Found 31 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cathepsin K
(Homo sapiens (Human)) | BDBM50179532
(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)Show SMILES CC[C@@H](CNc1ccc(OC)cc1)NC(=O)C1(CCCCC1)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C30H37N3O2/c1-3-25(22-31-26-15-17-28(35-2)18-16-26)32-29(34)30(19-8-5-9-20-30)33-27-14-10-13-24(21-27)23-11-6-4-7-12-23/h4,6-7,10-18,21,25,31,33H,3,5,8-9,19-20,22H2,1-2H3,(H,32,34)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179555
((S)-2-(biphenyl-3-ylamino)-4-methyl-pentanoic acid...)Show SMILES CC[C@@H](CNc1ccc(OC)cc1)NC(=O)[C@H](CC(C)C)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C29H37N3O2/c1-5-24(20-30-25-14-16-27(34-4)17-15-25)32-29(33)28(18-21(2)3)31-26-13-9-12-23(19-26)22-10-7-6-8-11-22/h6-17,19,21,24,28,30-31H,5,18,20H2,1-4H3,(H,32,33)/t24-,28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179548
(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)Show SMILES CCC[C@@H](CNc1ccc(OC)cc1)NC(=O)C1(CCCCC1)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C31H39N3O2/c1-3-11-28(23-32-26-16-18-29(36-2)19-17-26)33-30(35)31(20-8-5-9-21-31)34-27-15-10-14-25(22-27)24-12-6-4-7-13-24/h4,6-7,10,12-19,22,28,32,34H,3,5,8-9,11,20-21,23H2,1-2H3,(H,33,35)/t28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179543
((4-{(S)-2-[(S)-2-(biphenyl-3-ylamino)-4-methyl-pen...)Show SMILES CC[C@@H](CNc1ccc(OCC(O)=O)cc1)NC(=O)[C@H](CC(C)C)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C30H37N3O4/c1-4-24(19-31-25-13-15-27(16-14-25)37-20-29(34)35)33-30(36)28(17-21(2)3)32-26-12-8-11-23(18-26)22-9-6-5-7-10-22/h5-16,18,21,24,28,31-32H,4,17,19-20H2,1-3H3,(H,33,36)(H,34,35)/t24-,28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179547
(CHEMBL557986 | [4-((S)-2-{[1-(biphenyl-3-ylamino)-...)Show SMILES CC[C@@H](CNc1ccc(OCC(O)=O)cc1)NC(=O)C1(CCCCC1)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C31H37N3O4/c1-2-25(21-32-26-14-16-28(17-15-26)38-22-29(35)36)33-30(37)31(18-7-4-8-19-31)34-27-13-9-12-24(20-27)23-10-5-3-6-11-23/h3,5-6,9-17,20,25,32,34H,2,4,7-8,18-19,21-22H2,1H3,(H,33,37)(H,35,36)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179539
(CHEMBL383551 | [4-((S)-2-{[1-(biphenyl-3-ylamino)-...)Show SMILES CC[C@@H](CNc1ccc(OCC(=O)OC(C)(C)C)cc1)NC(=O)C1(CCCCC1)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C35H45N3O4/c1-5-28(24-36-29-17-19-31(20-18-29)41-25-32(39)42-34(2,3)4)37-33(40)35(21-10-7-11-22-35)38-30-16-12-15-27(23-30)26-13-8-6-9-14-26/h6,8-9,12-20,23,28,36,38H,5,7,10-11,21-22,24-25H2,1-4H3,(H,37,40)/t28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179542
(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)Show SMILES CCCC[C@@H](CNc1ccc(OC)cc1)NC(=O)C1(CCCCC1)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C32H41N3O2/c1-3-4-15-29(24-33-27-17-19-30(37-2)20-18-27)34-31(36)32(21-9-6-10-22-32)35-28-16-11-14-26(23-28)25-12-7-5-8-13-25/h5,7-8,11-14,16-20,23,29,33,35H,3-4,6,9-10,15,21-22,24H2,1-2H3,(H,34,36)/t29-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179558
((4-{(S)-2-[(S)-2-(biphenyl-3-ylamino)-4-methyl-pen...)Show SMILES CC[C@@H](CNc1ccc(OCC(=O)OC(C)(C)C)cc1)NC(=O)[C@H](CC(C)C)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C34H45N3O4/c1-7-27(22-35-28-16-18-30(19-17-28)40-23-32(38)41-34(4,5)6)37-33(39)31(20-24(2)3)36-29-15-11-14-26(21-29)25-12-9-8-10-13-25/h8-19,21,24,27,31,35-36H,7,20,22-23H2,1-6H3,(H,37,39)/t27-,31-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179551
(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)Show SMILES COc1ccc(NC[C@H](C)NC(=O)C2(CCCCC2)Nc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C29H35N3O2/c1-22(21-30-25-14-16-27(34-2)17-15-25)31-28(33)29(18-7-4-8-19-29)32-26-13-9-12-24(20-26)23-10-5-3-6-11-23/h3,5-6,9-17,20,22,30,32H,4,7-8,18-19,21H2,1-2H3,(H,31,33)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179559
((S)-2-(biphenyl-3-ylamino)-4-methyl-pentanoic acid...)Show SMILES COc1ccc(NC[C@H](C)NC(=O)[C@H](CC(C)C)Nc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C28H35N3O2/c1-20(2)17-27(31-25-12-8-11-23(18-25)22-9-6-5-7-10-22)28(32)30-21(3)19-29-24-13-15-26(33-4)16-14-24/h5-16,18,20-21,27,29,31H,17,19H2,1-4H3,(H,30,32)/t21-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179538
((S)-2-(biphenyl-3-ylamino)-4-methyl-pentanoic acid...)Show SMILES CC[C@@H](CNc1ccc(OCc2nnn[nH]2)cc1)NC(=O)[C@H](CC(C)C)Nc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C30H37N7O2/c1-4-24(19-31-25-13-15-27(16-14-25)39-20-29-34-36-37-35-29)33-30(38)28(17-21(2)3)32-26-12-8-11-23(18-26)22-9-6-5-7-10-22/h5-16,18,21,24,28,31-32H,4,17,19-20H2,1-3H3,(H,33,38)(H,34,35,36,37)/t24-,28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179549
((S)-2-(biphenyl-3-ylamino)-4-methyl-pentanoic acid...)Show SMILES COc1ccc(NCCNC(=O)[C@H](CC(C)C)Nc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C27H33N3O2/c1-20(2)18-26(27(31)29-17-16-28-23-12-14-25(32-3)15-13-23)30-24-11-7-10-22(19-24)21-8-5-4-6-9-21/h4-15,19-20,26,28,30H,16-18H2,1-3H3,(H,29,31)/t26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179556
((S)-2-(3-cyclohexylphenylamino)-N-(2-(4-methoxyphe...)Show SMILES COc1ccc(NCCNC(=O)[C@H](CC(C)C)Nc2cccc(c2)C2CCCCC2)cc1 Show InChI InChI=1S/C27H39N3O2/c1-20(2)18-26(27(31)29-17-16-28-23-12-14-25(32-3)15-13-23)30-24-11-7-10-22(19-24)21-8-5-4-6-9-21/h7,10-15,19-21,26,28,30H,4-6,8-9,16-18H2,1-3H3,(H,29,31)/t26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179560
(CHEMBL383473 | N-(2-(4-methoxyphenylamino)ethyl)-4...)Show SMILES COc1ccc(NCCNC(=O)C(CC(C)C)Oc2cccc(Oc3ccccc3)c2)cc1 Show InChI InChI=1S/C27H32N2O4/c1-20(2)18-26(27(30)29-17-16-28-21-12-14-22(31-3)15-13-21)33-25-11-7-10-24(19-25)32-23-8-5-4-6-9-23/h4-15,19-20,26,28H,16-18H2,1-3H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179550
(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)Show SMILES COc1ccc(NC[C@@H](C)NC(=O)C2(CCCCC2)Nc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C29H35N3O2/c1-22(21-30-25-14-16-27(34-2)17-15-25)31-28(33)29(18-7-4-8-19-29)32-26-13-9-12-24(20-26)23-10-5-3-6-11-23/h3,5-6,9-17,20,22,30,32H,4,7-8,18-19,21H2,1-2H3,(H,31,33)/t22-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179534
(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)Show SMILES COc1ccc(NCCNC(=O)C2(CCCCC2)Nc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C28H33N3O2/c1-33-26-15-13-24(14-16-26)29-19-20-30-27(32)28(17-6-3-7-18-28)31-25-12-8-11-23(21-25)22-9-4-2-5-10-22/h2,4-5,8-16,21,29,31H,3,6-7,17-20H2,1H3,(H,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179537
(2-(biphenyl-3-yloxy)-4-methyl-pentanoic acid [2-(4...)Show SMILES COc1ccc(NCCNC(=O)C(CC(C)C)Oc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C27H32N2O3/c1-20(2)18-26(27(30)29-17-16-28-23-12-14-24(31-3)15-13-23)32-25-11-7-10-22(19-25)21-8-5-4-6-9-21/h4-15,19-20,26,28H,16-18H2,1-3H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50113676
((S)-benzyl 1-(2-(4-methoxyphenylamino)ethylamino)-...)Show SMILES COc1ccc(NCCNC(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)cc1 Show InChI InChI=1S/C23H31N3O4/c1-17(2)15-21(26-23(28)30-16-18-7-5-4-6-8-18)22(27)25-14-13-24-19-9-11-20(29-3)12-10-19/h4-12,17,21,24H,13-16H2,1-3H3,(H,25,27)(H,26,28)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179553
(1-(4-cyclohexylphenoxy)-N-(2-(4-methoxyphenylamino...)Show SMILES COc1ccc(NCCNC(=O)C2(CCCCC2)Oc2ccc(cc2)C2CCCCC2)cc1 Show InChI InChI=1S/C28H38N2O3/c1-32-25-16-12-24(13-17-25)29-20-21-30-27(31)28(18-6-3-7-19-28)33-26-14-10-23(11-15-26)22-8-4-2-5-9-22/h10-17,22,29H,2-9,18-21H2,1H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179540
(1-(biphenyl-4-ylamino)-cyclohexanecarboxylic acid ...)Show SMILES COc1ccc(NCCNC(=O)C2(CCCCC2)Nc2ccc(cc2)-c2ccccc2)cc1 Show InChI InChI=1S/C28H33N3O2/c1-33-26-16-14-24(15-17-26)29-20-21-30-27(32)28(18-6-3-7-19-28)31-25-12-10-23(11-13-25)22-8-4-2-5-9-22/h2,4-5,8-17,29,31H,3,6-7,18-21H2,1H3,(H,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179561
(2-(biphenyl-4-yloxy)-4-methyl-pentanoic acid [2-(4...)Show SMILES COc1ccc(NCCNC(=O)C(CC(C)C)Oc2ccc(cc2)-c2ccccc2)cc1 Show InChI InChI=1S/C27H32N2O3/c1-20(2)19-26(27(30)29-18-17-28-23-11-15-24(31-3)16-12-23)32-25-13-9-22(10-14-25)21-7-5-4-6-8-21/h4-16,20,26,28H,17-19H2,1-3H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179557
(1-(4-ethylphenoxy)-N-(2-(4-methoxyphenylamino)ethy...)Show SMILES CCc1ccc(OC2(CCCCC2)C(=O)NCCNc2ccc(OC)cc2)cc1 Show InChI InChI=1S/C24H32N2O3/c1-3-19-7-11-22(12-8-19)29-24(15-5-4-6-16-24)23(27)26-18-17-25-20-9-13-21(28-2)14-10-20/h7-14,25H,3-6,15-18H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179546
(1-(biphenyl-4-yloxy)-cyclohexanecarboxylic acid [2...)Show SMILES COc1ccc(NCCNC(=O)C2(CCCCC2)Oc2ccc(cc2)-c2ccccc2)cc1 Show InChI InChI=1S/C28H32N2O3/c1-32-25-16-12-24(13-17-25)29-20-21-30-27(31)28(18-6-3-7-19-28)33-26-14-10-23(11-15-26)22-8-4-2-5-9-22/h2,4-5,8-17,29H,3,6-7,18-21H2,1H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179536
(1-(4-isopropylphenoxy)-N-(2-(4-methoxyphenylamino)...)Show SMILES COc1ccc(NCCNC(=O)C2(CCCCC2)Oc2ccc(cc2)C(C)C)cc1 Show InChI InChI=1S/C25H34N2O3/c1-19(2)20-7-11-23(12-8-20)30-25(15-5-4-6-16-25)24(28)27-18-17-26-21-9-13-22(29-3)14-10-21/h7-14,19,26H,4-6,15-18H2,1-3H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179541
(1-(biphenyl-3-yloxy)-cyclohexanecarboxylic acid [2...)Show SMILES COc1ccc(NCCNC(=O)C2(CCCCC2)Oc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C28H32N2O3/c1-32-25-15-13-24(14-16-25)29-19-20-30-27(31)28(17-6-3-7-18-28)33-26-12-8-11-23(21-26)22-9-4-2-5-10-22/h2,4-5,8-16,21,29H,3,6-7,17-20H2,1H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179545
(CHEMBL203176 | N-(2-(4-methoxyphenylamino)ethyl)-4...)Show SMILES COc1ccc(NCCNC(=O)C(CC(C)C)Oc2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C27H32N2O4/c1-20(2)19-26(27(30)29-18-17-28-21-9-11-22(31-3)12-10-21)33-25-15-13-24(14-16-25)32-23-7-5-4-6-8-23/h4-16,20,26,28H,17-19H2,1-3H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179533
(2-(biphenyl-2-yloxy)-4-methyl-pentanoic acid [2-(4...)Show SMILES COc1ccc(NCCNC(=O)C(CC(C)C)Oc2ccccc2-c2ccccc2)cc1 Show InChI InChI=1S/C27H32N2O3/c1-20(2)19-26(27(30)29-18-17-28-22-13-15-23(31-3)16-14-22)32-25-12-8-7-11-24(25)21-9-5-4-6-10-21/h4-16,20,26,28H,17-19H2,1-3H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179554
(CHEMBL203576 | N-(2-(4-methoxyphenylamino)ethyl)-1...)Show InChI InChI=1S/C22H28N2O3/c1-26-19-12-10-18(11-13-19)23-16-17-24-21(25)22(14-6-3-7-15-22)27-20-8-4-2-5-9-20/h2,4-5,8-13,23H,3,6-7,14-17H2,1H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179535
(CHEMBL205923 | N-(2-(4-methoxyphenylamino)ethyl)-4...)Show InChI InChI=1S/C21H28N2O3/c1-16(2)15-20(26-19-7-5-4-6-8-19)21(24)23-14-13-22-17-9-11-18(25-3)12-10-17/h4-12,16,20,22H,13-15H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179552
(CHEMBL203450 | N-(2-(4-methoxyphenylamino)ethyl)-1...)Show InChI InChI=1S/C22H29N3O2/c1-27-20-12-10-18(11-13-20)23-16-17-24-21(26)22(14-6-3-7-15-22)25-19-8-4-2-5-9-19/h2,4-5,8-13,23,25H,3,6-7,14-17H2,1H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179544
(1-(biphenyl-2-ylamino)-cyclohexanecarboxylic acid ...)Show SMILES COc1ccc(NCCNC(=O)C2(CCCCC2)Nc2ccccc2-c2ccccc2)cc1 Show InChI InChI=1S/C28H33N3O2/c1-33-24-16-14-23(15-17-24)29-20-21-30-27(32)28(18-8-3-9-19-28)31-26-13-7-6-12-25(26)22-10-4-2-5-11-22/h2,4-7,10-17,29,31H,3,8-9,18-21H2,1H3,(H,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human Cathepsin K |
Bioorg Med Chem Lett 16: 1502-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.053
BindingDB Entry DOI: 10.7270/Q2T154FS |
More data for this
Ligand-Target Pair | |
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