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PubMed code 15955699

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM24996
PNG
(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Show SMILES CCn1c(nc2cncc(CNC3CCNCC3)c12)-c1nonc1N
Show InChI InChI=1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23)
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n/an/a 0.5n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168854
PNG
(4-(1-Ethyl-7-piperazin-1-ylmethyl-1H-imidazo[4,5-c...)
Show SMILES CCn1c(nc2cncc(CN3CCNCC3)c12)-c1nonc1N
Show InChI InChI=1S/C15H20N8O/c1-2-23-13-10(9-22-5-3-17-4-6-22)7-18-8-11(13)19-15(23)12-14(16)21-24-20-12/h7-8,17H,2-6,9H2,1H3,(H2,16,21)
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n/an/a 1.40n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168577
PNG
(4-(1-Cyclopropyl-1H-imidazo[4,5-c]pyridin-2-yl)-fu...)
Show SMILES Nc1nonc1-c1nc2cnccc2n1C1CC1
Show InChI InChI=1S/C11H10N6O/c12-10-9(15-18-16-10)11-14-7-5-13-4-3-8(7)17(11)6-1-2-6/h3-6H,1-2H2,(H2,12,16)
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n/an/a 1.5n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168858
PNG
((R,S)-4-(1-Piperidin-3-yl-1H-imidazo[4,5-c]pyridin...)
Show SMILES Nc1nonc1-c1nc2cnccc2n1C1CCCNC1
Show InChI InChI=1S/C13H15N7O/c14-12-11(18-21-19-12)13-17-9-7-16-5-3-10(9)20(13)8-2-1-4-15-6-8/h3,5,7-8,15H,1-2,4,6H2,(H2,14,19)
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168856
PNG
(4-[1-(3-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyrid...)
Show SMILES NCc1cccc(c1)-n1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C15H13N7O/c16-7-9-2-1-3-10(6-9)22-12-4-5-18-8-11(12)19-15(22)13-14(17)21-23-20-13/h1-6,8H,7,16H2,(H2,17,21)
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n/an/a 2.5n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM14032
PNG
(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Show SMILES CCn1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C10H10N6O/c1-2-16-7-3-4-12-5-6(7)13-10(16)8-9(11)15-17-14-8/h3-5H,2H2,1H3,(H2,11,15)
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n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168869
PNG
(1-[2-(4-Amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5...)
Show SMILES CCn1c(nc2cncc(CN3CCC(N)CC3)c12)-c1nonc1N
Show InChI InChI=1S/C16H22N8O/c1-2-24-14-10(9-23-5-3-11(17)4-6-23)7-19-8-12(14)20-16(24)13-15(18)22-25-21-13/h7-8,11H,2-6,9,17H2,1H3,(H2,18,22)
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n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168587
PNG
(4-(1-Cyclohexyl-1H-imidazo[4,5-c]pyridin-2-yl)-fur...)
Show SMILES Nc1nonc1-c1nc2cnccc2n1C1CCCCC1
Show InChI InChI=1S/C14H16N6O/c15-13-12(18-21-19-13)14-17-10-8-16-7-6-11(10)20(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H2,15,19)
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n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168861
PNG
(4-(4-Chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Show SMILES CCn1c(nc2c(Cl)nccc12)-c1nonc1N
Show InChI InChI=1S/C10H9ClN6O/c1-2-17-5-3-4-13-8(11)6(5)14-10(17)7-9(12)16-18-15-7/h3-4H,2H2,1H3,(H2,12,16)
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n/an/a 4n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168862
PNG
(4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyrid...)
Show SMILES NCc1ccc(cc1)-n1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C15H13N7O/c16-7-9-1-3-10(4-2-9)22-12-5-6-18-8-11(12)19-15(22)13-14(17)21-23-20-13/h1-6,8H,7,16H2,(H2,17,21)
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n/an/a 4n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168581
PNG
(4-(1-Phenyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan...)
Show SMILES Nc1nonc1-c1nc2cnccc2n1-c1ccccc1
Show InChI InChI=1S/C14H10N6O/c15-13-12(18-21-19-13)14-17-10-8-16-7-6-11(10)20(14)9-4-2-1-3-5-9/h1-8H,(H2,15,19)
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n/an/a 6n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168853
PNG
(4-(1-Ethyl-7-piperidin-1-ylmethyl-1H-imidazo[4,5-c...)
Show SMILES CCn1c(nc2cncc(CN3CCCCC3)c12)-c1nonc1N
Show InChI InChI=1S/C16H21N7O/c1-2-23-14-11(10-22-6-4-3-5-7-22)8-18-9-12(14)19-16(23)13-15(17)21-24-20-13/h8-9H,2-7,10H2,1H3,(H2,17,21)
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n/an/a 7n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168866
PNG
(4-(1-Ethyl-4-methyl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Show SMILES CCn1c(nc2c(C)nccc12)-c1nonc1N
Show InChI InChI=1S/C11H12N6O/c1-3-17-7-4-5-13-6(2)8(7)14-11(17)9-10(12)16-18-15-9/h4-5H,3H2,1-2H3,(H2,12,16)
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n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168864
PNG
((R,S)-4-[1-(2-Amino-1-methyl-ethyl)-1H-imidazo[4,5...)
Show SMILES CC(CN)n1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C11H13N7O/c1-6(4-12)18-8-2-3-14-5-7(8)15-11(18)9-10(13)17-19-16-9/h2-3,5-6H,4,12H2,1H3,(H2,13,17)
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n/an/a 9n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168867
PNG
(4-(7-Bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-...)
Show SMILES CCn1c(nc2cncc(Br)c12)-c1nonc1N
Show InChI InChI=1S/C10H9BrN6O/c1-2-17-8-5(11)3-13-4-6(8)14-10(17)7-9(12)16-18-15-7/h3-4H,2H2,1H3,(H2,12,16)
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n/an/a 9n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168868
PNG
(4-[1-(4-Amino-butyl)-1H-imidazo[4,5-c]pyridin-2-yl...)
Show SMILES NCCCCn1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C12H15N7O/c13-4-1-2-6-19-9-3-5-15-7-8(9)16-12(19)10-11(14)18-20-17-10/h3,5,7H,1-2,4,6,13H2,(H2,14,18)
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM14032
PNG
(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Show SMILES CCn1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C10H10N6O/c1-2-16-7-3-4-12-5-6(7)13-10(16)8-9(11)15-17-14-8/h3-5H,2H2,1H3,(H2,11,15)
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against selected kinase ROCK1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168601
PNG
(4-(1-Piperidin-4-yl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Show SMILES Nc1nonc1-c1nc2cnccc2n1C1CCNCC1
Show InChI InChI=1S/C13H15N7O/c14-12-11(18-21-19-12)13-17-9-7-16-6-3-10(9)20(13)8-1-4-15-5-2-8/h3,6-8,15H,1-2,4-5H2,(H2,14,19)
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n/an/a 17n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168859
PNG
(4-[1-(3-Amino-propyl)-1H-imidazo[4,5-c]pyridin-2-y...)
Show SMILES NCCCn1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C11H13N7O/c12-3-1-5-18-8-2-4-14-6-7(8)15-11(18)9-10(13)17-19-16-9/h2,4,6H,1,3,5,12H2,(H2,13,17)
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n/an/a 22n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM14032
PNG
(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Show SMILES CCn1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C10H10N6O/c1-2-16-7-3-4-12-5-6(7)13-10(16)8-9(11)15-17-14-8/h3-5H,2H2,1H3,(H2,11,15)
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n/an/a 70n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against selected kinase p70S6K


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM24996
PNG
(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Show SMILES CCn1c(nc2cncc(CNC3CCNCC3)c12)-c1nonc1N
Show InChI InChI=1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23)
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against selected kinase ROCK1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM14032
PNG
(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Show SMILES CCn1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C10H10N6O/c1-2-16-7-3-4-12-5-6(7)13-10(16)8-9(11)15-17-14-8/h3-5H,2H2,1H3,(H2,11,15)
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n/an/a 110n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against selected kinase DYRK1-alpha


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM14032
PNG
(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Show SMILES CCn1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C10H10N6O/c1-2-16-7-3-4-12-5-6(7)13-10(16)8-9(11)15-17-14-8/h3-5H,2H2,1H3,(H2,11,15)
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n/an/a 169n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against selected kinase CDK2


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168863
PNG
(4-(4-Ethoxy-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Show SMILES CCOc1nccc2n(CC)c(nc12)-c1nonc1N
Show InChI InChI=1S/C12H14N6O2/c1-3-18-7-5-6-14-12(19-4-2)8(7)15-11(18)9-10(13)17-20-16-9/h5-6H,3-4H2,1-2H3,(H2,13,17)
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n/an/a 174n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168855
PNG
(4-(1-Ethyl-4-methoxy-1H-imidazo[4,5-c]pyridin-2-yl...)
Show SMILES CCn1c(nc2c(OC)nccc12)-c1nonc1N
Show InChI InChI=1S/C11H12N6O2/c1-3-17-6-4-5-13-11(18-2)7(6)14-10(17)8-9(12)16-19-15-8/h4-5H,3H2,1-2H3,(H2,12,16)
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n/an/a 209n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168865
PNG
(4-(1,4-Diethyl-1H-imidazo[4,5-c]pyridin-2-yl)-fura...)
Show SMILES CCc1nccc2n(CC)c(nc12)-c1nonc1N
Show InChI InChI=1S/C12H14N6O/c1-3-7-9-8(5-6-14-7)18(4-2)12(15-9)10-11(13)17-19-16-10/h5-6H,3-4H2,1-2H3,(H2,13,17)
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n/an/a 229n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM24996
PNG
(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Show SMILES CCn1c(nc2cncc(CNC3CCNCC3)c12)-c1nonc1N
Show InChI InChI=1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23)
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n/an/a 270n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against selected kinase p70S6K


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168852
PNG
(4-[1-(3-Dimethylamino-propyl)-1H-imidazo[4,5-c]pyr...)
Show SMILES CN(C)CCCn1c(nc2cnccc12)-c1nonc1N
Show InChI InChI=1S/C13H17N7O/c1-19(2)6-3-7-20-10-4-5-15-8-9(10)16-13(20)11-12(14)18-21-17-11/h4-5,8H,3,6-7H2,1-2H3,(H2,14,18)
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n/an/a 617n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168857
PNG
(4-(1-Ethyl-4-phenyl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Show SMILES CCn1c(nc2c(nccc12)-c1ccccc1)-c1nonc1N
Show InChI InChI=1S/C16H14N6O/c1-2-22-11-8-9-18-12(10-6-4-3-5-7-10)13(11)19-16(22)14-15(17)21-23-20-14/h3-9H,2H2,1H3,(H2,17,21)
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n/an/a 813n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168870
PNG
(4-(1-Ethyl-4-pyrrolidin-1-yl-1H-imidazo[4,5-c]pyri...)
Show SMILES CCn1c(nc2c(nccc12)N1CCCC1)-c1nonc1N
Show InChI InChI=1S/C14H17N7O/c1-2-21-9-5-6-16-13(20-7-3-4-8-20)10(9)17-14(21)11-12(15)19-22-18-11/h5-6H,2-4,7-8H2,1H3,(H2,15,19)
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n/an/a 2.24E+3n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM24996
PNG
(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Show SMILES CCn1c(nc2cncc(CNC3CCNCC3)c12)-c1nonc1N
Show InChI InChI=1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23)
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n/an/a 4.90E+3n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against selected kinase DYRK1-alpha


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50168860
PNG
(4-(1-Ethyl-4-phenoxy-1H-imidazo[4,5-c]pyridin-2-yl...)
Show SMILES CCn1c(nc2c(Oc3ccccc3)nccc12)-c1nonc1N
Show InChI InChI=1S/C16H14N6O2/c1-2-22-11-8-9-18-16(23-10-6-4-3-5-7-10)12(11)19-15(22)13-14(17)21-24-20-13/h3-9H,2H2,1H3,(H2,17,21)
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n/an/a 1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against MSK-1


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM24996
PNG
(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Show SMILES CCn1c(nc2cncc(CNC3CCNCC3)c12)-c1nonc1N
Show InChI InChI=1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against selected kinase CDK2


Bioorg Med Chem Lett 15: 3407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.020
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%