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PubMed code 16099648

Compile data set for download or QSAR
Found 128 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171770
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-11-7-8-13-15(21)14(10-18-16(13)20-11)17(22)19-9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,19,22)(H,18,20,21)
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30n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171759
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccco1
Show InChI InChI=1S/C15H13N3O3/c1-9-4-5-11-13(19)12(8-16-14(11)18-9)15(20)17-7-10-3-2-6-21-10/h2-6,8H,7H2,1H3,(H,17,20)(H,16,18,19)
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35n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171759
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccco1
Show InChI InChI=1S/C15H13N3O3/c1-9-4-5-11-13(19)12(8-16-14(11)18-9)15(20)17-7-10-3-2-6-21-10/h2-6,8H,7H2,1H3,(H,17,20)(H,16,18,19)
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45n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171770
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-11-7-8-13-15(21)14(10-18-16(13)20-11)17(22)19-9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,19,22)(H,18,20,21)
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50n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171782
PNG
(7-Dimethylamino-4-oxo-1,4-dihydro-[1,8]naphthyridi...)
Show SMILES CN(C)c1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C18H18N4O2/c1-22(2)15-9-8-13-16(23)14(11-19-17(13)21-15)18(24)20-10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,20,24)(H,19,21,23)
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57n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171779
PNG
(7-Chloro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Oc1c(cnc2nc(Cl)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H12ClN3O2/c17-13-7-6-11-14(21)12(9-18-15(11)20-13)16(22)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,22)(H,18,20,21)
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67n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171784
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C17H14N4O4/c1-10-2-7-13-15(22)14(9-18-16(13)20-10)17(23)19-8-11-3-5-12(6-4-11)21(24)25/h2-7,9H,8H2,1H3,(H,19,23)(H,18,20,22)
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99n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171751
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H14FN3O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8H2,1H3,(H,20,23)(H,19,21,22)
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115n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171755
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(NC(=O)c1cnc2nc(C)ccc2c1O)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-11-8-9-14-16(22)15(10-19-17(14)20-11)18(23)21-12(2)13-6-4-3-5-7-13/h3-10,12H,1-2H3,(H,21,23)(H,19,20,22)
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115n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171755
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(NC(=O)c1cnc2nc(C)ccc2c1O)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-11-8-9-14-16(22)15(10-19-17(14)20-11)18(23)21-12(2)13-6-4-3-5-7-13/h3-10,12H,1-2H3,(H,21,23)(H,19,20,22)
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120n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171782
PNG
(7-Dimethylamino-4-oxo-1,4-dihydro-[1,8]naphthyridi...)
Show SMILES CN(C)c1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C18H18N4O2/c1-22(2)15-9-8-13-16(23)14(11-19-17(13)21-15)18(24)20-10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,20,24)(H,19,21,23)
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122n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171753
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-12-7-8-14-16(22)15(11-20-17(14)21-12)18(23)19-10-9-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,19,23)(H,20,21,22)
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140n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171764
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(N)cc1
Show InChI InChI=1S/C17H16N4O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8,18H2,1H3,(H,20,23)(H,19,21,22)
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146n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171753
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-12-7-8-14-16(22)15(11-20-17(14)21-12)18(23)19-10-9-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,19,23)(H,20,21,22)
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150n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171783
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H14ClN3O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8H2,1H3,(H,20,23)(H,19,21,22)
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150n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171766
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C18H17N3O2/c1-11-3-6-13(7-4-11)9-20-18(23)15-10-19-17-14(16(15)22)8-5-12(2)21-17/h3-8,10H,9H2,1-2H3,(H,20,23)(H,19,21,22)
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159n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171769
PNG
(7-Amino-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H14N4O2/c17-13-7-6-11-14(21)12(9-18-15(11)20-13)16(22)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,22)(H3,17,18,20,21)
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160n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171766
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C18H17N3O2/c1-11-3-6-13(7-4-11)9-20-18(23)15-10-19-17-14(16(15)22)8-5-12(2)21-17/h3-8,10H,9H2,1-2H3,(H,20,23)(H,19,21,22)
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185n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171751
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H14FN3O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8H2,1H3,(H,20,23)(H,19,21,22)
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200n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171783
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H14ClN3O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8H2,1H3,(H,20,23)(H,19,21,22)
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210n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171762
PNG
((3-Benzyl-7-methyl-[1,8]naphthyridin-4-yl)-hydrazi...)
Show SMILES Cc1ccc2c(NN)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H16N4/c1-11-7-8-14-15(20-17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9,17H2,1H3,(H,18,19,20)
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220n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171770
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-11-7-8-13-15(21)14(10-18-16(13)20-11)17(22)19-9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,19,22)(H,18,20,21)
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280n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171769
PNG
(7-Amino-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H14N4O2/c17-13-7-6-11-14(21)12(9-18-15(11)20-13)16(22)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,22)(H3,17,18,20,21)
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300n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171759
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccco1
Show InChI InChI=1S/C15H13N3O3/c1-9-4-5-11-13(19)12(8-16-14(11)18-9)15(20)17-7-10-3-2-6-21-10/h2-6,8H,7H2,1H3,(H,17,20)(H,16,18,19)
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300n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171754
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC1CCC(CC1)NC(=O)c1cnc2nc(C)ccc2c1O |(7.36,-8.29,;7.36,-6.75,;6.03,-5.98,;6.03,-4.43,;7.36,-3.66,;8.69,-4.43,;8.69,-5.98,;7.35,-2.12,;6.02,-1.36,;6,.18,;4.67,-2.15,;4.7,-3.69,;3.37,-4.46,;2.03,-3.69,;.68,-4.48,;-.65,-3.71,;-1.98,-4.48,;-.65,-2.17,;.68,-1.38,;2.03,-2.15,;3.34,-1.38,;3.34,.16,)|
Show InChI InChI=1S/C17H21N3O2/c1-10-3-6-12(7-4-10)20-17(22)14-9-18-16-13(15(14)21)8-5-11(2)19-16/h5,8-10,12H,3-4,6-7H2,1-2H3,(H,20,22)(H,18,19,21)
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360n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171754
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC1CCC(CC1)NC(=O)c1cnc2nc(C)ccc2c1O |(7.36,-8.29,;7.36,-6.75,;6.03,-5.98,;6.03,-4.43,;7.36,-3.66,;8.69,-4.43,;8.69,-5.98,;7.35,-2.12,;6.02,-1.36,;6,.18,;4.67,-2.15,;4.7,-3.69,;3.37,-4.46,;2.03,-3.69,;.68,-4.48,;-.65,-3.71,;-1.98,-4.48,;-.65,-2.17,;.68,-1.38,;2.03,-2.15,;3.34,-1.38,;3.34,.16,)|
Show InChI InChI=1S/C17H21N3O2/c1-10-3-6-12(7-4-10)20-17(22)14-9-18-16-13(15(14)21)8-5-11(2)19-16/h5,8-10,12H,3-4,6-7H2,1-2H3,(H,20,22)(H,18,19,21)
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390n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171755
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(NC(=O)c1cnc2nc(C)ccc2c1O)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-11-8-9-14-16(22)15(10-19-17(14)20-11)18(23)21-12(2)13-6-4-3-5-7-13/h3-10,12H,1-2H3,(H,21,23)(H,19,20,22)
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418n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171771
PNG
(7-Amino-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN4O2/c17-10-3-1-9(2-4-10)7-20-16(23)12-8-19-15-11(14(12)22)5-6-13(18)21-15/h1-6,8H,7H2,(H,20,23)(H3,18,19,21,22)
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500n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171771
PNG
(7-Amino-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN4O2/c17-10-3-1-9(2-4-10)7-20-16(23)12-8-19-15-11(14(12)22)5-6-13(18)21-15/h1-6,8H,7H2,(H,20,23)(H3,18,19,21,22)
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540n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171779
PNG
(7-Chloro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Oc1c(cnc2nc(Cl)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H12ClN3O2/c17-13-7-6-11-14(21)12(9-18-15(11)20-13)16(22)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,22)(H,18,20,21)
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586n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171775
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C24H20N4O3/c1-15-7-12-19-21(29)20(14-25-22(19)27-15)24(31)26-13-16-8-10-18(11-9-16)28-23(30)17-5-3-2-4-6-17/h2-12,14H,13H2,1H3,(H,26,31)(H,28,30)(H,25,27,29)
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588n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171770
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-11-7-8-13-15(21)14(10-18-16(13)20-11)17(22)19-9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,19,22)(H,18,20,21)
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630n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171769
PNG
(7-Amino-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H14N4O2/c17-13-7-6-11-14(21)12(9-18-15(11)20-13)16(22)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,22)(H3,17,18,20,21)
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630n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171767
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(C)CCNC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C15H19N3O2/c1-9(2)6-7-16-15(20)12-8-17-14-11(13(12)19)5-4-10(3)18-14/h4-5,8-9H,6-7H2,1-3H3,(H,16,20)(H,17,18,19)
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640n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171768
PNG
(7-Benzylamino-4-oxo-1,4-dihydro-[1,8]naphthyridine...)
Show SMILES Oc1c(cnc2nc(NCc3ccccc3)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H20N4O2/c28-21-18-11-12-20(24-13-16-7-3-1-4-8-16)27-22(18)25-15-19(21)23(29)26-14-17-9-5-2-6-10-17/h1-12,15H,13-14H2,(H,26,29)(H2,24,25,27,28)
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677n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171753
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-12-7-8-14-16(22)15(11-20-17(14)21-12)18(23)19-10-9-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,19,23)(H,20,21,22)
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680n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171755
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(NC(=O)c1cnc2nc(C)ccc2c1O)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-11-8-9-14-16(22)15(10-19-17(14)20-11)18(23)21-12(2)13-6-4-3-5-7-13/h3-10,12H,1-2H3,(H,21,23)(H,19,20,22)
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717n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171762
PNG
((3-Benzyl-7-methyl-[1,8]naphthyridin-4-yl)-hydrazi...)
Show SMILES Cc1ccc2c(NN)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H16N4/c1-11-7-8-14-15(20-17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9,17H2,1H3,(H,18,19,20)
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720n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171753
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-12-7-8-14-16(22)15(11-20-17(14)21-12)18(23)19-10-9-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,19,23)(H,20,21,22)
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730n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171763
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES COc1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C18H17N3O3/c1-11-3-8-14-16(22)15(10-19-17(14)21-11)18(23)20-9-12-4-6-13(24-2)7-5-12/h3-8,10H,9H2,1-2H3,(H,20,23)(H,19,21,22)
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740n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171777
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C16H19N3O2/c1-10-7-8-12-14(20)13(9-17-15(12)18-10)16(21)19-11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,19,21)(H,17,18,20)
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830n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171774
PNG
(CHEMBL198874 | N-Benzyl-2-(7-methyl-4-oxo-1,4-dihy...)
Show SMILES Cc1ccc2c(O)c(CC(=O)NCc3ccccc3)cnc2n1
Show InChI InChI=1S/C18H17N3O2/c1-12-7-8-15-17(23)14(11-20-18(15)21-12)9-16(22)19-10-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,19,22)(H,20,21,23)
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870n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171777
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C16H19N3O2/c1-10-7-8-12-14(20)13(9-17-15(12)18-10)16(21)19-11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,19,21)(H,17,18,20)
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930n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171769
PNG
(7-Amino-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H14N4O2/c17-13-7-6-11-14(21)12(9-18-15(11)20-13)16(22)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,22)(H3,17,18,20,21)
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970n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171772
PNG
(4-Oxo-7-phenethylamino-1,4-dihydro-[1,8]naphthyrid...)
Show SMILES Oc1c(cnc2nc(NCCc3ccccc3)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H22N4O2/c29-22-19-11-12-21(25-14-13-17-7-3-1-4-8-17)28-23(19)26-16-20(22)24(30)27-15-18-9-5-2-6-10-18/h1-12,16H,13-15H2,(H,27,30)(H2,25,26,28,29)
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977n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171760
PNG
(3-(2-Chloro-benzyl)-7-methyl-[1,8]naphthyridin-4-o...)
Show SMILES Cc1ccc2c(O)c(Cc3ccccc3Cl)cnc2n1
Show InChI InChI=1S/C16H13ClN2O/c1-10-6-7-13-15(20)12(9-18-16(13)19-10)8-11-4-2-3-5-14(11)17/h2-7,9H,8H2,1H3,(H,18,19,20)
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980n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171776
PNG
(4-Oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic ...)
Show SMILES Oc1c(cnc2ncccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H13N3O2/c20-14-12-7-4-8-17-15(12)18-10-13(14)16(21)19-9-11-5-2-1-3-6-11/h1-8,10H,9H2,(H,19,21)(H,17,18,20)
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1.17E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171759
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccco1
Show InChI InChI=1S/C15H13N3O3/c1-9-4-5-11-13(19)12(8-16-14(11)18-9)15(20)17-7-10-3-2-6-21-10/h2-6,8H,7H2,1H3,(H,17,20)(H,16,18,19)
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1.35E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171767
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(C)CCNC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C15H19N3O2/c1-9(2)6-7-16-15(20)12-8-17-14-11(13(12)19)5-4-10(3)18-14/h4-5,8-9H,6-7H2,1-3H3,(H,16,20)(H,17,18,19)
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1.43E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171766
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C18H17N3O2/c1-11-3-6-13(7-4-11)9-20-18(23)15-10-19-17-14(16(15)22)8-5-12(2)21-17/h3-8,10H,9H2,1-2H3,(H,20,23)(H,19,21,22)
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1.58E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171783
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H14ClN3O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8H2,1H3,(H,20,23)(H,19,21,22)
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1.63E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171784
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C17H14N4O4/c1-10-2-7-13-15(22)14(9-18-16(13)20-10)17(23)19-8-11-3-5-12(6-4-11)21(24)25/h2-7,9H,8H2,1H3,(H,19,23)(H,18,20,22)
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1.63E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171752
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(=O)N(C(C)=O)c1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C21H20N4O4/c1-12-4-9-17-19(28)18(11-22-20(17)24-12)21(29)23-10-15-5-7-16(8-6-15)25(13(2)26)14(3)27/h4-9,11H,10H2,1-3H3,(H,23,29)(H,22,24,28)
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1.64E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171751
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H14FN3O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8H2,1H3,(H,20,23)(H,19,21,22)
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1.65E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171783
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H14ClN3O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8H2,1H3,(H,20,23)(H,19,21,22)
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1.74E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171765
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CN1CCN(CC1)NC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C15H19N5O2/c1-10-3-4-11-13(21)12(9-16-14(11)17-10)15(22)18-20-7-5-19(2)6-8-20/h3-4,9H,5-8H2,1-2H3,(H,18,22)(H,16,17,21)
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1.75E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171751
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H14FN3O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8H2,1H3,(H,20,23)(H,19,21,22)
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1.77E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171766
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C18H17N3O2/c1-11-3-6-13(7-4-11)9-20-18(23)15-10-19-17-14(16(15)22)8-5-12(2)21-17/h3-8,10H,9H2,1-2H3,(H,20,23)(H,19,21,22)
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2.23E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171763
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES COc1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C18H17N3O3/c1-11-3-8-14-16(22)15(10-19-17(14)21-11)18(23)20-9-12-4-6-13(24-2)7-5-12/h3-8,10H,9H2,1-2H3,(H,20,23)(H,19,21,22)
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2.41E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171776
PNG
(4-Oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic ...)
Show SMILES Oc1c(cnc2ncccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H13N3O2/c20-14-12-7-4-8-17-15(12)18-10-13(14)16(21)19-9-11-5-2-1-3-6-11/h1-8,10H,9H2,(H,19,21)(H,17,18,20)
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2.75E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171764
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(N)cc1
Show InChI InChI=1S/C17H16N4O2/c1-10-2-7-13-15(22)14(9-19-16(13)21-10)17(23)20-8-11-3-5-12(18)6-4-11/h2-7,9H,8,18H2,1H3,(H,20,23)(H,19,21,22)
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2.86E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171765
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CN1CCN(CC1)NC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C15H19N5O2/c1-10-3-4-11-13(21)12(9-16-14(11)17-10)15(22)18-20-7-5-19(2)6-8-20/h3-4,9H,5-8H2,1-2H3,(H,18,22)(H,16,17,21)
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2.87E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171758
PNG
(3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol | CHEMBL1...)
Show SMILES Cc1ccc2c(O)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H14N2O/c1-11-7-8-14-15(19)13(10-17-16(14)18-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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3.33E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171773
PNG
(5-Azido-6-benzyl-2-methyl-[1,8]naphthyridine | CHE...)
Show SMILES Cc1ccc2c(N=[N+]=[N-])c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H13N5/c1-11-7-8-14-15(20-21-17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3
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3.34E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171773
PNG
(5-Azido-6-benzyl-2-methyl-[1,8]naphthyridine | CHE...)
Show SMILES Cc1ccc2c(N=[N+]=[N-])c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H13N5/c1-11-7-8-14-15(20-21-17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3
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3.36E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171781
PNG
(7-Bromo-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Oc1c(cnc2nc(Br)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H12BrN3O2/c17-13-7-6-11-14(21)12(9-18-15(11)20-13)16(22)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,22)(H,18,20,21)
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3.54E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171760
PNG
(3-(2-Chloro-benzyl)-7-methyl-[1,8]naphthyridin-4-o...)
Show SMILES Cc1ccc2c(O)c(Cc3ccccc3Cl)cnc2n1
Show InChI InChI=1S/C16H13ClN2O/c1-10-6-7-13-15(20)12(9-18-16(13)19-10)8-11-4-2-3-5-14(11)17/h2-7,9H,8H2,1H3,(H,18,19,20)
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4.16E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171758
PNG
(3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol | CHEMBL1...)
Show SMILES Cc1ccc2c(O)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H14N2O/c1-11-7-8-14-15(19)13(10-17-16(14)18-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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4.18E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171763
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES COc1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C18H17N3O3/c1-11-3-8-14-16(22)15(10-19-17(14)21-11)18(23)20-9-12-4-6-13(24-2)7-5-12/h3-8,10H,9H2,1-2H3,(H,20,23)(H,19,21,22)
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4.37E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171771
PNG
(7-Amino-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN4O2/c17-10-3-1-9(2-4-10)7-20-16(23)12-8-19-15-11(14(12)22)5-6-13(18)21-15/h1-6,8H,7H2,(H,20,23)(H3,18,19,21,22)
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4.49E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171781
PNG
(7-Bromo-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Oc1c(cnc2nc(Br)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H12BrN3O2/c17-13-7-6-11-14(21)12(9-18-15(11)20-13)16(22)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,22)(H,18,20,21)
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5.32E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171773
PNG
(5-Azido-6-benzyl-2-methyl-[1,8]naphthyridine | CHE...)
Show SMILES Cc1ccc2c(N=[N+]=[N-])c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H13N5/c1-11-7-8-14-15(20-21-17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3
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5.36E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171754
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC1CCC(CC1)NC(=O)c1cnc2nc(C)ccc2c1O |(7.36,-8.29,;7.36,-6.75,;6.03,-5.98,;6.03,-4.43,;7.36,-3.66,;8.69,-4.43,;8.69,-5.98,;7.35,-2.12,;6.02,-1.36,;6,.18,;4.67,-2.15,;4.7,-3.69,;3.37,-4.46,;2.03,-3.69,;.68,-4.48,;-.65,-3.71,;-1.98,-4.48,;-.65,-2.17,;.68,-1.38,;2.03,-2.15,;3.34,-1.38,;3.34,.16,)|
Show InChI InChI=1S/C17H21N3O2/c1-10-3-6-12(7-4-10)20-17(22)14-9-18-16-13(15(14)21)8-5-11(2)19-16/h5,8-10,12H,3-4,6-7H2,1-2H3,(H,20,22)(H,18,19,21)
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5.60E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171754
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC1CCC(CC1)NC(=O)c1cnc2nc(C)ccc2c1O |(7.36,-8.29,;7.36,-6.75,;6.03,-5.98,;6.03,-4.43,;7.36,-3.66,;8.69,-4.43,;8.69,-5.98,;7.35,-2.12,;6.02,-1.36,;6,.18,;4.67,-2.15,;4.7,-3.69,;3.37,-4.46,;2.03,-3.69,;.68,-4.48,;-.65,-3.71,;-1.98,-4.48,;-.65,-2.17,;.68,-1.38,;2.03,-2.15,;3.34,-1.38,;3.34,.16,)|
Show InChI InChI=1S/C17H21N3O2/c1-10-3-6-12(7-4-10)20-17(22)14-9-18-16-13(15(14)21)8-5-11(2)19-16/h5,8-10,12H,3-4,6-7H2,1-2H3,(H,20,22)(H,18,19,21)
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6.00E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171771
PNG
(7-Amino-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-car...)
Show SMILES Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN4O2/c17-10-3-1-9(2-4-10)7-20-16(23)12-8-19-15-11(14(12)22)5-6-13(18)21-15/h1-6,8H,7H2,(H,20,23)(H3,18,19,21,22)
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6.24E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171749
PNG
(3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol | CHE...)
Show SMILES Cc1ccc2c(S)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H14N2S/c1-11-7-8-14-15(19)13(10-17-16(14)18-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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6.33E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171786
PNG
(7-Acetylamino-4-oxo-1,4-dihydro-[1,8]naphthyridine...)
Show SMILES CC(=O)Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C18H16N4O3/c1-11(23)21-15-8-7-13-16(24)14(10-19-17(13)22-15)18(25)20-9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,20,25)(H2,19,21,22,23,24)
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6.78E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171756
PNG
(CHEMBL198769 | N-Cyclohexyl-2-(7-methyl-4-oxo-1,4-...)
Show SMILES Cc1ccc2c(O)c(CC(=O)NC3CCCCC3)cnc2n1
Show InChI InChI=1S/C17H21N3O2/c1-11-7-8-14-16(22)12(10-18-17(14)19-11)9-15(21)20-13-5-3-2-4-6-13/h7-8,10,13H,2-6,9H2,1H3,(H,20,21)(H,18,19,22)
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7.14E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171775
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C24H20N4O3/c1-15-7-12-19-21(29)20(14-25-22(19)27-15)24(31)26-13-16-8-10-18(11-9-16)28-23(30)17-5-3-2-4-6-17/h2-12,14H,13H2,1H3,(H,26,31)(H,28,30)(H,25,27,29)
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7.59E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171761
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NN1CCOCC1
Show InChI InChI=1S/C14H16N4O3/c1-9-2-3-10-12(19)11(8-15-13(10)16-9)14(20)17-18-4-6-21-7-5-18/h2-3,8H,4-7H2,1H3,(H,17,20)(H,15,16,19)
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8.66E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171749
PNG
(3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol | CHE...)
Show SMILES Cc1ccc2c(S)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H14N2S/c1-11-7-8-14-15(19)13(10-17-16(14)18-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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8.72E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171760
PNG
(3-(2-Chloro-benzyl)-7-methyl-[1,8]naphthyridin-4-o...)
Show SMILES Cc1ccc2c(O)c(Cc3ccccc3Cl)cnc2n1
Show InChI InChI=1S/C16H13ClN2O/c1-10-6-7-13-15(20)12(9-18-16(13)19-10)8-11-4-2-3-5-14(11)17/h2-7,9H,8H2,1H3,(H,18,19,20)
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8.73E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171749
PNG
(3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol | CHE...)
Show SMILES Cc1ccc2c(S)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H14N2S/c1-11-7-8-14-15(19)13(10-17-16(14)18-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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9.14E+3n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171757
PNG
((3-Benzyl-7-methyl-[1,8]naphthyridin-4-yl)-cyclohe...)
Show SMILES Cc1ccc2c(NC3CCCCC3)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C22H25N3/c1-16-12-13-20-21(25-19-10-6-3-7-11-19)18(15-23-22(20)24-16)14-17-8-4-2-5-9-17/h2,4-5,8-9,12-13,15,19H,3,6-7,10-11,14H2,1H3,(H,23,24,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171780
PNG
(7-[Bis-(2-hydroxy-ethyl)-amino]-4-oxo-1,4-dihydro-...)
Show SMILES OCCN(CCO)c1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H22N4O4/c25-10-8-24(9-11-26)17-7-6-15-18(27)16(13-21-19(15)23-17)20(28)22-12-14-4-2-1-3-5-14/h1-7,13,25-26H,8-12H2,(H,22,28)(H,21,23,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171778
PNG
(6-Benzyl-5-chloro-2-methyl-[1,8]naphthyridine | CH...)
Show SMILES Cc1ccc2c(Cl)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H13ClN2/c1-11-7-8-14-15(17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171757
PNG
((3-Benzyl-7-methyl-[1,8]naphthyridin-4-yl)-cyclohe...)
Show SMILES Cc1ccc2c(NC3CCCCC3)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C22H25N3/c1-16-12-13-20-21(25-19-10-6-3-7-11-19)18(15-23-22(20)24-16)14-17-8-4-2-5-9-17/h2,4-5,8-9,12-13,15,19H,3,6-7,10-11,14H2,1H3,(H,23,24,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171780
PNG
(7-[Bis-(2-hydroxy-ethyl)-amino]-4-oxo-1,4-dihydro-...)
Show SMILES OCCN(CCO)c1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H22N4O4/c25-10-8-24(9-11-26)17-7-6-15-18(27)16(13-21-19(15)23-17)20(28)22-12-14-4-2-1-3-5-14/h1-7,13,25-26H,8-12H2,(H,22,28)(H,21,23,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171761
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NN1CCOCC1
Show InChI InChI=1S/C14H16N4O3/c1-9-2-3-10-12(19)11(8-15-13(10)16-9)14(20)17-18-4-6-21-7-5-18/h2-3,8H,4-7H2,1H3,(H,17,20)(H,15,16,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171786
PNG
(7-Acetylamino-4-oxo-1,4-dihydro-[1,8]naphthyridine...)
Show SMILES CC(=O)Nc1ccc2c(O)c(cnc2n1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C18H16N4O3/c1-11(23)21-15-8-7-13-16(24)14(10-19-17(13)22-15)18(25)20-9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,20,25)(H2,19,21,22,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171785
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C17H14N2O3/c1-11-7-8-13-15(20)14(9-18-16(13)19-11)17(21)22-10-12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171772
PNG
(4-Oxo-7-phenethylamino-1,4-dihydro-[1,8]naphthyrid...)
Show SMILES Oc1c(cnc2nc(NCCc3ccccc3)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H22N4O2/c29-22-19-11-12-21(25-14-13-17-7-3-1-4-8-17)28-23(19)26-16-20(22)24(30)27-15-18-9-5-2-6-10-18/h1-12,16H,13-15H2,(H,27,30)(H2,25,26,28,29)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171749
PNG
(3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol | CHE...)
Show SMILES Cc1ccc2c(S)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H14N2S/c1-11-7-8-14-15(19)13(10-17-16(14)18-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171787
PNG
(7-Cyclohexylamino-4-oxo-1,4-dihydro-[1,8]naphthyri...)
Show SMILES Oc1c(cnc2nc(NC3CCCCC3)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H24N4O2/c27-20-17-11-12-19(25-16-9-5-2-6-10-16)26-21(17)23-14-18(20)22(28)24-13-15-7-3-1-4-8-15/h1,3-4,7-8,11-12,14,16H,2,5-6,9-10,13H2,(H,24,28)(H2,23,25,26,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171774
PNG
(CHEMBL198874 | N-Benzyl-2-(7-methyl-4-oxo-1,4-dihy...)
Show SMILES Cc1ccc2c(O)c(CC(=O)NCc3ccccc3)cnc2n1
Show InChI InChI=1S/C18H17N3O2/c1-12-7-8-15-17(23)14(11-20-18(15)21-12)9-16(22)19-10-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,19,22)(H,20,21,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171777
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C16H19N3O2/c1-10-7-8-12-14(20)13(9-17-15(12)18-10)16(21)19-11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,19,21)(H,17,18,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM52672
PNG
(4-keto-7-methyl-1H-1,8-naphthyridine-3-carboxylic ...)
Show SMILES CCOC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C12H12N2O3/c1-3-17-12(16)9-6-13-11-8(10(9)15)5-4-7(2)14-11/h4-6H,3H2,1-2H3,(H,13,14,15)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171757
PNG
((3-Benzyl-7-methyl-[1,8]naphthyridin-4-yl)-cyclohe...)
Show SMILES Cc1ccc2c(NC3CCCCC3)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C22H25N3/c1-16-12-13-20-21(25-19-10-6-3-7-11-19)18(15-23-22(20)24-16)14-17-8-4-2-5-9-17/h2,4-5,8-9,12-13,15,19H,3,6-7,10-11,14H2,1H3,(H,23,24,25)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171756
PNG
(CHEMBL198769 | N-Cyclohexyl-2-(7-methyl-4-oxo-1,4-...)
Show SMILES Cc1ccc2c(O)c(CC(=O)NC3CCCCC3)cnc2n1
Show InChI InChI=1S/C17H21N3O2/c1-11-7-8-14-16(22)12(10-18-17(14)19-11)9-15(21)20-13-5-3-2-4-6-13/h7-8,10,13H,2-6,9H2,1H3,(H,20,21)(H,18,19,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171778
PNG
(6-Benzyl-5-chloro-2-methyl-[1,8]naphthyridine | CH...)
Show SMILES Cc1ccc2c(Cl)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H13ClN2/c1-11-7-8-14-15(17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171787
PNG
(7-Cyclohexylamino-4-oxo-1,4-dihydro-[1,8]naphthyri...)
Show SMILES Oc1c(cnc2nc(NC3CCCCC3)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H24N4O2/c27-20-17-11-12-19(25-16-9-5-2-6-10-16)26-21(17)23-14-18(20)22(28)24-13-15-7-3-1-4-8-15/h1,3-4,7-8,11-12,14,16H,2,5-6,9-10,13H2,(H,24,28)(H2,23,25,26,27)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171762
PNG
((3-Benzyl-7-methyl-[1,8]naphthyridin-4-yl)-hydrazi...)
Show SMILES Cc1ccc2c(NN)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H16N4/c1-11-7-8-14-15(20-17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9,17H2,1H3,(H,18,19,20)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171788
PNG
(7-Hydroxy-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-c...)
Show SMILES Oc1c(cnc2[nH]c(=O)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-13-7-6-11-14(21)12(9-17-15(11)19-13)16(22)18-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,18,22)(H2,17,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171752
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(=O)N(C(C)=O)c1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C21H20N4O4/c1-12-4-9-17-19(28)18(11-22-20(17)24-12)21(29)23-10-15-5-7-16(8-6-15)25(13(2)26)14(3)27/h4-9,11H,10H2,1-3H3,(H,23,29)(H,22,24,28)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171757
PNG
((3-Benzyl-7-methyl-[1,8]naphthyridin-4-yl)-cyclohe...)
Show SMILES Cc1ccc2c(NC3CCCCC3)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C22H25N3/c1-16-12-13-20-21(25-19-10-6-3-7-11-19)18(15-23-22(20)24-16)14-17-8-4-2-5-9-17/h2,4-5,8-9,12-13,15,19H,3,6-7,10-11,14H2,1H3,(H,23,24,25)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171765
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CN1CCN(CC1)NC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C15H19N5O2/c1-10-3-4-11-13(21)12(9-16-14(11)17-10)15(22)18-20-7-5-19(2)6-8-20/h3-4,9H,5-8H2,1-2H3,(H,18,22)(H,16,17,21)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171778
PNG
(6-Benzyl-5-chloro-2-methyl-[1,8]naphthyridine | CH...)
Show SMILES Cc1ccc2c(Cl)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H13ClN2/c1-11-7-8-14-15(17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171774
PNG
(CHEMBL198874 | N-Benzyl-2-(7-methyl-4-oxo-1,4-dihy...)
Show SMILES Cc1ccc2c(O)c(CC(=O)NCc3ccccc3)cnc2n1
Show InChI InChI=1S/C18H17N3O2/c1-12-7-8-15-17(23)14(11-20-18(15)21-12)9-16(22)19-10-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,19,22)(H,20,21,23)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171785
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C17H14N2O3/c1-11-7-8-13-15(20)14(9-18-16(13)19-11)17(21)22-10-12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,18,19,20)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171767
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(C)CCNC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C15H19N3O2/c1-9(2)6-7-16-15(20)12-8-17-14-11(13(12)19)5-4-10(3)18-14/h4-5,8-9H,6-7H2,1-3H3,(H,16,20)(H,17,18,19)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171758
PNG
(3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol | CHEMBL1...)
Show SMILES Cc1ccc2c(O)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H14N2O/c1-11-7-8-14-15(19)13(10-17-16(14)18-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171777
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C16H19N3O2/c1-10-7-8-12-14(20)13(9-17-15(12)18-10)16(21)19-11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,19,21)(H,17,18,20)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171756
PNG
(CHEMBL198769 | N-Cyclohexyl-2-(7-methyl-4-oxo-1,4-...)
Show SMILES Cc1ccc2c(O)c(CC(=O)NC3CCCCC3)cnc2n1
Show InChI InChI=1S/C17H21N3O2/c1-11-7-8-14-16(22)12(10-18-17(14)19-11)9-15(21)20-13-5-3-2-4-6-13/h7-8,10,13H,2-6,9H2,1H3,(H,20,21)(H,18,19,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171768
PNG
(7-Benzylamino-4-oxo-1,4-dihydro-[1,8]naphthyridine...)
Show SMILES Oc1c(cnc2nc(NCc3ccccc3)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H20N4O2/c28-21-18-11-12-20(24-13-16-7-3-1-4-8-16)27-22(18)25-15-19(21)23(29)26-14-17-9-5-2-6-10-17/h1-12,15H,13-14H2,(H,26,29)(H2,24,25,27,28)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171788
PNG
(7-Hydroxy-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-c...)
Show SMILES Oc1c(cnc2[nH]c(=O)ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-13-7-6-11-14(21)12(9-17-15(11)19-13)16(22)18-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,18,22)(H2,17,19,20,21)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171763
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES COc1ccc(CNC(=O)c2cnc3nc(C)ccc3c2O)cc1
Show InChI InChI=1S/C18H17N3O3/c1-11-3-8-14-16(22)15(10-19-17(14)21-11)18(23)20-9-12-4-6-13(24-2)7-5-12/h3-8,10H,9H2,1-2H3,(H,20,23)(H,19,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171774
PNG
(CHEMBL198874 | N-Benzyl-2-(7-methyl-4-oxo-1,4-dihy...)
Show SMILES Cc1ccc2c(O)c(CC(=O)NCc3ccccc3)cnc2n1
Show InChI InChI=1S/C18H17N3O2/c1-12-7-8-15-17(23)14(11-20-18(15)21-12)9-16(22)19-10-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,19,22)(H,20,21,23)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171773
PNG
(5-Azido-6-benzyl-2-methyl-[1,8]naphthyridine | CHE...)
Show SMILES Cc1ccc2c(N=[N+]=[N-])c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H13N5/c1-11-7-8-14-15(20-21-17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171767
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CC(C)CCNC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C15H19N3O2/c1-9(2)6-7-16-15(20)12-8-17-14-11(13(12)19)5-4-10(3)18-14/h4-5,8-9H,6-7H2,1-3H3,(H,16,20)(H,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171762
PNG
((3-Benzyl-7-methyl-[1,8]naphthyridin-4-yl)-hydrazi...)
Show SMILES Cc1ccc2c(NN)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H16N4/c1-11-7-8-14-15(20-17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9,17H2,1H3,(H,18,19,20)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of human striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171758
PNG
(3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol | CHEMBL1...)
Show SMILES Cc1ccc2c(O)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H14N2O/c1-11-7-8-14-15(19)13(10-17-16(14)18-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM52672
PNG
(4-keto-7-methyl-1H-1,8-naphthyridine-3-carboxylic ...)
Show SMILES CCOC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C12H12N2O3/c1-3-17-12(16)9-6-13-11-8(10(9)15)5-4-7(2)14-11/h4-6H,3H2,1-2H3,(H,13,14,15)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171756
PNG
(CHEMBL198769 | N-Cyclohexyl-2-(7-methyl-4-oxo-1,4-...)
Show SMILES Cc1ccc2c(O)c(CC(=O)NC3CCCCC3)cnc2n1
Show InChI InChI=1S/C17H21N3O2/c1-11-7-8-14-16(22)12(10-18-17(14)19-11)9-15(21)20-13-5-3-2-4-6-13/h7-8,10,13H,2-6,9H2,1H3,(H,20,21)(H,18,19,22)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171761
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NN1CCOCC1
Show InChI InChI=1S/C14H16N4O3/c1-9-2-3-10-12(19)11(8-15-13(10)16-9)14(20)17-18-4-6-21-7-5-18/h2-3,8H,4-7H2,1H3,(H,17,20)(H,15,16,19)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(BOVINE)
BDBM50171765
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES CN1CCN(CC1)NC(=O)c1cnc2nc(C)ccc2c1O
Show InChI InChI=1S/C15H19N5O2/c1-10-3-4-11-13(21)12(9-16-14(11)17-10)15(22)18-20-7-5-19(2)6-8-20/h3-4,9H,5-8H2,1-2H3,(H,18,22)(H,16,17,21)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171778
PNG
(6-Benzyl-5-chloro-2-methyl-[1,8]naphthyridine | CH...)
Show SMILES Cc1ccc2c(Cl)c(Cc3ccccc3)cnc2n1
Show InChI InChI=1S/C16H13ClN2/c1-11-7-8-14-15(17)13(10-18-16(14)19-11)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50171761
PNG
(7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-ca...)
Show SMILES Cc1ccc2c(O)c(cnc2n1)C(=O)NN1CCOCC1
Show InChI InChI=1S/C14H16N4O3/c1-9-2-3-10-12(19)11(8-15-13(10)16-9)14(20)17-18-4-6-21-7-5-18/h2-3,8H,4-7H2,1H3,(H,17,20)(H,15,16,19)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CHA binding to adenosine A1 receptor of human brain cortical membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50171760
PNG
(3-(2-Chloro-benzyl)-7-methyl-[1,8]naphthyridin-4-o...)
Show SMILES Cc1ccc2c(O)c(Cc3ccccc3Cl)cnc2n1
Show InChI InChI=1S/C16H13ClN2O/c1-10-6-7-13-15(20)12(9-18-16(13)19-10)8-11-4-2-3-5-14(11)17/h2-7,9H,8H2,1H3,(H,18,19,20)
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Dipartimento di Scienze Farmaceutiche

Curated by ChEMBL


Assay Description
Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane


Bioorg Med Chem Lett 15: 4604-10 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.064
BindingDB Entry DOI: 10.7270/Q2QV3M1S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%