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PubMed code 16321529

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4367
PNG
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3|
Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H
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n/an/a 2.80E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50178490
PNG
(7,12-dioxo-5-(2-piperidin-1-yl-ethoxy)-7,12-dihydr...)
Show SMILES COC(=O)c1c(OCCN2CCCCC2)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C29H25NO6/c1-34-29(33)23-21-22-24(31)17-9-3-4-10-18(17)25(32)28(22)36-27(21)20-12-6-5-11-19(20)26(23)35-16-15-30-13-7-2-8-14-30/h3-6,9-12H,2,7-8,13-16H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against EGFR kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4367
PNG
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3|
Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H
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n/an/a 4.10E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against EGFR kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4367
PNG
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3|
Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H
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n/an/a 4.30E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50178490
PNG
(7,12-dioxo-5-(2-piperidin-1-yl-ethoxy)-7,12-dihydr...)
Show SMILES COC(=O)c1c(OCCN2CCCCC2)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C29H25NO6/c1-34-29(33)23-21-22-24(31)17-9-3-4-10-18(17)25(32)28(22)36-27(21)20-12-6-5-11-19(20)26(23)35-16-15-30-13-7-2-8-14-30/h3-6,9-12H,2,7-8,13-16H2,1H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4367
PNG
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3|
Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H
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n/an/a 4.90E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50178494
PNG
(5-(2-diethylamino-ethoxy)-7,12-dioxo-7,12-dihydro-...)
Show SMILES CCN(CC)CCOc1c(C(=O)OC)c2c3c(oc2c2ccccc12)C(=O)c1ccccc1C3=O
Show InChI InChI=1S/C28H25NO6/c1-4-29(5-2)14-15-34-25-18-12-8-9-13-19(18)26-20(22(25)28(32)33-3)21-23(30)16-10-6-7-11-17(16)24(31)27(21)35-26/h6-13H,4-5,14-15H2,1-3H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against EGFR kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50178492
PNG
(7,12-dioxo-5-(2-pyrrolidin-1-yl-ethoxy)-7,12-dihyd...)
Show SMILES COC(=O)c1c(OCCN2CCCC2)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C28H23NO6/c1-33-28(32)22-20-21-23(30)16-8-2-3-9-17(16)24(31)27(21)35-26(20)19-11-5-4-10-18(19)25(22)34-15-14-29-12-6-7-13-29/h2-5,8-11H,6-7,12-15H2,1H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50178490
PNG
(7,12-dioxo-5-(2-piperidin-1-yl-ethoxy)-7,12-dihydr...)
Show SMILES COC(=O)c1c(OCCN2CCCCC2)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C29H25NO6/c1-34-29(33)23-21-22-24(31)17-9-3-4-10-18(17)25(32)28(22)36-27(21)20-12-6-5-11-19(20)26(23)35-16-15-30-13-7-2-8-14-30/h3-6,9-12H,2,7-8,13-16H2,1H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50178490
PNG
(7,12-dioxo-5-(2-piperidin-1-yl-ethoxy)-7,12-dihydr...)
Show SMILES COC(=O)c1c(OCCN2CCCCC2)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C29H25NO6/c1-34-29(33)23-21-22-24(31)17-9-3-4-10-18(17)25(32)28(22)36-27(21)20-12-6-5-11-19(20)26(23)35-16-15-30-13-7-2-8-14-30/h3-6,9-12H,2,7-8,13-16H2,1H3
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n/an/a 7.10E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50178495
PNG
(5-(2-dimethylamino-ethoxy)-7,12-dioxo-7,12-dihydro...)
Show SMILES COC(=O)c1c(OCCN(C)C)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C26H21NO6/c1-27(2)12-13-32-23-16-10-6-7-11-17(16)24-18(20(23)26(30)31-3)19-21(28)14-8-4-5-9-15(14)22(29)25(19)33-24/h4-11H,12-13H2,1-3H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50178492
PNG
(7,12-dioxo-5-(2-pyrrolidin-1-yl-ethoxy)-7,12-dihyd...)
Show SMILES COC(=O)c1c(OCCN2CCCC2)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C28H23NO6/c1-33-28(32)22-20-21-23(30)16-8-2-3-9-17(16)24(31)27(21)35-26(20)19-11-5-4-10-18(19)25(22)34-15-14-29-12-6-7-13-29/h2-5,8-11H,6-7,12-15H2,1H3
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n/an/a 8.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50178494
PNG
(5-(2-diethylamino-ethoxy)-7,12-dioxo-7,12-dihydro-...)
Show SMILES CCN(CC)CCOc1c(C(=O)OC)c2c3c(oc2c2ccccc12)C(=O)c1ccccc1C3=O
Show InChI InChI=1S/C28H25NO6/c1-4-29(5-2)14-15-34-25-18-12-8-9-13-19(18)26-20(22(25)28(32)33-3)21-23(30)16-10-6-7-11-17(16)24(31)27(21)35-26/h6-13H,4-5,14-15H2,1-3H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50178492
PNG
(7,12-dioxo-5-(2-pyrrolidin-1-yl-ethoxy)-7,12-dihyd...)
Show SMILES COC(=O)c1c(OCCN2CCCC2)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C28H23NO6/c1-33-28(32)22-20-21-23(30)16-8-2-3-9-17(16)24(31)27(21)35-26(20)19-11-5-4-10-18(19)25(22)34-15-14-29-12-6-7-13-29/h2-5,8-11H,6-7,12-15H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against EGFR kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50178491
PNG
(5-(3-dimethylamino-propoxy)-7,12-dioxo-7,12-dihydr...)
Show SMILES COC(=O)c1c(OCCCN(C)C)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C27H23NO6/c1-28(2)13-8-14-33-24-17-11-6-7-12-18(17)25-19(21(24)27(31)32-3)20-22(29)15-9-4-5-10-16(15)23(30)26(20)34-25/h4-7,9-12H,8,13-14H2,1-3H3
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n/an/a 1.02E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50178494
PNG
(5-(2-diethylamino-ethoxy)-7,12-dioxo-7,12-dihydro-...)
Show SMILES CCN(CC)CCOc1c(C(=O)OC)c2c3c(oc2c2ccccc12)C(=O)c1ccccc1C3=O
Show InChI InChI=1S/C28H25NO6/c1-4-29(5-2)14-15-34-25-18-12-8-9-13-19(18)26-20(22(25)28(32)33-3)21-23(30)16-10-6-7-11-17(16)24(31)27(21)35-26/h6-13H,4-5,14-15H2,1-3H3
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n/an/a 1.26E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50178493
PNG
(5-methoxy-7,12-dioxo-7,12-dihydro-dinaphtho[1,2-b;...)
Show SMILES COC(=O)c1c(OC)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C23H14O6/c1-27-20-13-9-5-6-10-14(13)21-15(17(20)23(26)28-2)16-18(24)11-7-3-4-8-12(11)19(25)22(16)29-21/h3-10H,1-2H3
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n/an/a 1.26E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against EGFR kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50178495
PNG
(5-(2-dimethylamino-ethoxy)-7,12-dioxo-7,12-dihydro...)
Show SMILES COC(=O)c1c(OCCN(C)C)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C26H21NO6/c1-27(2)12-13-32-23-16-10-6-7-11-17(16)24-18(20(23)26(30)31-3)19-21(28)14-8-4-5-9-15(14)22(29)25(19)33-24/h4-11H,12-13H2,1-3H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50178491
PNG
(5-(3-dimethylamino-propoxy)-7,12-dioxo-7,12-dihydr...)
Show SMILES COC(=O)c1c(OCCCN(C)C)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C27H23NO6/c1-28(2)13-8-14-33-24-17-11-6-7-12-18(17)25-19(21(24)27(31)32-3)20-22(29)15-9-4-5-10-16(15)23(30)26(20)34-25/h4-7,9-12H,8,13-14H2,1-3H3
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n/an/a 1.36E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against EGFR kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50178491
PNG
(5-(3-dimethylamino-propoxy)-7,12-dioxo-7,12-dihydr...)
Show SMILES COC(=O)c1c(OCCCN(C)C)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C27H23NO6/c1-28(2)13-8-14-33-24-17-11-6-7-12-18(17)25-19(21(24)27(31)32-3)20-22(29)15-9-4-5-10-16(15)23(30)26(20)34-25/h4-7,9-12H,8,13-14H2,1-3H3
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n/an/a 1.55E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50178494
PNG
(5-(2-diethylamino-ethoxy)-7,12-dioxo-7,12-dihydro-...)
Show SMILES CCN(CC)CCOc1c(C(=O)OC)c2c3c(oc2c2ccccc12)C(=O)c1ccccc1C3=O
Show InChI InChI=1S/C28H25NO6/c1-4-29(5-2)14-15-34-25-18-12-8-9-13-19(18)26-20(22(25)28(32)33-3)21-23(30)16-10-6-7-11-17(16)24(31)27(21)35-26/h6-13H,4-5,14-15H2,1-3H3
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n/an/a 1.59E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50178495
PNG
(5-(2-dimethylamino-ethoxy)-7,12-dioxo-7,12-dihydro...)
Show SMILES COC(=O)c1c(OCCN(C)C)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C26H21NO6/c1-27(2)12-13-32-23-16-10-6-7-11-17(16)24-18(20(23)26(30)31-3)19-21(28)14-8-4-5-9-15(14)22(29)25(19)33-24/h4-11H,12-13H2,1-3H3
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n/an/a 2.36E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50178492
PNG
(7,12-dioxo-5-(2-pyrrolidin-1-yl-ethoxy)-7,12-dihyd...)
Show SMILES COC(=O)c1c(OCCN2CCCC2)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C28H23NO6/c1-33-28(32)22-20-21-23(30)16-8-2-3-9-17(16)24(31)27(21)35-26(20)19-11-5-4-10-18(19)25(22)34-15-14-29-12-6-7-13-29/h2-5,8-11H,6-7,12-15H2,1H3
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n/an/a 2.38E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50178495
PNG
(5-(2-dimethylamino-ethoxy)-7,12-dioxo-7,12-dihydro...)
Show SMILES COC(=O)c1c(OCCN(C)C)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C26H21NO6/c1-27(2)12-13-32-23-16-10-6-7-11-17(16)24-18(20(23)26(30)31-3)19-21(28)14-8-4-5-9-15(14)22(29)25(19)33-24/h4-11H,12-13H2,1-3H3
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n/an/a 3.10E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against EGFR kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50178491
PNG
(5-(3-dimethylamino-propoxy)-7,12-dioxo-7,12-dihydr...)
Show SMILES COC(=O)c1c(OCCCN(C)C)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C27H23NO6/c1-28(2)13-8-14-33-24-17-11-6-7-12-18(17)25-19(21(24)27(31)32-3)20-22(29)15-9-4-5-10-16(15)23(30)26(20)34-25/h4-7,9-12H,8,13-14H2,1-3H3
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n/an/a 3.84E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50178493
PNG
(5-methoxy-7,12-dioxo-7,12-dihydro-dinaphtho[1,2-b;...)
Show SMILES COC(=O)c1c(OC)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C23H14O6/c1-27-20-13-9-5-6-10-14(13)21-15(17(20)23(26)28-2)16-18(24)11-7-3-4-8-12(11)19(25)22(16)29-21/h3-10H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50178493
PNG
(5-methoxy-7,12-dioxo-7,12-dihydro-dinaphtho[1,2-b;...)
Show SMILES COC(=O)c1c(OC)c2ccccc2c2oc3c(C(=O)c4ccccc4C3=O)c12
Show InChI InChI=1S/C23H14O6/c1-27-20-13-9-5-6-10-14(13)21-15(17(20)23(26)28-2)16-18(24)11-7-3-4-8-12(11)19(25)22(16)29-21/h3-10H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50178496
PNG
(7,12-dioxo-5-propoxy-7,12-dihydro-dinaphtho[1,2-b;...)
Show SMILES CCCOc1c(C(=O)OC)c2c3c(oc2c2ccccc12)C(=O)c1ccccc1C3=O
Show InChI InChI=1S/C25H18O6/c1-3-12-30-22-15-10-6-7-11-16(15)23-17(19(22)25(28)29-2)18-20(26)13-8-4-5-9-14(13)21(27)24(18)31-23/h4-11H,3,12H2,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50178496
PNG
(7,12-dioxo-5-propoxy-7,12-dihydro-dinaphtho[1,2-b;...)
Show SMILES CCCOc1c(C(=O)OC)c2c3c(oc2c2ccccc12)C(=O)c1ccccc1C3=O
Show InChI InChI=1S/C25H18O6/c1-3-12-30-22-15-10-6-7-11-16(15)23-17(19(22)25(28)29-2)18-20(26)13-8-4-5-9-14(13)21(27)24(18)31-23/h4-11H,3,12H2,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against EGFR kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50178496
PNG
(7,12-dioxo-5-propoxy-7,12-dihydro-dinaphtho[1,2-b;...)
Show SMILES CCCOc1c(C(=O)OC)c2c3c(oc2c2ccccc12)C(=O)c1ccccc1C3=O
Show InChI InChI=1S/C25H18O6/c1-3-12-30-22-15-10-6-7-11-16(15)23-17(19(22)25(28)29-2)18-20(26)13-8-4-5-9-14(13)21(27)24(18)31-23/h4-11H,3,12H2,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1 kinase


Bioorg Med Chem Lett 16: 737-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.115
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%