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PubMed code 16134949

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50170264
PNG
(CHEMBL361931 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(Cl)c2)cc1
Show InChI InChI=1S/C20H26ClN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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n/an/a 8.40n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20321
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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n/an/a 37n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172566
PNG
(CHEMBL196291 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(I)c2)cc1
Show InChI InChI=1S/C20H26IN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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n/an/a 41n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172563
PNG
(1-(1H-Benzotriazol-5-ylmethyl)-3-(4-tert-butyl-ben...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc3nn[nH]c3c2)cc1
Show InChI InChI=1S/C19H23N5S/c1-19(2,3)15-7-4-13(5-8-15)11-20-18(25)21-12-14-6-9-16-17(10-14)23-24-22-16/h4-10H,11-12H2,1-3H3,(H2,20,21,25)(H,22,23,24)
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n/an/a 50n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20321
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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n/an/a 54n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Concentration required to inhibit [3H]-RTX radioligand binding towards transient receptor potential cation channel (subfamily V, member 1) expressed ...

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50170263
PNG
(CHEMBL189418 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(C[N-]C(=[SH+])NCc2ccc(NS(C)(=O)=O)c(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C20H26N4O4S2/c1-20(2,3)16-8-5-14(6-9-16)12-21-19(29)22-13-15-7-10-17(23-30(4,27)28)18(11-15)24(25)26/h5-11,23H,12-13H2,1-4H3,(H2,21,22,29)
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n/an/a 71n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172578
PNG
(CHEMBL196085 | N-{2-Bromo-4-[3-(4-tert-butyl-benzy...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(Br)c2)cc1
Show InChI InChI=1S/C20H26BrN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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n/an/a 80n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20315
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C20H27N3O2S2/c1-20(2,3)17-9-5-15(6-10-17)13-21-19(26)22-14-16-7-11-18(12-8-16)23-27(4,24)25/h5-12,23H,13-14H2,1-4H3,(H2,21,22,26)
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n/an/a 110n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172590
PNG
(CHEMBL196255 | N-{4-[3-(3,5-Di-tert-butyl-benzyl)-...)
Show SMILES CC(C)(C)c1cc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc(c1)C(C)(C)C
Show InChI InChI=1S/C24H34FN3O2S2/c1-23(2,3)18-10-17(11-19(13-18)24(4,5)6)15-27-22(31)26-14-16-8-9-21(20(25)12-16)28-32(7,29)30/h8-13,28H,14-15H2,1-7H3,(H2,26,27,31)
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n/an/a 200n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172587
PNG
(CHEMBL197770 | N-{4-[3-(4-tert-Butyl-benzyl)-ureid...)
Show SMILES CC(C)(C)c1ccc(CNC(=O)NCc2ccc(NS(C)(=O)=O)c(Cl)c2)cc1
Show InChI InChI=1S/C20H26ClN3O3S/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(25)23-13-15-7-10-18(17(21)11-15)24-28(4,26)27/h5-11,24H,12-13H2,1-4H3,(H2,22,23,25)
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n/an/a 240n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172567
PNG
(CHEMBL197222 | N-{4-[3-(4-tert-Butyl-benzyl)-ureid...)
Show SMILES CC(C)(C)c1ccc(CNC(=O)NCc2ccc(NS(C)(=O)=O)c(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C20H26N4O5S/c1-20(2,3)16-8-5-14(6-9-16)12-21-19(25)22-13-15-7-10-17(23-30(4,28)29)18(11-15)24(26)27/h5-11,23H,12-13H2,1-4H3,(H2,21,22,25)
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n/an/a 240n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172598
PNG
(CHEMBL197781 | N-(4-[({4-tert-Butylbenzyl}aminocar...)
Show SMILES CC(C)(C)c1ccc(CNC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O3S/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(25)23-13-15-7-10-18(17(21)11-15)24-28(4,26)27/h5-11,24H,12-13H2,1-4H3,(H2,22,23,25)
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n/an/a 300n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172595
PNG
(CHEMBL196229 | N-{4-[3-(4-Chloro-benzyl)-thioureid...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=S)NCc2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C16H17ClFN3O2S2/c1-25(22,23)21-15-7-4-12(8-14(15)18)10-20-16(24)19-9-11-2-5-13(17)6-3-11/h2-8,21H,9-10H2,1H3,(H2,19,20,24)
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n/an/a 340n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172581
PNG
(CHEMBL194592 | N-(4-{3-[2-(4-tert-Butyl-phenyl)-et...)
Show SMILES CC(C)(C)c1ccc(CCNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C21H28FN3O2S2/c1-21(2,3)17-8-5-15(6-9-17)11-12-23-20(28)24-14-16-7-10-19(18(22)13-16)25-29(4,26)27/h5-10,13,25H,11-12,14H2,1-4H3,(H2,23,24,28)
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n/an/a 370n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172560
PNG
(CHEMBL382920 | N-{2-Fluoro-4-[3-(4-propyl-benzyl)-...)
Show SMILES CCCc1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C19H24FN3O2S2/c1-3-4-14-5-7-15(8-6-14)12-21-19(26)22-13-16-9-10-18(17(20)11-16)23-27(2,24)25/h5-11,23H,3-4,12-13H2,1-2H3,(H2,21,22,26)
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n/an/a 460n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172582
PNG
(CHEMBL198139 | N-{4-[3-(4-Butyl-benzyl)-thioureido...)
Show SMILES CCCCc1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-3-4-5-15-6-8-16(9-7-15)13-22-20(27)23-14-17-10-11-19(18(21)12-17)24-28(2,25)26/h6-12,24H,3-5,13-14H2,1-2H3,(H2,22,23,27)
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n/an/a 470n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172565
PNG
(CHEMBL198300 | N-{2-Fluoro-4-[3-(4-isopropyl-benzy...)
Show SMILES CC(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C19H24FN3O2S2/c1-13(2)16-7-4-14(5-8-16)11-21-19(26)22-12-15-6-9-18(17(20)10-15)23-27(3,24)25/h4-10,13,23H,11-12H2,1-3H3,(H2,21,22,26)
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n/an/a 520n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172593
PNG
(CHEMBL196281 | N-{4-[3-(4-Bromo-benzyl)-thioureido...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=S)NCc2ccc(Br)cc2)cc1F
Show InChI InChI=1S/C16H17BrFN3O2S2/c1-25(22,23)21-15-7-4-12(8-14(15)18)10-20-16(24)19-9-11-2-5-13(17)6-3-11/h2-8,21H,9-10H2,1H3,(H2,19,20,24)
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n/an/a 570n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172562
PNG
(CHEMBL197350 | N-{2-Fluoro-4-[3-(4-iodo-benzyl)-th...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=S)NCc2ccc(I)cc2)cc1F
Show InChI InChI=1S/C16H17FIN3O2S2/c1-25(22,23)21-15-7-4-12(8-14(15)17)10-20-16(24)19-9-11-2-5-13(18)6-3-11/h2-8,21H,9-10H2,1H3,(H2,19,20,24)
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n/an/a 630n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172586
PNG
(CHEMBL198457 | N-{2-Fluoro-4-[3-(2-methyl-benzyl)-...)
Show SMILES Cc1ccccc1CNC(=S)NCc1ccc(NS(C)(=O)=O)c(F)c1
Show InChI InChI=1S/C17H20FN3O2S2/c1-12-5-3-4-6-14(12)11-20-17(24)19-10-13-7-8-16(15(18)9-13)21-25(2,22)23/h3-9,21H,10-11H2,1-2H3,(H2,19,20,24)
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n/an/a 670n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172575
PNG
(5-[3-(4-tert-Butyl-benzyl)-thioureidomethyl]-2-met...)
Show SMILES COC(=O)c1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C22H29N3O4S2/c1-22(2,3)17-9-6-15(7-10-17)13-23-21(30)24-14-16-8-11-19(25-31(5,27)28)18(12-16)20(26)29-4/h6-12,25H,13-14H2,1-5H3,(H2,23,24,30)
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n/an/a 720n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172596
PNG
(CHEMBL198994 | N-{4-[4-(tert-butyl)benzylamino(1-c...)
Show SMILES CC(C)(C)c1ccc(CNC(NCc2ccc(NS(C)(=O)=O)c(F)c2)=NC#N)cc1 |w:25.26|
Show InChI InChI=1S/C21H26FN5O2S/c1-21(2,3)17-8-5-15(6-9-17)12-24-20(26-14-23)25-13-16-7-10-19(18(22)11-16)27-30(4,28)29/h5-11,27H,12-13H2,1-4H3,(H2,24,25,26)
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n/an/a 730n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172585
PNG
(1-(1H-Benzoimidazol-5-ylmethyl)-3-(4-tert-butyl-be...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc3nc[nH]c3c2)cc1
Show InChI InChI=1S/C20H24N4S/c1-20(2,3)16-7-4-14(5-8-16)11-21-19(25)22-12-15-6-9-17-18(10-15)24-13-23-17/h4-10,13H,11-12H2,1-3H3,(H,23,24)(H2,21,22,25)
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n/an/a 790n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172601
PNG
(CHEMBL197558 | N-{4-[(3-Anthracen-9-yl-thioureido)...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=S)Nc2c3ccccc3cc3ccccc23)cc1F
Show InChI InChI=1S/C23H20FN3O2S2/c1-31(28,29)27-21-11-10-15(12-20(21)24)14-25-23(30)26-22-18-8-4-2-6-16(18)13-17-7-3-5-9-19(17)22/h2-13,27H,14H2,1H3,(H2,25,26,30)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172572
PNG
(CHEMBL196553 | N-{4-[3-(4-Ethyl-benzyl)-thioureido...)
Show SMILES CCc1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C18H22FN3O2S2/c1-3-13-4-6-14(7-5-13)11-20-18(25)21-12-15-8-9-17(16(19)10-15)22-26(2,23)24/h4-10,22H,3,11-12H2,1-2H3,(H2,20,21,25)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172600
PNG
(CHEMBL198508 | N-{2-Fluoro-4-[3-(3-methyl-benzyl)-...)
Show SMILES Cc1cccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)c1
Show InChI InChI=1S/C17H20FN3O2S2/c1-12-4-3-5-13(8-12)10-19-17(24)20-11-14-6-7-16(15(18)9-14)21-25(2,22)23/h3-9,21H,10-11H2,1-2H3,(H2,19,20,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172579
PNG
(CHEMBL196372 | N-{2-Fluoro-4-[3-(4-methyl-benzyl)-...)
Show SMILES Cc1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C17H20FN3O2S2/c1-12-3-5-13(6-4-12)10-19-17(24)20-11-14-7-8-16(15(18)9-14)21-25(2,22)23/h3-9,21H,10-11H2,1-2H3,(H2,19,20,24)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172574
PNG
(CHEMBL370797 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(=O)Nc1ccc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)cc1F
Show InChI InChI=1S/C21H26FN3OS/c1-14(26)25-19-10-7-16(11-18(19)22)13-24-20(27)23-12-15-5-8-17(9-6-15)21(2,3)4/h5-11H,12-13H2,1-4H3,(H,25,26)(H2,23,24,27)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172561
PNG
(CHEMBL198443 | N-{4-[3-(4-tert-Butyl-phenyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(NC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C19H24FN3O2S2/c1-19(2,3)14-6-8-15(9-7-14)22-18(26)21-12-13-5-10-17(16(20)11-13)23-27(4,24)25/h5-11,23H,12H2,1-4H3,(H2,21,22,26)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172569
PNG
(1-(4-tert-Butyl-benzyl)-3-(1H-indol-5-ylmethyl)-th...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C21H25N3S/c1-21(2,3)18-7-4-15(5-8-18)13-23-20(25)24-14-16-6-9-19-17(12-16)10-11-22-19/h4-12,22H,13-14H2,1-3H3,(H2,23,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172564
PNG
(CHEMBL382921 | N-(4-{3-[3-(4-tert-Butyl-phenyl)-pr...)
Show SMILES CC(C)(C)c1ccc(CCCNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C22H30FN3O2S2/c1-22(2,3)18-10-7-16(8-11-18)6-5-13-24-21(29)25-15-17-9-12-20(19(23)14-17)26-30(4,27)28/h7-12,14,26H,5-6,13,15H2,1-4H3,(H2,24,25,29)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172589
PNG
(CHEMBL197516 | N-[4-(3-Benzhydryl-thioureidomethyl...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=S)NC(c2ccccc2)c2ccccc2)cc1F
Show InChI InChI=1S/C22H22FN3O2S2/c1-30(27,28)26-20-13-12-16(14-19(20)23)15-24-22(29)25-21(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-14,21,26H,15H2,1H3,(H2,24,25,29)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172594
PNG
(CHEMBL195919 | N-{2-Fluoro-4-[(3-naphthalen-1-yl-t...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=S)Nc2cccc3ccccc23)cc1F
Show InChI InChI=1S/C19H18FN3O2S2/c1-27(24,25)23-18-10-9-13(11-16(18)20)12-21-19(26)22-17-8-4-6-14-5-2-3-7-15(14)17/h2-11,23H,12H2,1H3,(H2,21,22,26)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172591
PNG
(CHEMBL194293 | N-{4-[4-(tert-butyl)benzylamino(met...)
Show SMILES CON=C(NCc1ccc(cc1)C(C)(C)C)NCc1ccc(NS(C)(=O)=O)c(F)c1 |w:2.1|
Show InChI InChI=1S/C21H29FN4O3S/c1-21(2,3)17-9-6-15(7-10-17)13-23-20(25-29-4)24-14-16-8-11-19(18(22)12-16)26-30(5,27)28/h6-12,26H,13-14H2,1-5H3,(H2,23,24,25)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172592
PNG
(CHEMBL373044 | {4-[3-(4-tert-Butyl-benzyl)-thioure...)
Show SMILES COC(=O)CNc1ccc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)cc1F
Show InChI InChI=1S/C22H28FN3O2S/c1-22(2,3)17-8-5-15(6-9-17)12-25-21(29)26-13-16-7-10-19(18(23)11-16)24-14-20(27)28-4/h5-11,24H,12-14H2,1-4H3,(H2,25,26,29)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172599
PNG
(5-[3-(4-tert-Butyl-benzyl)-ureidomethyl]-2-methane...)
Show SMILES COC(=O)c1cc(CNC(=O)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C22H29N3O5S/c1-22(2,3)17-9-6-15(7-10-17)13-23-21(27)24-14-16-8-11-19(25-31(5,28)29)18(12-16)20(26)30-4/h6-12,25H,13-14H2,1-5H3,(H2,23,24,27)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172573
PNG
(CHEMBL193908 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(c2)C#N)cc1
Show InChI InChI=1S/C21H26N4O2S2/c1-21(2,3)18-8-5-15(6-9-18)13-23-20(28)24-14-16-7-10-19(17(11-16)12-22)25-29(4,26)27/h5-11,25H,13-14H2,1-4H3,(H2,23,24,28)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172576
PNG
(CHEMBL196423 | N-{4-[4-(tert-butyl)benzylamino(eth...)
Show SMILES CCOC(=O)NC(NCc1ccc(NS(C)(=O)=O)c(F)c1)=NCc1ccc(cc1)C(C)(C)C |w:21.22|
Show InChI InChI=1S/C23H31FN4O4S/c1-6-32-22(29)27-21(25-14-16-7-10-18(11-8-16)23(2,3)4)26-15-17-9-12-20(19(24)13-17)28-33(5,30)31/h7-13,28H,6,14-15H2,1-5H3,(H2,25,26,27,29)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172584
PNG
(CHEMBL372982 | N-[4-(3-Benzyl-thioureidomethyl)-2-...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=S)NCc2ccccc2)cc1F
Show InChI InChI=1S/C16H18FN3O2S2/c1-24(21,22)20-15-8-7-13(9-14(15)17)11-19-16(23)18-10-12-5-3-2-4-6-12/h2-9,20H,10-11H2,1H3,(H2,18,19,23)
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n/an/a 9.70E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172580
PNG
(CHEMBL198455 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES COCC(=O)Nc1ccc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)cc1F
Show InChI InChI=1S/C22H28FN3O2S/c1-22(2,3)17-8-5-15(6-9-17)12-24-21(29)25-13-16-7-10-19(18(23)11-16)26-20(27)14-28-4/h5-11H,12-14H2,1-4H3,(H,26,27)(H2,24,25,29)
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n/an/a 1.09E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172558
PNG
(CHEMBL195954 | {4-[3-(4-tert-Butyl-benzyl)-thioure...)
Show SMILES CCOC(=O)CNc1ccc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)cc1F
Show InChI InChI=1S/C23H30FN3O2S/c1-5-29-21(28)15-25-20-11-8-17(12-19(20)24)14-27-22(30)26-13-16-6-9-18(10-7-16)23(2,3)4/h6-12,25H,5,13-15H2,1-4H3,(H2,26,27,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172588
PNG
(CHEMBL197933 | N-[4-(3-tert-Butyl-thioureidomethyl...)
Show SMILES CC(C)(C)NC(=S)NCc1ccc(NS(C)(=O)=O)c(F)c1
Show InChI InChI=1S/C13H20FN3O2S2/c1-13(2,3)16-12(20)15-8-9-5-6-11(10(14)7-9)17-21(4,18)19/h5-7,17H,8H2,1-4H3,(H2,15,16,20)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172597
PNG
(5-[3-(4-tert-Butyl-benzyl)-thioureidomethyl]-2-met...)
Show SMILES CONC(=O)c1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C22H30N4O4S2/c1-22(2,3)17-9-6-15(7-10-17)13-23-21(31)24-14-16-8-11-19(26-32(5,28)29)18(12-16)20(27)25-30-4/h6-12,26H,13-14H2,1-5H3,(H,25,27)(H2,23,24,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172559
PNG
(CHEMBL383591 | N-(4-{3-[1-(4-tert-Butyl-phenyl)-1-...)
Show SMILES CC(C)(C)c1ccc(cc1)C(C)(C)NC(=S)NCc1ccc(NS(C)(=O)=O)c(F)c1
Show InChI InChI=1S/C22H30FN3O2S2/c1-21(2,3)16-8-10-17(11-9-16)22(4,5)25-20(29)24-14-15-7-12-19(18(23)13-15)26-30(6,27)28/h7-13,26H,14H2,1-6H3,(H2,24,25,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172571
PNG
(5-[3-(4-tert-Butyl-benzyl)-thioureidomethyl]-2-met...)
Show SMILES CC(C)OC(=O)c1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C24H33N3O4S2/c1-16(2)31-22(28)20-13-18(9-12-21(20)27-33(6,29)30)15-26-23(32)25-14-17-7-10-19(11-8-17)24(3,4)5/h7-13,16,27H,14-15H2,1-6H3,(H2,25,26,32)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172583
PNG
(CHEMBL197769 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NC(=O)C(F)(F)F)c(F)c2)cc1
Show InChI InChI=1S/C21H23F4N3OS/c1-20(2,3)15-7-4-13(5-8-15)11-26-19(30)27-12-14-6-9-17(16(22)10-14)28-18(29)21(23,24)25/h4-10H,11-12H2,1-3H3,(H,28,29)(H2,26,27,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172570
PNG
(CHEMBL372573 | N-[4-(3-Biphenyl-4-ylmethyl-thioure...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=S)NCc2ccc(cc2)-c2ccccc2)cc1F
Show InChI InChI=1S/C22H22FN3O2S2/c1-30(27,28)26-21-12-9-17(13-20(21)23)15-25-22(29)24-14-16-7-10-19(11-8-16)18-5-3-2-4-6-18/h2-13,26H,14-15H2,1H3,(H2,24,25,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172568
PNG
(5-[3-(4-tert-Butyl-benzyl)-thioureidomethyl]-N-hyd...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(c2)C(=O)NO)cc1
Show InChI InChI=1S/C21H28N4O4S2/c1-21(2,3)16-8-5-14(6-9-16)12-22-20(30)23-13-15-7-10-18(25-31(4,28)29)17(11-15)19(26)24-27/h5-11,25,27H,12-13H2,1-4H3,(H,24,26)(H2,22,23,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172577
PNG
(CHEMBL199190 | {4-[3-(4-tert-Butyl-benzyl)-thioure...)
Show SMILES CCOC(=O)Nc1ccc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)cc1F
Show InChI InChI=1S/C22H28FN3O2S/c1-5-28-21(27)26-19-11-8-16(12-18(19)23)14-25-20(29)24-13-15-6-9-17(10-7-15)22(2,3)4/h6-12H,5,13-14H2,1-4H3,(H,26,27)(H2,24,25,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20321
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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n/an/an/an/a 8n/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Concentration required to antagonized capsaicin-induced calcium uptake at the transient receptor potential cation channel (subfamily V member 1) expr...

J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%