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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM16589 (4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 26 | -44.0 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description For Ki determinations a matrix of inhibitor and substrate concentrations were tested. Inhibitor concentrations were tested from four times IC50 with ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM16591 ((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 659 | -35.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description For Ki determinations a matrix of inhibitor and substrate concentrations were tested. Inhibitor concentrations were tested from four times IC50 with ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM16590 (2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 8.58E+3 | -29.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description For Ki determinations a matrix of inhibitor and substrate concentrations were tested. Inhibitor concentrations were tested from four times IC50 with ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM16589 (4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM16589 (4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM16589 (4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 104 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM16591 ((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 168 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM16591 ((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM16591 ((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 266 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM16589 (4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 314 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM16591 ((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 353 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human)) | BDBM16589 (4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 443 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM16590 (2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 744 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM16590 (2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 845 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM16591 ((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 856 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human)) | BDBM16590 (2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.71E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM16590 (2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| 3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human)) | BDBM16591 ((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.83E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM16590 (2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.43E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16589 (4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.36E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16591 ((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16590 (2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM16589 (4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.72E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM16590 (2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ... | Bioorg Med Chem 14: 1792-804 (2006) Article DOI: 10.1016/j.bmc.2005.10.022 BindingDB Entry DOI: 10.7270/Q2154F9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
