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PubMed code 15999997

Compile data set for download or QSAR
Found 85 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169985
PNG
(4-(2-(4-(benzo[d]thiazol-2(3H)-ylidene(cyano)methy...)
Show SMILES NS(=O)(=O)c1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H18N6O2S2/c22-13-16(20-26-18-3-1-2-4-19(18)30-20)17-10-12-25-21(27-17)24-11-9-14-5-7-15(8-6-14)31(23,28)29/h1-8,10,12,16H,9,11H2,(H2,23,28,29)(H,24,25,27)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169980
PNG
(CHEMBL363254 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Cn1cnc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C19H17N7S/c1-26-11-13(23-12-26)6-8-21-19-22-9-7-15(25-19)14(10-20)18-24-16-4-2-3-5-17(16)27-18/h2-5,7,9,11-12,14H,6,8H2,1H3,(H,21,22,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun N-Terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169998
PNG
(CHEMBL191581 | CHEMBL254651 | [3H-Benzothiazol-(2Z...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cnc[nH]2)n1
Show InChI InChI=1S/C18H15N7S/c19-9-13(17-24-15-3-1-2-4-16(15)26-17)14-6-8-22-18(25-14)21-7-5-12-10-20-11-23-12/h1-4,6,8,10-11,13H,5,7H2,(H,20,23)(H,21,22,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170008
PNG
(CHEMBL372708 | {2-[2-(4-Amino-phenyl)-ethylamino]-...)
Show SMILES Nc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H18N6S/c22-13-16(20-26-18-3-1-2-4-19(18)28-20)17-10-12-25-21(27-17)24-11-9-14-5-7-15(23)8-6-14/h1-8,10,12,16H,9,11,23H2,(H,24,25,27)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169999
PNG
(CHEMBL371113 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Cn1cncc1CCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C19H17N7S/c1-26-12-21-11-13(26)6-8-22-19-23-9-7-15(25-19)14(10-20)18-24-16-4-2-3-5-17(16)27-18/h2-5,7,9,11-12,14H,6,8H2,1H3,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170017
PNG
(CHEMBL189841 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCCn2ccnc2)n1
Show InChI InChI=1S/C19H17N7S/c20-12-14(18-24-16-4-1-2-5-17(16)27-18)15-6-8-23-19(25-15)22-7-3-10-26-11-9-21-13-26/h1-2,4-6,8-9,11,13-14H,3,7,10H2,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun N-Terminal kinase 1


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against c-Jun N-Terminal kinase 2


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169966
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(2-chloropyrimi...)
Show SMILES Clc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C13H7ClN4S/c14-13-16-6-5-9(18-13)8(7-15)12-17-10-3-1-2-4-11(10)19-12/h1-6,8H
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170001
PNG
(CHEMBL364637 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2ccccn2)n1
Show InChI InChI=1S/C20H16N6S/c21-13-15(19-25-17-6-1-2-7-18(17)27-19)16-9-12-24-20(26-16)23-11-8-14-5-3-4-10-22-14/h1-7,9-10,12,15H,8,11H2,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169965
PNG
(CHEMBL363253 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Fc1ccccc1CCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C21H16FN5S/c22-16-6-2-1-5-14(16)9-11-24-21-25-12-10-17(27-21)15(13-23)20-26-18-7-3-4-8-19(18)28-20/h1-8,10,12,15H,9,11H2,(H,24,25,27)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169977
PNG
(CHEMBL190742 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCc2cccnc2)n1
Show InChI InChI=1S/C19H14N6S/c20-10-14(18-24-16-5-1-2-6-17(16)26-18)15-7-9-22-19(25-15)23-12-13-4-3-8-21-11-13/h1-9,11,14H,12H2,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169994
PNG
(CHEMBL189852 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCc2ccncc2)n1
Show InChI InChI=1S/C19H14N6S/c20-11-14(18-24-16-3-1-2-4-17(16)26-18)15-7-10-22-19(25-15)23-12-13-5-8-21-9-6-13/h1-10,14H,12H2,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170014
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(6-bromo-2-chlo...)
Show SMILES Clc1nc(Br)cc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C13H6BrClN4S/c14-11-5-9(18-13(15)19-11)7(6-16)12-17-8-3-1-2-4-10(8)20-12/h1-5,7H
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169967
PNG
(CHEMBL189223 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCn2cncn2)n1
Show InChI InChI=1S/C17H14N8S/c18-9-12(16-23-14-3-1-2-4-15(14)26-16)13-5-6-20-17(24-13)21-7-8-25-11-19-10-22-25/h1-6,10-12H,7-8H2,(H,20,21,24)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169976
PNG
(CHEMBL191376 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCCN2CCOCC2)n1
Show InChI InChI=1S/C20H22N6OS/c21-14-15(19-24-17-4-1-2-5-18(17)28-19)16-6-8-23-20(25-16)22-7-3-9-26-10-12-27-13-11-26/h1-2,4-6,8,15H,3,7,9-13H2,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169978
PNG
(CHEMBL365963 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCn2ccc3ccccc23)n1
Show InChI InChI=1S/C23H18N6S/c24-15-17(22-27-19-6-2-4-8-21(19)30-22)18-9-11-25-23(28-18)26-12-14-29-13-10-16-5-1-3-7-20(16)29/h1-11,13,17H,12,14H2,(H,25,26,28)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169983
PNG
(CHEMBL424815 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES CN1CCN(CCCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)CC1
Show InChI InChI=1S/C21H25N7S/c1-27-11-13-28(14-12-27)10-4-8-23-21-24-9-7-17(26-21)16(15-22)20-25-18-5-2-3-6-19(18)29-20/h2-3,5-7,9,16H,4,8,10-14H2,1H3,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169972
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(2-hydrazinopyr...)
Show SMILES NNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C13H10N6S/c14-7-8(9-5-6-16-13(18-9)19-15)12-17-10-3-1-2-4-11(10)20-12/h1-6,8H,15H2,(H,16,18,19)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170016
PNG
(CHEMBL190597 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES OCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C15H13N5OS/c16-9-10(11-5-6-17-15(20-11)18-7-8-21)14-19-12-3-1-2-4-13(12)22-14/h1-6,10,21H,7-8H2,(H,17,18,20)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169968
PNG
(CHEMBL370889 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCCn2cccn2)n1
Show InChI InChI=1S/C19H17N7S/c20-13-14(18-24-16-5-1-2-6-17(16)27-18)15-7-10-22-19(25-15)21-8-3-11-26-12-4-9-23-26/h1-2,4-7,9-10,12,14H,3,8,11H2,(H,21,22,25)
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n/an/a 583n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170006
PNG
(CHEMBL190250 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES [O-][N+](=O)c1ccc(CCNc2nccc(n2)C(=C=[N-])c2[nH+]c3ccccc3s2)cc1
Show InChI InChI=1S/C21H15N6O2S/c22-13-16(20-25-18-3-1-2-4-19(18)30-20)17-10-12-24-21(26-17)23-11-9-14-5-7-15(8-6-14)27(28)29/h1-8,10,12H,9,11H2,(H,23,24,26)/q-1/p+1
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n/an/a 600n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169960
PNG
(CHEMBL364940 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCc2ccccn2)n1
Show InChI InChI=1S/C19H14N6S/c20-11-14(18-24-16-6-1-2-7-17(16)26-18)15-8-10-22-19(25-15)23-12-13-5-3-4-9-21-13/h1-10,14H,12H2,(H,22,23,25)
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n/an/a 650n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170013
PNG
(CHEMBL191465 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES OCCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C16H15N5OS/c17-10-11(15-20-13-4-1-2-5-14(13)23-15)12-6-8-19-16(21-12)18-7-3-9-22/h1-2,4-6,8,11,22H,3,7,9H2,(H,18,19,21)
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n/an/a 660n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169979
PNG
(CHEMBL191021 | [2-(3-Amino-propylamino)-pyrimidin-...)
Show SMILES NCCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C16H16N6S/c17-7-3-8-19-16-20-9-6-12(22-16)11(10-18)15-21-13-4-1-2-5-14(13)23-15/h1-2,4-6,9,11H,3,7-8,17H2,(H,19,20,22)
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n/an/a 707n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169963
PNG
(CHEMBL370899 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCN2CCOCC2)n1
Show InChI InChI=1S/C19H20N6OS/c20-13-14(18-23-16-3-1-2-4-17(16)27-18)15-5-6-21-19(24-15)22-7-8-25-9-11-26-12-10-25/h1-6,14H,7-12H2,(H,21,22,24)
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n/an/a 760n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170012
PNG
(CHEMBL191269 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES COCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C16H15N5OS/c1-22-9-8-19-16-18-7-6-12(21-16)11(10-17)15-20-13-4-2-3-5-14(13)23-15/h2-7,11H,8-9H2,1H3,(H,18,19,21)
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n/an/a 820n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169970
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene[2-(methylamino...)
Show SMILES CNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C14H11N5S/c1-16-14-17-7-6-10(19-14)9(8-15)13-18-11-4-2-3-5-12(11)20-13/h2-7,9H,1H3,(H,16,17,19)
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n/an/a 950n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169982
PNG
((2Z)-(2-chloropyrimidin-4-yl)[5-(trifluoromethyl)-...)
Show SMILES FC(F)(F)c1ccc2sc(nc2c1)C(C#N)c1ccnc(Cl)n1
Show InChI InChI=1S/C14H6ClF3N4S/c15-13-20-4-3-9(22-13)8(6-19)12-21-10-5-7(14(16,17)18)1-2-11(10)23-12/h1-5,8H
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n/an/a 993n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-SRC tyrosine kinase


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of RAF proto-oncogene serine/threonine protein kinase


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169993
PNG
(CHEMBL425553 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES CN(C)CCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C17H18N6S/c1-23(2)10-9-20-17-19-8-7-13(22-17)12(11-18)16-21-14-5-3-4-6-15(14)24-16/h3-8,12H,9-10H2,1-2H3,(H,19,20,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170011
PNG
(CHEMBL370960 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES CNCCCN(C)c1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C18H20N6S/c1-20-9-5-11-24(2)18-21-10-8-14(23-18)13(12-19)17-22-15-6-3-4-7-16(15)25-17/h3-4,6-8,10,13,20H,5,9,11H2,1-2H3
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n/an/a 1.32E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170015
PNG
(CHEMBL191543 | N-[3-(4-{[3H-Benzothiazol-(2Z)-ylid...)
Show SMILES CCCN(CCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1)C(=O)CC
Show InChI InChI=1S/C22H26N6OS/c1-3-13-28(20(29)4-2)14-7-11-24-22-25-12-10-17(27-22)16(15-23)21-26-18-8-5-6-9-19(18)30-21/h5-6,8-10,12,16H,3-4,7,11,13-14H2,1-2H3,(H,24,25,27)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin A


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169961
PNG
(CHEMBL363556 | [2-(2-Amino-ethylamino)-pyrimidin-4...)
Show SMILES NCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C15H14N6S/c16-6-8-19-15-18-7-5-11(21-15)10(9-17)14-20-12-3-1-2-4-13(12)22-14/h1-5,7,10H,6,8,16H2,(H,18,19,21)
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n/an/a 1.49E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170000
PNG
(CHEMBL190859 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES CN(C)CCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C18H20N6S/c1-24(2)11-5-9-20-18-21-10-8-14(23-18)13(12-19)17-22-15-6-3-4-7-16(15)25-17/h3-4,6-8,10,13H,5,9,11H2,1-2H3,(H,20,21,23)
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n/an/a 1.64E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170005
PNG
(CHEMBL189421 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Fc1cccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C21H16FN5S/c22-15-5-3-4-14(12-15)8-10-24-21-25-11-9-17(27-21)16(13-23)20-26-18-6-1-2-7-19(18)28-20/h1-7,9,11-12,16H,8,10H2,(H,24,25,27)
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n/an/a 1.81E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169975
PNG
(CHEMBL188499 | [3H-Benzothiazol-(2Z)-ylidene]-(2-m...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(n1)N1CCOCC1
Show InChI InChI=1S/C17H15N5OS/c18-11-12(16-20-14-3-1-2-4-15(14)24-16)13-5-6-19-17(21-13)22-7-9-23-10-8-22/h1-6,12H,7-10H2
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n/an/a 2.90E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169995
PNG
(2-(2-(4-methoxyphenethylamino)pyrimidin-4-yl)-2-(b...)
Show SMILES COc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C22H19N5OS/c1-28-16-8-6-15(7-9-16)10-12-24-22-25-13-11-18(27-22)17(14-23)21-26-19-4-2-3-5-20(19)29-21/h2-9,11,13,17H,10,12H2,1H3,(H,24,25,27)
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n/an/a 3.08E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170009
PNG
(CHEMBL373086 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Oc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H17N5OS/c22-13-16(20-25-18-3-1-2-4-19(18)28-20)17-10-12-24-21(26-17)23-11-9-14-5-7-15(27)8-6-14/h1-8,10,12,16,27H,9,11H2,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169996
PNG
(CHEMBL365191 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCN2CCCCC2)n1
Show InChI InChI=1S/C20H22N6S/c21-14-15(19-24-17-6-2-3-7-18(17)27-19)16-8-9-22-20(25-16)23-10-13-26-11-4-1-5-12-26/h2-3,6-9,15H,1,4-5,10-13H2,(H,22,23,25)
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n/an/a 3.74E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MAP kinase p38 alpha


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169971
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(6-chloropyridi...)
Show SMILES Clc1cccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C14H8ClN3S/c15-13-7-3-5-10(17-13)9(8-16)14-18-11-4-1-2-6-12(11)19-14/h1-7,9H
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169997
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(2-chloro-6-met...)
Show SMILES Cc1cc(nc(Cl)n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C14H9ClN4S/c1-8-6-11(19-14(15)17-8)9(7-16)13-18-10-4-2-3-5-12(10)20-13/h2-6,9H,1H3
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169964
PNG
(CHEMBL370950 | [3H-Benzothiazol-(2Z)-ylidene]-(2-p...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2ccccc2)n1
Show InChI InChI=1S/C21H17N5S/c22-14-16(20-25-18-8-4-5-9-19(18)27-20)17-11-13-24-21(26-17)23-12-10-15-6-2-1-3-7-15/h1-9,11,13,16H,10,12H2,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169986
PNG
(CHEMBL191172 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Fc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H16FN5S/c22-15-7-5-14(6-8-15)9-11-24-21-25-12-10-17(27-21)16(13-23)20-26-18-3-1-2-4-19(18)28-20/h1-8,10,12,16H,9,11H2,(H,24,25,27)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169962
PNG
(CHEMBL372035 | [3H-Benzothiazol-(2Z)-ylidene]-(2-p...)
Show SMILES CCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C16H15N5S/c1-2-8-18-16-19-9-7-12(21-16)11(10-17)15-20-13-5-3-4-6-14(13)22-15/h3-7,9,11H,2,8H2,1H3,(H,18,19,21)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169988
PNG
(CHEMBL362932 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Clc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1Cl
Show InChI InChI=1S/C21H15Cl2N5S/c22-15-6-5-13(11-16(15)23)7-9-25-21-26-10-8-17(28-21)14(12-24)20-27-18-3-1-2-4-19(18)29-20/h1-6,8,10-11,14H,7,9H2,(H,25,26,28)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170007
PNG
(CHEMBL190363 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES Cc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C22H19N5S/c1-15-6-8-16(9-7-15)10-12-24-22-25-13-11-18(27-22)17(14-23)21-26-19-4-2-3-5-20(19)28-21/h2-9,11,13,17H,10,12H2,1H3,(H,24,25,27)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170010
PNG
(CHEMBL189538 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCc2nnn[nH]2)n1
Show InChI InChI=1S/C15H11N9S/c16-7-9(14-19-11-3-1-2-4-12(11)25-14)10-5-6-17-15(20-10)18-8-13-21-23-24-22-13/h1-6,9H,8H2,(H,17,18,20)(H,21,22,23,24)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169992
PNG
((5-Bromo-2-chloro-pyrimidin-4-yl)-(1,3-dihydro-ben...)
Show SMILES Clc1ncc(Br)c(n1)C(C#N)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C13H7BrClN5/c14-8-6-17-13(15)20-11(8)7(5-16)12-18-9-3-1-2-4-10(9)19-12/h1-4,6-7H,(H,18,19)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169969
PNG
(CHEMBL362926 | [3H-Benzothiazol-(2Z)-ylidene]-(2-c...)
Show SMILES CCOC(=O)C(c1nc2ccccc2s1)c1ccnc(Cl)n1
Show InChI InChI=1S/C15H12ClN3O2S/c1-2-21-14(20)12(10-7-8-17-15(16)19-10)13-18-9-5-3-4-6-11(9)22-13/h3-8,12H,2H2,1H3
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169987
PNG
(CHEMBL361265 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Brc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H16BrN5S/c22-15-7-5-14(6-8-15)9-11-24-21-25-12-10-17(27-21)16(13-23)20-26-18-3-1-2-4-19(18)28-20/h1-8,10,12,16H,9,11H2,(H,24,25,27)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169981
PNG
(CHEMBL425722 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Clc1cccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C21H16ClN5S/c22-15-5-3-4-14(12-15)8-10-24-21-25-11-9-17(27-21)16(13-23)20-26-18-6-1-2-7-19(18)28-20/h1-7,9,11-12,16H,8,10H2,(H,24,25,27)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170003
PNG
((2Z)-(2-chloropyrimidin-4-yl)(3-methyl-1,3-benzoth...)
Show SMILES CN1\C(Sc2ccccc12)=C(\C#N)c1ccnc(Cl)n1
Show InChI InChI=1S/C14H9ClN4S/c1-19-11-4-2-3-5-12(11)20-13(19)9(8-16)10-6-7-17-14(15)18-10/h2-7H,1H3/b13-9+
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169973
PNG
(CHEMBL190591 | [3H-Benzothiazol-(2Z)-ylidene]-(2-d...)
Show SMILES CCCN(CCC)c1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C19H21N5S/c1-3-11-24(12-4-2)19-21-10-9-15(23-19)14(13-20)18-22-16-7-5-6-8-17(16)25-18/h5-10,14H,3-4,11-12H2,1-2H3
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169984
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(pyrimidin-4-yl...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccncn1
Show InChI InChI=1S/C13H8N4S/c14-7-9(10-5-6-15-8-16-10)13-17-11-3-1-2-4-12(11)18-13/h1-6,8-9H
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169991
PNG
(CHEMBL364053 | [3H-Benzothiazol-(2Z)-ylidene]-(2-b...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCc2ccccc2)n1
Show InChI InChI=1S/C20H15N5S/c21-12-15(19-24-17-8-4-5-9-18(17)26-19)16-10-11-22-20(25-16)23-13-14-6-2-1-3-7-14/h1-11,15H,13H2,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169990
PNG
(CHEMBL362934 | [3H-Benzothiazol-(2Z)-ylidene]-(2-p...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(n1)N1CCNCC1
Show InChI InChI=1S/C17H16N6S/c18-11-12(16-21-14-3-1-2-4-15(14)24-16)13-5-6-20-17(22-13)23-9-7-19-8-10-23/h1-6,12,19H,7-10H2
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170002
PNG
(CHEMBL365146 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES CN1CCN(CC1)c1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C18H18N6S/c1-23-8-10-24(11-9-23)18-20-7-6-14(22-18)13(12-19)17-21-15-4-2-3-5-16(15)25-17/h2-7,13H,8-11H2,1H3
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170004
PNG
(CHEMBL191536 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES COC1CCN(CC1)c1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C19H19N5OS/c1-25-13-7-10-24(11-8-13)19-21-9-6-15(23-19)14(12-20)18-22-16-4-2-3-5-17(16)26-18/h2-6,9,13-14H,7-8,10-11H2,1H3
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169989
PNG
((2Z)-(2-aminopyrimidin-4-yl)(1,3-benzothiazol-2(3H...)
Show SMILES Nc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C13H9N5S/c14-7-8(9-5-6-16-13(15)18-9)12-17-10-3-1-2-4-11(10)19-12/h1-6,8H,(H2,15,16,18)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169974
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene[2-(dimethylami...)
Show SMILES CN(C)c1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C15H13N5S/c1-20(2)15-17-8-7-11(19-15)10(9-16)14-18-12-5-3-4-6-13(12)21-14/h3-8,10H,1-2H3
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n/an/a 9.40E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mitogen activated protein kinase kinase 1 (MEK1)


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of SGK; Range is 5-10


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein kinase ROCK2; Range is 5-10


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein kinase PRAK


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of AKT kinase


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CHK1 kinase


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IKKB kinase


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 6


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Mitogen activated protein kinase 6; Range is 5-10


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Ribosomal S6 kinase 2; Range is 5-10


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MSK-1 kinase; Range is 5-10


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mitogen activated protein kinase kinase 7 beta


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MAP kinase-activated protein kinase 2


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ERK1 kinase


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase 2/S6K1


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C alpha


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of BLK; Range is 5-10


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 4


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Mitogen activated protein kinase kinase 4


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against PDK 1


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor


J Med Chem 48: 4596-607 (2005)


Article DOI: 10.1021/jm0310986
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%