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PubMed code 16153834

Compile data set for download or QSAR
Found 102 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173245
PNG
(1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dih...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(F)ccc12
Show InChI InChI=1S/C22H31FN2O/c1-24-20-10-9-18(23)15-19(20)22(21(24)26)11-13-25(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3
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n/an/a 23n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173251
PNG
(1'-cyclooctylmethyl-1-methylspiro[2,3-dihydro-1H-i...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C22H32N2O/c1-23-20-12-8-7-11-19(20)22(21(23)25)13-15-24(16-14-22)17-18-9-5-3-2-4-6-10-18/h7-8,11-12,18H,2-6,9-10,13-17H2,1H3
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n/an/a 32n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173256
PNG
(1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2c1cccc2C
Show InChI InChI=1S/C23H34N2O/c1-18-9-8-12-20-21(18)23(22(26)24(20)2)13-15-25(16-14-23)17-19-10-6-4-3-5-7-11-19/h8-9,12,19H,3-7,10-11,13-17H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173275
PNG
(1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-...)
Show SMILES O=C1N(CC2CO2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C24H34N2O2/c27-23-24(21-10-6-7-11-22(21)26(23)17-20-18-28-20)12-14-25(15-13-24)16-19-8-4-2-1-3-5-9-19/h6-7,10-11,19-20H,1-5,8-9,12-18H2
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n/an/a 83n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173246
PNG
(1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-...)
Show SMILES CC(C)c1ccc2N(C)C(=O)C3(CCN(CC4CCCCCCC4)CC3)c2c1
Show InChI InChI=1S/C25H38N2O/c1-19(2)21-11-12-23-22(17-21)25(24(28)26(23)3)13-15-27(16-14-25)18-20-9-7-5-4-6-8-10-20/h11-12,17,19-20H,4-10,13-16,18H2,1-3H3
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n/an/a 97n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173254
PNG
(CHEMBL434944 | methyl 2-[1'-cyclooctylmethyl-2-oxo...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C24H34N2O3/c1-29-22(27)18-26-21-12-8-7-11-20(21)24(23(26)28)13-15-25(16-14-24)17-19-9-5-3-2-4-6-10-19/h7-8,11-12,19H,2-6,9-10,13-18H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173244
PNG
(1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazina...)
Show SMILES OC(CNCCN1CCOCC1)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C30H48N4O3/c35-26(22-31-14-17-32-18-20-37-21-19-32)24-34-28-11-7-6-10-27(28)30(29(34)36)12-15-33(16-13-30)23-25-8-4-2-1-3-5-9-25/h6-7,10-11,25-26,31,35H,1-5,8-9,12-24H2
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n/an/a 100n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173264
PNG
(CHEMBL197942 | methyl 2-[1'-[4-(tert-butyl)cyclohe...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCC(CC3)C(C)(C)C)CC2)c2ccccc12 |(5.06,2.61,;3.55,2.29,;2.53,3.43,;2.99,4.89,;1.03,3.1,;.54,1.65,;1.45,.39,;2.99,.39,;.54,-.87,;2.06,-1.17,;2.53,-2.64,;1.5,-3.79,;1.97,-5.26,;.92,-6.4,;-.58,-6.07,;-1.6,-7.19,;-1.14,-8.66,;.36,-9.01,;1.41,-7.86,;-2.19,-9.81,;-1.07,-10.88,;-3.28,-8.73,;-3.28,-10.9,;-.02,-3.46,;-.48,-2.01,;-.93,-.38,;-2.26,-1.15,;-3.59,-.38,;-3.59,1.16,;-2.26,1.93,;-.93,1.16,)|
Show InChI InChI=1S/C26H38N2O3/c1-25(2,3)20-11-9-19(10-12-20)17-27-15-13-26(14-16-27)21-7-5-6-8-22(21)28(24(26)30)18-23(29)31-4/h5-8,19-20H,9-18H2,1-4H3
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n/an/a 100n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173252
PNG
(1'-cyclooctylmethyl-6-hydroxy-1-methylspiro[2,3-di...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(O)cc12
Show InChI InChI=1S/C22H32N2O2/c1-23-20-15-18(25)9-10-19(20)22(21(23)26)11-13-24(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17,25H,2-8,11-14,16H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173244
PNG
(1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazina...)
Show SMILES OC(CNCCN1CCOCC1)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C30H48N4O3/c35-26(22-31-14-17-32-18-20-37-21-19-32)24-34-28-11-7-6-10-27(28)30(29(34)36)12-15-33(16-13-30)23-25-8-4-2-1-3-5-9-25/h6-7,10-11,25-26,31,35H,1-5,8-9,12-24H2
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n/an/a 120n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173243
PNG
(1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-i...)
Show SMILES O=C1N(Cc2ccccc2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C28H36N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h4,7-10,13-16,23H,1-3,5-6,11-12,17-22H2
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n/an/a 120n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173266
PNG
(CHEMBL264066 | methyl 2-[2-oxo-1'-(3-trifluorometh...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3cccc(c3)C(F)(F)F)CC2)c2ccccc12
Show InChI InChI=1S/C23H23F3N2O3/c1-31-20(29)15-28-19-8-3-2-7-18(19)22(21(28)30)9-11-27(12-10-22)14-16-5-4-6-17(13-16)23(24,25)26/h2-8,13H,9-12,14-15H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173268
PNG
(1'-cyclooctylmethyl-1,6-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(C)cc12
Show InChI InChI=1S/C23H34N2O/c1-18-10-11-20-21(16-18)24(2)22(26)23(20)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3
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n/an/a 150n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173253
PNG
(2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...)
Show SMILES CC(=O)OCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C25H36N2O3/c1-20(28)30-18-17-27-23-12-8-7-11-22(23)25(24(27)29)13-15-26(16-14-25)19-21-9-5-3-2-4-6-10-21/h7-8,11-12,21H,2-6,9-10,13-19H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173269
PNG
(1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amin...)
Show SMILES CCN(CC(O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12)Cc1ccc(C)cc1
Show InChI InChI=1S/C34H49N3O2/c1-3-35(23-29-17-15-27(2)16-18-29)25-30(38)26-37-32-14-10-9-13-31(32)34(33(37)39)19-21-36(22-20-34)24-28-11-7-5-4-6-8-12-28/h9-10,13-18,28,30,38H,3-8,11-12,19-26H2,1-2H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173271
PNG
(CHEMBL444620 | methyl 2-[1'-(2-naphthylmethyl)-2-o...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccc4ccccc4c3)CC2)c2ccccc12
Show InChI InChI=1S/C26H26N2O3/c1-31-24(29)18-28-23-9-5-4-8-22(23)26(25(28)30)12-14-27(15-13-26)17-19-10-11-20-6-2-3-7-21(20)16-19/h2-11,16H,12-15,17-18H2,1H3
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n/an/a 250n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173245
PNG
(1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dih...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(F)ccc12
Show InChI InChI=1S/C22H31FN2O/c1-24-20-10-9-18(23)15-19(20)22(21(24)26)11-13-25(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3
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n/an/a 250n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173267
PNG
(1'-cyclooctylmethyl-1-(2-hydroxyethyl)spiro[2,3-di...)
Show SMILES OCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H34N2O2/c26-17-16-25-21-11-7-6-10-20(21)23(22(25)27)12-14-24(15-13-23)18-19-8-4-2-1-3-5-9-19/h6-7,10-11,19,26H,1-5,8-9,12-18H2
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n/an/a 290n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173252
PNG
(1'-cyclooctylmethyl-6-hydroxy-1-methylspiro[2,3-di...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(O)cc12
Show InChI InChI=1S/C22H32N2O2/c1-23-20-15-18(25)9-10-19(20)22(21(23)26)11-13-24(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17,25H,2-8,11-14,16H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173269
PNG
(1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amin...)
Show SMILES CCN(CC(O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12)Cc1ccc(C)cc1
Show InChI InChI=1S/C34H49N3O2/c1-3-35(23-29-17-15-27(2)16-18-29)25-30(38)26-37-32-14-10-9-13-31(32)34(33(37)39)19-21-36(22-20-34)24-28-11-7-5-4-6-8-12-28/h9-10,13-18,28,30,38H,3-8,11-12,19-26H2,1-2H3
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n/an/a 320n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173281
PNG
(CHEMBL198046 | methyl 2-[1'-(1,2-dihydro-5-acenaph...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC2)c2ccc3CCc4cccc2c34)c2ccccc12
Show InChI InChI=1S/C27H26N2O3/c1-32-24(30)17-29-23-8-3-2-7-21(23)27(26(29)31)13-15-28(16-14-27)22-12-11-19-10-9-18-5-4-6-20(22)25(18)19/h2-8,11-12H,9-10,13-17H2,1H3
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n/an/a 350n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173247
PNG
(1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4...)
Show SMILES O=C1Nc2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C21H30N2O/c24-20-21(18-10-6-7-11-19(18)22-20)12-14-23(15-13-21)16-17-8-4-2-1-3-5-9-17/h6-7,10-11,17H,1-5,8-9,12-16H2,(H,22,24)
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n/an/a 380n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173247
PNG
(1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4...)
Show SMILES O=C1Nc2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C21H30N2O/c24-20-21(18-10-6-7-11-19(18)22-20)12-14-23(15-13-21)16-17-8-4-2-1-3-5-9-17/h6-7,10-11,17H,1-5,8-9,12-16H2,(H,22,24)
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n/an/a 430n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173250
PNG
(1'-cyclooctylmethyl-1,5-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(C)ccc12
Show InChI InChI=1S/C23H34N2O/c1-18-10-11-21-20(16-18)23(22(26)24(21)2)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3
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n/an/a 450n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173280
PNG
(CHEMBL198678 | methyl 2-[1'-(1-naphthylmethyl)-2-o...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3cccc4ccccc34)CC2)c2ccccc12
Show InChI InChI=1S/C26H26N2O3/c1-31-24(29)18-28-23-12-5-4-11-22(23)26(25(28)30)13-15-27(16-14-26)17-20-9-6-8-19-7-2-3-10-21(19)20/h2-12H,13-18H2,1H3
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n/an/a 470n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173256
PNG
(1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2c1cccc2C
Show InChI InChI=1S/C23H34N2O/c1-18-9-8-12-20-21(18)23(22(26)24(20)2)13-15-25(16-14-23)17-19-10-6-4-3-5-7-11-19/h8-9,12,19H,3-7,10-11,13-17H2,1-2H3
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n/an/a 480n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173275
PNG
(1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-...)
Show SMILES O=C1N(CC2CO2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C24H34N2O2/c27-23-24(21-10-6-7-11-22(21)26(23)17-20-18-28-20)12-14-25(15-13-24)16-19-8-4-2-1-3-5-9-19/h6-7,10-11,19-20H,1-5,8-9,12-18H2
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n/an/a 480n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173244
PNG
(1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazina...)
Show SMILES OC(CNCCN1CCOCC1)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C30H48N4O3/c35-26(22-31-14-17-32-18-20-37-21-19-32)24-34-28-11-7-6-10-27(28)30(29(34)36)12-15-33(16-13-30)23-25-8-4-2-1-3-5-9-25/h6-7,10-11,25-26,31,35H,1-5,8-9,12-24H2
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n/an/a 500n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173284
PNG
(CHEMBL427010 | methyl 2-[1'-cycloheptylmethyl-2-ox...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H32N2O3/c1-28-21(26)17-25-20-11-7-6-10-19(20)23(22(25)27)12-14-24(15-13-23)16-18-8-4-2-3-5-9-18/h6-7,10-11,18H,2-5,8-9,12-17H2,1H3
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n/an/a 510n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173250
PNG
(1'-cyclooctylmethyl-1,5-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(C)ccc12
Show InChI InChI=1S/C23H34N2O/c1-18-10-11-21-20(16-18)23(22(26)24(21)2)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3
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n/an/a 540n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173256
PNG
(1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2c1cccc2C
Show InChI InChI=1S/C23H34N2O/c1-18-9-8-12-20-21(18)23(22(26)24(20)2)13-15-25(16-14-23)17-19-10-6-4-3-5-7-11-19/h8-9,12,19H,3-7,10-11,13-17H2,1-2H3
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n/an/a 560n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173274
PNG
(1'-cyclooctylmethyl-1-methyl-5-trifluoromethylspir...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C23H31F3N2O/c1-27-20-10-9-18(23(24,25)26)15-19(20)22(21(27)29)11-13-28(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3
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n/an/a 600n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173269
PNG
(1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amin...)
Show SMILES CCN(CC(O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12)Cc1ccc(C)cc1
Show InChI InChI=1S/C34H49N3O2/c1-3-35(23-29-17-15-27(2)16-18-29)25-30(38)26-37-32-14-10-9-13-31(32)34(33(37)39)19-21-36(22-20-34)24-28-11-7-5-4-6-8-12-28/h9-10,13-18,28,30,38H,3-8,11-12,19-26H2,1-2H3
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n/an/a 620n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173254
PNG
(CHEMBL434944 | methyl 2-[1'-cyclooctylmethyl-2-oxo...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C24H34N2O3/c1-29-22(27)18-26-21-12-8-7-11-20(21)24(23(26)28)13-15-25(16-14-24)17-19-9-5-3-2-4-6-10-19/h7-8,11-12,19H,2-6,9-10,13-18H2,1H3
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n/an/a 640n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173283
PNG
(1-cyclohexylmethyl-1'-cyclooctylmethylspiro[2,3-di...)
Show SMILES O=C1N(CC2CCCCC2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C28H42N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h9-10,15-16,23-24H,1-8,11-14,17-22H2
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n/an/a 680n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173248
PNG
(CHEMBL373222 | methyl 2-[1'-(4-chlorobenzyl)-2-oxo...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C22H23ClN2O3/c1-28-20(26)15-25-19-5-3-2-4-18(19)22(21(25)27)10-12-24(13-11-22)14-16-6-8-17(23)9-7-16/h2-9H,10-15H2,1H3
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n/an/a 710n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173261
PNG
(CHEMBL198099 | methyl 2-[1'-cyclohexylmethyl-2-oxo...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C22H30N2O3/c1-27-20(25)16-24-19-10-6-5-9-18(19)22(21(24)26)11-13-23(14-12-22)15-17-7-3-2-4-8-17/h5-6,9-10,17H,2-4,7-8,11-16H2,1H3
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n/an/a 800n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173263
PNG
(CHEMBL198167 | methyl 2-[1'-hexyl-2-oxospiro[2,3-d...)
Show SMILES CCCCCCN1CCC2(CC1)C(=O)N(CC(=O)OC)c1ccccc21
Show InChI InChI=1S/C21H30N2O3/c1-3-4-5-8-13-22-14-11-21(12-15-22)17-9-6-7-10-18(17)23(20(21)25)16-19(24)26-2/h6-7,9-10H,3-5,8,11-16H2,1-2H3
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n/an/a 820n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173275
PNG
(1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-...)
Show SMILES O=C1N(CC2CO2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C24H34N2O2/c27-23-24(21-10-6-7-11-22(21)26(23)17-20-18-28-20)12-14-25(15-13-24)16-19-8-4-2-1-3-5-9-19/h6-7,10-11,19-20H,1-5,8-9,12-18H2
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n/an/a 840n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173249
PNG
(CHEMBL197880 | methyl 2-[2-oxo-1'-(4-trifluorometh...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccc(cc3)C(F)(F)F)CC2)c2ccccc12
Show InChI InChI=1S/C23H23F3N2O3/c1-31-20(29)15-28-19-5-3-2-4-18(19)22(21(28)30)10-12-27(13-11-22)14-16-6-8-17(9-7-16)23(24,25)26/h2-9H,10-15H2,1H3
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n/an/a 880n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173276
PNG
(CHEMBL380580 | methyl 2-[2-oxo-1'-perhydro-2-napht...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC2)C2CCC3CCCCC3C2)c2ccccc12
Show InChI InChI=1S/C25H34N2O3/c1-30-23(28)17-27-22-9-5-4-8-21(22)25(24(27)29)12-14-26(15-13-25)20-11-10-18-6-2-3-7-19(18)16-20/h4-5,8-9,18-20H,2-3,6-7,10-17H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173251
PNG
(1'-cyclooctylmethyl-1-methylspiro[2,3-dihydro-1H-i...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C22H32N2O/c1-23-20-12-8-7-11-19(20)22(21(23)25)13-15-24(16-14-22)17-18-9-5-3-2-4-6-10-18/h7-8,11-12,18H,2-6,9-10,13-17H2,1H3
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n/an/a 930n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173243
PNG
(1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-i...)
Show SMILES O=C1N(Cc2ccccc2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C28H36N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h4,7-10,13-16,23H,1-3,5-6,11-12,17-22H2
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n/an/a 960n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173246
PNG
(1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-...)
Show SMILES CC(C)c1ccc2N(C)C(=O)C3(CCN(CC4CCCCCCC4)CC3)c2c1
Show InChI InChI=1S/C25H38N2O/c1-19(2)21-11-12-23-22(17-21)25(24(28)26(23)3)13-15-27(16-14-25)18-20-9-7-5-4-6-8-10-20/h11-12,17,19-20H,4-10,13-16,18H2,1-3H3
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n/an/a 980n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173245
PNG
(1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dih...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(F)ccc12
Show InChI InChI=1S/C22H31FN2O/c1-24-20-10-9-18(23)15-19(20)22(21(24)26)11-13-25(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173272
PNG
(CHEMBL370226 | methyl 2-[2-oxo-1'-(1,2,3,4-tetrahy...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC2)C2CCc3ccccc3C2)c2ccccc12
Show InChI InChI=1S/C25H28N2O3/c1-30-23(28)17-27-22-9-5-4-8-21(22)25(24(27)29)12-14-26(15-13-25)20-11-10-18-6-2-3-7-19(18)16-20/h2-9,20H,10-17H2,1H3
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n/an/a 1.08E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173243
PNG
(1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-i...)
Show SMILES O=C1N(Cc2ccccc2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C28H36N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h4,7-10,13-16,23H,1-3,5-6,11-12,17-22H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173247
PNG
(1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4...)
Show SMILES O=C1Nc2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C21H30N2O/c24-20-21(18-10-6-7-11-19(18)22-20)12-14-23(15-13-21)16-17-8-4-2-1-3-5-9-17/h6-7,10-11,17H,1-5,8-9,12-16H2,(H,22,24)
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n/an/a 1.11E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173270
PNG
(CHEMBL370782 | methyl 2-[1'-cyclododecylmethyl-2-o...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C28H42N2O3/c1-33-26(31)22-30-25-16-12-11-15-24(25)28(27(30)32)17-19-29(20-18-28)21-23-13-9-7-5-3-2-4-6-8-10-14-23/h11-12,15-16,23H,2-10,13-14,17-22H2,1H3
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n/an/a 1.12E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173255
PNG
(1'-cyclooctylmethyl-6-methoxy-1-methylspiro[2,3-di...)
Show SMILES COc1ccc2c(c1)N(C)C(=O)C21CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C23H34N2O2/c1-24-21-16-19(27-2)10-11-20(21)23(22(24)26)12-14-25(15-13-23)17-18-8-6-4-3-5-7-9-18/h10-11,16,18H,3-9,12-15,17H2,1-2H3
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n/an/a 1.22E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173251
PNG
(1'-cyclooctylmethyl-1-methylspiro[2,3-dihydro-1H-i...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C22H32N2O/c1-23-20-12-8-7-11-19(20)22(21(23)25)13-15-24(16-14-22)17-18-9-5-3-2-4-6-10-18/h7-8,11-12,18H,2-6,9-10,13-17H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173277
PNG
(1'-cyclooctylmethyl-1-(4-methoxybenzyl)spiro[2,3-d...)
Show SMILES COc1ccc(CN2C(=O)C3(CCN(CC4CCCCCCC4)CC3)c3ccccc23)cc1
Show InChI InChI=1S/C29H38N2O2/c1-33-25-15-13-24(14-16-25)22-31-27-12-8-7-11-26(27)29(28(31)32)17-19-30(20-18-29)21-23-9-5-3-2-4-6-10-23/h7-8,11-16,23H,2-6,9-10,17-22H2,1H3
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n/an/a 1.31E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173253
PNG
(2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...)
Show SMILES CC(=O)OCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C25H36N2O3/c1-20(28)30-18-17-27-23-12-8-7-11-22(23)25(24(27)29)13-15-26(16-14-25)19-21-9-5-3-2-4-6-10-21/h7-8,11-12,21H,2-6,9-10,13-19H2,1H3
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n/an/a 1.41E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173259
PNG
(1'-cyclooctylmethyl-1-ethyl-6-methoxyspiro[2,3-dih...)
Show SMILES CCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(OC)cc12
Show InChI InChI=1S/C24H36N2O2/c1-3-26-22-17-20(28-2)11-12-21(22)24(23(26)27)13-15-25(16-14-24)18-19-9-7-5-4-6-8-10-19/h11-12,17,19H,3-10,13-16,18H2,1-2H3
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n/an/a 1.46E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173255
PNG
(1'-cyclooctylmethyl-6-methoxy-1-methylspiro[2,3-di...)
Show SMILES COc1ccc2c(c1)N(C)C(=O)C21CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C23H34N2O2/c1-24-21-16-19(27-2)10-11-20(21)23(22(24)26)12-14-25(15-13-23)17-18-8-6-4-3-5-7-9-18/h10-11,16,18H,3-9,12-15,17H2,1-2H3
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n/an/a 1.61E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173267
PNG
(1'-cyclooctylmethyl-1-(2-hydroxyethyl)spiro[2,3-di...)
Show SMILES OCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H34N2O2/c26-17-16-25-21-11-7-6-10-20(21)23(22(25)27)12-14-24(15-13-23)18-19-8-4-2-1-3-5-9-19/h6-7,10-11,19,26H,1-5,8-9,12-18H2
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n/an/a 1.69E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173268
PNG
(1'-cyclooctylmethyl-1,6-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(C)cc12
Show InChI InChI=1S/C23H34N2O/c1-18-10-11-20-21(16-18)24(2)22(26)23(20)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3
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n/an/a 2.38E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173255
PNG
(1'-cyclooctylmethyl-6-methoxy-1-methylspiro[2,3-di...)
Show SMILES COc1ccc2c(c1)N(C)C(=O)C21CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C23H34N2O2/c1-24-21-16-19(27-2)10-11-20(21)23(22(24)26)12-14-25(15-13-23)17-18-8-6-4-3-5-7-9-18/h10-11,16,18H,3-9,12-15,17H2,1-2H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173253
PNG
(2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...)
Show SMILES CC(=O)OCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C25H36N2O3/c1-20(28)30-18-17-27-23-12-8-7-11-22(23)25(24(27)29)13-15-26(16-14-25)19-21-9-5-3-2-4-6-10-21/h7-8,11-12,21H,2-6,9-10,13-19H2,1H3
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n/an/a 2.64E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173252
PNG
(1'-cyclooctylmethyl-6-hydroxy-1-methylspiro[2,3-di...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(O)cc12
Show InChI InChI=1S/C22H32N2O2/c1-23-20-15-18(25)9-10-19(20)22(21(23)26)11-13-24(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17,25H,2-8,11-14,16H2,1H3
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n/an/a 2.68E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173259
PNG
(1'-cyclooctylmethyl-1-ethyl-6-methoxyspiro[2,3-dih...)
Show SMILES CCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(OC)cc12
Show InChI InChI=1S/C24H36N2O2/c1-3-26-22-17-20(28-2)11-12-21(22)24(23(26)27)13-15-25(16-14-24)18-19-9-7-5-4-6-8-10-19/h11-12,17,19H,3-10,13-16,18H2,1-2H3
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n/an/a 2.75E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173254
PNG
(CHEMBL434944 | methyl 2-[1'-cyclooctylmethyl-2-oxo...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C24H34N2O3/c1-29-22(27)18-26-21-12-8-7-11-20(21)24(23(26)28)13-15-25(16-14-24)17-19-9-5-3-2-4-6-10-19/h7-8,11-12,19H,2-6,9-10,13-18H2,1H3
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n/an/a 3.55E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173279
PNG
(CHEMBL383561 | methyl [1'-(cyclopropylmethyl)-2-ox...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CC3)CC2)c2ccccc12
Show InChI InChI=1S/C19H24N2O3/c1-24-17(22)13-21-16-5-3-2-4-15(16)19(18(21)23)8-10-20(11-9-19)12-14-6-7-14/h2-5,14H,6-13H2,1H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173262
PNG
(1'-cyclooctylmethyl-5-isopropyl-1-propylspiro[2,3-...)
Show SMILES CCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(ccc12)C(C)C
Show InChI InChI=1S/C27H42N2O/c1-4-16-29-25-13-12-23(21(2)3)19-24(25)27(26(29)30)14-17-28(18-15-27)20-22-10-8-6-5-7-9-11-22/h12-13,19,21-22H,4-11,14-18,20H2,1-3H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173250
PNG
(1'-cyclooctylmethyl-1,5-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(C)ccc12
Show InChI InChI=1S/C23H34N2O/c1-18-10-11-21-20(16-18)23(22(26)24(21)2)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3
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n/an/a 4.28E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173274
PNG
(1'-cyclooctylmethyl-1-methyl-5-trifluoromethylspir...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C23H31F3N2O/c1-27-20-10-9-18(23(24,25)26)15-19(20)22(21(27)29)11-13-28(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3
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n/an/a 5.31E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173262
PNG
(1'-cyclooctylmethyl-5-isopropyl-1-propylspiro[2,3-...)
Show SMILES CCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(ccc12)C(C)C
Show InChI InChI=1S/C27H42N2O/c1-4-16-29-25-13-12-23(21(2)3)19-24(25)27(26(29)30)14-17-28(18-15-27)20-22-10-8-6-5-7-9-11-22/h12-13,19,21-22H,4-11,14-18,20H2,1-3H3
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n/an/a 5.70E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173268
PNG
(1'-cyclooctylmethyl-1,6-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(C)cc12
Show InChI InChI=1S/C23H34N2O/c1-18-10-11-20-21(16-18)24(2)22(26)23(20)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3
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n/an/a 6.47E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173246
PNG
(1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-...)
Show SMILES CC(C)c1ccc2N(C)C(=O)C3(CCN(CC4CCCCCCC4)CC3)c2c1
Show InChI InChI=1S/C25H38N2O/c1-19(2)21-11-12-23-22(17-21)25(24(28)26(23)3)13-15-27(16-14-25)18-20-9-7-5-4-6-8-10-20/h11-12,17,19-20H,4-10,13-16,18H2,1-3H3
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n/an/a 7.40E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173268
PNG
(1'-cyclooctylmethyl-1,6-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(C)cc12
Show InChI InChI=1S/C23H34N2O/c1-18-10-11-20-21(16-18)24(2)22(26)23(20)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173250
PNG
(1'-cyclooctylmethyl-1,5-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(C)ccc12
Show InChI InChI=1S/C23H34N2O/c1-18-10-11-21-20(16-18)23(22(26)24(21)2)12-14-25(15-13-23)17-19-8-6-4-3-5-7-9-19/h10-11,16,19H,3-9,12-15,17H2,1-2H3
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n/an/a 9.40E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173273
PNG
(CHEMBL372135 | methyl 2-[2-oxo-1'-(1-phenylethyl)s...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC2)C(C)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H26N2O3/c1-17(18-8-4-3-5-9-18)24-14-12-23(13-15-24)19-10-6-7-11-20(19)25(22(23)27)16-21(26)28-2/h3-11,17H,12-16H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173278
PNG
(CHEMBL198322 | methyl 2-[2-oxo-1'-(4-phenylbenzyl)...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccc(cc3)-c3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C28H28N2O3/c1-33-26(31)20-30-25-10-6-5-9-24(25)28(27(30)32)15-17-29(18-16-28)19-21-11-13-23(14-12-21)22-7-3-2-4-8-22/h2-14H,15-20H2,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173262
PNG
(1'-cyclooctylmethyl-5-isopropyl-1-propylspiro[2,3-...)
Show SMILES CCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(ccc12)C(C)C
Show InChI InChI=1S/C27H42N2O/c1-4-16-29-25-13-12-23(21(2)3)19-24(25)27(26(29)30)14-17-28(18-15-27)20-22-10-8-6-5-7-9-11-22/h12-13,19,21-22H,4-11,14-18,20H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173282
PNG
(CHEMBL382086 | methyl 2-[1'-(2-butyloctyl)-2-oxosp...)
Show SMILES CCCCCCC(CCCC)CN1CCC2(CC1)C(=O)N(CC(=O)OC)c1ccccc21
Show InChI InChI=1S/C27H42N2O3/c1-4-6-8-9-13-22(12-7-5-2)20-28-18-16-27(17-19-28)23-14-10-11-15-24(23)29(26(27)31)21-25(30)32-3/h10-11,14-15,22H,4-9,12-13,16-21H2,1-3H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173253
PNG
(2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...)
Show SMILES CC(=O)OCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C25H36N2O3/c1-20(28)30-18-17-27-23-12-8-7-11-22(23)25(24(27)29)13-15-26(16-14-25)19-21-9-5-3-2-4-6-10-21/h7-8,11-12,21H,2-6,9-10,13-19H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173274
PNG
(1'-cyclooctylmethyl-1-methyl-5-trifluoromethylspir...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C23H31F3N2O/c1-27-20-10-9-18(23(24,25)26)15-19(20)22(21(27)29)11-13-28(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173255
PNG
(1'-cyclooctylmethyl-6-methoxy-1-methylspiro[2,3-di...)
Show SMILES COc1ccc2c(c1)N(C)C(=O)C21CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C23H34N2O2/c1-24-21-16-19(27-2)10-11-20(21)23(22(24)26)12-14-25(15-13-23)17-18-8-6-4-3-5-7-9-18/h10-11,16,18H,3-9,12-15,17H2,1-2H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173258
PNG
(1'-cyclooctylmethyl-1-cyclopropylmethyl-6-methoxys...)
Show SMILES COc1ccc2c(c1)N(CC1CC1)C(=O)C21CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C26H38N2O2/c1-30-22-11-12-23-24(17-22)28(19-21-9-10-21)25(29)26(23)13-15-27(16-14-26)18-20-7-5-3-2-4-6-8-20/h11-12,17,20-21H,2-10,13-16,18-19H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173285
PNG
(CHEMBL198829 | methyl 2-[2-oxo-1'-(4-oxo-4-phenylb...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC2)C(=O)CCC(=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H26N2O5/c1-32-23(30)17-27-20-10-6-5-9-19(20)25(24(27)31)13-15-26(16-14-25)22(29)12-11-21(28)18-7-3-2-4-8-18/h2-10H,11-17H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173247
PNG
(1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4...)
Show SMILES O=C1Nc2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C21H30N2O/c24-20-21(18-10-6-7-11-19(18)22-20)12-14-23(15-13-21)16-17-8-4-2-1-3-5-9-17/h6-7,10-11,17H,1-5,8-9,12-16H2,(H,22,24)
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173265
PNG
(2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...)
Show SMILES OC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H32N2O3/c26-21(27)17-25-20-11-7-6-10-19(20)23(22(25)28)12-14-24(15-13-23)16-18-8-4-2-1-3-5-9-18/h6-7,10-11,18H,1-5,8-9,12-17H2,(H,26,27)
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173258
PNG
(1'-cyclooctylmethyl-1-cyclopropylmethyl-6-methoxys...)
Show SMILES COc1ccc2c(c1)N(CC1CC1)C(=O)C21CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C26H38N2O2/c1-30-22-11-12-23-24(17-22)28(19-21-9-10-21)25(29)26(23)13-15-27(16-14-26)18-20-7-5-3-2-4-6-8-20/h11-12,17,20-21H,2-10,13-16,18-19H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173265
PNG
(2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...)
Show SMILES OC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H32N2O3/c26-21(27)17-25-20-11-7-6-10-19(20)23(22(25)28)12-14-24(15-13-23)16-18-8-4-2-1-3-5-9-18/h6-7,10-11,18H,1-5,8-9,12-17H2,(H,26,27)
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173275
PNG
(1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-...)
Show SMILES O=C1N(CC2CO2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C24H34N2O2/c27-23-24(21-10-6-7-11-22(21)26(23)17-20-18-28-20)12-14-25(15-13-24)16-19-8-4-2-1-3-5-9-19/h6-7,10-11,19-20H,1-5,8-9,12-18H2
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173269
PNG
(1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amin...)
Show SMILES CCN(CC(O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12)Cc1ccc(C)cc1
Show InChI InChI=1S/C34H49N3O2/c1-3-35(23-29-17-15-27(2)16-18-29)25-30(38)26-37-32-14-10-9-13-31(32)34(33(37)39)19-21-36(22-20-34)24-28-11-7-5-4-6-8-12-28/h9-10,13-18,28,30,38H,3-8,11-12,19-26H2,1-2H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173256
PNG
(1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2c1cccc2C
Show InChI InChI=1S/C23H34N2O/c1-18-9-8-12-20-21(18)23(22(26)24(20)2)13-15-25(16-14-23)17-19-10-6-4-3-5-7-11-19/h8-9,12,19H,3-7,10-11,13-17H2,1-2H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173254
PNG
(CHEMBL434944 | methyl 2-[1'-cyclooctylmethyl-2-oxo...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C24H34N2O3/c1-29-22(27)18-26-21-12-8-7-11-20(21)24(23(26)28)13-15-25(16-14-24)17-19-9-5-3-2-4-6-10-19/h7-8,11-12,19H,2-6,9-10,13-18H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173258
PNG
(1'-cyclooctylmethyl-1-cyclopropylmethyl-6-methoxys...)
Show SMILES COc1ccc2c(c1)N(CC1CC1)C(=O)C21CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C26H38N2O2/c1-30-22-11-12-23-24(17-22)28(19-21-9-10-21)25(29)26(23)13-15-27(16-14-26)18-20-7-5-3-2-4-6-8-20/h11-12,17,20-21H,2-10,13-16,18-19H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173260
PNG
(CHEMBL440038 | methyl 2-[1'-(4-methoxycyclohexylca...)
Show SMILES COC1CCC(CC1)C(=O)N1CCC2(CC1)C(=O)N(CC(=O)OC)c1ccccc21 |(7.52,-8.29,;7.05,-6.84,;5.55,-6.51,;4.51,-7.64,;3.02,-7.31,;2.55,-5.84,;3.58,-4.7,;5.09,-5.04,;1.03,-5.51,;.01,-6.66,;.57,-4.04,;-.93,-3.72,;-1.4,-2.27,;-.37,-1.13,;1.13,-1.43,;1.61,-2.9,;.54,.13,;2.08,.13,;-.37,1.39,;.1,2.85,;1.61,3.17,;2.08,4.64,;2.64,2.03,;4.14,2.36,;-1.84,.9,;-3.19,1.67,;-4.52,.9,;-4.52,-.64,;-3.19,-1.41,;-1.84,-.64,)|
Show InChI InChI=1S/C23H30N2O5/c1-29-17-9-7-16(8-10-17)21(27)24-13-11-23(12-14-24)18-5-3-4-6-19(18)25(22(23)28)15-20(26)30-2/h3-6,16-17H,7-15H2,1-2H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50173265
PNG
(2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...)
Show SMILES OC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H32N2O3/c26-21(27)17-25-20-11-7-6-10-19(20)23(22(25)28)12-14-24(15-13-23)16-18-8-4-2-1-3-5-9-18/h6-7,10-11,18H,1-5,8-9,12-17H2,(H,26,27)
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor kappa 1 expressed in HEK293 cells using 3H-U69,593 radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173257
PNG
(CHEMBL372779 | methyl 2-[2-oxo-1'-[2-(3-thienyl)be...)
Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccccc3-c3ccsc3)CC2)c2ccccc12
Show InChI InChI=1S/C26H26N2O3S/c1-31-24(29)17-28-23-9-5-4-8-22(23)26(25(28)30)11-13-27(14-12-26)16-19-6-2-3-7-21(19)20-10-15-32-18-20/h2-10,15,18H,11-14,16-17H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173262
PNG
(1'-cyclooctylmethyl-5-isopropyl-1-propylspiro[2,3-...)
Show SMILES CCCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(ccc12)C(C)C
Show InChI InChI=1S/C27H42N2O/c1-4-16-29-25-13-12-23(21(2)3)19-24(25)27(26(29)30)14-17-28(18-15-27)20-22-10-8-6-5-7-9-11-22/h12-13,19,21-22H,4-11,14-18,20H2,1-3H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173258
PNG
(1'-cyclooctylmethyl-1-cyclopropylmethyl-6-methoxys...)
Show SMILES COc1ccc2c(c1)N(CC1CC1)C(=O)C21CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C26H38N2O2/c1-30-22-11-12-23-24(17-22)28(19-21-9-10-21)25(29)26(23)13-15-27(16-14-26)18-20-7-5-3-2-4-6-8-20/h11-12,17,20-21H,2-10,13-16,18-19H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173246
PNG
(1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-...)
Show SMILES CC(C)c1ccc2N(C)C(=O)C3(CCN(CC4CCCCCCC4)CC3)c2c1
Show InChI InChI=1S/C25H38N2O/c1-19(2)21-11-12-23-22(17-21)25(24(28)26(23)3)13-15-27(16-14-25)18-20-9-7-5-4-6-8-10-20/h11-12,17,19-20H,4-10,13-16,18H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173244
PNG
(1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazina...)
Show SMILES OC(CNCCN1CCOCC1)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C30H48N4O3/c35-26(22-31-14-17-32-18-20-37-21-19-32)24-34-28-11-7-6-10-27(28)30(29(34)36)12-15-33(16-13-30)23-25-8-4-2-1-3-5-9-25/h6-7,10-11,25-26,31,35H,1-5,8-9,12-24H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173259
PNG
(1'-cyclooctylmethyl-1-ethyl-6-methoxyspiro[2,3-dih...)
Show SMILES CCN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(OC)cc12
Show InChI InChI=1S/C24H36N2O2/c1-3-26-22-17-20(28-2)11-12-21(22)24(23(26)27)13-15-25(16-14-24)18-19-9-7-5-4-6-8-10-19/h11-12,17,19H,3-10,13-16,18H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173243
PNG
(1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-i...)
Show SMILES O=C1N(Cc2ccccc2)c2ccccc2C11CCN(CC2CCCCCCC2)CC1
Show InChI InChI=1S/C28H36N2O/c31-27-28(17-19-29(20-18-28)21-23-11-5-2-1-3-6-12-23)25-15-9-10-16-26(25)30(27)22-24-13-7-4-8-14-24/h4,7-10,13-16,23H,1-3,5-6,11-12,17-22H2
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173251
PNG
(1'-cyclooctylmethyl-1-methylspiro[2,3-dihydro-1H-i...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C22H32N2O/c1-23-20-12-8-7-11-19(20)22(21(23)25)13-15-24(16-14-22)17-18-9-5-3-2-4-6-10-18/h7-8,11-12,18H,2-6,9-10,13-17H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50173252
PNG
(1'-cyclooctylmethyl-6-hydroxy-1-methylspiro[2,3-di...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccc(O)cc12
Show InChI InChI=1S/C22H32N2O2/c1-23-20-15-18(25)9-10-19(20)22(21(23)26)11-13-24(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17,25H,2-8,11-14,16H2,1H3
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor mu 1 expressed in HEK293 cells using [3H]DAMGO radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50173245
PNG
(1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dih...)
Show SMILES CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2cc(F)ccc12
Show InChI InChI=1S/C22H31FN2O/c1-24-20-10-9-18(23)15-19(20)22(21(24)26)11-13-25(14-12-22)16-17-7-5-3-2-4-6-8-17/h9-10,15,17H,2-8,11-14,16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human opioid receptor delta 1 expressed in HEK293 cells using [3H]DDPDE radioligand


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50173265
PNG
(2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-i...)
Show SMILES OC(=O)CN1C(=O)C2(CCN(CC3CCCCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H32N2O3/c26-21(27)17-25-20-11-7-6-10-19(20)23(22(25)28)12-14-24(15-13-23)16-18-8-4-2-1-3-5-9-18/h6-7,10-11,18H,1-5,8-9,12-17H2,(H,26,27)
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...


Bioorg Med Chem Lett 15: 5022-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.009
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%