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PubMed code 16000000

Compile data set for download or QSAR
Found 188 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6151
PNG
(1,6-naphthyridine 20 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H43N7O3/c1-30(2,3)35-29(38)34-28-25(21-15-23(39-5)18-24(16-21)40-6)17-22-20-32-27(19-26(22)33-28)31-9-7-8-10-37-13-11-36(4)12-14-37/h15-20H,7-14H2,1-6H3,(H,31,32)(H2,33,34,35,38)
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n/an/a 3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6157
PNG
(1,6-naphthyridine 26 | 3-tert-butyl-1-(7-{[5-(diet...)
Show SMILES CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C30H44N6O3/c1-8-36(9-2)14-12-10-11-13-31-27-19-26-22(20-32-27)17-25(21-15-23(38-6)18-24(16-21)39-7)28(33-26)34-29(37)35-30(3,4)5/h15-20H,8-14H2,1-7H3,(H,31,32)(H2,33,34,35,37)
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n/an/a 4n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6178
PNG
(1,6-naphthyridine 75 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H31N5O4/c1-24(2,3)29-23(31)28-22-19(15-9-17(32-4)12-18(10-15)33-5)11-16-14-26-21(13-20(16)27-22)25-7-6-8-30/h9-14,30H,6-8H2,1-5H3,(H,25,26)(H2,27,28,29,31)
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n/an/a 5n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6148
PNG
(1,6-naphthyridine 17 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H41N7O3/c1-29(2,3)34-28(37)33-27-24(20-14-22(38-5)17-23(15-20)39-6)16-21-19-31-26(18-25(21)32-27)30-8-7-9-36-12-10-35(4)11-13-36/h14-19H,7-13H2,1-6H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 5n/an/an/an/a7.822



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6150
PNG
(1,6-naphthyridine 19 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H40N6O4/c1-29(2,3)34-28(36)33-27-24(20-14-22(37-4)17-23(15-20)38-5)16-21-19-31-26(18-25(21)32-27)30-8-6-7-9-35-10-12-39-13-11-35/h14-19H,6-13H2,1-5H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 6n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6180
PNG
(1,6-naphthyridine 77 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C26H35N5O4/c1-26(2,3)31-25(33)30-24-21(17-11-19(34-4)14-20(12-17)35-5)13-18-16-28-23(15-22(18)29-24)27-9-7-6-8-10-32/h11-16,32H,6-10H2,1-5H3,(H,27,28)(H2,29,30,31,33)
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n/an/a 6n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6154
PNG
(1,6-naphthyridine 23 | 3-tert-butyl-1-(7-{[4-(diet...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C29H42N6O3/c1-8-35(9-2)13-11-10-12-30-26-18-25-21(19-31-26)16-24(20-14-22(37-6)17-23(15-20)38-7)27(32-25)33-28(36)34-29(3,4)5/h14-19H,8-13H2,1-7H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 6n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6155
PNG
(1,6-naphthyridine 24 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H42N6O4/c1-30(2,3)35-29(37)34-28-25(21-15-23(38-4)18-24(16-21)39-5)17-22-20-32-27(19-26(22)33-28)31-9-7-6-8-10-36-11-13-40-14-12-36/h15-20H,6-14H2,1-5H3,(H,31,32)(H2,33,34,35,37)
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n/an/a 7n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6156
PNG
(1,6-naphthyridine 25 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C31H45N7O3/c1-31(2,3)36-30(39)35-29-26(22-16-24(40-5)19-25(17-22)41-6)18-23-21-33-28(20-27(23)34-29)32-10-8-7-9-11-38-14-12-37(4)13-15-38/h16-21H,7-15H2,1-6H3,(H,32,33)(H2,34,35,36,39)
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n/an/a 8n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6179
PNG
(1,6-naphthyridine 76 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C25H33N5O4/c1-25(2,3)30-24(32)29-23-20(16-10-18(33-4)13-19(11-16)34-5)12-17-15-27-22(14-21(17)28-23)26-8-6-7-9-31/h10-15,31H,6-9H2,1-5H3,(H,26,27)(H2,28,29,30,32)
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n/an/a 8n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4618
PNG
(1,6-naphthyridine 14 | 1,6-naphthyridine deriv. 20...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N6O4/c1-28(2,3)33-27(35)32-26-23(19-13-21(36-4)16-22(14-19)37-5)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-9-11-38-12-10-34/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 9n/an/an/an/a7.822



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6167
PNG
(1,6-naphthyridine 36 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1c(Cl)cccc1Cl |(2.55,-3.89,;3.88,-3.12,;3.88,-1.58,;5.22,-.81,;6.55,-1.58,;5.22,.73,;3.88,1.5,;2.55,.73,;1.22,1.5,;-.12,.73,;-1.45,1.5,;-2.78,.73,;-4.27,1.13,;-5.36,.04,;-6.85,.44,;-7.94,-.65,;-9.42,-.25,;-9.82,1.24,;-11.31,1.64,;-10.51,-1.34,;-12,-.94,;-1.45,3.05,;-.12,3.82,;1.22,3.05,;2.55,3.82,;3.88,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C25H32Cl2N6O/c1-4-28-25(34)32-24-18(23-19(26)10-9-11-20(23)27)14-17-16-30-22(15-21(17)31-24)29-12-7-8-13-33(5-2)6-3/h9-11,14-16H,4-8,12-13H2,1-3H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 14n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6165
PNG
(1,6-naphthyridine 34 | 3-tert-butyl-1-[3-(2,6-dich...)
Show SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-11.94,-2.96,;-10.6,-2.19,;-10.6,-.65,;-9.27,.12,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;5.22,-.81,;6.55,-1.58,;3.88,-1.58,;3.88,-3.12,;2.55,-3.89,;5.22,-3.89,;3.88,-4.66,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,;-7.94,-2.19,;-9.27,-2.96,)|
Show InChI InChI=1S/C27H35Cl2N7O/c1-27(2,3)34-26(37)33-25-19(24-20(28)7-5-8-21(24)29)15-18-17-31-23(16-22(18)32-25)30-9-6-10-36-13-11-35(4)12-14-36/h5,7-8,15-17H,6,9-14H2,1-4H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 14n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6168
PNG
(1,6-naphthyridine 37 | 3-tert-butyl-1-[3-(2,6-dich...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1c(Cl)cccc1Cl |(-11.31,1.64,;-9.82,1.24,;-9.42,-.25,;-10.51,-1.34,;-12,-.94,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;5.22,-.81,;6.55,-1.58,;3.88,-1.58,;3.88,-3.12,;2.55,-3.89,;5.22,-3.89,;3.88,-4.66,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C27H36Cl2N6O/c1-6-35(7-2)14-9-8-13-30-23-16-22-18(17-31-23)15-19(24-20(28)11-10-12-21(24)29)25(32-22)33-26(36)34-27(3,4)5/h10-12,15-17H,6-9,13-14H2,1-5H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 14n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6149
PNG
(1,6-naphthyridine 18 | 3-tert-butyl-1-(7-{[3-(diet...)
Show SMILES CCN(CC)CCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H40N6O3/c1-8-34(9-2)12-10-11-29-25-17-24-20(18-30-25)15-23(19-13-21(36-6)16-22(14-19)37-7)26(31-24)32-27(35)33-28(3,4)5/h13-18H,8-12H2,1-7H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 15n/an/an/an/a7.822



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6188
PNG
(3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-m...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H40N8O3/c1-28(2,3)34-27(37)33-25-23(19-14-21(38-5)17-22(15-19)39-6)16-20-18-30-26(32-24(20)31-25)29-8-7-9-36-12-10-35(4)11-13-36/h14-18H,7-13H2,1-6H3,(H3,29,30,31,32,33,34,37)
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n/an/a 19n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6164
PNG
(1,6-naphthyridine 33 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl |(2.8,-4.2,;3.88,-3.12,;3.88,-1.58,;5.22,-.81,;6.55,-1.58,;5.22,.73,;3.88,1.5,;2.55,.73,;1.22,1.5,;-.12,.73,;-1.45,1.5,;-2.78,.73,;-4.27,1.13,;-5.36,.04,;-6.85,.44,;-7.94,-.65,;-9.27,.12,;-10.6,-.65,;-10.6,-2.19,;-11.94,-2.96,;-9.27,-2.96,;-7.94,-2.19,;-1.45,3.05,;-.12,3.82,;1.22,3.05,;2.55,3.82,;3.88,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C25H31Cl2N7O/c1-3-28-25(35)32-24-18(23-19(26)6-4-7-20(23)27)14-17-16-30-22(15-21(17)31-24)29-8-5-9-34-12-10-33(2)11-13-34/h4,6-7,14-16H,3,5,8-13H2,1-2H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 19n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6165
PNG
(1,6-naphthyridine 34 | 3-tert-butyl-1-[3-(2,6-dich...)
Show SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-11.94,-2.96,;-10.6,-2.19,;-10.6,-.65,;-9.27,.12,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;5.22,-.81,;6.55,-1.58,;3.88,-1.58,;3.88,-3.12,;2.55,-3.89,;5.22,-3.89,;3.88,-4.66,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,;-7.94,-2.19,;-9.27,-2.96,)|
Show InChI InChI=1S/C27H35Cl2N7O/c1-27(2,3)34-26(37)33-25-19(24-20(28)7-5-8-21(24)29)15-18-17-31-23(16-22(18)32-25)30-9-6-10-36-13-11-35(4)12-14-36/h5,7-8,15-17H,6,9-14H2,1-4H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 19n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6147
PNG
(1,6-naphthyridine 16 | 1-[3-(3,5-dimethoxyphenyl)-...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H37N7O3/c1-5-28-27(35)32-26-23(19-13-21(36-3)16-22(14-19)37-4)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-11-9-33(2)10-12-34/h13-18H,5-12H2,1-4H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 21n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6188
PNG
(3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-m...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H40N8O3/c1-28(2,3)34-27(37)33-25-23(19-14-21(38-5)17-22(15-19)39-6)16-20-18-30-26(32-24(20)31-25)29-8-7-9-36-12-10-35(4)11-13-36/h14-18H,7-13H2,1-6H3,(H3,29,30,31,32,33,34,37)
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n/an/a 21n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6151
PNG
(1,6-naphthyridine 20 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H43N7O3/c1-30(2,3)35-29(38)34-28-25(21-15-23(39-5)18-24(16-21)40-6)17-22-20-32-27(19-26(22)33-28)31-9-7-8-10-37-13-11-36(4)12-14-37/h15-20H,7-14H2,1-6H3,(H,31,32)(H2,33,34,35,38)
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n/an/a 24n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6153
PNG
(1,6-naphthyridine 22 | 1-(7-{[4-(diethylamino)buty...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H38N6O3/c1-6-28-27(34)32-26-23(19-13-21(35-4)16-22(14-19)36-5)15-20-18-30-25(17-24(20)31-26)29-11-9-10-12-33(7-2)8-3/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 24n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6148
PNG
(1,6-naphthyridine 17 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H41N7O3/c1-29(2,3)34-28(37)33-27-24(20-14-22(38-5)17-23(15-20)39-6)16-21-19-31-26(18-25(21)32-27)30-8-7-9-36-12-10-35(4)11-13-36/h14-19H,7-13H2,1-6H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 24n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6154
PNG
(1,6-naphthyridine 23 | 3-tert-butyl-1-(7-{[4-(diet...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C29H42N6O3/c1-8-35(9-2)13-11-10-12-30-26-18-25-21(19-31-26)16-24(20-14-22(37-6)17-23(15-20)38-7)27(32-25)33-28(36)34-29(3,4)5/h14-19H,8-13H2,1-7H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 25n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6168
PNG
(1,6-naphthyridine 37 | 3-tert-butyl-1-[3-(2,6-dich...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1c(Cl)cccc1Cl |(-11.31,1.64,;-9.82,1.24,;-9.42,-.25,;-10.51,-1.34,;-12,-.94,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;5.22,-.81,;6.55,-1.58,;3.88,-1.58,;3.88,-3.12,;2.55,-3.89,;5.22,-3.89,;3.88,-4.66,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C27H36Cl2N6O/c1-6-35(7-2)14-9-8-13-30-23-16-22-18(17-31-23)15-19(24-20(28)11-10-12-21(24)29)25(32-22)33-26(36)34-27(3,4)5/h10-12,15-17H,6-9,13-14H2,1-5H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 25n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6168
PNG
(1,6-naphthyridine 37 | 3-tert-butyl-1-[3-(2,6-dich...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1c(Cl)cccc1Cl |(-11.31,1.64,;-9.82,1.24,;-9.42,-.25,;-10.51,-1.34,;-12,-.94,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;5.22,-.81,;6.55,-1.58,;3.88,-1.58,;3.88,-3.12,;2.55,-3.89,;5.22,-3.89,;3.88,-4.66,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C27H36Cl2N6O/c1-6-35(7-2)14-9-8-13-30-23-16-22-18(17-31-23)15-19(24-20(28)11-10-12-21(24)29)25(32-22)33-26(36)34-27(3,4)5/h10-12,15-17H,6-9,13-14H2,1-5H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 25n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6165
PNG
(1,6-naphthyridine 34 | 3-tert-butyl-1-[3-(2,6-dich...)
Show SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-11.94,-2.96,;-10.6,-2.19,;-10.6,-.65,;-9.27,.12,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;5.22,-.81,;6.55,-1.58,;3.88,-1.58,;3.88,-3.12,;2.55,-3.89,;5.22,-3.89,;3.88,-4.66,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,;-7.94,-2.19,;-9.27,-2.96,)|
Show InChI InChI=1S/C27H35Cl2N7O/c1-27(2,3)34-26(37)33-25-19(24-20(28)7-5-8-21(24)29)15-18-17-31-23(16-22(18)32-25)30-9-6-10-36-13-11-35(4)12-14-36/h5,7-8,15-17H,6,9-14H2,1-4H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 26n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6190
PNG
(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
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n/an/a 28n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6157
PNG
(1,6-naphthyridine 26 | 3-tert-butyl-1-(7-{[5-(diet...)
Show SMILES CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C30H44N6O3/c1-8-36(9-2)14-12-10-11-13-31-27-19-26-22(20-32-27)17-25(21-15-23(38-6)18-24(16-21)39-7)28(33-26)34-29(37)35-30(3,4)5/h15-20H,8-14H2,1-7H3,(H,31,32)(H2,33,34,35,37)
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n/an/a 28n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6167
PNG
(1,6-naphthyridine 36 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1c(Cl)cccc1Cl |(2.55,-3.89,;3.88,-3.12,;3.88,-1.58,;5.22,-.81,;6.55,-1.58,;5.22,.73,;3.88,1.5,;2.55,.73,;1.22,1.5,;-.12,.73,;-1.45,1.5,;-2.78,.73,;-4.27,1.13,;-5.36,.04,;-6.85,.44,;-7.94,-.65,;-9.42,-.25,;-9.82,1.24,;-11.31,1.64,;-10.51,-1.34,;-12,-.94,;-1.45,3.05,;-.12,3.82,;1.22,3.05,;2.55,3.82,;3.88,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C25H32Cl2N6O/c1-4-28-25(34)32-24-18(23-19(26)10-9-11-20(23)27)14-17-16-30-22(15-21(17)31-24)29-12-7-8-13-33(5-2)6-3/h9-11,14-16H,4-8,12-13H2,1-3H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 29n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6150
PNG
(1,6-naphthyridine 19 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H40N6O4/c1-29(2,3)34-28(36)33-27-24(20-14-22(37-4)17-23(15-20)38-5)16-21-19-31-26(18-25(21)32-27)30-8-6-7-9-35-10-12-39-13-11-35/h14-19H,6-13H2,1-5H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 30n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4618
PNG
(1,6-naphthyridine 14 | 1,6-naphthyridine deriv. 20...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N6O4/c1-28(2,3)33-27(35)32-26-23(19-13-21(36-4)16-22(14-19)37-5)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-9-11-38-12-10-34/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 31n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6164
PNG
(1,6-naphthyridine 33 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl |(2.8,-4.2,;3.88,-3.12,;3.88,-1.58,;5.22,-.81,;6.55,-1.58,;5.22,.73,;3.88,1.5,;2.55,.73,;1.22,1.5,;-.12,.73,;-1.45,1.5,;-2.78,.73,;-4.27,1.13,;-5.36,.04,;-6.85,.44,;-7.94,-.65,;-9.27,.12,;-10.6,-.65,;-10.6,-2.19,;-11.94,-2.96,;-9.27,-2.96,;-7.94,-2.19,;-1.45,3.05,;-.12,3.82,;1.22,3.05,;2.55,3.82,;3.88,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C25H31Cl2N7O/c1-3-28-25(35)32-24-18(23-19(26)6-4-7-20(23)27)14-17-16-30-22(15-21(17)31-24)29-8-5-9-34-12-10-33(2)11-13-34/h4,6-7,14-16H,3,5,8-13H2,1-2H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 32n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6187
PNG
(1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-methylpiperazi...)
Show SMILES CCNC(=O)Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H36N8O3/c1-5-27-26(35)32-24-22(18-13-20(36-3)16-21(14-18)37-4)15-19-17-29-25(31-23(19)30-24)28-7-6-8-34-11-9-33(2)10-12-34/h13-17H,5-12H2,1-4H3,(H3,27,28,29,30,31,32,35)
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n/an/a 33n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6155
PNG
(1,6-naphthyridine 24 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H42N6O4/c1-30(2,3)35-29(37)34-28-25(21-15-23(38-4)18-24(16-21)39-5)17-22-20-32-27(19-26(22)33-28)31-9-7-6-8-10-36-11-13-40-14-12-36/h15-20H,6-14H2,1-5H3,(H,31,32)(H2,33,34,35,37)
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n/an/a 33n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6189
PNG
(1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimetho...)
Show SMILES CCNC(=O)Nc1nc2nc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H37N7O3/c1-6-27-26(34)32-24-22(18-13-20(35-4)16-21(14-18)36-5)15-19-17-29-25(31-23(19)30-24)28-11-9-10-12-33(7-2)8-3/h13-17H,6-12H2,1-5H3,(H3,27,28,29,30,31,32,34)
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n/an/a 35n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6191
PNG
(3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-[(3-hydr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCO)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C23H30N6O4/c1-23(2,3)29-22(31)28-20-18(14-9-16(32-4)12-17(10-14)33-5)11-15-13-25-21(24-7-6-8-30)27-19(15)26-20/h9-13,30H,6-8H2,1-5H3,(H3,24,25,26,27,28,29,31)
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n/an/a 38n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6166
PNG
(1,6-naphthyridine 35 | 3-(2,6-Dichlorophenyl)-N7-[...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1c(Cl)cccc1Cl |(-11.31,1.64,;-9.82,1.24,;-9.42,-.25,;-10.51,-1.34,;-12,-.94,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C22H27Cl2N5/c1-3-29(4-2)11-6-5-10-26-20-13-19-15(14-27-20)12-16(22(25)28-19)21-17(23)8-7-9-18(21)24/h7-9,12-14H,3-6,10-11H2,1-2H3,(H2,25,28)(H,26,27)
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n/an/a 42n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6146
PNG
(1,6-naphthyridine 15 | 3-(3,5-Dimethoxyphenyl)-N7-...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1N
Show InChI InChI=1S/C24H32N6O2/c1-29-7-9-30(10-8-29)6-4-5-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(31-2)14-20(12-17)32-3/h11-16H,4-10H2,1-3H3,(H2,25,28)(H,26,27)
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n/an/a 44n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6153
PNG
(1,6-naphthyridine 22 | 1-(7-{[4-(diethylamino)buty...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H38N6O3/c1-6-28-27(34)32-26-23(19-13-21(35-4)16-22(14-19)36-5)15-20-18-30-25(17-24(20)31-26)29-11-9-10-12-33(7-2)8-3/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 46n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6178
PNG
(1,6-naphthyridine 75 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H31N5O4/c1-24(2,3)29-23(31)28-22-19(15-9-17(32-4)12-18(10-15)33-5)11-16-14-26-21(13-20(16)27-22)25-7-6-8-30/h9-14,30H,6-8H2,1-5H3,(H,25,26)(H2,27,28,29,31)
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n/an/a 49n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6147
PNG
(1,6-naphthyridine 16 | 1-[3-(3,5-dimethoxyphenyl)-...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H37N7O3/c1-5-28-27(35)32-26-23(19-13-21(36-3)16-22(14-19)37-4)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-11-9-33(2)10-12-34/h13-18H,5-12H2,1-4H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 51n/an/an/an/a7.822



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6179
PNG
(1,6-naphthyridine 76 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C25H33N5O4/c1-25(2,3)30-24(32)29-23-20(16-10-18(33-4)13-19(11-16)34-5)12-17-15-27-22(14-21(17)28-23)26-8-6-7-9-31/h10-15,31H,6-9H2,1-5H3,(H,26,27)(H2,28,29,30,32)
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n/an/a 52n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6159
PNG
(1,6-naphthyridine 28 | 3-tert-butyl-1-(7-{[3-(4-me...)
Show SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H37N7O/c1-27(2,3)32-26(35)31-25-22(20-9-6-5-7-10-20)17-21-19-29-24(18-23(21)30-25)28-11-8-12-34-15-13-33(4)14-16-34/h5-7,9-10,17-19H,8,11-16H2,1-4H3,(H,28,29)(H2,30,31,32,35)
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n/an/a 54n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6149
PNG
(1,6-naphthyridine 18 | 3-tert-butyl-1-(7-{[3-(diet...)
Show SMILES CCN(CC)CCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H40N6O3/c1-8-34(9-2)12-10-11-29-25-17-24-20(18-30-25)15-23(19-13-21(36-6)16-22(14-19)37-7)26(31-24)32-27(35)33-28(3,4)5/h13-18H,8-12H2,1-7H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 60n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6187
PNG
(1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-methylpiperazi...)
Show SMILES CCNC(=O)Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H36N8O3/c1-5-27-26(35)32-24-22(18-13-20(36-3)16-21(14-18)37-4)15-19-17-29-25(31-23(19)30-24)28-7-6-8-34-11-9-33(2)10-12-34/h13-17H,5-12H2,1-4H3,(H3,27,28,29,30,31,32,35)
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n/an/a 62n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6163
PNG
(1,6-naphthyridine 32 | 3-(2,6-dichlorophenyl)-7-N-...)
Show SMILES CN1CCN(CCCNc2cc3nc(N)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-11.94,-2.96,;-10.6,-2.19,;-10.6,-.65,;-9.27,.12,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,;-7.94,-2.19,;-9.27,-2.96,)|
Show InChI InChI=1S/C22H26Cl2N6/c1-29-8-10-30(11-9-29)7-3-6-26-20-13-19-15(14-27-20)12-16(22(25)28-19)21-17(23)4-2-5-18(21)24/h2,4-5,12-14H,3,6-11H2,1H3,(H2,25,28)(H,26,27)
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n/an/a 69n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6156
PNG
(1,6-naphthyridine 25 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C31H45N7O3/c1-31(2,3)36-30(39)35-29-26(22-16-24(40-5)19-25(17-22)41-6)18-23-21-33-28(20-27(23)34-29)32-10-8-7-9-11-38-14-12-37(4)13-15-38/h16-21H,7-15H2,1-6H3,(H,32,33)(H2,34,35,36,39)
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n/an/a 70n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6191
PNG
(3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-[(3-hydr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCO)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C23H30N6O4/c1-23(2,3)29-22(31)28-20-18(14-9-16(32-4)12-17(10-14)33-5)11-15-13-25-21(24-7-6-8-30)27-19(15)26-20/h9-13,30H,6-8H2,1-5H3,(H3,24,25,26,27,28,29,31)
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n/an/a 71n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6169
PNG
(1,6-naphthyridine 38 | N-[3-(Benzyloxy)propyl]-N-[...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C33H39N5O5/c1-22(39)38(13-10-14-43-21-23-11-8-7-9-12-23)30-19-29-25(20-34-30)17-28(24-15-26(41-5)18-27(16-24)42-6)31(35-29)36-32(40)37-33(2,3)4/h7-9,11-12,15-20H,10,13-14,21H2,1-6H3,(H2,35,36,37,40)
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n/an/a 84n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6152
PNG
(1,6-naphthyridine 21 | 7-N-[4-(diethylamino)butyl]...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C24H33N5O2/c1-5-29(6-2)10-8-7-9-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(30-3)14-20(12-17)31-4/h11-16H,5-10H2,1-4H3,(H2,25,28)(H,26,27)
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n/an/a 87n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6180
PNG
(1,6-naphthyridine 77 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C26H35N5O4/c1-26(2,3)31-25(33)30-24-21(17-11-19(34-4)14-20(12-17)35-5)13-18-16-28-23(15-22(18)29-24)27-9-7-6-8-10-32/h11-16,32H,6-10H2,1-5H3,(H,27,28)(H2,29,30,31,33)
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n/an/a 93n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6177
PNG
(1,6-naphthyridine 43 | 1-(7-{[5-(benzyloxy)pentyl]...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C33H41N5O4/c1-33(2,3)38-32(39)37-31-28(24-16-26(40-4)19-27(17-24)41-5)18-25-21-35-30(20-29(25)36-31)34-14-10-7-11-15-42-22-23-12-8-6-9-13-23/h6,8-9,12-13,16-21H,7,10-11,14-15,22H2,1-5H3,(H,34,35)(H2,36,37,38,39)
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n/an/a 96n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6162
PNG
(1,6-naphthyridine 31 | 3-tert-butyl-1-(7-{[4-(diet...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C27H38N6O/c1-6-33(7-2)16-12-11-15-28-24-18-23-21(19-29-24)17-22(20-13-9-8-10-14-20)25(30-23)31-26(34)32-27(3,4)5/h8-10,13-14,17-19H,6-7,11-12,15-16H2,1-5H3,(H,28,29)(H2,30,31,32,34)
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n/an/a 110n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6164
PNG
(1,6-naphthyridine 33 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl |(2.8,-4.2,;3.88,-3.12,;3.88,-1.58,;5.22,-.81,;6.55,-1.58,;5.22,.73,;3.88,1.5,;2.55,.73,;1.22,1.5,;-.12,.73,;-1.45,1.5,;-2.78,.73,;-4.27,1.13,;-5.36,.04,;-6.85,.44,;-7.94,-.65,;-9.27,.12,;-10.6,-.65,;-10.6,-2.19,;-11.94,-2.96,;-9.27,-2.96,;-7.94,-2.19,;-1.45,3.05,;-.12,3.82,;1.22,3.05,;2.55,3.82,;3.88,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C25H31Cl2N7O/c1-3-28-25(35)32-24-18(23-19(26)6-4-7-20(23)27)14-17-16-30-22(15-21(17)31-24)29-8-5-9-34-12-10-33(2)11-13-34/h4,6-7,14-16H,3,5,8-13H2,1-2H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 110n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6163
PNG
(1,6-naphthyridine 32 | 3-(2,6-dichlorophenyl)-7-N-...)
Show SMILES CN1CCN(CCCNc2cc3nc(N)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-11.94,-2.96,;-10.6,-2.19,;-10.6,-.65,;-9.27,.12,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,;-7.94,-2.19,;-9.27,-2.96,)|
Show InChI InChI=1S/C22H26Cl2N6/c1-29-8-10-30(11-9-29)7-3-6-26-20-13-19-15(14-27-20)12-16(22(25)28-19)21-17(23)4-2-5-18(21)24/h2,4-5,12-14H,3,6-11H2,1H3,(H2,25,28)(H,26,27)
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n/an/a 120n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6190
PNG
(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
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n/an/a 120n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6167
PNG
(1,6-naphthyridine 36 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1c(Cl)cccc1Cl |(2.55,-3.89,;3.88,-3.12,;3.88,-1.58,;5.22,-.81,;6.55,-1.58,;5.22,.73,;3.88,1.5,;2.55,.73,;1.22,1.5,;-.12,.73,;-1.45,1.5,;-2.78,.73,;-4.27,1.13,;-5.36,.04,;-6.85,.44,;-7.94,-.65,;-9.42,-.25,;-9.82,1.24,;-11.31,1.64,;-10.51,-1.34,;-12,-.94,;-1.45,3.05,;-.12,3.82,;1.22,3.05,;2.55,3.82,;3.88,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C25H32Cl2N6O/c1-4-28-25(34)32-24-18(23-19(26)10-9-11-20(23)27)14-17-16-30-22(15-21(17)31-24)29-12-7-8-13-33(5-2)6-3/h9-11,14-16H,4-8,12-13H2,1-3H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 130n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6167
PNG
(1,6-naphthyridine 36 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1c(Cl)cccc1Cl |(2.55,-3.89,;3.88,-3.12,;3.88,-1.58,;5.22,-.81,;6.55,-1.58,;5.22,.73,;3.88,1.5,;2.55,.73,;1.22,1.5,;-.12,.73,;-1.45,1.5,;-2.78,.73,;-4.27,1.13,;-5.36,.04,;-6.85,.44,;-7.94,-.65,;-9.42,-.25,;-9.82,1.24,;-11.31,1.64,;-10.51,-1.34,;-12,-.94,;-1.45,3.05,;-.12,3.82,;1.22,3.05,;2.55,3.82,;3.88,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C25H32Cl2N6O/c1-4-28-25(34)32-24-18(23-19(26)10-9-11-20(23)27)14-17-16-30-22(15-21(17)31-24)29-12-7-8-13-33(5-2)6-3/h9-11,14-16H,4-8,12-13H2,1-3H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 160n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6175
PNG
(1,6-naphthyridine 41 | 1-(7-{[3-(benzyloxy)propyl]...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C31H37N5O4/c1-31(2,3)36-30(37)35-29-26(22-14-24(38-4)17-25(15-22)39-5)16-23-19-33-28(18-27(23)34-29)32-12-9-13-40-20-21-10-7-6-8-11-21/h6-8,10-11,14-19H,9,12-13,20H2,1-5H3,(H,32,33)(H2,34,35,36,37)
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n/an/a 180n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6176
PNG
(1,6-naphthyridine 42 | 1-(7-{[4-(benzyloxy)butyl]a...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C32H39N5O4/c1-32(2,3)37-31(38)36-30-27(23-15-25(39-4)18-26(16-23)40-5)17-24-20-34-29(19-28(24)35-30)33-13-9-10-14-41-21-22-11-7-6-8-12-22/h6-8,11-12,15-20H,9-10,13-14,21H2,1-5H3,(H,33,34)(H2,35,36,37,38)
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n/an/a 180n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6146
PNG
(1,6-naphthyridine 15 | 3-(3,5-Dimethoxyphenyl)-N7-...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1N
Show InChI InChI=1S/C24H32N6O2/c1-29-7-9-30(10-8-29)6-4-5-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(31-2)14-20(12-17)32-3/h11-16H,4-10H2,1-3H3,(H2,25,28)(H,26,27)
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n/an/a 180n/an/an/an/a7.822



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6162
PNG
(1,6-naphthyridine 31 | 3-tert-butyl-1-(7-{[4-(diet...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C27H38N6O/c1-6-33(7-2)16-12-11-15-28-24-18-23-21(19-29-24)17-22(20-13-9-8-10-14-20)25(30-23)31-26(34)32-27(3,4)5/h8-10,13-14,17-19H,6-7,11-12,15-16H2,1-5H3,(H,28,29)(H2,30,31,32,34)
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n/an/a 180n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6189
PNG
(1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimetho...)
Show SMILES CCNC(=O)Nc1nc2nc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H37N7O3/c1-6-27-26(34)32-24-22(18-13-20(35-4)16-21(14-18)36-5)15-19-17-29-25(31-23(19)30-24)28-11-9-10-12-33(7-2)8-3/h13-17H,6-12H2,1-5H3,(H3,27,28,29,30,31,32,34)
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n/an/a 190n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6159
PNG
(1,6-naphthyridine 28 | 3-tert-butyl-1-(7-{[3-(4-me...)
Show SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H37N7O/c1-27(2,3)32-26(35)31-25-22(20-9-6-5-7-10-20)17-21-19-29-24(18-23(21)30-25)28-11-8-12-34-15-13-33(4)14-16-34/h5-7,9-10,17-19H,8,11-16H2,1-4H3,(H,28,29)(H2,30,31,32,35)
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n/an/a 190n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6152
PNG
(1,6-naphthyridine 21 | 7-N-[4-(diethylamino)butyl]...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C24H33N5O2/c1-5-29(6-2)10-8-7-9-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(30-3)14-20(12-17)31-4/h11-16H,5-10H2,1-4H3,(H2,25,28)(H,26,27)
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n/an/a 220n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6159
PNG
(1,6-naphthyridine 28 | 3-tert-butyl-1-(7-{[3-(4-me...)
Show SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H37N7O/c1-27(2,3)32-26(35)31-25-22(20-9-6-5-7-10-20)17-21-19-29-24(18-23(21)30-25)28-11-8-12-34-15-13-33(4)14-16-34/h5-7,9-10,17-19H,8,11-16H2,1-4H3,(H,28,29)(H2,30,31,32,35)
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n/an/a 230n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6162
PNG
(1,6-naphthyridine 31 | 3-tert-butyl-1-(7-{[4-(diet...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C27H38N6O/c1-6-33(7-2)16-12-11-15-28-24-18-23-21(19-29-24)17-22(20-13-9-8-10-14-20)25(30-23)31-26(34)32-27(3,4)5/h8-10,13-14,17-19H,6-7,11-12,15-16H2,1-5H3,(H,28,29)(H2,30,31,32,34)
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n/an/a 300n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6166
PNG
(1,6-naphthyridine 35 | 3-(2,6-Dichlorophenyl)-N7-[...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1c(Cl)cccc1Cl |(-11.31,1.64,;-9.82,1.24,;-9.42,-.25,;-10.51,-1.34,;-12,-.94,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C22H27Cl2N5/c1-3-29(4-2)11-6-5-10-26-20-13-19-15(14-27-20)12-16(22(25)28-19)21-17(23)8-7-9-18(21)24/h7-9,12-14H,3-6,10-11H2,1-2H3,(H2,25,28)(H,26,27)
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n/an/a 350n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6162
PNG
(1,6-naphthyridine 31 | 3-tert-butyl-1-(7-{[4-(diet...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C27H38N6O/c1-6-33(7-2)16-12-11-15-28-24-18-23-21(19-29-24)17-22(20-13-9-8-10-14-20)25(30-23)31-26(34)32-27(3,4)5/h8-10,13-14,17-19H,6-7,11-12,15-16H2,1-5H3,(H,28,29)(H2,30,31,32,34)
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n/an/a 450n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6168
PNG
(1,6-naphthyridine 37 | 3-tert-butyl-1-[3-(2,6-dich...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1c(Cl)cccc1Cl |(-11.31,1.64,;-9.82,1.24,;-9.42,-.25,;-10.51,-1.34,;-12,-.94,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;5.22,-.81,;6.55,-1.58,;3.88,-1.58,;3.88,-3.12,;2.55,-3.89,;5.22,-3.89,;3.88,-4.66,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C27H36Cl2N6O/c1-6-35(7-2)14-9-8-13-30-23-16-22-18(17-31-23)15-19(24-20(28)11-10-12-21(24)29)25(32-22)33-26(36)34-27(3,4)5/h10-12,15-17H,6-9,13-14H2,1-5H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 480n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6164
PNG
(1,6-naphthyridine 33 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl |(2.8,-4.2,;3.88,-3.12,;3.88,-1.58,;5.22,-.81,;6.55,-1.58,;5.22,.73,;3.88,1.5,;2.55,.73,;1.22,1.5,;-.12,.73,;-1.45,1.5,;-2.78,.73,;-4.27,1.13,;-5.36,.04,;-6.85,.44,;-7.94,-.65,;-9.27,.12,;-10.6,-.65,;-10.6,-2.19,;-11.94,-2.96,;-9.27,-2.96,;-7.94,-2.19,;-1.45,3.05,;-.12,3.82,;1.22,3.05,;2.55,3.82,;3.88,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C25H31Cl2N7O/c1-3-28-25(35)32-24-18(23-19(26)6-4-7-20(23)27)14-17-16-30-22(15-21(17)31-24)29-8-5-9-34-12-10-33(2)11-13-34/h4,6-7,14-16H,3,5,8-13H2,1-2H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 540n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6165
PNG
(1,6-naphthyridine 34 | 3-tert-butyl-1-[3-(2,6-dich...)
Show SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-11.94,-2.96,;-10.6,-2.19,;-10.6,-.65,;-9.27,.12,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;5.22,-.81,;6.55,-1.58,;3.88,-1.58,;3.88,-3.12,;2.55,-3.89,;5.22,-3.89,;3.88,-4.66,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,;-7.94,-2.19,;-9.27,-2.96,)|
Show InChI InChI=1S/C27H35Cl2N7O/c1-27(2,3)34-26(37)33-25-19(24-20(28)7-5-8-21(24)29)15-18-17-31-23(16-22(18)32-25)30-9-6-10-36-13-11-35(4)12-14-36/h5,7-8,15-17H,6,9-14H2,1-4H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 620n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6171
PNG
(1,6-naphthyridine 40 | N-[5-(Benzyloxy)pentyl]-N-[...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C35H43N5O5/c1-24(41)40(15-11-8-12-16-45-23-25-13-9-7-10-14-25)32-21-31-27(22-36-32)19-30(26-17-28(43-5)20-29(18-26)44-6)33(37-31)38-34(42)39-35(2,3)4/h7,9-10,13-14,17-22H,8,11-12,15-16,23H2,1-6H3,(H2,37,38,39,42)
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n/an/a 650n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6170
PNG
(1,6-naphthyridine 39 | N-[4-(Benzyloxy)butyl]-N-[2...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C34H41N5O5/c1-23(40)39(14-10-11-15-44-22-24-12-8-7-9-13-24)31-20-30-26(21-35-31)18-29(25-16-27(42-5)19-28(17-25)43-6)32(36-30)37-33(41)38-34(2,3)4/h7-9,12-13,16-21H,10-11,14-15,22H2,1-6H3,(H2,36,37,38,41)
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n/an/a 670n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6175
PNG
(1,6-naphthyridine 41 | 1-(7-{[3-(benzyloxy)propyl]...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C31H37N5O4/c1-31(2,3)36-30(37)35-29-26(22-14-24(38-4)17-25(15-22)39-5)16-23-19-33-28(18-27(23)34-29)32-12-9-13-40-20-21-10-7-6-8-11-21/h6-8,10-11,14-19H,9,12-13,20H2,1-5H3,(H,32,33)(H2,34,35,36,37)
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n/an/a 910n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6176
PNG
(1,6-naphthyridine 42 | 1-(7-{[4-(benzyloxy)butyl]a...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C32H39N5O4/c1-32(2,3)37-31(38)36-30-27(23-15-25(39-4)18-26(16-23)40-5)17-24-20-34-29(19-28(24)35-30)33-13-9-10-14-41-21-22-11-7-6-8-12-22/h6-8,11-12,15-20H,9-10,13-14,21H2,1-5H3,(H,33,34)(H2,35,36,37,38)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6166
PNG
(1,6-naphthyridine 35 | 3-(2,6-Dichlorophenyl)-N7-[...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1c(Cl)cccc1Cl |(-11.31,1.64,;-9.82,1.24,;-9.42,-.25,;-10.51,-1.34,;-12,-.94,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C22H27Cl2N5/c1-3-29(4-2)11-6-5-10-26-20-13-19-15(14-27-20)12-16(22(25)28-19)21-17(23)8-7-9-18(21)24/h7-9,12-14H,3-6,10-11H2,1-2H3,(H2,25,28)(H,26,27)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6159
PNG
(1,6-naphthyridine 28 | 3-tert-butyl-1-(7-{[3-(4-me...)
Show SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H37N7O/c1-27(2,3)32-26(35)31-25-22(20-9-6-5-7-10-20)17-21-19-29-24(18-23(21)30-25)28-11-8-12-34-15-13-33(4)14-16-34/h5-7,9-10,17-19H,8,11-16H2,1-4H3,(H,28,29)(H2,30,31,32,35)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6182
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 49 | N-[4-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C34H43N5O5/c1-23(40)39(14-10-11-15-44-22-24-12-8-7-9-13-24)31-20-30-26(21-35-31)18-29(25-16-27(42-5)19-28(17-25)43-6)32(36-30)37-33(41)38-34(2,3)4/h7-9,12-13,16-17,19-21,29H,10-11,14-15,18,22H2,1-6H3,(H2,36,37,38,41)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6161
PNG
(1,6-naphthyridine 30 | 7-N-[4-(diethylamino)butyl]...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C22H29N5/c1-3-27(4-2)13-9-8-12-24-21-15-20-18(16-25-21)14-19(22(23)26-20)17-10-6-5-7-11-17/h5-7,10-11,14-16H,3-4,8-9,12-13H2,1-2H3,(H2,23,26)(H,24,25)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6169
PNG
(1,6-naphthyridine 38 | N-[3-(Benzyloxy)propyl]-N-[...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C33H39N5O5/c1-22(39)38(13-10-14-43-21-23-11-8-7-9-12-23)30-19-29-25(20-34-30)17-28(24-15-26(41-5)18-27(16-24)42-6)31(35-29)36-32(40)37-33(2,3)4/h7-9,11-12,15-20H,10,13-14,21H2,1-6H3,(H2,35,36,37,40)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6158
PNG
(1,6-naphthyridine 27 | 7-N-[3-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CCCNc2cc3nc(N)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C22H28N6/c1-27-10-12-28(13-11-27)9-5-8-24-21-15-20-18(16-25-21)14-19(22(23)26-20)17-6-3-2-4-7-17/h2-4,6-7,14-16H,5,8-13H2,1H3,(H2,23,26)(H,24,25)
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6163
PNG
(1,6-naphthyridine 32 | 3-(2,6-dichlorophenyl)-7-N-...)
Show SMILES CN1CCN(CCCNc2cc3nc(N)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-11.94,-2.96,;-10.6,-2.19,;-10.6,-.65,;-9.27,.12,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,;-7.94,-2.19,;-9.27,-2.96,)|
Show InChI InChI=1S/C22H26Cl2N6/c1-29-8-10-30(11-9-29)7-3-6-26-20-13-19-15(14-27-20)12-16(22(25)28-19)21-17(23)4-2-5-18(21)24/h2,4-5,12-14H,3,6-11H2,1H3,(H2,25,28)(H,26,27)
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6172
PNG
(1,6-naphthyridine 44 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCO)C(C)=O
Show InChI InChI=1S/C26H33N5O5/c1-16(33)31(8-7-9-32)23-14-22-18(15-27-23)12-21(17-10-19(35-5)13-20(11-17)36-6)24(28-22)29-25(34)30-26(2,3)4/h10-15,32H,7-9H2,1-6H3,(H2,28,29,30,34)
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6158
PNG
(1,6-naphthyridine 27 | 7-N-[3-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CCCNc2cc3nc(N)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C22H28N6/c1-27-10-12-28(13-11-27)9-5-8-24-21-15-20-18(16-25-21)14-19(22(23)26-20)17-6-3-2-4-7-17/h2-4,6-7,14-16H,5,8-13H2,1H3,(H2,23,26)(H,24,25)
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6154
PNG
(1,6-naphthyridine 23 | 3-tert-butyl-1-(7-{[4-(diet...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C29H42N6O3/c1-8-35(9-2)13-11-10-12-30-26-18-25-21(19-31-26)16-24(20-14-22(37-6)17-23(15-20)38-7)27(32-25)33-28(36)34-29(3,4)5/h14-19H,8-13H2,1-7H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6158
PNG
(1,6-naphthyridine 27 | 7-N-[3-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CCCNc2cc3nc(N)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C22H28N6/c1-27-10-12-28(13-11-27)9-5-8-24-21-15-20-18(16-25-21)14-19(22(23)26-20)17-6-3-2-4-7-17/h2-4,6-7,14-16H,5,8-13H2,1H3,(H2,23,26)(H,24,25)
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6177
PNG
(1,6-naphthyridine 43 | 1-(7-{[5-(benzyloxy)pentyl]...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C33H41N5O4/c1-33(2,3)38-32(39)37-31-28(24-16-26(40-4)19-27(17-24)41-5)18-25-21-35-30(20-29(25)36-31)34-14-10-7-11-15-42-22-23-12-8-6-9-13-23/h6,8-9,12-13,16-21H,7,10-11,14-15,22H2,1-5H3,(H,34,35)(H2,36,37,38,39)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6151
PNG
(1,6-naphthyridine 20 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H43N7O3/c1-30(2,3)35-29(38)34-28-25(21-15-23(39-5)18-24(16-21)40-6)17-22-20-32-27(19-26(22)33-28)31-9-7-8-10-37-13-11-36(4)12-14-37/h15-20H,7-14H2,1-6H3,(H,31,32)(H2,33,34,35,38)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6157
PNG
(1,6-naphthyridine 26 | 3-tert-butyl-1-(7-{[5-(diet...)
Show SMILES CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C30H44N6O3/c1-8-36(9-2)14-12-10-11-13-31-27-19-26-22(20-32-27)17-25(21-15-23(38-6)18-24(16-21)39-7)28(33-26)34-29(37)35-30(3,4)5/h15-20H,8-14H2,1-7H3,(H,31,32)(H2,33,34,35,37)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6161
PNG
(1,6-naphthyridine 30 | 7-N-[4-(diethylamino)butyl]...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C22H29N5/c1-3-27(4-2)13-9-8-12-24-21-15-20-18(16-25-21)14-19(22(23)26-20)17-10-6-5-7-11-17/h5-7,10-11,14-16H,3-4,8-9,12-13H2,1-2H3,(H2,23,26)(H,24,25)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6166
PNG
(1,6-naphthyridine 35 | 3-(2,6-Dichlorophenyl)-N7-[...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1c(Cl)cccc1Cl |(-11.31,1.64,;-9.82,1.24,;-9.42,-.25,;-10.51,-1.34,;-12,-.94,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,)|
Show InChI InChI=1S/C22H27Cl2N5/c1-3-29(4-2)11-6-5-10-26-20-13-19-15(14-27-20)12-16(22(25)28-19)21-17(23)8-7-9-18(21)24/h7-9,12-14H,3-6,10-11H2,1-2H3,(H2,25,28)(H,26,27)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6151
PNG
(1,6-naphthyridine 20 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H43N7O3/c1-30(2,3)35-29(38)34-28-25(21-15-23(39-5)18-24(16-21)40-6)17-22-20-32-27(19-26(22)33-28)31-9-7-8-10-37-13-11-36(4)12-14-37/h15-20H,7-14H2,1-6H3,(H,31,32)(H2,33,34,35,38)
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6154
PNG
(1,6-naphthyridine 23 | 3-tert-butyl-1-(7-{[4-(diet...)
Show SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C29H42N6O3/c1-8-35(9-2)13-11-10-12-30-26-18-25-21(19-31-26)16-24(20-14-22(37-6)17-23(15-20)38-7)27(32-25)33-28(36)34-29(3,4)5/h14-19H,8-13H2,1-7H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 4.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6163
PNG
(1,6-naphthyridine 32 | 3-(2,6-dichlorophenyl)-7-N-...)
Show SMILES CN1CCN(CCCNc2cc3nc(N)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-11.94,-2.96,;-10.6,-2.19,;-10.6,-.65,;-9.27,.12,;-7.94,-.65,;-6.85,.44,;-5.36,.04,;-4.27,1.13,;-2.78,.73,;-1.45,1.5,;-.12,.73,;1.22,1.5,;2.55,.73,;3.88,1.5,;5.22,.73,;3.88,3.05,;2.55,3.82,;1.22,3.05,;-.12,3.82,;-1.45,3.05,;5.22,3.82,;6.52,3,;6.47,1.46,;7.88,3.72,;7.94,5.26,;6.63,6.08,;5.27,5.35,;3.97,6.17,;-7.94,-2.19,;-9.27,-2.96,)|
Show InChI InChI=1S/C22H26Cl2N6/c1-29-8-10-30(11-9-29)7-3-6-26-20-13-19-15(14-27-20)12-16(22(25)28-19)21-17(23)4-2-5-18(21)24/h2,4-5,12-14H,3,6-11H2,1H3,(H2,25,28)(H,26,27)
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6157
PNG
(1,6-naphthyridine 26 | 3-tert-butyl-1-(7-{[5-(diet...)
Show SMILES CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C30H44N6O3/c1-8-36(9-2)14-12-10-11-13-31-27-19-26-22(20-32-27)17-25(21-15-23(38-6)18-24(16-21)39-7)28(33-26)34-29(37)35-30(3,4)5/h15-20H,8-14H2,1-7H3,(H,31,32)(H2,33,34,35,37)
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6170
PNG
(1,6-naphthyridine 39 | N-[4-(Benzyloxy)butyl]-N-[2...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C34H41N5O5/c1-23(40)39(14-10-11-15-44-22-24-12-8-7-9-13-24)31-20-30-26(21-35-31)18-29(25-16-27(42-5)19-28(17-25)43-6)32(36-30)37-33(41)38-34(2,3)4/h7-9,12-13,16-21H,10-11,14-15,22H2,1-6H3,(H2,36,37,38,41)
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6156
PNG
(1,6-naphthyridine 25 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C31H45N7O3/c1-31(2,3)36-30(39)35-29-26(22-16-24(40-5)19-25(17-22)41-6)18-23-21-33-28(20-27(23)34-29)32-10-8-7-9-11-38-14-12-37(4)13-15-38/h16-21H,7-15H2,1-6H3,(H,32,33)(H2,34,35,36,39)
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n/an/a 6.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6153
PNG
(1,6-naphthyridine 22 | 1-(7-{[4-(diethylamino)buty...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H38N6O3/c1-6-28-27(34)32-26-23(19-13-21(35-4)16-22(14-19)36-5)15-20-18-30-25(17-24(20)31-26)29-11-9-10-12-33(7-2)8-3/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6184
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 51 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCO)C(C)=O |c:20|
Show InChI InChI=1S/C26H35N5O5/c1-16(33)31(8-7-9-32)23-14-22-18(15-27-23)12-21(17-10-19(35-5)13-20(11-17)36-6)24(28-22)29-25(34)30-26(2,3)4/h10-11,13-15,21,32H,7-9,12H2,1-6H3,(H2,28,29,30,34)
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n/an/a 6.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6160
PNG
(1,6-naphthyridine 29 | 2-N,7-N-bis[3-(4-methylpipe...)
Show SMILES CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C30H44N8/c1-35-14-18-37(19-15-35)12-6-10-31-29-23-28-26(24-33-29)22-27(25-8-4-3-5-9-25)30(34-28)32-11-7-13-38-20-16-36(2)17-21-38/h3-5,8-9,22-24H,6-7,10-21H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 6.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6153
PNG
(1,6-naphthyridine 22 | 1-(7-{[4-(diethylamino)buty...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H38N6O3/c1-6-28-27(34)32-26-23(19-13-21(35-4)16-22(14-19)36-5)15-20-18-30-25(17-24(20)31-26)29-11-9-10-12-33(7-2)8-3/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6161
PNG
(1,6-naphthyridine 30 | 7-N-[4-(diethylamino)butyl]...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C22H29N5/c1-3-27(4-2)13-9-8-12-24-21-15-20-18(16-25-21)14-19(22(23)26-20)17-10-6-5-7-11-17/h5-7,10-11,14-16H,3-4,8-9,12-13H2,1-2H3,(H2,23,26)(H,24,25)
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n/an/a 7.30E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6174
PNG
(1,6-naphthyridine 46 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCCO)C(C)=O
Show InChI InChI=1S/C28H37N5O5/c1-18(35)33(10-8-7-9-11-34)25-16-24-20(17-29-25)14-23(19-12-21(37-5)15-22(13-19)38-6)26(30-24)31-27(36)32-28(2,3)4/h12-17,34H,7-11H2,1-6H3,(H2,30,31,32,36)
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n/an/a 7.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6160
PNG
(1,6-naphthyridine 29 | 2-N,7-N-bis[3-(4-methylpipe...)
Show SMILES CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C30H44N8/c1-35-14-18-37(19-15-35)12-6-10-31-29-23-28-26(24-33-29)22-27(25-8-4-3-5-9-25)30(34-28)32-11-7-13-38-20-16-36(2)17-21-38/h3-5,8-9,22-24H,6-7,10-21H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 8.70E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6158
PNG
(1,6-naphthyridine 27 | 7-N-[3-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CCCNc2cc3nc(N)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C22H28N6/c1-27-10-12-28(13-11-27)9-5-8-24-21-15-20-18(16-25-21)14-19(22(23)26-20)17-6-3-2-4-7-17/h2-4,6-7,14-16H,5,8-13H2,1H3,(H2,23,26)(H,24,25)
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n/an/a 8.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6148
PNG
(1,6-naphthyridine 17 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H41N7O3/c1-29(2,3)34-28(37)33-27-24(20-14-22(38-5)17-23(15-20)39-6)16-21-19-31-26(18-25(21)32-27)30-8-7-9-36-12-10-35(4)11-13-36/h14-19H,7-13H2,1-6H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 9.10E+3n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6185
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 52 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCO)C(C)=O |c:20|
Show InChI InChI=1S/C27H37N5O5/c1-17(34)32(9-7-8-10-33)24-15-23-19(16-28-24)13-22(18-11-20(36-5)14-21(12-18)37-6)25(29-23)30-26(35)31-27(2,3)4/h11-12,14-16,22,33H,7-10,13H2,1-6H3,(H2,29,30,31,35)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6180
PNG
(1,6-naphthyridine 77 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C26H35N5O4/c1-26(2,3)31-25(33)30-24-21(17-11-19(34-4)14-20(12-17)35-5)13-18-16-28-23(15-22(18)29-24)27-9-7-6-8-10-32/h11-16,32H,6-10H2,1-5H3,(H,27,28)(H2,29,30,31,33)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6171
PNG
(1,6-naphthyridine 40 | N-[5-(Benzyloxy)pentyl]-N-[...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C35H43N5O5/c1-24(41)40(15-11-8-12-16-45-23-25-13-9-7-10-14-25)32-21-31-27(22-36-32)19-30(26-17-28(43-5)20-29(18-26)44-6)33(37-31)38-34(42)39-35(2,3)4/h7,9-10,13-14,17-22H,8,11-12,15-16,23H2,1-6H3,(H2,37,38,39,42)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6161
PNG
(1,6-naphthyridine 30 | 7-N-[4-(diethylamino)butyl]...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C22H29N5/c1-3-27(4-2)13-9-8-12-24-21-15-20-18(16-25-21)14-19(22(23)26-20)17-10-6-5-7-11-17/h5-7,10-11,14-16H,3-4,8-9,12-13H2,1-2H3,(H2,23,26)(H,24,25)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6160
PNG
(1,6-naphthyridine 29 | 2-N,7-N-bis[3-(4-methylpipe...)
Show SMILES CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C30H44N8/c1-35-14-18-37(19-15-35)12-6-10-31-29-23-28-26(24-33-29)22-27(25-8-4-3-5-9-25)30(34-28)32-11-7-13-38-20-16-36(2)17-21-38/h3-5,8-9,22-24H,6-7,10-21H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6173
PNG
(1,6-naphthyridine 45 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCO)C(C)=O
Show InChI InChI=1S/C27H35N5O5/c1-17(34)32(9-7-8-10-33)24-15-23-19(16-28-24)13-22(18-11-20(36-5)14-21(12-18)37-6)25(29-23)30-26(35)31-27(2,3)4/h11-16,33H,7-10H2,1-6H3,(H2,29,30,31,35)
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6147
PNG
(1,6-naphthyridine 16 | 1-[3-(3,5-dimethoxyphenyl)-...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H37N7O3/c1-5-28-27(35)32-26-23(19-13-21(36-3)16-22(14-19)37-4)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-11-9-33(2)10-12-34/h13-18H,5-12H2,1-4H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 1.40E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6182
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 49 | N-[4-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C34H43N5O5/c1-23(40)39(14-10-11-15-44-22-24-12-8-7-9-13-24)31-20-30-26(21-35-31)18-29(25-16-27(42-5)19-28(17-25)43-6)32(36-30)37-33(41)38-34(2,3)4/h7-9,12-13,16-17,19-21,29H,10-11,14-15,18,22H2,1-6H3,(H2,36,37,38,41)
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6190
PNG
(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6181
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 48 | N-[3-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C33H41N5O5/c1-22(39)38(13-10-14-43-21-23-11-8-7-9-12-23)30-19-29-25(20-34-30)17-28(24-15-26(41-5)18-27(16-24)42-6)31(35-29)36-32(40)37-33(2,3)4/h7-9,11-12,15-16,18-20,28H,10,13-14,17,21H2,1-6H3,(H2,35,36,37,40)
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6150
PNG
(1,6-naphthyridine 19 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H40N6O4/c1-29(2,3)34-28(36)33-27-24(20-14-22(37-4)17-23(15-20)38-5)16-21-19-31-26(18-25(21)32-27)30-8-6-7-9-35-10-12-39-13-11-35/h14-19H,6-13H2,1-5H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6149
PNG
(1,6-naphthyridine 18 | 3-tert-butyl-1-(7-{[3-(diet...)
Show SMILES CCN(CC)CCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H40N6O3/c1-8-34(9-2)12-10-11-29-25-17-24-20(18-30-25)15-23(19-13-21(36-6)16-22(14-19)37-7)26(31-24)32-27(35)33-28(3,4)5/h13-18H,8-12H2,1-7H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 1.60E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6148
PNG
(1,6-naphthyridine 17 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H41N7O3/c1-29(2,3)34-28(37)33-27-24(20-14-22(38-5)17-23(15-20)39-6)16-21-19-31-26(18-25(21)32-27)30-8-7-9-36-12-10-35(4)11-13-36/h14-19H,7-13H2,1-6H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 1.60E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6155
PNG
(1,6-naphthyridine 24 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H42N6O4/c1-30(2,3)35-29(37)34-28-25(21-15-23(38-4)18-24(16-21)39-5)17-22-20-32-27(19-26(22)33-28)31-9-7-6-8-10-36-11-13-40-14-12-36/h15-20H,6-14H2,1-5H3,(H,31,32)(H2,33,34,35,37)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6149
PNG
(1,6-naphthyridine 18 | 3-tert-butyl-1-(7-{[3-(diet...)
Show SMILES CCN(CC)CCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H40N6O3/c1-8-34(9-2)12-10-11-29-25-17-24-20(18-30-25)15-23(19-13-21(36-6)16-22(14-19)37-7)26(31-24)32-27(35)33-28(3,4)5/h13-18H,8-12H2,1-7H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 1.80E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6186
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 53 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCCO)C(C)=O |c:20|
Show InChI InChI=1S/C28H39N5O5/c1-18(35)33(10-8-7-9-11-34)25-16-24-20(17-29-25)14-23(19-12-21(37-5)15-22(13-19)38-6)26(30-24)31-27(36)32-28(2,3)4/h12-13,15-17,23,34H,7-11,14H2,1-6H3,(H2,30,31,32,36)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6190
PNG
(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6150
PNG
(1,6-naphthyridine 19 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H40N6O4/c1-29(2,3)34-28(36)33-27-24(20-14-22(37-4)17-23(15-20)38-5)16-21-19-31-26(18-25(21)32-27)30-8-6-7-9-35-10-12-39-13-11-35/h14-19H,6-13H2,1-5H3,(H,30,31)(H2,32,33,34,36)
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6189
PNG
(1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimetho...)
Show SMILES CCNC(=O)Nc1nc2nc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H37N7O3/c1-6-27-26(34)32-24-22(18-13-20(35-4)16-21(14-18)36-5)15-19-17-29-25(31-23(19)30-24)28-11-9-10-12-33(7-2)8-3/h13-17H,6-12H2,1-5H3,(H3,27,28,29,30,31,32,34)
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6179
PNG
(1,6-naphthyridine 76 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C25H33N5O4/c1-25(2,3)30-24(32)29-23-20(16-10-18(33-4)13-19(11-16)34-5)12-17-15-27-22(14-21(17)28-23)26-8-6-7-9-31/h10-15,31H,6-9H2,1-5H3,(H,26,27)(H2,28,29,30,32)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6188
PNG
(3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-m...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H40N8O3/c1-28(2,3)34-27(37)33-25-23(19-14-21(38-5)17-22(15-19)39-6)16-20-18-30-26(32-24(20)31-25)29-8-7-9-36-12-10-35(4)11-13-36/h14-18H,7-13H2,1-6H3,(H3,29,30,31,32,33,34,37)
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6152
PNG
(1,6-naphthyridine 21 | 7-N-[4-(diethylamino)butyl]...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C24H33N5O2/c1-5-29(6-2)10-8-7-9-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(30-3)14-20(12-17)31-4/h11-16H,5-10H2,1-4H3,(H2,25,28)(H,26,27)
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6189
PNG
(1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimetho...)
Show SMILES CCNC(=O)Nc1nc2nc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H37N7O3/c1-6-27-26(34)32-24-22(18-13-20(35-4)16-21(14-18)36-5)15-19-17-29-25(31-23(19)30-24)28-11-9-10-12-33(7-2)8-3/h13-17H,6-12H2,1-5H3,(H3,27,28,29,30,31,32,34)
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6156
PNG
(1,6-naphthyridine 25 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C31H45N7O3/c1-31(2,3)36-30(39)35-29-26(22-16-24(40-5)19-25(17-22)41-6)18-23-21-33-28(20-27(23)34-29)32-10-8-7-9-11-38-14-12-37(4)13-15-38/h16-21H,7-15H2,1-6H3,(H,32,33)(H2,34,35,36,39)
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6172
PNG
(1,6-naphthyridine 44 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCO)C(C)=O
Show InChI InChI=1S/C26H33N5O5/c1-16(33)31(8-7-9-32)23-14-22-18(15-27-23)12-21(17-10-19(35-5)13-20(11-17)36-6)24(28-22)29-25(34)30-26(2,3)4/h10-15,32H,7-9H2,1-6H3,(H2,28,29,30,34)
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6147
PNG
(1,6-naphthyridine 16 | 1-[3-(3,5-dimethoxyphenyl)-...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H37N7O3/c1-5-28-27(35)32-26-23(19-13-21(36-3)16-22(14-19)37-4)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-11-9-33(2)10-12-34/h13-18H,5-12H2,1-4H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 3.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6188
PNG
(3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-m...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H40N8O3/c1-28(2,3)34-27(37)33-25-23(19-14-21(38-5)17-22(15-19)39-6)16-20-18-30-26(32-24(20)31-25)29-8-7-9-36-12-10-35(4)11-13-36/h14-18H,7-13H2,1-6H3,(H3,29,30,31,32,33,34,37)
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6178
PNG
(1,6-naphthyridine 75 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H31N5O4/c1-24(2,3)29-23(31)28-22-19(15-9-17(32-4)12-18(10-15)33-5)11-16-14-26-21(13-20(16)27-22)25-7-6-8-30/h9-14,30H,6-8H2,1-5H3,(H,25,26)(H2,27,28,29,31)
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n/an/a 3.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6187
PNG
(1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-methylpiperazi...)
Show SMILES CCNC(=O)Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H36N8O3/c1-5-27-26(35)32-24-22(18-13-20(36-3)16-21(14-18)37-4)15-19-17-29-25(31-23(19)30-24)28-7-6-8-34-11-9-33(2)10-12-34/h13-17H,5-12H2,1-4H3,(H3,27,28,29,30,31,32,35)
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n/an/a 3.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM4618
PNG
(1,6-naphthyridine 14 | 1,6-naphthyridine deriv. 20...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N6O4/c1-28(2,3)33-27(35)32-26-23(19-13-21(36-4)16-22(14-19)37-5)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-9-11-38-12-10-34/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 4.50E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6187
PNG
(1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-methylpiperazi...)
Show SMILES CCNC(=O)Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H36N8O3/c1-5-27-26(35)32-24-22(18-13-20(36-3)16-21(14-18)37-4)15-19-17-29-25(31-23(19)30-24)28-7-6-8-34-11-9-33(2)10-12-34/h13-17H,5-12H2,1-4H3,(H3,27,28,29,30,31,32,35)
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n/an/a 4.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6186
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 53 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCCO)C(C)=O |c:20|
Show InChI InChI=1S/C28H39N5O5/c1-18(35)33(10-8-7-9-11-34)25-16-24-20(17-29-25)14-23(19-12-21(37-5)15-22(13-19)38-6)26(30-24)31-27(36)32-28(2,3)4/h12-13,15-17,23,34H,7-11,14H2,1-6H3,(H2,30,31,32,36)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6160
PNG
(1,6-naphthyridine 29 | 2-N,7-N-bis[3-(4-methylpipe...)
Show SMILES CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1
Show InChI InChI=1S/C30H44N8/c1-35-14-18-37(19-15-35)12-6-10-31-29-23-28-26(24-33-29)22-27(25-8-4-3-5-9-25)30(34-28)32-11-7-13-38-20-16-36(2)17-21-38/h3-5,8-9,22-24H,6-7,10-21H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6171
PNG
(1,6-naphthyridine 40 | N-[5-(Benzyloxy)pentyl]-N-[...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C35H43N5O5/c1-24(41)40(15-11-8-12-16-45-23-25-13-9-7-10-14-25)32-21-31-27(22-36-32)19-30(26-17-28(43-5)20-29(18-26)44-6)33(37-31)38-34(42)39-35(2,3)4/h7,9-10,13-14,17-22H,8,11-12,15-16,23H2,1-6H3,(H2,37,38,39,42)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6172
PNG
(1,6-naphthyridine 44 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCO)C(C)=O
Show InChI InChI=1S/C26H33N5O5/c1-16(33)31(8-7-9-32)23-14-22-18(15-27-23)12-21(17-10-19(35-5)13-20(11-17)36-6)24(28-22)29-25(34)30-26(2,3)4/h10-15,32H,7-9H2,1-6H3,(H2,28,29,30,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6171
PNG
(1,6-naphthyridine 40 | N-[5-(Benzyloxy)pentyl]-N-[...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C35H43N5O5/c1-24(41)40(15-11-8-12-16-45-23-25-13-9-7-10-14-25)32-21-31-27(22-36-32)19-30(26-17-28(43-5)20-29(18-26)44-6)33(37-31)38-34(42)39-35(2,3)4/h7,9-10,13-14,17-22H,8,11-12,15-16,23H2,1-6H3,(H2,37,38,39,42)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6183
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 50 | N-[5-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C35H45N5O5/c1-24(41)40(15-11-8-12-16-45-23-25-13-9-7-10-14-25)32-21-31-27(22-36-32)19-30(26-17-28(43-5)20-29(18-26)44-6)33(37-31)38-34(42)39-35(2,3)4/h7,9-10,13-14,17-18,20-22,30H,8,11-12,15-16,19,23H2,1-6H3,(H2,37,38,39,42)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6181
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 48 | N-[3-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C33H41N5O5/c1-22(39)38(13-10-14-43-21-23-11-8-7-9-12-23)30-19-29-25(20-34-30)17-28(24-15-26(41-5)18-27(16-24)42-6)31(35-29)36-32(40)37-33(2,3)4/h7-9,11-12,15-16,18-20,28H,10,13-14,17,21H2,1-6H3,(H2,35,36,37,40)
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University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6184
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 51 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCO)C(C)=O |c:20|
Show InChI InChI=1S/C26H35N5O5/c1-16(33)31(8-7-9-32)23-14-22-18(15-27-23)12-21(17-10-19(35-5)13-20(11-17)36-6)24(28-22)29-25(34)30-26(2,3)4/h10-11,13-15,21,32H,7-9,12H2,1-6H3,(H2,28,29,30,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6170
PNG
(1,6-naphthyridine 39 | N-[4-(Benzyloxy)butyl]-N-[2...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C34H41N5O5/c1-23(40)39(14-10-11-15-44-22-24-12-8-7-9-13-24)31-20-30-26(21-35-31)18-29(25-16-27(42-5)19-28(17-25)43-6)32(36-30)37-33(41)38-34(2,3)4/h7-9,12-13,16-21H,10-11,14-15,22H2,1-6H3,(H2,36,37,38,41)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6177
PNG
(1,6-naphthyridine 43 | 1-(7-{[5-(benzyloxy)pentyl]...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C33H41N5O4/c1-33(2,3)38-32(39)37-31-28(24-16-26(40-4)19-27(17-24)41-5)18-25-21-35-30(20-29(25)36-31)34-14-10-7-11-15-42-22-23-12-8-6-9-13-23/h6,8-9,12-13,16-21H,7,10-11,14-15,22H2,1-5H3,(H,34,35)(H2,36,37,38,39)
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University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6185
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 52 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCO)C(C)=O |c:20|
Show InChI InChI=1S/C27H37N5O5/c1-17(34)32(9-7-8-10-33)24-15-23-19(16-28-24)13-22(18-11-20(36-5)14-21(12-18)37-6)25(29-23)30-26(35)31-27(2,3)4/h11-12,14-16,22,33H,7-10,13H2,1-6H3,(H2,29,30,31,35)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6186
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 53 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCCO)C(C)=O |c:20|
Show InChI InChI=1S/C28H39N5O5/c1-18(35)33(10-8-7-9-11-34)25-16-24-20(17-29-25)14-23(19-12-21(37-5)15-22(13-19)38-6)26(30-24)31-27(36)32-28(2,3)4/h12-13,15-17,23,34H,7-11,14H2,1-6H3,(H2,30,31,32,36)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6191
PNG
(3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-[(3-hydr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCO)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C23H30N6O4/c1-23(2,3)29-22(31)28-20-18(14-9-16(32-4)12-17(10-14)33-5)11-15-13-25-21(24-7-6-8-30)27-19(15)26-20/h9-13,30H,6-8H2,1-5H3,(H3,24,25,26,27,28,29,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6169
PNG
(1,6-naphthyridine 38 | N-[3-(Benzyloxy)propyl]-N-[...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C33H39N5O5/c1-22(39)38(13-10-14-43-21-23-11-8-7-9-12-23)30-19-29-25(20-34-30)17-28(24-15-26(41-5)18-27(16-24)42-6)31(35-29)36-32(40)37-33(2,3)4/h7-9,11-12,15-20H,10,13-14,21H2,1-6H3,(H2,35,36,37,40)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6174
PNG
(1,6-naphthyridine 46 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCCO)C(C)=O
Show InChI InChI=1S/C28H37N5O5/c1-18(35)33(10-8-7-9-11-34)25-16-24-20(17-29-25)14-23(19-12-21(37-5)15-22(13-19)38-6)26(30-24)31-27(36)32-28(2,3)4/h12-17,34H,7-11H2,1-6H3,(H2,30,31,32,36)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6176
PNG
(1,6-naphthyridine 42 | 1-(7-{[4-(benzyloxy)butyl]a...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C32H39N5O4/c1-32(2,3)37-31(38)36-30-27(23-15-25(39-4)18-26(16-23)40-5)17-24-20-34-29(19-28(24)35-30)33-13-9-10-14-41-21-22-11-7-6-8-12-22/h6-8,11-12,15-20H,9-10,13-14,21H2,1-5H3,(H,33,34)(H2,35,36,37,38)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6184
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 51 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCO)C(C)=O |c:20|
Show InChI InChI=1S/C26H35N5O5/c1-16(33)31(8-7-9-32)23-14-22-18(15-27-23)12-21(17-10-19(35-5)13-20(11-17)36-6)24(28-22)29-25(34)30-26(2,3)4/h10-11,13-15,21,32H,7-9,12H2,1-6H3,(H2,28,29,30,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6183
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 50 | N-[5-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C35H45N5O5/c1-24(41)40(15-11-8-12-16-45-23-25-13-9-7-10-14-25)32-21-31-27(22-36-32)19-30(26-17-28(43-5)20-29(18-26)44-6)33(37-31)38-34(42)39-35(2,3)4/h7,9-10,13-14,17-18,20-22,30H,8,11-12,15-16,19,23H2,1-6H3,(H2,37,38,39,42)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6185
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 52 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCO)C(C)=O |c:20|
Show InChI InChI=1S/C27H37N5O5/c1-17(34)32(9-7-8-10-33)24-15-23-19(16-28-24)13-22(18-11-20(36-5)14-21(12-18)37-6)25(29-23)30-26(35)31-27(2,3)4/h11-12,14-16,22,33H,7-10,13H2,1-6H3,(H2,29,30,31,35)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6173
PNG
(1,6-naphthyridine 45 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCO)C(C)=O
Show InChI InChI=1S/C27H35N5O5/c1-17(34)32(9-7-8-10-33)24-15-23-19(16-28-24)13-22(18-11-20(36-5)14-21(12-18)37-6)25(29-23)30-26(35)31-27(2,3)4/h11-16,33H,7-10H2,1-6H3,(H2,29,30,31,35)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6176
PNG
(1,6-naphthyridine 42 | 1-(7-{[4-(benzyloxy)butyl]a...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C32H39N5O4/c1-32(2,3)37-31(38)36-30-27(23-15-25(39-4)18-26(16-23)40-5)17-24-20-34-29(19-28(24)35-30)33-13-9-10-14-41-21-22-11-7-6-8-12-22/h6-8,11-12,15-20H,9-10,13-14,21H2,1-5H3,(H,33,34)(H2,35,36,37,38)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6181
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 48 | N-[3-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C33H41N5O5/c1-22(39)38(13-10-14-43-21-23-11-8-7-9-12-23)30-19-29-25(20-34-30)17-28(24-15-26(41-5)18-27(16-24)42-6)31(35-29)36-32(40)37-33(2,3)4/h7-9,11-12,15-16,18-20,28H,10,13-14,17,21H2,1-6H3,(H2,35,36,37,40)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6180
PNG
(1,6-naphthyridine 77 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C26H35N5O4/c1-26(2,3)31-25(33)30-24-21(17-11-19(34-4)14-20(12-17)35-5)13-18-16-28-23(15-22(18)29-24)27-9-7-6-8-10-32/h11-16,32H,6-10H2,1-5H3,(H,27,28)(H2,29,30,31,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6172
PNG
(1,6-naphthyridine 44 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCO)C(C)=O
Show InChI InChI=1S/C26H33N5O5/c1-16(33)31(8-7-9-32)23-14-22-18(15-27-23)12-21(17-10-19(35-5)13-20(11-17)36-6)24(28-22)29-25(34)30-26(2,3)4/h10-15,32H,7-9H2,1-6H3,(H2,28,29,30,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6175
PNG
(1,6-naphthyridine 41 | 1-(7-{[3-(benzyloxy)propyl]...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C31H37N5O4/c1-31(2,3)36-30(37)35-29-26(22-14-24(38-4)17-25(15-22)39-5)16-23-19-33-28(18-27(23)34-29)32-12-9-13-40-20-21-10-7-6-8-11-21/h6-8,10-11,14-19H,9,12-13,20H2,1-5H3,(H,32,33)(H2,34,35,36,37)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6183
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 50 | N-[5-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C35H45N5O5/c1-24(41)40(15-11-8-12-16-45-23-25-13-9-7-10-14-25)32-21-31-27(22-36-32)19-30(26-17-28(43-5)20-29(18-26)44-6)33(37-31)38-34(42)39-35(2,3)4/h7,9-10,13-14,17-18,20-22,30H,8,11-12,15-16,19,23H2,1-6H3,(H2,37,38,39,42)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6184
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 51 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCO)C(C)=O |c:20|
Show InChI InChI=1S/C26H35N5O5/c1-16(33)31(8-7-9-32)23-14-22-18(15-27-23)12-21(17-10-19(35-5)13-20(11-17)36-6)24(28-22)29-25(34)30-26(2,3)4/h10-11,13-15,21,32H,7-9,12H2,1-6H3,(H2,28,29,30,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6182
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 49 | N-[4-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C34H43N5O5/c1-23(40)39(14-10-11-15-44-22-24-12-8-7-9-13-24)31-20-30-26(21-35-31)18-29(25-16-27(42-5)19-28(17-25)43-6)32(36-30)37-33(41)38-34(2,3)4/h7-9,12-13,16-17,19-21,29H,10-11,14-15,18,22H2,1-6H3,(H2,36,37,38,41)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4618
PNG
(1,6-naphthyridine 14 | 1,6-naphthyridine deriv. 20...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N6O4/c1-28(2,3)33-27(35)32-26-23(19-13-21(36-4)16-22(14-19)37-5)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-9-11-38-12-10-34/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,31,32,33,35)
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6169
PNG
(1,6-naphthyridine 38 | N-[3-(Benzyloxy)propyl]-N-[...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C33H39N5O5/c1-22(39)38(13-10-14-43-21-23-11-8-7-9-12-23)30-19-29-25(20-34-30)17-28(24-15-26(41-5)18-27(16-24)42-6)31(35-29)36-32(40)37-33(2,3)4/h7-9,11-12,15-20H,10,13-14,21H2,1-6H3,(H2,35,36,37,40)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6177
PNG
(1,6-naphthyridine 43 | 1-(7-{[5-(benzyloxy)pentyl]...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C33H41N5O4/c1-33(2,3)38-32(39)37-31-28(24-16-26(40-4)19-27(17-24)41-5)18-25-21-35-30(20-29(25)36-31)34-14-10-7-11-15-42-22-23-12-8-6-9-13-23/h6,8-9,12-13,16-21H,7,10-11,14-15,22H2,1-5H3,(H,34,35)(H2,36,37,38,39)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6181
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 48 | N-[3-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C33H41N5O5/c1-22(39)38(13-10-14-43-21-23-11-8-7-9-12-23)30-19-29-25(20-34-30)17-28(24-15-26(41-5)18-27(16-24)42-6)31(35-29)36-32(40)37-33(2,3)4/h7-9,11-12,15-16,18-20,28H,10,13-14,17,21H2,1-6H3,(H2,35,36,37,40)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6182
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 49 | N-[4-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C34H43N5O5/c1-23(40)39(14-10-11-15-44-22-24-12-8-7-9-13-24)31-20-30-26(21-35-31)18-29(25-16-27(42-5)19-28(17-25)43-6)32(36-30)37-33(41)38-34(2,3)4/h7-9,12-13,16-17,19-21,29H,10-11,14-15,18,22H2,1-6H3,(H2,36,37,38,41)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6179
PNG
(1,6-naphthyridine 76 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C25H33N5O4/c1-25(2,3)30-24(32)29-23-20(16-10-18(33-4)13-19(11-16)34-5)12-17-15-27-22(14-21(17)28-23)26-8-6-7-9-31/h10-15,31H,6-9H2,1-5H3,(H,26,27)(H2,28,29,30,32)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6175
PNG
(1,6-naphthyridine 41 | 1-(7-{[3-(benzyloxy)propyl]...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCOCc3ccccc3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C31H37N5O4/c1-31(2,3)36-30(37)35-29-26(22-14-24(38-4)17-25(15-22)39-5)16-23-19-33-28(18-27(23)34-29)32-12-9-13-40-20-21-10-7-6-8-11-21/h6-8,10-11,14-19H,9,12-13,20H2,1-5H3,(H,32,33)(H2,34,35,36,37)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6170
PNG
(1,6-naphthyridine 39 | N-[4-(Benzyloxy)butyl]-N-[2...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCOCc1ccccc1)C(C)=O
Show InChI InChI=1S/C34H41N5O5/c1-23(40)39(14-10-11-15-44-22-24-12-8-7-9-13-24)31-20-30-26(21-35-31)18-29(25-16-27(42-5)19-28(17-25)43-6)32(36-30)37-33(41)38-34(2,3)4/h7-9,12-13,16-21H,10-11,14-15,22H2,1-6H3,(H2,36,37,38,41)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6186
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 53 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCCO)C(C)=O |c:20|
Show InChI InChI=1S/C28H39N5O5/c1-18(35)33(10-8-7-9-11-34)25-16-24-20(17-29-25)14-23(19-12-21(37-5)15-22(13-19)38-6)26(30-24)31-27(36)32-28(2,3)4/h12-13,15-17,23,34H,7-11,14H2,1-6H3,(H2,30,31,32,36)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6178
PNG
(1,6-naphthyridine 75 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCO)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H31N5O4/c1-24(2,3)29-23(31)28-22-19(15-9-17(32-4)12-18(10-15)33-5)11-16-14-26-21(13-20(16)27-22)25-7-6-8-30/h9-14,30H,6-8H2,1-5H3,(H,25,26)(H2,27,28,29,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6173
PNG
(1,6-naphthyridine 45 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCO)C(C)=O
Show InChI InChI=1S/C27H35N5O5/c1-17(34)32(9-7-8-10-33)24-15-23-19(16-28-24)13-22(18-11-20(36-5)14-21(12-18)37-6)25(29-23)30-26(35)31-27(2,3)4/h11-16,33H,7-10H2,1-6H3,(H2,29,30,31,35)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6174
PNG
(1,6-naphthyridine 46 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCCO)C(C)=O
Show InChI InChI=1S/C28H37N5O5/c1-18(35)33(10-8-7-9-11-34)25-16-24-20(17-29-25)14-23(19-12-21(37-5)15-22(13-19)38-6)26(30-24)31-27(36)32-28(2,3)4/h12-17,34H,7-11H2,1-6H3,(H2,30,31,32,36)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6173
PNG
(1,6-naphthyridine 45 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCO)C(C)=O
Show InChI InChI=1S/C27H35N5O5/c1-17(34)32(9-7-8-10-33)24-15-23-19(16-28-24)13-22(18-11-20(36-5)14-21(12-18)37-6)25(29-23)30-26(35)31-27(2,3)4/h11-16,33H,7-10H2,1-6H3,(H2,29,30,31,35)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6174
PNG
(1,6-naphthyridine 46 | N-[2-[[(tert-Butylamino)car...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2nc1NC(=O)NC(C)(C)C)N(CCCCCO)C(C)=O
Show InChI InChI=1S/C28H37N5O5/c1-18(35)33(10-8-7-9-11-34)25-16-24-20(17-29-25)14-23(19-12-21(37-5)15-22(13-19)38-6)26(30-24)31-27(36)32-28(2,3)4/h12-17,34H,7-11H2,1-6H3,(H2,30,31,32,36)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6155
PNG
(1,6-naphthyridine 24 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H42N6O4/c1-30(2,3)35-29(37)34-28-25(21-15-23(38-4)18-24(16-21)39-5)17-22-20-32-27(19-26(22)33-28)31-9-7-6-8-10-36-11-13-40-14-12-36/h15-20H,6-14H2,1-5H3,(H,31,32)(H2,33,34,35,37)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6152
PNG
(1,6-naphthyridine 21 | 7-N-[4-(diethylamino)butyl]...)
Show SMILES CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C24H33N5O2/c1-5-29(6-2)10-8-7-9-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(30-3)14-20(12-17)31-4/h11-16H,5-10H2,1-4H3,(H2,25,28)(H,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6185
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 52 | N-[2-[...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCO)C(C)=O |c:20|
Show InChI InChI=1S/C27H37N5O5/c1-17(34)32(9-7-8-10-33)24-15-23-19(16-28-24)13-22(18-11-20(36-5)14-21(12-18)37-6)25(29-23)30-26(35)31-27(2,3)4/h11-12,14-16,22,33H,7-10,13H2,1-6H3,(H2,29,30,31,35)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6146
PNG
(1,6-naphthyridine 15 | 3-(3,5-Dimethoxyphenyl)-N7-...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1N
Show InChI InChI=1S/C24H32N6O2/c1-29-7-9-30(10-8-29)6-4-5-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(31-2)14-20(12-17)32-3/h11-16H,4-10H2,1-3H3,(H2,25,28)(H,26,27)
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n/an/a 5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6146
PNG
(1,6-naphthyridine 15 | 3-(3,5-Dimethoxyphenyl)-N7-...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1N
Show InChI InChI=1S/C24H32N6O2/c1-29-7-9-30(10-8-29)6-4-5-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(31-2)14-20(12-17)32-3/h11-16H,4-10H2,1-3H3,(H2,25,28)(H,26,27)
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM6191
PNG
(3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-[(3-hydr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCO)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C23H30N6O4/c1-23(2,3)29-22(31)28-20-18(14-9-16(32-4)12-17(10-14)33-5)11-15-13-25-21(24-7-6-8-30)27-19(15)26-20/h9-13,30H,6-8H2,1-5H3,(H3,24,25,26,27,28,29,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6183
PNG
(3,4-Dihydro-1,6-naphthyridine analogue 50 | N-[5-(...)
Show SMILES COc1cc(OC)cc(c1)C1Cc2cnc(cc2N=C1NC(=O)NC(C)(C)C)N(CCCCCOCc1ccccc1)C(C)=O |c:20|
Show InChI InChI=1S/C35H45N5O5/c1-24(41)40(15-11-8-12-16-45-23-25-13-9-7-10-14-25)32-21-31-27(22-36-32)19-30(26-17-28(43-5)20-29(18-26)44-6)33(37-31)38-34(42)39-35(2,3)4/h7,9-10,13-14,17-18,20-22,30H,8,11-12,15-16,19,23H2,1-6H3,(H2,37,38,39,42)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%