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PubMed code 16297618

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177564
PNG
(CHEMBL380540 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1Cc2ccccc2C(C)(C)N1)c1ccccc1F
Show InChI InChI=1S/C37H47ClFN5O2/c1-5-42(6-2)25-34(29-12-8-10-14-31(29)39)43-19-21-44(22-20-43)36(46)33(23-26-15-17-28(38)18-16-26)40-35(45)32-24-27-11-7-9-13-30(27)37(3,4)41-32/h7-18,32-34,41H,5-6,19-25H2,1-4H3,(H,40,45)/t32?,33-,34?/m1/s1
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 5.80n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177560
PNG
(CHEMBL206042 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C36H45Cl2N5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1
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 6.40n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177560
PNG
(CHEMBL206042 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C36H45Cl2N5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1
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 6.40n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177563
PNG
(CHEMBL380855 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1
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 7.30n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177557
PNG
(CHEMBL380365 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1
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 10n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177565
PNG
(CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1N(C)Cc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-34(30-12-8-9-13-31(30)38)42-18-20-43(21-19-42)36(45)32(22-26-14-16-28(37)17-15-26)39-35(44)23-33-29-11-7-6-10-27(29)24-40(33)3/h6-17,32-34H,4-5,18-25H2,1-3H3,(H,39,44)/t32-,33?,34?/m1/s1
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 17n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177561
PNG
((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamin...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)c1ccccc1F
Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31-,32-,33?/m1/s1
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 41n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177558
PNG
(CHEMBL438432 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1(C)NCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-33(29-11-7-9-13-31(29)38)42-18-20-43(21-19-42)35(45)32(22-26-14-16-28(37)17-15-26)40-34(44)23-36(3)30-12-8-6-10-27(30)24-39-36/h6-17,32-33,39H,4-5,18-25H2,1-3H3,(H,40,44)/t32-,33?,36?/m1/s1
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 74n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177562
PNG
(CHEMBL206840 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)c1cc2ccccc2cn1)c1ccccc1F
Show InChI InChI=1S/C35H39ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,22-23,32-33H,3-4,17-21,24H2,1-2H3,(H,39,43)/t32-,33?/m1/s1
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 96n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177559
PNG
(CHEMBL379352 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C35H43Cl2N5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1
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 107n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50177559
PNG
(CHEMBL379352 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C35H43Cl2N5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1
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 107n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50177564
PNG
(CHEMBL380540 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1Cc2ccccc2C(C)(C)N1)c1ccccc1F
Show InChI InChI=1S/C37H47ClFN5O2/c1-5-42(6-2)25-34(29-12-8-10-14-31(29)39)43-19-21-44(22-20-43)36(46)33(23-26-15-17-28(38)18-16-26)40-35(45)32-24-27-11-7-9-13-30(27)37(3,4)41-32/h7-18,32-34,41H,5-6,19-25H2,1-4H3,(H,40,45)/t32?,33-,34?/m1/s1
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 420n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50177557
PNG
(CHEMBL380365 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1
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 910n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50177562
PNG
(CHEMBL206840 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)c1cc2ccccc2cn1)c1ccccc1F
Show InChI InChI=1S/C35H39ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,22-23,32-33H,3-4,17-21,24H2,1-2H3,(H,39,43)/t32-,33?/m1/s1
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 920n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50177561
PNG
((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamin...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)c1ccccc1F
Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31-,32-,33?/m1/s1
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 950n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50177563
PNG
(CHEMBL380855 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1
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 1.20E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50177558
PNG
(CHEMBL438432 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1(C)NCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-33(29-11-7-9-13-31(29)38)42-18-20-43(21-19-42)35(45)32(22-26-14-16-28(37)17-15-26)40-34(44)23-36(3)30-12-8-6-10-27(30)24-39-36/h6-17,32-33,39H,4-5,18-25H2,1-3H3,(H,40,44)/t32-,33?,36?/m1/s1
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 1.40E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50177562
PNG
(CHEMBL206840 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)c1cc2ccccc2cn1)c1ccccc1F
Show InChI InChI=1S/C35H39ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,22-23,32-33H,3-4,17-21,24H2,1-2H3,(H,39,43)/t32-,33?/m1/s1
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 1.40E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50177564
PNG
(CHEMBL380540 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1Cc2ccccc2C(C)(C)N1)c1ccccc1F
Show InChI InChI=1S/C37H47ClFN5O2/c1-5-42(6-2)25-34(29-12-8-10-14-31(29)39)43-19-21-44(22-20-43)36(46)33(23-26-15-17-28(38)18-16-26)40-35(45)32-24-27-11-7-9-13-30(27)37(3,4)41-32/h7-18,32-34,41H,5-6,19-25H2,1-4H3,(H,40,45)/t32?,33-,34?/m1/s1
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 1.90E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50177565
PNG
(CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1N(C)Cc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-34(30-12-8-9-13-31(30)38)42-18-20-43(21-19-42)36(45)32(22-26-14-16-28(37)17-15-26)39-35(44)23-33-29-11-7-6-10-27(29)24-40(33)3/h6-17,32-34H,4-5,18-25H2,1-3H3,(H,39,44)/t32-,33?,34?/m1/s1
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 2.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50177557
PNG
(CHEMBL380365 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1
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 3.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC1R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50177563
PNG
(CHEMBL380855 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1
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 3.40E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50177557
PNG
(CHEMBL380365 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1
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 4.20E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50177565
PNG
(CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1N(C)Cc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-34(30-12-8-9-13-31(30)38)42-18-20-43(21-19-42)36(45)32(22-26-14-16-28(37)17-15-26)39-35(44)23-33-29-11-7-6-10-27(29)24-40(33)3/h6-17,32-34H,4-5,18-25H2,1-3H3,(H,39,44)/t32-,33?,34?/m1/s1
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 4.60E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50177561
PNG
((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamin...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)c1ccccc1F
Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31-,32-,33?/m1/s1
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 5.80E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC1R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50177563
PNG
(CHEMBL380855 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1
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 6.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC1R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50177562
PNG
(CHEMBL206840 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)c1cc2ccccc2cn1)c1ccccc1F
Show InChI InChI=1S/C35H39ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,22-23,32-33H,3-4,17-21,24H2,1-2H3,(H,39,43)/t32-,33?/m1/s1
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 7.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC1R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50177561
PNG
((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamin...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)c1ccccc1F
Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31-,32-,33?/m1/s1
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 7.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50177564
PNG
(CHEMBL380540 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1Cc2ccccc2C(C)(C)N1)c1ccccc1F
Show InChI InChI=1S/C37H47ClFN5O2/c1-5-42(6-2)25-34(29-12-8-10-14-31(29)39)43-19-21-44(22-20-43)36(46)33(23-26-15-17-28(38)18-16-26)40-35(45)32-24-27-11-7-9-13-30(27)37(3,4)41-32/h7-18,32-34,41H,5-6,19-25H2,1-4H3,(H,40,45)/t32?,33-,34?/m1/s1
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 7.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC1R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50177565
PNG
(CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1N(C)Cc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-34(30-12-8-9-13-31(30)38)42-18-20-43(21-19-42)36(45)32(22-26-14-16-28(37)17-15-26)39-35(44)23-33-29-11-7-6-10-27(29)24-40(33)3/h6-17,32-34H,4-5,18-25H2,1-3H3,(H,39,44)/t32-,33?,34?/m1/s1
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 8.60E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC1R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50177558
PNG
(CHEMBL438432 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1(C)NCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-33(29-11-7-9-13-31(29)38)42-18-20-43(21-19-42)35(45)32(22-26-14-16-28(37)17-15-26)40-34(44)23-36(3)30-12-8-6-10-27(30)24-39-36/h6-17,32-33,39H,4-5,18-25H2,1-3H3,(H,40,44)/t32-,33?,36?/m1/s1
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 1.60E+4n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50177558
PNG
(CHEMBL438432 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...)
Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1(C)NCc2ccccc12)c1ccccc1F
Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-33(29-11-7-9-13-31(29)38)42-18-20-43(21-19-42)35(45)32(22-26-14-16-28(37)17-15-26)40-34(44)23-36(3)30-12-8-6-10-27(30)24-39-36/h6-17,32-33,39H,4-5,18-25H2,1-3H3,(H,40,44)/t32-,33?,36?/m1/s1
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 2.00E+4n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-alpha-MSH from cloned human MC1R expressed in HEK293 cell

Bioorg Med Chem Lett 16: 2341-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.103
BindingDB Entry DOI: 10.7270/Q2NS0TF6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%