Found 51 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179206
(3-trifluoromethyl-N-(6,7-dimethoxy-2,4-dihydroinde...)Show SMILES COc1cc2Cc3c(Nc4cccc(c4)C(F)(F)F)[nH]nc3-c2cc1OC Show InChI InChI=1S/C19H16F3N3O2/c1-26-15-7-10-6-14-17(13(10)9-16(15)27-2)24-25-18(14)23-12-5-3-4-11(8-12)19(20,21)22/h3-5,7-9H,6H2,1-2H3,(H2,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179212
(3-chloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16ClN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179211
(3-bromo-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]p...)Show InChI InChI=1S/C18H16BrN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179209
((6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-y...)Show InChI InChI=1S/C18H17N3O2/c1-22-15-9-11-8-14-17(13(11)10-16(15)23-2)20-21-18(14)19-12-6-4-3-5-7-12/h3-7,9-10H,8H2,1-2H3,(H2,19,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179209
((6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-y...)Show InChI InChI=1S/C18H17N3O2/c1-22-15-9-11-8-14-17(13(11)10-16(15)23-2)20-21-18(14)19-12-6-4-3-5-7-12/h3-7,9-10H,8H2,1-2H3,(H2,19,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179210
((7-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...)Show InChI InChI=1S/C17H15N3O/c1-21-13-8-7-11-9-15-16(14(11)10-13)19-20-17(15)18-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179204
(3-methoxy-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c...)Show SMILES COc1cccc(Nc2[nH]nc-3c2Cc2cc(OC)c(OC)cc-32)c1 Show InChI InChI=1S/C19H19N3O3/c1-23-13-6-4-5-12(9-13)20-19-15-7-11-8-16(24-2)17(25-3)10-14(11)18(15)21-22-19/h4-6,8-10H,7H2,1-3H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179204
(3-methoxy-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c...)Show SMILES COc1cccc(Nc2[nH]nc-3c2Cc2cc(OC)c(OC)cc-32)c1 Show InChI InChI=1S/C19H19N3O3/c1-23-13-6-4-5-12(9-13)20-19-15-7-11-8-16(24-2)17(25-3)10-14(11)18(15)21-22-19/h4-6,8-10H,7H2,1-3H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179216
(3-carbomethoxy-N-(6,7-dimethoxy-2,4-dihydroindeno[...)Show SMILES COC(=O)c1cccc(Nc2[nH]nc-3c2Cc2cc(OC)c(OC)cc-32)c1 Show InChI InChI=1S/C20H19N3O4/c1-25-16-9-12-8-15-18(14(12)10-17(16)26-2)22-23-19(15)21-13-6-4-5-11(7-13)20(24)27-3/h4-7,9-10H,8H2,1-3H3,(H2,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179216
(3-carbomethoxy-N-(6,7-dimethoxy-2,4-dihydroindeno[...)Show SMILES COC(=O)c1cccc(Nc2[nH]nc-3c2Cc2cc(OC)c(OC)cc-32)c1 Show InChI InChI=1S/C20H19N3O4/c1-25-16-9-12-8-15-18(14(12)10-17(16)26-2)22-23-19(15)21-13-6-4-5-11(7-13)20(24)27-3/h4-7,9-10H,8H2,1-3H3,(H2,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179217
(3-methyl-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C19H19N3O2/c1-11-5-4-6-13(7-11)20-19-15-8-12-9-16(23-2)17(24-3)10-14(12)18(15)21-22-19/h4-7,9-10H,8H2,1-3H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179208
(6,7-dimethoxy-3-phenyl-1,4-dihydroindeno[1,2-c]pyr...)Show InChI InChI=1S/C18H16N2O2/c1-21-15-9-12-8-14-17(11-6-4-3-5-7-11)19-20-18(14)13(12)10-16(15)22-2/h3-7,9-10H,8H2,1-2H3,(H,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179208
(6,7-dimethoxy-3-phenyl-1,4-dihydroindeno[1,2-c]pyr...)Show InChI InChI=1S/C18H16N2O2/c1-21-15-9-12-8-14-17(11-6-4-3-5-7-11)19-20-18(14)13(12)10-16(15)22-2/h3-7,9-10H,8H2,1-2H3,(H,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179210
((7-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...)Show InChI InChI=1S/C17H15N3O/c1-21-13-8-7-11-9-15-16(14(11)10-13)19-20-17(15)18-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against c-ABL |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179211
(3-bromo-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]p...)Show InChI InChI=1S/C18H16BrN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179206
(3-trifluoromethyl-N-(6,7-dimethoxy-2,4-dihydroinde...)Show SMILES COc1cc2Cc3c(Nc4cccc(c4)C(F)(F)F)[nH]nc3-c2cc1OC Show InChI InChI=1S/C19H16F3N3O2/c1-26-15-7-10-6-14-17(13(10)9-16(15)27-2)24-25-18(14)23-12-5-3-4-11(8-12)19(20,21)22/h3-5,7-9H,6H2,1-2H3,(H2,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRalpha |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179213
((5-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...)Show InChI InChI=1S/C17H15N3O/c1-21-15-9-5-8-12-13(15)10-14-16(12)19-20-17(14)18-11-6-3-2-4-7-11/h2-9H,10H2,1H3,(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against LCK |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179221
(2-chloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16ClN3O2/c1-23-15-8-10-7-12-17(11(10)9-16(15)24-2)21-22-18(12)20-14-6-4-3-5-13(14)19/h3-6,8-9H,7H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179214
(3-cyano-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]p...)Show InChI InChI=1S/C19H16N4O2/c1-24-16-8-12-7-15-18(14(12)9-17(16)25-2)22-23-19(15)21-13-5-3-4-11(6-13)10-20/h3-6,8-9H,7H2,1-2H3,(H2,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 137 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against c-SRC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179217
(3-methyl-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C19H19N3O2/c1-11-5-4-6-13(7-11)20-19-15-8-12-9-16(23-2)17(24-3)10-14(12)18(15)21-22-19/h4-7,9-10H,8H2,1-3H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 188 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179215
((6-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...)Show InChI InChI=1S/C17H15N3O/c1-21-13-7-8-14-11(9-13)10-15-16(14)19-20-17(15)18-12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 217 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179212
(3-chloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16ClN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 268 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179220
(3,5-dichloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,...)Show SMILES COc1cc2Cc3c(Nc4cc(Cl)cc(Cl)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H15Cl2N3O2/c1-24-15-4-9-3-14-17(13(9)8-16(15)25-2)22-23-18(14)21-12-6-10(19)5-11(20)7-12/h4-8H,3H2,1-2H3,(H2,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179205
((2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine ...)Show InChI InChI=1S/C16H13N3/c1-2-7-12(8-3-1)17-16-14-10-11-6-4-5-9-13(11)15(14)18-19-16/h1-9H,10H2,(H2,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 317 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Fyn
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 378 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against FYN |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179222
(3,4-dichloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,...)Show SMILES COc1cc2Cc3c(Nc4ccc(Cl)c(Cl)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H15Cl2N3O2/c1-24-15-6-9-5-12-17(11(9)8-16(15)25-2)22-23-18(12)21-10-3-4-13(19)14(20)7-10/h3-4,6-8H,5H2,1-2H3,(H2,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179213
((5-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...)Show InChI InChI=1S/C17H15N3O/c1-21-15-9-5-8-12-13(15)10-14-16(12)19-20-17(14)18-11-6-3-2-4-7-11/h2-9H,10H2,1H3,(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 487 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antiproliferative activity against PDGF-BB stimulated HCASMC |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179223
(4-chloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16ClN3O2/c1-23-15-8-10-7-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-11(19)4-6-12/h3-6,8-9H,7H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 659 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179219
(3-carboxy-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c...)Show SMILES COc1cc2Cc3c(Nc4cccc(c4)C(O)=O)[nH]nc3-c2cc1OC Show InChI InChI=1S/C19H17N3O4/c1-25-15-8-11-7-14-17(13(11)9-16(15)26-2)21-22-18(14)20-12-5-3-4-10(6-12)19(23)24/h3-6,8-9H,7H2,1-2H3,(H,23,24)(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >800 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against VEGFR |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179218
(2,4-dichloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,...)Show SMILES COc1cc2Cc3c(Nc4ccc(Cl)cc4Cl)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H15Cl2N3O2/c1-24-15-6-9-5-12-17(11(9)8-16(15)25-2)22-23-18(12)21-14-4-3-10(19)7-13(14)20/h3-4,6-8H,5H2,1-2H3,(H2,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50179224
(2,5-dichloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,...)Show SMILES COc1cc2Cc3c(Nc4cc(Cl)ccc4Cl)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H15Cl2N3O2/c1-24-15-6-9-5-12-17(11(9)8-16(15)25-2)22-23-18(12)21-14-7-10(19)3-4-13(14)20/h3-4,6-8H,5H2,1-2H3,(H2,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PDGFRbeta kinase |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform alpha/delta/epsilon/gamma-1/gamma-2
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against Casein Kinase 1 |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against HER2 |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against CDK2 |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase-3
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against GSK3 |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| Purchase
CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 4.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against bFGFR1 |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 7
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against CDK7 |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
Reactome pathway
KEGG
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CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against CDK1 |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against FAK |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against MAPK |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
antibodypedia
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against PKA |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against IRK |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against CDK4 |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50179207
(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against EGFR |
J Med Chem 48: 8163-73 (2005)
Article DOI: 10.1021/jm050680m
BindingDB Entry DOI: 10.7270/Q2W095HW |
More data for this
Ligand-Target Pair | |
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