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PubMed code 15943473

Compile data set for download or QSAR
Found 136 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a 0.0620n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (VEGFR-2)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168394
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27)
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168410
PNG
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)
Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 1.80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168390
PNG
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)
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n/an/a 2.10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168398
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 2.10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168391
PNG
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 3.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168388
PNG
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168398
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 4.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168410
PNG
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)
Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168391
PNG
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 5.30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 6.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168390
PNG
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)
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n/an/a 6.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168393
PNG
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26)
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n/an/a 6.70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168400
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26)
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n/an/a 6.80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168393
PNG
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26)
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n/an/a 7.30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168400
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26)
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n/an/a 7.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 7.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168388
PNG
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 9.20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168393
PNG
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26)
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168391
PNG
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168421
PNG
(4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C20H21F2N5O4/c1-5-31-20(29)12-8-27-17(16(12)10(2)3)18(23-9-24-27)25-15-6-11(19(28)26-30-4)13(21)7-14(15)22/h6-10H,5H2,1-4H3,(H,26,28)(H,23,24,25)
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168391
PNG
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 14n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168398
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 16n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168398
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 16n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168388
PNG
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168410
PNG
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)
Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168394
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168393
PNG
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168420
PNG
(CHEMBL191594 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OC4CCN(C)CC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C24H29F2N7O4/c1-13(2)20-19(30-24(35)37-14-5-7-32(3)8-6-14)11-33-21(20)22(27-12-28-33)29-18-9-15(23(34)31-36-4)16(25)10-17(18)26/h9-14H,5-8H2,1-4H3,(H,30,35)(H,31,34)(H,27,28,29)
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 21n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168394
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27)
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n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168390
PNG
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)
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n/an/a 23n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168395
PNG
(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(F)(F)F)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H18F5N7O3/c1-9(2)16-11(20-31-30-15(36-20)6-21(24,25)26)7-33-17(16)18(27-8-28-33)29-14-4-10(19(34)32-35-3)12(22)5-13(14)23/h4-5,7-9H,6H2,1-3H3,(H,32,34)(H,27,28,29)
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n/an/a 25n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168388
PNG
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 27n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a 27n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168410
PNG
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)
Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 28n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168395
PNG
(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(F)(F)F)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H18F5N7O3/c1-9(2)16-11(20-31-30-15(36-20)6-21(24,25)26)7-33-17(16)18(27-8-28-33)29-14-4-10(19(34)32-35-3)12(22)5-13(14)23/h4-5,7-9H,6H2,1-3H3,(H,32,34)(H,27,28,29)
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n/an/a 29n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168399
PNG
(CHEMBL366019 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CCOC(=O)Nc1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C20H22F2N6O4/c1-5-32-20(30)26-15-8-28-17(16(15)10(2)3)18(23-9-24-28)25-14-6-11(19(29)27-31-4)12(21)7-13(14)22/h6-10H,5H2,1-4H3,(H,26,30)(H,27,29)(H,23,24,25)
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n/an/a 31n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168390
PNG
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)
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n/an/a 33n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168407
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H16F5N7O3/c1-8(2)14-10(18-29-30-19(35-18)20(23,24)25)6-32-15(14)16(26-7-27-32)28-13-4-9(17(33)31-34-3)11(21)5-12(13)22/h4-8H,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 33n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168411
PNG
(4-(2-Fluoro-5-methoxycarbamoyl-phenylamino)-5-isop...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(ccc3F)C(=O)NOC)c2c1C(C)C
Show InChI InChI=1S/C20H22FN5O4/c1-5-30-20(28)13-9-26-17(16(13)11(2)3)18(22-10-23-26)24-15-8-12(6-7-14(15)21)19(27)25-29-4/h6-11H,5H2,1-4H3,(H,25,27)(H,22,23,24)
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n/an/a 34n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168407
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H16F5N7O3/c1-8(2)14-10(18-29-30-19(35-18)20(23,24)25)6-32-15(14)16(26-7-27-32)28-13-4-9(17(33)31-34-3)11(21)5-12(13)22/h4-8H,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168420
PNG
(CHEMBL191594 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OC4CCN(C)CC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C24H29F2N7O4/c1-13(2)20-19(30-24(35)37-14-5-7-32(3)8-6-14)11-33-21(20)22(27-12-28-33)29-18-9-15(23(34)31-36-4)16(25)10-17(18)26/h9-14H,5-8H2,1-4H3,(H,30,35)(H,31,34)(H,27,28,29)
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n/an/a 36n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168394
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27)
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n/an/a 39n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168408
PNG
(4-(5-Ethoxycarbamoyl-2,4-difluoro-phenylamino)-5-i...)
Show SMILES CCONC(=O)c1cc(Nc2ncnn3cc(C(=O)OCC)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H23F2N5O4/c1-5-31-21(30)13-9-28-18(17(13)11(3)4)19(24-10-25-28)26-16-7-12(14(22)8-15(16)23)20(29)27-32-6-2/h7-11H,5-6H2,1-4H3,(H,27,29)(H,24,25,26)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168395
PNG
(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(F)(F)F)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H18F5N7O3/c1-9(2)16-11(20-31-30-15(36-20)6-21(24,25)26)7-33-17(16)18(27-8-28-33)29-14-4-10(19(34)32-35-3)12(22)5-13(14)23/h4-5,7-9H,6H2,1-3H3,(H,32,34)(H,27,28,29)
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n/an/a 44n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168406
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-4H-[1,2,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)[nH]4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H20F2N8O2/c1-9(2)16-12(18-25-10(3)27-28-18)7-30-17(16)19(23-8-24-30)26-15-5-11(20(31)29-32-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,29,31)(H,23,24,26)(H,25,27,28)
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n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168400
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26)
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n/an/a 49n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168406
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-4H-[1,2,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)[nH]4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H20F2N8O2/c1-9(2)16-12(18-25-10(3)27-28-18)7-30-17(16)19(23-8-24-30)26-15-5-11(20(31)29-32-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,29,31)(H,23,24,26)(H,25,27,28)
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n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168406
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-4H-[1,2,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)[nH]4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H20F2N8O2/c1-9(2)16-12(18-25-10(3)27-28-18)7-30-17(16)19(23-8-24-30)26-15-5-11(20(31)29-32-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,29,31)(H,23,24,26)(H,25,27,28)
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n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a 53n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 kinase activity


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168404
PNG
(2,4-Difluoro-5-(5-isopropyl-6-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnco4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C19H17F2N7O3/c1-9(2)15-11(19-26-23-8-31-19)6-28-16(15)17(22-7-24-28)25-14-4-10(18(29)27-30-3)12(20)5-13(14)21/h4-9H,1-3H3,(H,27,29)(H,22,24,25)
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n/an/a 54n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 57n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a 58n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a 58n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168417
PNG
(CHEMBL192318 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCN4CCCCC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C26H33F2N7O4/c1-16(2)22-21(32-26(37)39-11-7-10-34-8-5-4-6-9-34)14-35-23(22)24(29-15-30-35)31-20-12-17(25(36)33-38-3)18(27)13-19(20)28/h12-16H,4-11H2,1-3H3,(H,32,37)(H,33,36)(H,29,30,31)
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n/an/a 62n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a 62n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 64n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cytochrome P450 1A2


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168399
PNG
(CHEMBL366019 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CCOC(=O)Nc1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C20H22F2N6O4/c1-5-32-20(30)26-15-8-28-17(16(15)10(2)3)18(23-9-24-28)25-14-6-11(19(29)27-31-4)12(21)7-13(14)22/h6-10H,5H2,1-4H3,(H,26,30)(H,27,29)(H,23,24,25)
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n/an/a 66n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168418
PNG
(5-[6-(5-Dimethylaminomethyl-[1,3,4]oxadiazol-2-yl)...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CN(C)C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H24F2N8O3/c1-11(2)18-13(22-29-28-17(35-22)9-31(3)4)8-32-19(18)20(25-10-26-32)27-16-6-12(21(33)30-34-5)14(23)7-15(16)24/h6-8,10-11H,9H2,1-5H3,(H,30,33)(H,25,26,27)
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n/an/a 66n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168395
PNG
(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(F)(F)F)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H18F5N7O3/c1-9(2)16-11(20-31-30-15(36-20)6-21(24,25)26)7-33-17(16)18(27-8-28-33)29-14-4-10(19(34)32-35-3)12(22)5-13(14)23/h4-5,7-9H,6H2,1-3H3,(H,32,34)(H,27,28,29)
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n/an/a 68n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168406
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-4H-[1,2,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)[nH]4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H20F2N8O2/c1-9(2)16-12(18-25-10(3)27-28-18)7-30-17(16)19(23-8-24-30)26-15-5-11(20(31)29-32-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,29,31)(H,23,24,26)(H,25,27,28)
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n/an/a 71n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168407
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H16F5N7O3/c1-8(2)14-10(18-29-30-19(35-18)20(23,24)25)6-32-15(14)16(26-7-27-32)28-13-4-9(17(33)31-34-3)11(21)5-12(13)22/h4-8H,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 76n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168404
PNG
(2,4-Difluoro-5-(5-isopropyl-6-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnco4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C19H17F2N7O3/c1-9(2)15-11(19-26-23-8-31-19)6-28-16(15)17(22-7-24-28)25-14-4-10(18(29)27-30-3)12(20)5-13(14)21/h4-9H,1-3H3,(H,27,29)(H,22,24,25)
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n/an/a 77n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168416
PNG
(4-(4-Fluoro-3-methoxycarbamoyl-phenylamino)-5-isop...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3ccc(F)c(c3)C(=O)NOC)c2c1C(C)C
Show InChI InChI=1S/C20H22FN5O4/c1-5-30-20(28)14-9-26-17(16(14)11(2)3)18(22-10-23-26)24-12-6-7-15(21)13(8-12)19(27)25-29-4/h6-11H,5H2,1-4H3,(H,25,27)(H,22,23,24)
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n/an/a 79n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168417
PNG
(CHEMBL192318 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCN4CCCCC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C26H33F2N7O4/c1-16(2)22-21(32-26(37)39-11-7-10-34-8-5-4-6-9-34)14-35-23(22)24(29-15-30-35)31-20-12-17(25(36)33-38-3)18(27)13-19(20)28/h12-16H,4-11H2,1-3H3,(H,32,37)(H,33,36)(H,29,30,31)
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n/an/a 79n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168407
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H16F5N7O3/c1-8(2)14-10(18-29-30-19(35-18)20(23,24)25)6-32-15(14)16(26-7-27-32)28-13-4-9(17(33)31-34-3)11(21)5-12(13)22/h4-8H,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 84n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 86n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168404
PNG
(2,4-Difluoro-5-(5-isopropyl-6-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnco4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C19H17F2N7O3/c1-9(2)15-11(19-26-23-8-31-19)6-28-16(15)17(22-7-24-28)25-14-4-10(18(29)27-30-3)12(20)5-13(14)21/h4-9H,1-3H3,(H,27,29)(H,22,24,25)
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n/an/a 91n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168400
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168405
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,2,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4noc(C)n4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(18-25-10(3)32-27-18)7-29-17(16)19(23-8-24-29)26-15-5-11(20(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168414
PNG
(5-Isopropyl-4-(3-methoxycarbamoyl-4-methyl-phenyla...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3ccc(C)c(c3)C(=O)NOC)c2c1C(C)C
Show InChI InChI=1S/C21H25N5O4/c1-6-30-21(28)16-10-26-18(17(16)12(2)3)19(22-11-23-26)24-14-8-7-13(4)15(9-14)20(27)25-29-5/h7-12H,6H2,1-5H3,(H,25,27)(H,22,23,24)
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168413
PNG
(5-Isopropyl-4-(3-methoxycarbamoyl-phenylamino)-pyr...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3cccc(c3)C(=O)NOC)c2c1C(C)C
Show InChI InChI=1S/C20H23N5O4/c1-5-29-20(27)15-10-25-17(16(15)12(2)3)18(21-11-22-25)23-14-8-6-7-13(9-14)19(26)24-28-4/h6-12H,5H2,1-4H3,(H,24,26)(H,21,22,23)
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168405
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,2,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4noc(C)n4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(18-25-10(3)32-27-18)7-29-17(16)19(23-8-24-29)26-15-5-11(20(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26)
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n/an/a 140n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168418
PNG
(5-[6-(5-Dimethylaminomethyl-[1,3,4]oxadiazol-2-yl)...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CN(C)C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H24F2N8O3/c1-11(2)18-13(22-29-28-17(35-22)9-31(3)4)8-32-19(18)20(25-10-26-32)27-16-6-12(21(33)30-34-5)14(23)7-15(16)24/h6-8,10-11H,9H2,1-5H3,(H,30,33)(H,25,26,27)
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n/an/a 149n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168404
PNG
(2,4-Difluoro-5-(5-isopropyl-6-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnco4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C19H17F2N7O3/c1-9(2)15-11(19-26-23-8-31-19)6-28-16(15)17(22-7-24-28)25-14-4-10(18(29)27-30-3)12(20)5-13(14)21/h4-9H,1-3H3,(H,27,29)(H,22,24,25)
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168409
PNG
(CHEMBL436117 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCc4ccccc4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C25H24F2N6O4/c1-14(2)21-20(31-25(35)37-12-15-7-5-4-6-8-15)11-33-22(21)23(28-13-29-33)30-19-9-16(24(34)32-36-3)17(26)10-18(19)27/h4-11,13-14H,12H2,1-3H3,(H,31,35)(H,32,34)(H,28,29,30)
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n/an/a 180n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168396
PNG
(4-(5-Cyclopropylmethoxycarbamoyl-2,4-difluoro-phen...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOCC4CC4)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C23H25F2N5O4/c1-4-33-23(32)15-9-30-20(19(15)12(2)3)21(26-11-27-30)28-18-7-14(16(24)8-17(18)25)22(31)29-34-10-13-5-6-13/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,31)(H,26,27,28)
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a 220n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human fibroblast growth factor receptor 1


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168415
PNG
(5-Isopropyl-4-(3-methoxycarbamoyl-phenoxy)-pyrrolo...)
Show SMILES CCOC(=O)c1cn2ncnc(Oc3cccc(c3)C(=O)NOC)c2c1C(C)C
Show InChI InChI=1S/C20H22N4O5/c1-5-28-20(26)15-10-24-17(16(15)12(2)3)19(21-11-22-24)29-14-8-6-7-13(9-14)18(25)23-27-4/h6-12H,5H2,1-4H3,(H,23,25)
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n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168419
PNG
(4-(4-Bromo-3-methoxycarbamoyl-phenylamino)-5-isopr...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3ccc(Br)c(c3)C(=O)NOC)c2c1C(C)C
Show InChI InChI=1S/C20H22BrN5O4/c1-5-30-20(28)14-9-26-17(16(14)11(2)3)18(22-10-23-26)24-12-6-7-15(21)13(8-12)19(27)25-29-4/h6-11H,5H2,1-4H3,(H,25,27)(H,22,23,24)
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n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168412
PNG
(4-(2,4-Difluoro-5-isopropoxycarbamoyl-phenylamino)...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC(C)C)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C22H25F2N5O4/c1-6-32-22(31)14-9-29-19(18(14)11(2)3)20(25-10-26-29)27-17-7-13(15(23)8-16(17)24)21(30)28-33-12(4)5/h7-12H,6H2,1-5H3,(H,28,30)(H,25,26,27)
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n/an/a 350n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a 420n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 500n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 lck tyrosine kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 840n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168401
PNG
(4-(2,4-Difluoro-5-isobutoxycarbamoyl-phenylamino)-...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOCC(C)C)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C23H27F2N5O4/c1-6-33-23(32)15-9-30-20(19(15)13(4)5)21(26-11-27-30)28-18-7-14(16(24)8-17(18)25)22(31)29-34-10-12(2)3/h7-9,11-13H,6,10H2,1-5H3,(H,29,31)(H,26,27,28)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet-derived growth factor receptor beta


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet-derived growth factor receptor beta


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet-derived growth factor receptor beta


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet-derived growth factor receptor beta


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet-derived growth factor receptor beta


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cytochrome P450 2C9


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor (HER-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 lck tyrosine kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cytochrome P450 3A4


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 lck tyrosine kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition against human HER2 kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor (HER-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 lck tyrosine kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition against human HER2 kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition against human HER2 kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor (HER-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition against human HER2 kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor (HER-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 lck tyrosine kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human insulin-like growth factor I receptor


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human insulin-like growth factor I receptor


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition against human HER2 kinase


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human insulin-like growth factor I receptor


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor (HER-1)


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human insulin-like growth factor I receptor


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human insulin-like growth factor I receptor


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human protein kinase C alpha


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human protein kinase C alpha


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human cyclin-dependent kinase 2


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human protein kinase C alpha


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50168389
PNG
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human cyclin-dependent kinase 2


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human protein kinase C alpha


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50168392
PNG
(CHEMBL370266 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCC4CCCO4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H26F2N6O5/c1-12(2)19-18(29-23(33)36-10-13-5-4-6-35-13)9-31-20(19)21(26-11-27-31)28-17-7-14(22(32)30-34-3)15(24)8-16(17)25/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,33)(H,30,32)(H,26,27,28)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human cyclin-dependent kinase 2


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human cyclin-dependent kinase 2


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human cyclin-dependent kinase 2


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human protein kinase C alpha


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%