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PubMed code 16033269

Compile data set for download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6417
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
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n/an/a 63n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6421
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cncn3)c2)c1
Show InChI InChI=1S/C20H19ClN8/c21-16-3-1-4-17(8-16)27-20-12-23-11-19(28-20)15-7-18(10-22-9-15)25-5-2-6-29-14-24-13-26-29/h1,3-4,7-14,25H,2,5-6H2,(H,27,28)
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n/an/a 67n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6419
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-6-1-7-20(11-19)29-23-16-27-15-22(30-23)18-10-21(14-26-13-18)28-9-3-5-17-4-2-8-25-12-17/h1-2,4,6-8,10-16,28H,3,5,9H2,(H,29,30)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6391
PNG
((3-Chloro-phenyl)-{6-[5-(3-pyridin-4-yl-propylamin...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3ccncc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-4-1-5-20(12-19)29-23-16-27-15-22(30-23)18-11-21(14-26-13-18)28-8-2-3-17-6-9-25-10-7-17/h1,4-7,9-16,28H,2-3,8H2,(H,29,30)
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n/an/a 76n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 84n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6420
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1
Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6418
PNG
(N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]a...)
Show SMILES CN(C)CCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H21ClN6/c1-26(2)7-6-23-17-8-14(10-21-11-17)18-12-22-13-19(25-18)24-16-5-3-4-15(20)9-16/h3-5,8-13,23H,6-7H2,1-2H3,(H,24,25)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6408
PNG
((3-Chlorophenyl)-(6-{5-[3-(4-methyl-piperazin-1-yl...)
Show SMILES CN1CCN(CCCNc2cncc(c2)-c2cncc(Nc3cccc(Cl)c3)n2)CC1
Show InChI InChI=1S/C23H28ClN7/c1-30-8-10-31(11-9-30)7-3-6-27-21-12-18(14-25-15-21)22-16-26-17-23(29-22)28-20-5-2-4-19(24)13-20/h2,4-5,12-17,27H,3,6-11H2,1H3,(H,28,29)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6398
PNG
(N-(3-chlorophenyl)-6-(5-{[3-(dimethylamino)propyl]...)
Show SMILES CN(C)CCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C20H23ClN6/c1-27(2)8-4-7-24-18-9-15(11-22-12-18)19-13-23-14-20(26-19)25-17-6-3-5-16(21)10-17/h3,5-6,9-14,24H,4,7-8H2,1-2H3,(H,25,26)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM6421
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cncn3)c2)c1
Show InChI InChI=1S/C20H19ClN8/c21-16-3-1-4-17(8-16)27-20-12-23-11-19(28-20)15-7-18(10-22-9-15)25-5-2-6-29-14-24-13-26-29/h1,3-4,7-14,25H,2,5-6H2,(H,27,28)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6388
PNG
(3-[(5-{6-[(3-fluorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(F)c2)n1
Show InChI InChI=1S/C18H18FN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6409
PNG
(N-(3-chlorophenyl)-6-(5-{[3-(morpholin-4-yl)propyl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCOCC3)c2)c1
Show InChI InChI=1S/C22H25ClN6O/c23-18-3-1-4-19(12-18)27-22-16-25-15-21(28-22)17-11-20(14-24-13-17)26-5-2-6-29-7-9-30-10-8-29/h1,3-4,11-16,26H,2,5-10H2,(H,27,28)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6393
PNG
((3,4-Dichloro-phenyl)-{6-[5-(3-pyridin-4-yl-propyl...)
Show SMILES Clc1ccc(Nc2cncc(n2)-c2cncc(NCCCc3ccncc3)c2)cc1Cl
Show InChI InChI=1S/C23H20Cl2N6/c24-20-4-3-18(11-21(20)25)30-23-15-28-14-22(31-23)17-10-19(13-27-12-17)29-7-1-2-16-5-8-26-9-6-16/h3-6,8-15,29H,1-2,7H2,(H,30,31)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6421
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cncn3)c2)c1
Show InChI InChI=1S/C20H19ClN8/c21-16-3-1-4-17(8-16)27-20-12-23-11-19(28-20)15-7-18(10-22-9-15)25-5-2-6-29-14-24-13-26-29/h1,3-4,7-14,25H,2,5-6H2,(H,27,28)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6407
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1-piperazinyl)propyl]...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCNCC3)c2)c1
Show InChI InChI=1S/C22H26ClN7/c23-18-3-1-4-19(12-18)28-22-16-26-15-21(29-22)17-11-20(14-25-13-17)27-5-2-8-30-9-6-24-7-10-30/h1,3-4,11-16,24,27H,2,5-10H2,(H,28,29)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6423
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-6-fl...)
Show SMILES OCCCNc1cnc(F)c(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H17ClFN5O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H,24,25)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6412
PNG
(N-(3-Chlorophenyl)-6-[5-[[4-(4-pyridinyl)butyl]ami...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCCc3ccncc3)c2)c1
Show InChI InChI=1S/C24H23ClN6/c25-20-5-3-6-21(13-20)30-24-17-28-16-23(31-24)19-12-22(15-27-14-19)29-9-2-1-4-18-7-10-26-11-8-18/h3,5-8,10-17,29H,1-2,4,9H2,(H,30,31)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6397
PNG
(2-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H16ClN5O/c18-13-2-1-3-14(7-13)22-17-11-20-10-16(23-17)12-6-15(9-19-8-12)21-4-5-24/h1-3,6-11,21,24H,4-5H2,(H,22,23)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM6419
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-6-1-7-20(11-19)29-23-16-27-15-22(30-23)18-10-21(14-26-13-18)28-9-3-5-17-4-2-8-25-12-17/h1-2,4,6-8,10-16,28H,3,5,9H2,(H,29,30)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6402
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES COCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H16ClN5O2/c1-26-11-18(25)23-15-5-12(7-20-8-15)16-9-21-10-17(24-16)22-14-4-2-3-13(19)6-14/h2-10H,11H2,1H3,(H,22,24)(H,23,25)
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n/an/a 303n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6419
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-6-1-7-20(11-19)29-23-16-27-15-22(30-23)18-10-21(14-26-13-18)28-9-3-5-17-4-2-8-25-12-17/h1-2,4,6-8,10-16,28H,3,5,9H2,(H,29,30)
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n/an/a 318n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM6420
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1
Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)
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n/an/a 326n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6401
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES OCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H14ClN5O2/c18-12-2-1-3-13(5-12)21-16-9-20-8-15(23-16)11-4-14(7-19-6-11)22-17(25)10-24/h1-9,24H,10H2,(H,21,23)(H,22,25)
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n/an/a 346n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 360n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6411
PNG
(N-(3-Chlorophenyl)-6-[5-[[(tetrahydro-2H-pyran-4-y...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCC3CCOCC3)c2)c1
Show InChI InChI=1S/C21H22ClN5O/c22-17-2-1-3-18(9-17)26-21-14-24-13-20(27-21)16-8-19(12-23-11-16)25-10-15-4-6-28-7-5-15/h1-3,8-9,11-15,25H,4-7,10H2,(H,26,27)
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n/an/a 391n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6410
PNG
((3-Chlorophenyl)-{6-[5-(3-piperidin-1-yl-propylami...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCCCC3)c2)c1
Show InChI InChI=1S/C23H27ClN6/c24-19-6-4-7-20(13-19)28-23-17-26-16-22(29-23)18-12-21(15-25-14-18)27-8-5-11-30-9-2-1-3-10-30/h4,6-7,12-17,27H,1-3,5,8-11H2,(H,28,29)
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n/an/a 399n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 478n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6415
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OC(=O)CCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H18ClN5O2/c20-14-3-1-4-15(8-14)24-18-12-22-11-17(25-18)13-7-16(10-21-9-13)23-6-2-5-19(26)27/h1,3-4,7-12,23H,2,5-6H2,(H,24,25)(H,26,27)
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n/an/a 568n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6403
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES COCCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H18ClN5O2/c1-27-6-5-19(26)24-16-7-13(9-21-10-16)17-11-22-12-18(25-17)23-15-4-2-3-14(20)8-15/h2-4,7-12H,5-6H2,1H3,(H,23,25)(H,24,26)
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n/an/a 593n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6420
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1
Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)
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n/an/a 606n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6422
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCC(=O)N3CCCCC3)c2)c1
Show InChI InChI=1S/C24H27ClN6O/c25-19-6-4-7-20(13-19)29-23-17-27-16-22(30-23)18-12-21(15-26-14-18)28-9-5-8-24(32)31-10-2-1-3-11-31/h4,6-7,12-17,28H,1-3,5,8-11H2,(H,29,30)
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n/an/a 610n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6421
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cncn3)c2)c1
Show InChI InChI=1S/C20H19ClN8/c21-16-3-1-4-17(8-16)27-20-12-23-11-19(28-20)15-7-18(10-22-9-15)25-5-2-6-29-14-24-13-26-29/h1,3-4,7-14,25H,2,5-6H2,(H,27,28)
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n/an/a 725n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6389
PNG
(3-[(5-{6-[(3-methoxyphenyl)amino]pyrazin-2-yl}pyri...)
Show SMILES COc1cccc(Nc2cncc(n2)-c2cncc(NCCCO)c2)c1
Show InChI InChI=1S/C19H21N5O2/c1-26-17-5-2-4-15(9-17)23-19-13-21-12-18(24-19)14-8-16(11-20-10-14)22-6-3-7-25/h2,4-5,8-13,22,25H,3,6-7H2,1H3,(H,23,24)
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n/an/a 740n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6419
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-6-1-7-20(11-19)29-23-16-27-15-22(30-23)18-10-21(14-26-13-18)28-9-3-5-17-4-2-8-25-12-17/h1-2,4,6-8,10-16,28H,3,5,9H2,(H,29,30)
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n/an/a 876n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6392
PNG
((4-Chloro-phenyl)-{6-[5-(3-pyridin-4-yl-propylamin...)
Show SMILES Clc1ccc(Nc2cncc(n2)-c2cncc(NCCCc3ccncc3)c2)cc1
Show InChI InChI=1S/C23H21ClN6/c24-19-3-5-20(6-4-19)29-23-16-27-15-22(30-23)18-12-21(14-26-13-18)28-9-1-2-17-7-10-25-11-8-17/h3-8,10-16,28H,1-2,9H2,(H,29,30)
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n/an/a 1.00E+3n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6390
PNG
(3-[(5-{6-[(2-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2ccccc2Cl)n1
Show InChI InChI=1S/C18H18ClN5O/c19-15-4-1-2-5-16(15)23-18-12-21-11-17(24-18)13-8-14(10-20-9-13)22-6-3-7-25/h1-2,4-5,8-12,22,25H,3,6-7H2,(H,23,24)
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n/an/a 1.01E+3n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6394
PNG
(3-({5-[6-(benzylamino)pyrazin-2-yl]pyridin-3-yl}am...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(NCc2ccccc2)n1
Show InChI InChI=1S/C19H21N5O/c25-8-4-7-22-17-9-16(11-20-12-17)18-13-21-14-19(24-18)23-10-15-5-2-1-3-6-15/h1-3,5-6,9,11-14,22,25H,4,7-8,10H2,(H,23,24)
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n/an/a 1.05E+3n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6396
PNG
(6-(5-aminopyridin-3-yl)-N-(3-chlorophenyl)pyrazin-...)
Show SMILES Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C15H12ClN5/c16-11-2-1-3-13(5-11)20-15-9-19-8-14(21-15)10-4-12(17)7-18-6-10/h1-9H,17H2,(H,20,21)
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n/an/a 1.16E+3n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6425
PNG
(3-[(6-amino-5-{6-[(3-chlorophenyl)amino]pyrazin-2-...)
Show SMILES Nc1ncc(NCCCO)cc1-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H19ClN6O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H2,20,23)(H,24,25)
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n/an/a 1.36E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 1.36E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM6418
PNG
(N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]a...)
Show SMILES CN(C)CCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H21ClN6/c1-26(2)7-6-23-17-8-14(10-21-11-17)18-12-22-13-19(25-18)24-16-5-3-4-15(20)9-16/h3-5,8-13,23H,6-7H2,1-2H3,(H,24,25)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6420
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1
Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6413
PNG
((3-Chloro-phenyl)-{6-[5-(3-phenyl-propylamino)-pyr...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3ccccc3)c2)c1
Show InChI InChI=1S/C24H22ClN5/c25-20-9-4-10-21(13-20)29-24-17-27-16-23(30-24)19-12-22(15-26-14-19)28-11-5-8-18-6-2-1-3-7-18/h1-4,6-7,9-10,12-17,28H,5,8,11H2,(H,29,30)
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n/an/a 2.28E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM6417
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
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n/an/a 2.36E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6400
PNG
(5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-N-(3-hyd...)
Show SMILES OCCCNC(=O)c1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H18ClN5O2/c20-15-3-1-4-16(8-15)24-18-12-22-11-17(25-18)13-7-14(10-21-9-13)19(27)23-5-2-6-26/h1,3-4,7-12,26H,2,5-6H2,(H,23,27)(H,24,25)
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n/an/a 2.38E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6417
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6399
PNG
(5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-N-(2-(di...)
Show SMILES CN(C)CCNC(=O)c1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C20H21ClN6O/c1-27(2)7-6-24-20(28)15-8-14(10-22-11-15)18-12-23-13-19(26-18)25-17-5-3-4-16(21)9-17/h3-5,8-13H,6-7H2,1-2H3,(H,24,28)(H,25,26)
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n/an/a 3.69E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6417
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
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n/an/a 4.02E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6399
PNG
(5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-N-(2-(di...)
Show SMILES CN(C)CCNC(=O)c1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C20H21ClN6O/c1-27(2)7-6-24-20(28)15-8-14(10-22-11-15)18-12-23-13-19(26-18)25-17-5-3-4-16(21)9-17/h3-5,8-13H,6-7H2,1-2H3,(H,24,28)(H,25,26)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6415
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OC(=O)CCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H18ClN5O2/c20-14-3-1-4-15(8-14)24-18-12-22-11-17(25-18)13-7-16(10-21-9-13)23-6-2-5-19(26)27/h1,3-4,7-12,23H,2,5-6H2,(H,24,25)(H,26,27)
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n/an/a 5.22E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6410
PNG
((3-Chlorophenyl)-{6-[5-(3-piperidin-1-yl-propylami...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCCCC3)c2)c1
Show InChI InChI=1S/C23H27ClN6/c24-19-6-4-7-20(13-19)28-23-17-26-16-22(29-23)18-12-21(15-25-14-18)27-8-5-11-30-9-2-1-3-10-30/h4,6-7,12-17,27H,1-3,5,8-11H2,(H,28,29)
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n/an/a 5.39E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6407
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1-piperazinyl)propyl]...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCNCC3)c2)c1
Show InChI InChI=1S/C22H26ClN7/c23-18-3-1-4-19(12-18)28-22-16-26-15-21(29-22)17-11-20(14-25-13-17)27-5-2-8-30-9-6-24-7-10-30/h1,3-4,11-16,24,27H,2,5-10H2,(H,28,29)
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n/an/a 5.62E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM6417
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
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n/an/a 7.40E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6390
PNG
(3-[(5-{6-[(2-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2ccccc2Cl)n1
Show InChI InChI=1S/C18H18ClN5O/c19-15-4-1-2-5-16(15)23-18-12-21-11-17(24-18)13-8-14(10-20-9-13)22-6-3-7-25/h1-2,4-5,8-12,22,25H,3,6-7H2,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6418
PNG
(N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]a...)
Show SMILES CN(C)CCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H21ClN6/c1-26(2)7-6-23-17-8-14(10-21-11-17)18-12-22-13-19(25-18)24-16-5-3-4-15(20)9-16/h3-5,8-13,23H,6-7H2,1-2H3,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6409
PNG
(N-(3-chlorophenyl)-6-(5-{[3-(morpholin-4-yl)propyl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCOCC3)c2)c1
Show InChI InChI=1S/C22H25ClN6O/c23-18-3-1-4-19(12-18)27-22-16-25-15-21(28-22)17-11-20(14-24-13-17)26-5-2-6-29-7-9-30-10-8-29/h1,3-4,11-16,26H,2,5-10H2,(H,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6418
PNG
(N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]a...)
Show SMILES CN(C)CCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H21ClN6/c1-26(2)7-6-23-17-8-14(10-21-11-17)18-12-22-13-19(25-18)24-16-5-3-4-15(20)9-16/h3-5,8-13,23H,6-7H2,1-2H3,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6393
PNG
((3,4-Dichloro-phenyl)-{6-[5-(3-pyridin-4-yl-propyl...)
Show SMILES Clc1ccc(Nc2cncc(n2)-c2cncc(NCCCc3ccncc3)c2)cc1Cl
Show InChI InChI=1S/C23H20Cl2N6/c24-20-4-3-18(11-21(20)25)30-23-15-28-14-22(31-23)17-10-19(13-27-12-17)29-7-1-2-16-5-8-26-9-6-16/h3-6,8-15,29H,1-2,7H2,(H,30,31)
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6418
PNG
(N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]a...)
Show SMILES CN(C)CCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H21ClN6/c1-26(2)7-6-23-17-8-14(10-21-11-17)18-12-22-13-19(25-18)24-16-5-3-4-15(20)9-16/h3-5,8-13,23H,6-7H2,1-2H3,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6420
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1
Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6392
PNG
((4-Chloro-phenyl)-{6-[5-(3-pyridin-4-yl-propylamin...)
Show SMILES Clc1ccc(Nc2cncc(n2)-c2cncc(NCCCc3ccncc3)c2)cc1
Show InChI InChI=1S/C23H21ClN6/c24-19-3-5-20(6-4-19)29-23-16-27-15-22(30-23)18-12-21(14-26-13-18)28-9-1-2-17-7-10-25-11-8-17/h3-8,10-16,28H,1-2,9H2,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6396
PNG
(6-(5-aminopyridin-3-yl)-N-(3-chlorophenyl)pyrazin-...)
Show SMILES Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C15H12ClN5/c16-11-2-1-3-13(5-11)20-15-9-19-8-14(21-15)10-4-12(17)7-18-6-10/h1-9H,17H2,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6395
PNG
(3-({5-[6-(3-chlorophenoxy)pyrazin-2-yl]pyridin-3-y...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Oc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H17ClN4O2/c19-14-3-1-4-16(8-14)25-18-12-21-11-17(23-18)13-7-15(10-20-9-13)22-5-2-6-24/h1,3-4,7-12,22,24H,2,5-6H2
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6404
PNG
(2-(benzyloxy)-N-(5-{6-[(3-chlorophenyl)amino]pyraz...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NC(=O)COCc3ccccc3)c2)c1
Show InChI InChI=1S/C24H20ClN5O2/c25-19-7-4-8-20(10-19)28-23-14-27-13-22(30-23)18-9-21(12-26-11-18)29-24(31)16-32-15-17-5-2-1-3-6-17/h1-14H,15-16H2,(H,28,30)(H,29,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6405
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NC(=O)COc3ccccc3)c2)c1
Show InChI InChI=1S/C23H18ClN5O2/c24-17-5-4-6-18(10-17)27-22-14-26-13-21(29-22)16-9-19(12-25-11-16)28-23(30)15-31-20-7-2-1-3-8-20/h1-14H,15H2,(H,27,29)(H,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6408
PNG
((3-Chlorophenyl)-(6-{5-[3-(4-methyl-piperazin-1-yl...)
Show SMILES CN1CCN(CCCNc2cncc(c2)-c2cncc(Nc3cccc(Cl)c3)n2)CC1
Show InChI InChI=1S/C23H28ClN7/c1-30-8-10-31(11-9-30)7-3-6-27-21-12-18(14-25-15-21)22-16-26-17-23(29-22)28-20-5-2-4-19(24)13-20/h2,4-5,12-17,27H,3,6-11H2,1H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6417
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6419
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-6-1-7-20(11-19)29-23-16-27-15-22(30-23)18-10-21(14-26-13-18)28-9-3-5-17-4-2-8-25-12-17/h1-2,4,6-8,10-16,28H,3,5,9H2,(H,29,30)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6394
PNG
(3-({5-[6-(benzylamino)pyrazin-2-yl]pyridin-3-yl}am...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(NCc2ccccc2)n1
Show InChI InChI=1S/C19H21N5O/c25-8-4-7-22-17-9-16(11-20-12-17)18-13-21-14-19(24-18)23-10-15-5-2-1-3-6-15/h1-3,5-6,9,11-14,22,25H,4,7-8,10H2,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6397
PNG
(2-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H16ClN5O/c18-13-2-1-3-14(7-13)22-17-11-20-10-16(23-17)12-6-15(9-19-8-12)21-4-5-24/h1-3,6-11,21,24H,4-5H2,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6398
PNG
(N-(3-chlorophenyl)-6-(5-{[3-(dimethylamino)propyl]...)
Show SMILES CN(C)CCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C20H23ClN6/c1-27(2)8-4-7-24-18-9-15(11-22-12-18)19-13-23-14-20(26-19)25-17-6-3-5-16(21)10-17/h3,5-6,9-14,24H,4,7-8H2,1-2H3,(H,25,26)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6401
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES OCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H14ClN5O2/c18-12-2-1-3-13(5-12)21-16-9-20-8-15(23-16)11-4-14(7-19-6-11)22-17(25)10-24/h1-9,24H,10H2,(H,21,23)(H,22,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6405
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NC(=O)COc3ccccc3)c2)c1
Show InChI InChI=1S/C23H18ClN5O2/c24-17-5-4-6-18(10-17)27-22-14-26-13-21(29-22)16-9-19(12-25-11-16)28-23(30)15-31-20-7-2-1-3-8-20/h1-14H,15H2,(H,27,29)(H,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6406
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C24H21ClN6O/c1-31(2)21-8-6-16(7-9-21)24(32)29-20-10-17(12-26-13-20)22-14-27-15-23(30-22)28-19-5-3-4-18(25)11-19/h3-15H,1-2H3,(H,28,30)(H,29,32)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6413
PNG
((3-Chloro-phenyl)-{6-[5-(3-phenyl-propylamino)-pyr...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3ccccc3)c2)c1
Show InChI InChI=1S/C24H22ClN5/c25-20-9-4-10-21(13-20)29-24-17-27-16-23(30-24)19-12-22(15-26-14-19)28-11-5-8-18-6-2-1-3-7-18/h1-4,6-7,9-10,12-17,28H,5,8,11H2,(H,29,30)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6424
PNG
(3-[(6-chloro-5-{6-[(3-chlorophenyl)amino]pyrazin-2...)
Show SMILES OCCCNc1cnc(Cl)c(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H17Cl2N5O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H,24,25)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6388
PNG
(3-[(5-{6-[(3-fluorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(F)c2)n1
Show InChI InChI=1S/C18H18FN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6402
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES COCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H16ClN5O2/c1-26-11-18(25)23-15-5-12(7-20-8-15)16-9-21-10-17(24-16)22-14-4-2-3-13(19)6-14/h2-10H,11H2,1H3,(H,22,24)(H,23,25)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM6418
PNG
(N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]a...)
Show SMILES CN(C)CCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H21ClN6/c1-26(2)7-6-23-17-8-14(10-21-11-17)18-12-22-13-19(25-18)24-16-5-3-4-15(20)9-16/h3-5,8-13,23H,6-7H2,1-2H3,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6391
PNG
((3-Chloro-phenyl)-{6-[5-(3-pyridin-4-yl-propylamin...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3ccncc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-4-1-5-20(12-19)29-23-16-27-15-22(30-23)18-11-21(14-26-13-18)28-8-2-3-17-6-9-25-10-7-17/h1,4-7,9-16,28H,2-3,8H2,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6414
PNG
((3-Chloro-phenyl)-{6-[5-(2-phenoxy-ethylamino)-pyr...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCOc3ccccc3)c2)c1
Show InChI InChI=1S/C23H20ClN5O/c24-18-5-4-6-19(12-18)28-23-16-26-15-22(29-23)17-11-20(14-25-13-17)27-9-10-30-21-7-2-1-3-8-21/h1-8,11-16,27H,9-10H2,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6414
PNG
((3-Chloro-phenyl)-{6-[5-(2-phenoxy-ethylamino)-pyr...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCOc3ccccc3)c2)c1
Show InChI InChI=1S/C23H20ClN5O/c24-18-5-4-6-19(12-18)28-23-16-26-15-22(29-23)17-11-20(14-25-13-17)27-9-10-30-21-7-2-1-3-8-21/h1-8,11-16,27H,9-10H2,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6422
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCC(=O)N3CCCCC3)c2)c1
Show InChI InChI=1S/C24H27ClN6O/c25-19-6-4-7-20(13-19)29-23-17-27-16-22(30-23)18-12-21(15-26-14-18)28-9-5-8-24(32)31-10-2-1-3-11-31/h4,6-7,12-17,28H,1-3,5,8-11H2,(H,29,30)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6423
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-6-fl...)
Show SMILES OCCCNc1cnc(F)c(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H17ClFN5O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6424
PNG
(3-[(6-chloro-5-{6-[(3-chlorophenyl)amino]pyrazin-2...)
Show SMILES OCCCNc1cnc(Cl)c(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H17Cl2N5O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H,24,25)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6389
PNG
(3-[(5-{6-[(3-methoxyphenyl)amino]pyrazin-2-yl}pyri...)
Show SMILES COc1cccc(Nc2cncc(n2)-c2cncc(NCCCO)c2)c1
Show InChI InChI=1S/C19H21N5O2/c1-26-17-5-2-4-15(9-17)23-19-13-21-12-18(24-19)14-8-16(11-20-10-14)22-6-3-7-25/h2,4-5,8-13,22,25H,3,6-7H2,1H3,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6395
PNG
(3-({5-[6-(3-chlorophenoxy)pyrazin-2-yl]pyridin-3-y...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Oc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H17ClN4O2/c19-14-3-1-4-16(8-14)25-18-12-21-11-17(23-18)13-7-15(10-20-9-13)22-5-2-6-24/h1,3-4,7-12,22,24H,2,5-6H2
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n/an/a>1.00E+4n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6406
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C24H21ClN6O/c1-31(2)21-8-6-16(7-9-21)24(32)29-20-10-17(12-26-13-20)22-14-27-15-23(30-22)28-19-5-3-4-18(25)11-19/h3-15H,1-2H3,(H,28,30)(H,29,32)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6412
PNG
(N-(3-Chlorophenyl)-6-[5-[[4-(4-pyridinyl)butyl]ami...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCCc3ccncc3)c2)c1
Show InChI InChI=1S/C24H23ClN6/c25-20-5-3-6-21(13-20)30-24-17-28-16-23(31-24)19-12-22(15-27-14-19)29-9-2-1-4-18-7-10-26-11-8-18/h3,5-8,10-17,29H,1-2,4,9H2,(H,30,31)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6425
PNG
(3-[(6-amino-5-{6-[(3-chlorophenyl)amino]pyrazin-2-...)
Show SMILES Nc1ncc(NCCCO)cc1-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H19ClN6O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H2,20,23)(H,24,25)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM6419
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-6-1-7-20(11-19)29-23-16-27-15-22(30-23)18-10-21(14-26-13-18)28-9-3-5-17-4-2-8-25-12-17/h1-2,4,6-8,10-16,28H,3,5,9H2,(H,29,30)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6403
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES COCCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H18ClN5O2/c1-27-6-5-19(26)24-16-7-13(9-21-10-16)17-11-22-12-18(25-17)23-15-4-2-3-14(20)8-15/h2-4,7-12H,5-6H2,1H3,(H,23,25)(H,24,26)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6404
PNG
(2-(benzyloxy)-N-(5-{6-[(3-chlorophenyl)amino]pyraz...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NC(=O)COCc3ccccc3)c2)c1
Show InChI InChI=1S/C24H20ClN5O2/c25-19-7-4-8-20(10-19)28-23-14-27-13-22(30-23)18-9-21(12-26-11-18)29-24(31)16-32-15-17-5-2-1-3-6-17/h1-14H,15-16H2,(H,28,30)(H,29,31)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6411
PNG
(N-(3-Chlorophenyl)-6-[5-[[(tetrahydro-2H-pyran-4-y...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCC3CCOCC3)c2)c1
Show InChI InChI=1S/C21H22ClN5O/c22-17-2-1-3-18(9-17)26-21-14-24-13-20(27-21)16-8-19(12-23-11-16)25-10-15-4-6-28-7-5-15/h1-3,8-9,11-15,25H,4-7,10H2,(H,26,27)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6421
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cncn3)c2)c1
Show InChI InChI=1S/C20H19ClN8/c21-16-3-1-4-17(8-16)27-20-12-23-11-19(28-20)15-7-18(10-22-9-15)25-5-2-6-29-14-24-13-26-29/h1,3-4,7-14,25H,2,5-6H2,(H,27,28)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6400
PNG
(5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-N-(3-hyd...)
Show SMILES OCCCNC(=O)c1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H18ClN5O2/c20-15-3-1-4-16(8-15)24-18-12-22-11-17(25-18)13-7-14(10-21-9-13)19(27)23-5-2-6-26/h1,3-4,7-12,26H,2,5-6H2,(H,23,27)(H,24,25)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%