-5-15(6-8-17)14-1-3-16(4-2-14)20(22(29)27-19-9-10-19)21(26)23(30)28-12-11-18(25)13-28/h1-8,18-21H,9-13,26H2,(H,27,29)/p+1/t18-,20-,21-/m0/s1
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n/an/a 71n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11202
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)NCCO)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C22H25F2N3O3/c23-17-7-5-15(6-8-17)14-1-3-16(4-2-14)19(21(29)26-10-12-28)20(25)22(30)27-11-9-18(24)13-27/h1-8,18-20,28H,9-13,25H2,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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n/an/a 94n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11200
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CC(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H27F2N3O2/c1-14(2)27-22(29)20(21(26)23(30)28-12-11-19(25)13-28)17-5-3-15(4-6-17)16-7-9-18(24)10-8-16/h3-10,14,19-21H,11-13,26H2,1-2H3,(H,27,29)/p+1/t19-,20-,21-/m0/s1
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n/an/a 99n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11210
PNG
((2S,3S)-1-(azetidin-1-yl)-3-(dimethylcarbamoyl)-3-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O2/c1-24(2)20(26)18(19(23)21(27)25-12-3-13-25)16-6-4-14(5-7-16)15-8-10-17(22)11-9-15/h4-11,18-19H,3,12-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11199
PNG
((1S,2S)-1-(ethylcarbamoyl)-1-[4-(4-fluorophenyl)ph...)
Show SMILES CCNC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-2-26-21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,2,11-13,25H2,1H3,(H,26,28)/p+1/t18-,19-,20-/m0/s1
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n/an/a 110n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11195
PNG
((1S,2S)-1-carbamoyl-1-[4-(4-fluorophenyl)phenyl]-3...)
Show SMILES NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H21F2N3O2/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(24)26)18(23)20(27)25-10-9-16(22)11-25/h1-8,16-18H,9-11,23H2,(H2,24,26)/p+1/t16-,17-,18-/m0/s1
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n/an/a 110n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11198
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](c1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H20F2N6O/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19-24-26-27-25-19)18(23)20(29)28-10-9-16(22)11-28/h1-8,16-18H,9-11,23H2,(H,24,25,26,27)/p+1/t16-,17-,18-/m0/s1
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n/an/a 192n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11194
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES COC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H22F2N2O3/c1-28-21(27)18(19(24)20(26)25-11-10-17(23)12-25)15-4-2-13(3-5-15)14-6-8-16(22)9-7-14/h2-9,17-19H,10-12,24H2,1H3/p+1/t17-,18-,19-/m0/s1
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n/an/a 220n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11217
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-(1,1-dioxo-1,3-thi...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCS(=O)(=O)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O4S/c1-24(2)20(26)18(19(23)21(27)25-11-12-30(28,29)13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11190
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CO)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H22F2N2O2/c21-16-7-5-14(6-8-16)13-1-3-15(4-2-13)18(12-25)19(23)20(26)24-10-9-17(22)11-24/h1-8,17-19,25H,9-12,23H2/p+1/t17-,18-,19-/m0/s1
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n/an/a 390n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11224
PNG
((1S,2S)-1-[4-(3-cyanophenyl)phenyl]-1-(dimethylcar...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-11-10-19(24)14-28)17-8-6-16(7-9-17)18-5-3-4-15(12-18)13-25/h3-9,12,19-21H,10-11,14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 460n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11220
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCOCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26FN3O3/c1-25(2)21(27)19(20(24)22(28)26-11-13-29-14-12-26)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-20H,11-14,24H2,1-2H3/p+1/t19-,20-/m0/s1
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n/an/a 520n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11219
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H28FN3O2/c1-26(2)22(28)20(21(25)23(29)27-14-4-3-5-15-27)18-8-6-16(7-9-18)17-10-12-19(24)13-11-17/h6-13,20-21H,3-5,14-15,25H2,1-2H3/p+1/t20-,21-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11192
PNG
((2S,3R)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CN1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C24H29F2N3O/c25-20-9-7-18(8-10-20)17-3-5-19(6-4-17)22(16-28-12-1-2-13-28)23(27)24(30)29-14-11-21(26)15-29/h3-10,21-23H,1-2,11-16,27H2/p+1/t21-,22-,23-/m0/s1
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n/an/a 700n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11188
PNG
((2S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoro...)
Show SMILES [NH3+][C@@H](Cc1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C19H20F2N2O/c20-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-18(22)19(24)23-10-9-17(21)12-23/h1-8,17-18H,9-12,22H2/p+1/t17-,18-/m0/s1
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n/an/a 980n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11191
PNG
((2S,3R)-4-(dimethylamino)-3-[4-(4-fluorophenyl)phe...)
Show SMILES CN(C)C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H27F2N3O/c1-26(2)14-20(21(25)22(28)27-12-11-19(24)13-27)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-21H,11-14,25H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 1.60E+3n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11218
PNG
((2S,3S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC[C@H]1C#N)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-13-3-4-19(28)14-25)17-7-5-15(6-8-17)16-9-11-18(24)12-10-16/h5-12,19-21H,3-4,13,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11191
PNG
((2S,3R)-4-(dimethylamino)-3-[4-(4-fluorophenyl)phe...)
Show SMILES CN(C)C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H27F2N3O/c1-26(2)14-20(21(25)22(28)27-12-11-19(24)13-27)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-21H,11-14,25H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11218
PNG
((2S,3S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC[C@H]1C#N)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-13-3-4-19(28)14-25)17-7-5-15(6-8-17)16-9-11-18(24)12-10-16/h5-12,19-21H,3-4,13,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11189
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H22F2N2O/c1-13(19(23)20(25)24-11-10-18(22)12-24)14-2-4-15(5-3-14)16-6-8-17(21)9-7-16/h2-9,13,18-19H,10-12,23H2,1H3/p+1/t13-,18-,19-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM11192
PNG
((2S,3R)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CN1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C24H29F2N3O/c25-20-9-7-18(8-10-20)17-3-5-19(6-4-17)22(16-28-12-1-2-13-28)23(27)24(30)29-14-11-21(26)15-29/h3-10,21-23H,1-2,11-16,27H2/p+1/t21-,22-,23-/m0/s1
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n/an/a 3.50E+3n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11206
PNG
((2S,3S)-4-(azetidin-1-yl)-3-[4-(4-fluorophenyl)phe...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C23H25F2N3O2/c24-18-8-6-16(7-9-18)15-2-4-17(5-3-15)20(22(29)27-11-1-12-27)21(26)23(30)28-13-10-19(25)14-28/h2-9,19-21H,1,10-14,26H2/p+1/t19-,20-,21-/m0/s1
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n/an/a 5.30E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11207
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C24H27F2N3O2/c25-19-9-7-17(8-10-19)16-3-5-18(6-4-16)21(23(30)28-12-1-2-13-28)22(27)24(31)29-14-11-20(26)15-29/h3-10,20-22H,1-2,11-15,27H2/p+1/t20-,21-,22-/m0/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11223
PNG
((1S,2S)-1-[4-(2,5-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cc(F)ccc1F |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-11-15(23)7-8-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 6.90E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11215
PNG
((2S,3S)-1-(3,3-difluoropyrrolidin-1-yl)-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)20(29)18(19(26)21(30)28-12-11-22(24,25)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-19H,11-13,26H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 7.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11215
PNG
((2S,3S)-1-(3,3-difluoropyrrolidin-1-yl)-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)20(29)18(19(26)21(30)28-12-11-22(24,25)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-19H,11-13,26H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11216
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCSC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O2S/c1-24(2)20(26)18(19(23)21(27)25-11-12-28-13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 8.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11212
PNG
((2S,3S)-1-(3,3-difluoroazetidin-1-yl)-3-(dimethylc...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H22F3N3O2/c1-26(2)19(28)17(18(25)20(29)27-11-21(23,24)12-27)15-5-3-13(4-6-15)14-7-9-16(22)10-8-14/h3-10,17-18H,11-12,25H2,1-2H3/p+1/t17-,18-/m0/s1
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n/an/a 9.40E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11223
PNG
((1S,2S)-1-[4-(2,5-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cc(F)ccc1F |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-11-15(23)7-8-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11227
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccnc1 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-11-9-17(22)13-26)15-7-5-14(6-8-15)16-4-3-10-24-12-16/h3-8,10,12,17-19H,9,11,13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11216
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCSC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O2S/c1-24(2)20(26)18(19(23)21(27)25-11-12-28-13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11222
PNG
((1S,2S)-1-[4-(3,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(23)12-28)14-5-3-13(4-6-14)15-7-8-17(24)18(25)11-15/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11221
PNG
((1S,2S)-1-[4-(2,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-8-7-15(23)11-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11207
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C24H27F2N3O2/c25-19-9-7-17(8-10-19)16-3-5-18(6-4-16)21(23(30)28-12-1-2-13-28)22(27)24(31)29-14-11-20(26)15-29/h3-10,20-22H,1-2,11-15,27H2/p+1/t20-,21-,22-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11190
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CO)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H22F2N2O2/c21-16-7-5-14(6-8-16)13-1-3-15(4-2-13)18(12-25)19(23)20(26)24-10-9-17(22)11-24/h1-8,17-19,25H,9-12,23H2/p+1/t17-,18-,19-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11191
PNG
((2S,3R)-4-(dimethylamino)-3-[4-(4-fluorophenyl)phe...)
Show SMILES CN(C)C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H27F2N3O/c1-26(2)14-20(21(25)22(28)27-12-11-19(24)13-27)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-21H,11-14,25H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11204
PNG
((1S,2S)-1-[ethyl(methyl)carbamoyl]-1-[4-(4-fluorop...)
Show SMILES CCN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H27F2N3O2/c1-3-27(2)22(29)20(21(26)23(30)28-13-12-19(25)14-28)17-6-4-15(5-7-17)16-8-10-18(24)11-9-16/h4-11,19-21H,3,12-14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11203
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)Nc1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C21H21F2N7O2/c22-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(31)25-21-26-28-29-27-21)18(24)20(32)30-10-9-16(23)11-30/h1-8,16-18H,9-11,24H2,(H2,25,26,27,28,29,31)/p+1/t16-,17-,18-/m0/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11194
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES COC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H22F2N2O3/c1-28-21(27)18(19(24)20(26)25-11-10-17(23)12-25)15-4-2-13(3-5-15)14-6-8-16(22)9-7-14/h2-9,17-19H,10-12,24H2,1H3/p+1/t17-,18-,19-/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11213
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26FN3O2/c1-25(2)21(27)19(20(24)22(28)26-13-3-4-14-26)17-7-5-15(6-8-17)16-9-11-18(23)12-10-16/h5-12,19-20H,3-4,13-14,24H2,1-2H3/p+1/t19-,20-/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11209
PNG
((1S,2S)-1-(N',N'-dimethylhydrazinecarbonyl)-1-[4-(...)
Show SMILES CN(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26F2N4O2/c1-27(2)26-21(29)19(20(25)22(30)28-12-11-18(24)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11213
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26FN3O2/c1-25(2)21(27)19(20(24)22(28)26-13-3-4-14-26)17-7-5-15(6-8-17)16-9-11-18(23)12-10-16/h5-12,19-20H,3-4,13-14,24H2,1-2H3/p+1/t19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11200
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CC(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H27F2N3O2/c1-14(2)27-22(29)20(21(26)23(30)28-12-11-19(25)13-28)17-5-3-15(4-6-17)16-7-9-18(24)10-8-16/h3-10,14,19-21H,11-13,26H2,1-2H3,(H,27,29)/p+1/t19-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11216
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCSC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O2S/c1-24(2)20(26)18(19(23)21(27)25-11-12-28-13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11201
PNG
((1S,2S)-1-(cyclopropylcarbamoyl)-1-[4-(4-fluorophe...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)NC1CC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C23H25F2N3O2/c24-17-7-5-15(6-8-17)14-1-3-16(4-2-14)20(22(29)27-19-9-10-19)21(26)23(30)28-12-11-18(25)13-28/h1-8,18-21H,9-13,26H2,(H,27,29)/p+1/t18-,20-,21-/m0/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11208
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CON(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O3/c1-26(30-2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19-,20-/m0/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11225
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1 |r|
Show InChI InChI=1S/C23H26FN7O2/c1-30(2)22(32)19(20(25)23(33)31-11-10-18(24)13-31)15-8-6-14(7-9-15)16-4-3-5-17(12-16)21-26-28-29-27-21/h3-9,12,18-20H,10-11,13,25H2,1-2H3,(H,26,27,28,29)/p+1/t18-,19-,20-/m0/s1
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n/an/a 2.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11202
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)NCCO)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C22H25F2N3O3/c23-17-7-5-15(6-8-17)14-1-3-16(4-2-14)19(21(29)26-10-12-28)20(25)22(30)27-11-9-18(24)13-27/h1-8,18-20,28H,9-13,25H2,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11214
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-26(2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19+,20+/m1/s1
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n/an/a 3.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11219
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H28FN3O2/c1-26(2)22(28)20(21(25)23(29)27-14-4-3-5-15-27)18-8-6-16(7-9-18)17-10-12-19(24)13-11-17/h6-13,20-21H,3-5,14-15,25H2,1-2H3/p+1/t20-,21-/m0/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11221
PNG
((1S,2S)-1-[4-(2,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-8-7-15(23)11-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11218
PNG
((2S,3S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC[C@H]1C#N)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-13-3-4-19(28)14-25)17-7-5-15(6-8-17)16-9-11-18(24)12-10-16/h5-12,19-21H,3-4,13,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11196
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CNC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H23F2N3O2/c1-25-20(27)18(19(24)21(28)26-11-10-17(23)12-26)15-4-2-13(3-5-15)14-6-8-16(22)9-7-14/h2-9,17-19H,10-12,24H2,1H3,(H,25,27)/p+1/t17-,18-,19-/m0/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11204
PNG
((1S,2S)-1-[ethyl(methyl)carbamoyl]-1-[4-(4-fluorop...)
Show SMILES CCN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H27F2N3O2/c1-3-27(2)22(29)20(21(26)23(30)28-13-12-19(25)14-28)17-6-4-15(5-7-17)16-8-10-18(24)11-9-16/h4-11,19-21H,3,12-14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 4.30E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11222
PNG
((1S,2S)-1-[4-(3,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(23)12-28)14-5-3-13(4-6-14)15-7-8-17(24)18(25)11-15/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 4.40E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11140
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-26(2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19-,20-/m0/s1
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n/an/a 4.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11215
PNG
((2S,3S)-1-(3,3-difluoropyrrolidin-1-yl)-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)20(29)18(19(26)21(30)28-12-11-22(24,25)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-19H,11-13,26H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 4.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11206
PNG
((2S,3S)-4-(azetidin-1-yl)-3-[4-(4-fluorophenyl)phe...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C23H25F2N3O2/c24-18-8-6-16(7-9-18)15-2-4-17(5-3-15)20(22(29)27-11-1-12-27)21(26)23(30)28-13-10-19(25)14-28/h2-9,19-21H,1,10-14,26H2/p+1/t19-,20-,21-/m0/s1
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n/an/a 4.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11205
PNG
((1S,2S)-1-(diethylcarbamoyl)-1-[4-(4-fluorophenyl)...)
Show SMILES CCN(CC)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H29F2N3O2/c1-3-28(4-2)23(30)21(22(27)24(31)29-14-13-20(26)15-29)18-7-5-16(6-8-18)17-9-11-19(25)12-10-17/h5-12,20-22H,3-4,13-15,27H2,1-2H3/p+1/t20-,21-,22-/m0/s1
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n/an/a 4.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11192
PNG
((2S,3R)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CN1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C24H29F2N3O/c25-20-9-7-18(8-10-20)17-3-5-19(6-4-17)22(16-28-12-1-2-13-28)23(27)24(30)29-14-11-21(26)15-29/h3-10,21-23H,1-2,11-16,27H2/p+1/t21-,22-,23-/m0/s1
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n/an/a 4.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11205
PNG
((1S,2S)-1-(diethylcarbamoyl)-1-[4-(4-fluorophenyl)...)
Show SMILES CCN(CC)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H29F2N3O2/c1-3-28(4-2)23(30)21(22(27)24(31)29-14-13-20(26)15-29)18-7-5-16(6-8-18)17-9-11-19(25)12-10-17/h5-12,20-22H,3-4,13-15,27H2,1-2H3/p+1/t20-,21-,22-/m0/s1
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n/an/a 5.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11201
PNG
((1S,2S)-1-(cyclopropylcarbamoyl)-1-[4-(4-fluorophe...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)NC1CC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C23H25F2N3O2/c24-17-7-5-15(6-8-17)14-1-3-16(4-2-14)20(22(29)27-19-9-10-19)21(26)23(30)28-12-11-18(25)13-28/h1-8,18-21H,9-13,26H2,(H,27,29)/p+1/t18-,20-,21-/m0/s1
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n/an/a 5.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11224
PNG
((1S,2S)-1-[4-(3-cyanophenyl)phenyl]-1-(dimethylcar...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-11-10-19(24)14-28)17-8-6-16(7-9-17)18-5-3-4-15(12-18)13-25/h3-9,12,19-21H,10-11,14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 5.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11227
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccnc1 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-11-9-17(22)13-26)15-7-5-14(6-8-15)16-4-3-10-24-12-16/h3-8,10,12,17-19H,9,11,13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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n/an/a 5.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11224
PNG
((1S,2S)-1-[4-(3-cyanophenyl)phenyl]-1-(dimethylcar...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-11-10-19(24)14-28)17-8-6-16(7-9-17)18-5-3-4-15(12-18)13-25/h3-9,12,19-21H,10-11,14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 5.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11211
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-(3-fluoroazetidin-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H23F2N3O2/c1-25(2)20(27)18(19(24)21(28)26-11-17(23)12-26)15-5-3-13(4-6-15)14-7-9-16(22)10-8-14/h3-10,17-19H,11-12,24H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 5.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11207
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C24H27F2N3O2/c25-19-9-7-17(8-10-19)16-3-5-18(6-4-16)21(23(30)28-12-1-2-13-28)22(27)24(31)29-14-11-20(26)15-29/h3-10,20-22H,1-2,11-15,27H2/p+1/t20-,21-,22-/m0/s1
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n/an/a 6.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11213
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26FN3O2/c1-25(2)21(27)19(20(24)22(28)26-13-3-4-14-26)17-7-5-15(6-8-17)16-9-11-18(23)12-10-16/h5-12,19-20H,3-4,13-14,24H2,1-2H3/p+1/t19-,20-/m0/s1
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n/an/a 6.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11140
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-26(2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19-,20-/m0/s1
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n/an/a 6.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11217
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-(1,1-dioxo-1,3-thi...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCS(=O)(=O)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O4S/c1-24(2)20(26)18(19(23)21(27)25-11-12-30(28,29)13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11200
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CC(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H27F2N3O2/c1-14(2)27-22(29)20(21(26)23(30)28-12-11-19(25)13-28)17-5-3-15(4-6-17)16-7-9-18(24)10-8-16/h3-10,14,19-21H,11-13,26H2,1-2H3,(H,27,29)/p+1/t19-,20-,21-/m0/s1
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n/an/a 7.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11220
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCOCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26FN3O3/c1-25(2)21(27)19(20(24)22(28)26-11-13-29-14-12-26)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-20H,11-14,24H2,1-2H3/p+1/t19-,20-/m0/s1
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n/an/a 7.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11222
PNG
((1S,2S)-1-[4-(3,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(23)12-28)14-5-3-13(4-6-14)15-7-8-17(24)18(25)11-15/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 8.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11226
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O |r|
Show InChI InChI=1S/C23H28FN3O4S/c1-26(2)22(28)20(21(25)23(29)27-12-11-18(24)14-27)16-9-7-15(8-10-16)17-5-4-6-19(13-17)32(3,30)31/h4-10,13,18,20-21H,11-12,14,25H2,1-3H3/p+1/t18-,20-,21-/m0/s1
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n/an/a 8.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11189
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H22F2N2O/c1-13(19(23)20(25)24-11-10-18(22)12-24)14-2-4-15(5-3-14)16-6-8-17(21)9-7-16/h2-9,13,18-19H,10-12,23H2,1H3/p+1/t13-,18-,19-/m0/s1
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n/an/a 8.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11189
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H22F2N2O/c1-13(19(23)20(25)24-11-10-18(22)12-24)14-2-4-15(5-3-14)16-6-8-17(21)9-7-16/h2-9,13,18-19H,10-12,23H2,1H3/p+1/t13-,18-,19-/m0/s1
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n/an/a 8.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11228
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccncc1 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-12-9-17(22)13-26)16-5-3-14(4-6-16)15-7-10-24-11-8-15/h3-8,10-11,17-19H,9,12-13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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n/an/a 8.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11199
PNG
((1S,2S)-1-(ethylcarbamoyl)-1-[4-(4-fluorophenyl)ph...)
Show SMILES CCNC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-2-26-21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,2,11-13,25H2,1H3,(H,26,28)/p+1/t18-,19-,20-/m0/s1
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n/an/a 9.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11214
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-26(2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19+,20+/m1/s1
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n/an/a 9.40E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11193
PNG
((1S,2S)-1-carboxy-1-[4-(4-fluorophenyl)phenyl]-3-[...)
Show SMILES [NH3+][C@@H]([C@@H](C(O)=O)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H20F2N2O3/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(20(26)27)18(23)19(25)24-10-9-16(22)11-24/h1-8,16-18H,9-11,23H2,(H,26,27)/p+1/t16-,17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11190
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CO)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H22F2N2O2/c21-16-7-5-14(6-8-16)13-1-3-15(4-2-13)18(12-25)19(23)20(26)24-10-9-17(22)11-24/h1-8,17-19,25H,9-12,23H2/p+1/t17-,18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11210
PNG
((2S,3S)-1-(azetidin-1-yl)-3-(dimethylcarbamoyl)-3-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O2/c1-24(2)20(26)18(19(23)21(27)25-12-3-13-25)16-6-4-14(5-7-16)15-8-10-17(22)11-9-15/h4-11,18-19H,3,12-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11225
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1 |r|
Show InChI InChI=1S/C23H26FN7O2/c1-30(2)22(32)19(20(25)23(33)31-11-10-18(24)13-31)15-8-6-14(7-9-15)16-4-3-5-17(12-16)21-26-28-29-27-21/h3-9,12,18-20H,10-11,13,25H2,1-2H3,(H,26,27,28,29)/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11191
PNG
((2S,3R)-4-(dimethylamino)-3-[4-(4-fluorophenyl)phe...)
Show SMILES CN(C)C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H27F2N3O/c1-26(2)14-20(21(25)22(28)27-12-11-19(24)13-27)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-21H,11-14,25H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11202
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)NCCO)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C22H25F2N3O3/c23-17-7-5-15(6-8-17)14-1-3-16(4-2-14)19(21(29)26-10-12-28)20(25)22(30)27-11-9-18(24)13-27/h1-8,18-20,28H,9-13,25H2,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11204
PNG
((1S,2S)-1-[ethyl(methyl)carbamoyl]-1-[4-(4-fluorop...)
Show SMILES CCN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H27F2N3O2/c1-3-27(2)22(29)20(21(26)23(30)28-13-12-19(25)14-28)17-6-4-15(5-7-17)16-8-10-18(24)11-9-16/h4-11,19-21H,3,12-14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11212
PNG
((2S,3S)-1-(3,3-difluoroazetidin-1-yl)-3-(dimethylc...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H22F3N3O2/c1-26(2)19(28)17(18(25)20(29)27-11-21(23,24)12-27)15-5-3-13(4-6-15)14-7-9-16(22)10-8-14/h3-10,17-18H,11-12,25H2,1-2H3/p+1/t17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11217
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-(1,1-dioxo-1,3-thi...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCS(=O)(=O)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O4S/c1-24(2)20(26)18(19(23)21(27)25-11-12-30(28,29)13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11226
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O |r|
Show InChI InChI=1S/C23H28FN3O4S/c1-26(2)22(28)20(21(25)23(29)27-12-11-18(24)14-27)16-9-7-15(8-10-16)17-5-4-6-19(13-17)32(3,30)31/h4-10,13,18,20-21H,11-12,14,25H2,1-3H3/p+1/t18-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11198
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](c1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H20F2N6O/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19-24-26-27-25-19)18(23)20(29)28-10-9-16(22)11-28/h1-8,16-18H,9-11,23H2,(H,24,25,26,27)/p+1/t16-,17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11209
PNG
((1S,2S)-1-(N',N'-dimethylhydrazinecarbonyl)-1-[4-(...)
Show SMILES CN(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26F2N4O2/c1-27(2)26-21(29)19(20(25)22(30)28-12-11-18(24)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11228
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccncc1 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-12-9-17(22)13-26)16-5-3-14(4-6-16)15-7-10-24-11-8-15/h3-8,10-11,17-19H,9,12-13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11193
PNG
((1S,2S)-1-carboxy-1-[4-(4-fluorophenyl)phenyl]-3-[...)
Show SMILES [NH3+][C@@H]([C@@H](C(O)=O)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H20F2N2O3/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(20(26)27)18(23)19(25)24-10-9-16(22)11-24/h1-8,16-18H,9-11,23H2,(H,26,27)/p+1/t16-,17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11225
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1 |r|
Show InChI InChI=1S/C23H26FN7O2/c1-30(2)22(32)19(20(25)23(33)31-11-10-18(24)13-31)15-8-6-14(7-9-15)16-4-3-5-17(12-16)21-26-28-29-27-21/h3-9,12,18-20H,10-11,13,25H2,1-2H3,(H,26,27,28,29)/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11193
PNG
((1S,2S)-1-carboxy-1-[4-(4-fluorophenyl)phenyl]-3-[...)
Show SMILES [NH3+][C@@H]([C@@H](C(O)=O)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H20F2N2O3/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(20(26)27)18(23)19(25)24-10-9-16(22)11-24/h1-8,16-18H,9-11,23H2,(H,26,27)/p+1/t16-,17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11140
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-26(2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11188
PNG
((2S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoro...)
Show SMILES [NH3+][C@@H](Cc1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C19H20F2N2O/c20-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-18(22)19(24)23-10-9-17(21)12-23/h1-8,17-18H,9-12,22H2/p+1/t17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11196
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CNC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H23F2N3O2/c1-25-20(27)18(19(24)21(28)26-11-10-17(23)12-26)15-4-2-13(3-5-15)14-6-8-16(22)9-7-14/h2-9,17-19H,10-12,24H2,1H3,(H,25,27)/p+1/t17-,18-,19-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11201
PNG
((1S,2S)-1-(cyclopropylcarbamoyl)-1-[4-(4-fluorophe...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)NC1CC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C23H25F2N3O2/c24-17-7-5-15(6-8-17)14-1-3-16(4-2-14)20(22(29)27-19-9-10-19)21(26)23(30)28-12-11-18(25)13-28/h1-8,18-21H,9-13,26H2,(H,27,29)/p+1/t18-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11203
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)Nc1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C21H21F2N7O2/c22-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(31)25-21-26-28-29-27-21)18(24)20(32)30-10-9-16(23)11-30/h1-8,16-18H,9-11,24H2,(H2,25,26,27,28,29,31)/p+1/t16-,17-,18-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11211
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-(3-fluoroazetidin-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H23F2N3O2/c1-25(2)20(27)18(19(24)21(28)26-11-17(23)12-26)15-5-3-13(4-6-15)14-7-9-16(22)10-8-14/h3-10,17-19H,11-12,24H2,1-2H3/p+1/t18-,19-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11227
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccnc1 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-11-9-17(22)13-26)15-7-5-14(6-8-15)16-4-3-10-24-12-16/h3-8,10,12,17-19H,9,11,13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11188
PNG
((2S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoro...)
Show SMILES [NH3+][C@@H](Cc1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C19H20F2N2O/c20-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-18(22)19(24)23-10-9-17(21)12-23/h1-8,17-18H,9-12,22H2/p+1/t17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11195
PNG
((1S,2S)-1-carbamoyl-1-[4-(4-fluorophenyl)phenyl]-3...)
Show SMILES NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H21F2N3O2/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(24)26)18(23)20(27)25-10-9-16(22)11-25/h1-8,16-18H,9-11,23H2,(H2,24,26)/p+1/t16-,17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11210
PNG
((2S,3S)-1-(azetidin-1-yl)-3-(dimethylcarbamoyl)-3-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O2/c1-24(2)20(26)18(19(23)21(27)25-12-3-13-25)16-6-4-14(5-7-16)15-8-10-17(22)11-9-15/h4-11,18-19H,3,12-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11198
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](c1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H20F2N6O/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19-24-26-27-25-19)18(23)20(29)28-10-9-16(22)11-28/h1-8,16-18H,9-11,23H2,(H,24,25,26,27)/p+1/t16-,17-,18-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11199
PNG
((1S,2S)-1-(ethylcarbamoyl)-1-[4-(4-fluorophenyl)ph...)
Show SMILES CCNC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-2-26-21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,2,11-13,25H2,1H3,(H,26,28)/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11199
PNG
((1S,2S)-1-(ethylcarbamoyl)-1-[4-(4-fluorophenyl)ph...)
Show SMILES CCNC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-2-26-21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,2,11-13,25H2,1H3,(H,26,28)/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11206
PNG
((2S,3S)-4-(azetidin-1-yl)-3-[4-(4-fluorophenyl)phe...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C23H25F2N3O2/c24-18-8-6-16(7-9-18)15-2-4-17(5-3-15)20(22(29)27-11-1-12-27)21(26)23(30)28-13-10-19(25)14-28/h2-9,19-21H,1,10-14,26H2/p+1/t19-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11210
PNG
((2S,3S)-1-(azetidin-1-yl)-3-(dimethylcarbamoyl)-3-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O2/c1-24(2)20(26)18(19(23)21(27)25-12-3-13-25)16-6-4-14(5-7-16)15-8-10-17(22)11-9-15/h4-11,18-19H,3,12-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11188
PNG
((2S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoro...)
Show SMILES [NH3+][C@@H](Cc1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C19H20F2N2O/c20-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-18(22)19(24)23-10-9-17(21)12-23/h1-8,17-18H,9-12,22H2/p+1/t17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11194
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES COC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H22F2N2O3/c1-28-21(27)18(19(24)20(26)25-11-10-17(23)12-25)15-4-2-13(3-5-15)14-6-8-16(22)9-7-14/h2-9,17-19H,10-12,24H2,1H3/p+1/t17-,18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11226
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O |r|
Show InChI InChI=1S/C23H28FN3O4S/c1-26(2)22(28)20(21(25)23(29)27-12-11-18(24)14-27)16-9-7-15(8-10-16)17-5-4-6-19(13-17)32(3,30)31/h4-10,13,18,20-21H,11-12,14,25H2,1-3H3/p+1/t18-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11195
PNG
((1S,2S)-1-carbamoyl-1-[4-(4-fluorophenyl)phenyl]-3...)
Show SMILES NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H21F2N3O2/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(24)26)18(23)20(27)25-10-9-16(22)11-25/h1-8,16-18H,9-11,23H2,(H2,24,26)/p+1/t16-,17-,18-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11208
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CON(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O3/c1-26(30-2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11228
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccncc1 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-12-9-17(22)13-26)16-5-3-14(4-6-16)15-7-10-24-11-8-15/h3-8,10-11,17-19H,9,12-13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11196
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CNC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H23F2N3O2/c1-25-20(27)18(19(24)21(28)26-11-10-17(23)12-26)15-4-2-13(3-5-15)14-6-8-16(22)9-7-14/h2-9,17-19H,10-12,24H2,1H3,(H,25,27)/p+1/t17-,18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11208
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CON(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O3/c1-26(30-2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19-,20-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11195
PNG
((1S,2S)-1-carbamoyl-1-[4-(4-fluorophenyl)phenyl]-3...)
Show SMILES NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H21F2N3O2/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(24)26)18(23)20(27)25-10-9-16(22)11-25/h1-8,16-18H,9-11,23H2,(H2,24,26)/p+1/t16-,17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11209
PNG
((1S,2S)-1-(N',N'-dimethylhydrazinecarbonyl)-1-[4-(...)
Show SMILES CN(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26F2N4O2/c1-27(2)26-21(29)19(20(25)22(30)28-12-11-18(24)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11219
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H28FN3O2/c1-26(2)22(28)20(21(25)23(29)27-14-4-3-5-15-27)18-8-6-16(7-9-18)17-10-12-19(24)13-11-17/h6-13,20-21H,3-5,14-15,25H2,1-2H3/p+1/t20-,21-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11223
PNG
((1S,2S)-1-[4-(2,5-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cc(F)ccc1F |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-11-15(23)7-8-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11202
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)NCCO)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C22H25F2N3O3/c23-17-7-5-15(6-8-17)14-1-3-16(4-2-14)19(21(29)26-10-12-28)20(25)22(30)27-11-9-18(24)13-27/h1-8,18-20,28H,9-13,25H2,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM11203
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)Nc1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C21H21F2N7O2/c22-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(31)25-21-26-28-29-27-21)18(24)20(32)30-10-9-16(23)11-30/h1-8,16-18H,9-11,24H2,(H2,25,26,27,28,29,31)/p+1/t16-,17-,18-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11217
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-(1,1-dioxo-1,3-thi...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCS(=O)(=O)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H24FN3O4S/c1-24(2)20(26)18(19(23)21(27)25-11-12-30(28,29)13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11219
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H28FN3O2/c1-26(2)22(28)20(21(25)23(29)27-14-4-3-5-15-27)18-8-6-16(7-9-18)17-10-12-19(24)13-11-17/h6-13,20-21H,3-5,14-15,25H2,1-2H3/p+1/t20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11192
PNG
((2S,3R)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CN1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C24H29F2N3O/c25-20-9-7-18(8-10-20)17-3-5-19(6-4-17)22(16-28-12-1-2-13-28)23(27)24(30)29-14-11-21(26)15-29/h3-10,21-23H,1-2,11-16,27H2/p+1/t21-,22-,23-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11194
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES COC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H22F2N2O3/c1-28-21(27)18(19(24)20(26)25-11-10-17(23)12-25)15-4-2-13(3-5-15)14-6-8-16(22)9-7-14/h2-9,17-19H,10-12,24H2,1H3/p+1/t17-,18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11198
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](c1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H20F2N6O/c21-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19-24-26-27-25-19)18(23)20(29)28-10-9-16(22)11-28/h1-8,16-18H,9-11,23H2,(H,24,25,26,27)/p+1/t16-,17-,18-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11214
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H25F2N3O2/c1-26(2)21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3/p+1/t18-,19+,20+/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11220
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCOCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26FN3O3/c1-25(2)21(27)19(20(24)22(28)26-11-13-29-14-12-26)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-20H,11-14,24H2,1-2H3/p+1/t19-,20-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11221
PNG
((1S,2S)-1-[4-(2,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-8-7-15(23)11-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11211
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-(3-fluoroazetidin-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H23F2N3O2/c1-25(2)20(27)18(19(24)21(28)26-11-17(23)12-26)15-5-3-13(4-6-15)14-7-9-16(22)10-8-14/h3-10,17-19H,11-12,24H2,1-2H3/p+1/t18-,19-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11212
PNG
((2S,3S)-1-(3,3-difluoroazetidin-1-yl)-3-(dimethylc...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H22F3N3O2/c1-26(2)19(28)17(18(25)20(29)27-11-21(23,24)12-27)15-5-3-13(4-6-15)14-7-9-16(22)10-8-14/h3-10,17-18H,11-12,25H2,1-2H3/p+1/t17-,18-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11220
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCOCC1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H26FN3O3/c1-25(2)21(27)19(20(24)22(28)26-11-13-29-14-12-26)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-20H,11-14,24H2,1-2H3/p+1/t19-,20-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11190
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CO)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1 |r|
Show InChI InChI=1S/C20H22F2N2O2/c21-16-7-5-14(6-8-16)13-1-3-15(4-2-13)18(12-25)19(23)20(26)24-10-9-17(22)11-24/h1-8,17-19,25H,9-12,23H2/p+1/t17-,18-,19-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11200
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES CC(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H27F2N3O2/c1-14(2)27-22(29)20(21(26)23(30)28-12-11-19(25)13-28)17-5-3-15(4-6-17)16-7-9-18(24)10-8-16/h3-10,14,19-21H,11-13,26H2,1-2H3,(H,27,29)/p+1/t19-,20-,21-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11205
PNG
((1S,2S)-1-(diethylcarbamoyl)-1-[4-(4-fluorophenyl)...)
Show SMILES CCN(CC)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H29F2N3O2/c1-3-28(4-2)23(30)21(22(27)24(31)29-14-13-20(26)15-29)18-7-5-16(6-8-18)17-9-11-19(25)12-10-17/h5-12,20-22H,3-4,13-15,27H2,1-2H3/p+1/t20-,21-,22-/m0/s1
PDB

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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...

Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%