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PubMed code 16279768

Compile data set for download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7804
PNG
(1-benzyl-2,5-dihydro-1H-pyrrole-2,5-dione | Maleim...)
Show SMILES O=C1C=CC(=O)N1Cc1ccccc1 |c:2|
Show InChI InChI=1S/C11H9NO2/c13-10-6-7-11(14)12(10)8-9-4-2-1-3-5-9/h1-7H,8H2
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n/an/a 1.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7852
PNG
(Thiadiazolidinone (TDZD) deriv. 59 | ethyl 2-(2-me...)
Show SMILES CCOC(=O)Cn1c(=O)sn(C)c1=O
Show InChI InChI=1S/C7H10N2O4S/c1-3-13-5(10)4-9-6(11)8(2)14-7(9)12/h3-4H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7807
PNG
(1-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-2,5-dione...)
Show SMILES O=C1C=CC(=O)N1CCc1ccccc1 |c:2|
Show InChI InChI=1S/C12H11NO2/c14-11-6-7-12(15)13(11)9-8-10-4-2-1-3-5-10/h1-7H,8-9H2
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n/an/a 2.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7806
PNG
(1-[(4-methoxyphenyl)methyl]-2,5-dihydro-1H-pyrrole...)
Show SMILES COc1ccc(CN2C(=O)C=CC2=O)cc1 |c:10|
Show InChI InChI=1S/C12H11NO3/c1-16-10-4-2-9(3-5-10)8-13-11(14)6-7-12(13)15/h2-7H,8H2,1H3
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n/an/a 2.50E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7808
PNG
(1-[2-(4-methoxyphenyl)ethyl]-2,5-dihydro-1H-pyrrol...)
Show SMILES COc1ccc(CCN2C(=O)C=CC2=O)cc1 |c:11|
Show InChI InChI=1S/C13H13NO3/c1-17-11-4-2-10(3-5-11)8-9-14-12(15)6-7-13(14)16/h2-7H,8-9H2,1H3
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n/an/a 3.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7805
PNG
(Maleimide-Related Compound 4 | N-(Ethoxycarbonylme...)
Show SMILES CCOC(=O)CN1C(=O)C=CC1=O |c:9|
Show InChI InChI=1S/C8H9NO4/c1-2-13-8(12)5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7810
PNG
(1-(5-phenylpentyl)-2,5-dihydro-1H-pyrrole-2,5-dion...)
Show SMILES O=C1C=CC(=O)N1CCCCCc1ccccc1 |c:2|
Show InChI InChI=1S/C15H17NO2/c17-14-10-11-15(18)16(14)12-6-2-5-9-13-7-3-1-4-8-13/h1,3-4,7-8,10-11H,2,5-6,9,12H2
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n/an/a 3.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7809
PNG
(1-(3-phenylpropyl)-2,5-dihydro-1H-pyrrole-2,5-dion...)
Show SMILES O=C1C=CC(=O)N1CCCc1ccccc1 |c:2|
Show InChI InChI=1S/C13H13NO2/c15-12-8-9-13(16)14(12)10-4-7-11-5-2-1-3-6-11/h1-3,5-6,8-9H,4,7,10H2
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7803
PNG
(1-methyl-2,5-dihydro-1H-pyrrole-2,5-dione | Maleim...)
Show SMILES CN1C(=O)C=CC1=O |c:4|
Show InChI InChI=1S/C5H5NO2/c1-6-4(7)2-3-5(6)8/h2-3H,1H3
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n/an/a 5.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7802
PNG
(2,5-dihydro-1H-pyrrole-2,5-dione | Maleimide-Relat...)
Show SMILES O=C1NC(=O)C=C1 |c:5|
Show InChI InChI=1S/C4H3NO2/c6-3-1-2-4(7)5-3/h1-2H,(H,5,6,7)
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n/an/a 6.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7851
PNG
(2-Ethyl-4-phenyl-1,2,4-thiadiazolidine-3,5-dione |...)
Show SMILES CCn1sc(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C10H10N2O2S/c1-2-11-9(13)12(10(14)15-11)8-6-4-3-5-7-8/h3-7H,2H2,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7848
PNG
(2-Ethyl-4-(4-nitrophenyl)-1,2,4-thiadiazolidine-3,...)
Show SMILES CCn1sc(=O)n(-c2ccc(cc2)N(=O)=O)c1=O
Show InChI InChI=1S/C10H9N3O4S/c1-2-11-9(14)12(10(15)18-11)7-3-5-8(6-4-7)13(16)17/h3-6H,2H2,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7831
PNG
(4-Benzyl-1,2,4-dithiazolidine-3,5-dione | Dithiazo...)
Show SMILES O=c1ssc(=O)n1Cc1ccccc1
Show InChI InChI=1S/C9H7NO2S2/c11-8-10(9(12)14-13-8)6-7-4-2-1-3-5-7/h1-5H,6H2
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7830
PNG
(4-Phenyl-1,2,4-dithiazolidine-3,5-dione | Dithiazo...)
Show SMILES O=c1ssc(=O)n1-c1ccccc1
Show InChI InChI=1S/C8H5NO2S2/c10-7-9(8(11)13-12-7)6-4-2-1-3-5-6/h1-5H
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7811
PNG
(Maleimide-Related Compound 10 | cyclopent-4-ene-1,...)
Show SMILES O=C1CC(=O)C=C1 |c:5|
Show InChI InChI=1S/C5H4O2/c6-4-1-2-5(7)3-4/h1-2H,3H2
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7823
PNG
(3-benzyl-2-sulfanylidene-1,3-thiazolidin-4-one | N...)
Show SMILES Oc1csc(=S)n1Cc1ccccc1
Show InChI InChI=1S/C10H9NOS2/c12-9-7-14-10(13)11(9)6-8-4-2-1-3-5-8/h1-5,7,12H,6H2
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7824
PNG
(3-(2-phenylethyl)-2-sulfanylidene-1,3-thiazolidin-...)
Show SMILES Oc1csc(=S)n1CCc1ccccc1
Show InChI InChI=1S/C11H11NOS2/c13-10-8-15-11(14)12(10)7-6-9-4-2-1-3-5-9/h1-5,8,13H,6-7H2
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Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7825
PNG
(3-(2-oxo-2-phenylethyl)-2-sulfanylidene-1,3-thiazo...)
Show SMILES Oc1csc(=S)n1CC(=O)c1ccccc1
Show InChI InChI=1S/C11H9NO2S2/c13-9(8-4-2-1-3-5-8)6-12-10(14)7-16-11(12)15/h1-5,7,14H,6H2
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Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7827
PNG
(3-[(4-methoxyphenyl)methyl]-2-sulfanylidene-1,3-th...)
Show SMILES COc1ccc(Cn2c(O)csc2=S)cc1
Show InChI InChI=1S/C11H11NO2S2/c1-14-9-4-2-8(3-5-9)6-12-10(13)7-16-11(12)15/h2-5,7,13H,6H2,1H3
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Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7838
PNG
(3-benzylimidazolidine-2,4-dione | Hydantoin Deriva...)
Show SMILES Oc1c[nH]c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C10H10N2O2/c13-9-6-11-10(14)12(9)7-8-4-2-1-3-5-8/h1-6,13H,7H2,(H,11,14)
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Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7837
PNG
(CHEMBL122334 | Hydantoin Derivative 36 | imidazoli...)
Show SMILES Oc1c[nH]c(=O)[nH]1
Show InChI InChI=1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1,6H,(H2,4,5,7)
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Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7834
PNG
(1,2-Dibenzoyl-4-phenyl-1,2,4-triazolidine-3,5-dion...)
Show SMILES O=C(c1ccccc1)n1n(C(=O)c2ccccc2)c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C22H15N3O4/c26-19(16-10-4-1-5-11-16)24-21(28)23(18-14-8-3-9-15-18)22(29)25(24)20(27)17-12-6-2-7-13-17/h1-15H
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Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7833
PNG
(1,2-Dimethyl-4-Phenyl-1,2,4-triazolidine-3,5-dione...)
Show SMILES Cn1n(C)c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C10H11N3O2/c1-11-9(14)13(10(15)12(11)2)8-6-4-3-5-7-8/h3-7H,1-2H3
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7812
PNG
(2,5-dihydrofuran-2,5-dione | Maleimide-Related Com...)
Show SMILES O=C1OC(=O)C=C1 |c:5|
Show InChI InChI=1S/C4H2O3/c5-3-1-2-4(6)7-3/h1-2H
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n/an/a>1.00E+5n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7829
PNG
(4-Methyl-1,2,4-dithiazolidine-3,5-dione | Dithiazo...)
Show SMILES Cn1c(=O)ssc1=O
Show InChI InChI=1S/C3H3NO2S2/c1-4-2(5)7-8-3(4)6/h1H3
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7815
PNG
(1-benzylpyrrolidine-2,5-dione | Maleimide-Related ...)
Show SMILES O=C1CCC(=O)N1Cc1ccccc1
Show InChI InChI=1S/C11H11NO2/c13-10-6-7-11(14)12(10)8-9-4-2-1-3-5-9/h1-5H,6-8H2
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n/an/a>1.00E+5n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7814
PNG
(Maleimide-Related Compound 13 | pyrrolidine-2,5-di...)
Show SMILES O=C1CCC(=O)N1
Show InChI InChI=1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)
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n/an/a>1.00E+5n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7828
PNG
(3-[2-(4-methoxyphenyl)ethyl]-2-sulfanylidene-1,3-t...)
Show SMILES COc1ccc(CCn2c(O)csc2=S)cc1
Show InChI InChI=1S/C12H13NO2S2/c1-15-10-4-2-9(3-5-10)6-7-13-11(14)8-17-12(13)16/h2-5,8,14H,6-7H2,1H3
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7819
PNG
(3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one | R...)
Show SMILES Cn1c(O)csc1=S
Show InChI InChI=1S/C4H5NOS2/c1-5-3(6)2-8-4(5)7/h2,6H,1H3
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7821
PNG
(3-amino-2-sulfanylidene-1,3-thiazolidin-4-one | Rh...)
Show SMILES Nn1c(O)csc1=S
Show InChI InChI=1S/C3H4N2OS2/c4-5-2(6)1-8-3(5)7/h1,6H,4H2
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7832
PNG
(4-phenyl-1,2,4-triazolidine-3,5-dione | Triazolidi...)
Show SMILES O=c1[nH][nH]c(=O)n1-c1ccccc1
Show InChI InChI=1S/C8H7N3O2/c12-7-9-10-8(13)11(7)6-4-2-1-3-5-6/h1-5H,(H,9,12)(H,10,13)
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7816
PNG
(1-benzylpyrrolidin-2-one | Maleimide-Related Compo...)
Show SMILES O=C1CCCN1Cc1ccccc1
Show InChI InChI=1S/C11H13NO/c13-11-7-4-8-12(11)9-10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H2
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n/an/a>1.00E+5n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7836
PNG
(4-phenyl-4,5-dihydro-3H-1,2,4-triazole-3,5-dione |...)
Show SMILES O=C1N=NC(=O)N1c1ccccc1 |c:2|
Show InChI InChI=1S/C8H5N3O2/c12-7-9-10-8(13)11(7)6-4-2-1-3-5-6/h1-5H
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7822
PNG
(1,3-thiazolidine-2,4-dione | CHEMBL2071163 | thiaz...)
Show SMILES Oc1csc(=O)[nH]1
Show InChI InChI=1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1,5H,(H,4,6)
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7835
PNG
(1,2-Bis-(phenylcarbonylmethyl)-4-phenyl-1,2,4-tria...)
Show SMILES O=C(Cn1n(CC(=O)c2ccccc2)c(=O)n(-c2ccccc2)c1=O)c1ccccc1
Show InChI InChI=1S/C24H19N3O4/c28-21(18-10-4-1-5-11-18)16-25-23(30)27(20-14-8-3-9-15-20)24(31)26(25)17-22(29)19-12-6-2-7-13-19/h1-15H,16-17H2
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7826
PNG
(3-benzyl-1,3-thiazolidine-2,4-dione | 4-Benzyl-2,4...)
Show SMILES Oc1csc(=O)n1Cc1ccccc1
Show InChI InChI=1S/C10H9NO2S/c12-9-7-14-10(13)11(9)6-8-4-2-1-3-5-8/h1-5,7,12H,6H2
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7820
PNG
(2-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)acet...)
Show SMILES OC(=O)Cn1c(O)csc1=S
Show InChI InChI=1S/C5H5NO3S2/c7-3-2-11-5(10)6(3)1-4(8)9/h2,7H,1H2,(H,8,9)
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7813
PNG
(Maleimide-Related Compound 12 | cyclopentane-1,3-d...)
Show SMILES O=C1CCC(=O)C1
Show InChI InChI=1S/C5H6O2/c6-4-1-2-5(7)3-4/h1-3H2
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n/an/a>1.00E+5n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7818
PNG
(2-sulfanylidene-1,3-thiazolidin-4-one | Rhodanine-...)
Show SMILES Oc1csc(S)n1
Show InChI InChI=1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1,5H,(H,4,6)
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n/an/a 1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta [7-25]


(Oryctolagus cuniculus (rabbit))		BDBM7817
PNG
(1-benzyl-2,5-dihydro-1H-pyrrole | Maleimide-Relate...)
Show SMILES C(N1CC=CC1)c1ccccc1 |c:3|
Show InChI InChI=1S/C11H13N/c1-2-6-11(7-3-1)10-12-8-4-5-9-12/h1-7H,8-10H2
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n/an/a>1.00E+5n/an/an/an/an/a37



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...

J Med Chem 48: 7103-12 (2005)


Article DOI: 10.1021/jm040895g
BindingDB Entry DOI: 10.7270/Q2J964MP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%