Found 28 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180699
(6(4-chloro-3-ethoxy-phenyl)-7-isopropyl-2-methyl-3...)Show SMILES CCOc1cc(ccc1Cl)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C20H21ClN2O2/c1-5-25-19-8-13(6-7-17(19)21)15-9-16-18(10-14(15)11(2)3)22-12(4)23-20(16)24/h6-11H,5H2,1-4H3,(H,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180715
(6-(4-chloro-phenyl)-7-isopropyl-2-methyl-3H-quinaz...)Show InChI InChI=1S/C18H17ClN2O/c1-10(2)14-9-17-16(18(22)21-11(3)20-17)8-15(14)12-4-6-13(19)7-5-12/h4-10H,1-3H3,(H,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180717
(6(4-chloro-3-methoxy-phenyl)-7-isopropyl-2-methyl-...)Show SMILES COc1cc(ccc1Cl)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C19H19ClN2O2/c1-10(2)13-9-17-15(19(23)22-11(3)21-17)8-14(13)12-5-6-16(20)18(7-12)24-4/h5-10H,1-4H3,(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180711
(7-tert-butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihy...)Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C17H16ClN3OS/c1-17(2,3)13-11(9-4-6-10(18)7-5-9)8-12-14(19-13)20-16(23)21-15(12)22/h4-8H,1-3H3,(H2,19,20,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of low pH activation of human TRPV1 |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180706
(6-(4-chloro-3fluoro-phenyl)-7-isopropyl-2-methyl-3...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C18H16ClFN2O/c1-9(2)12-8-17-14(18(23)22-10(3)21-17)7-13(12)11-4-5-15(19)16(20)6-11/h4-9H,1-3H3,(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50180708
(7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...)Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1 Show InChI InChI=1S/C17H17N3OS/c1-17(2,3)13-11(10-7-5-4-6-8-10)9-12-14(18-13)19-16(22)20-15(12)21/h4-9H,1-3H3,(H2,18,19,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of low pH activation of rat TRPV1 |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180698
(6-1,3-benzdioxolo-5-yl-7-isopropyl-2-methyl-3H-qui...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc2OCOc2c1 Show InChI InChI=1S/C19H18N2O3/c1-10(2)13-8-16-15(19(22)21-11(3)20-16)7-14(13)12-4-5-17-18(6-12)24-9-23-17/h4-8,10H,9H2,1-3H3,(H,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180719
(6-(2,4-dichloro-5-ethoxy-phenyl)-7-isopropyl-2-met...)Show SMILES CCOc1cc(c(Cl)cc1Cl)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C20H20Cl2N2O2/c1-5-26-19-8-14(16(21)9-17(19)22)13-6-15-18(7-12(13)10(2)3)23-11(4)24-20(15)25/h6-10H,5H2,1-4H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180701
(6(4-chloro-3-propoxy-phenyl)-7-isopropyl-2-methyl-...)Show SMILES CCCOc1cc(ccc1Cl)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C21H23ClN2O2/c1-5-8-26-20-9-14(6-7-18(20)22)16-10-17-19(11-15(16)12(2)3)23-13(4)24-21(17)25/h6-7,9-12H,5,8H2,1-4H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180703
(6(3-chloro-4-methyl-phenyl)-7-isopropyl-2-methyl-3...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(C)c(Cl)c1 Show InChI InChI=1S/C19H19ClN2O/c1-10(2)14-9-18-16(19(23)22-12(4)21-18)8-15(14)13-6-5-11(3)17(20)7-13/h5-10H,1-4H3,(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180708
(7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...)Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1 Show InChI InChI=1S/C17H17N3OS/c1-17(2,3)13-11(10-7-5-4-6-8-10)9-12-14(18-13)19-16(22)20-15(12)21/h4-9H,1-3H3,(H2,18,19,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of low pH activation of human TRPV1 |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50212312
(6(4-chloro-3-cyclopropylmethoxy-phenyl)-7-isopropy...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C22H23ClN2O2/c1-12(2)16-10-20-18(22(26)25-13(3)24-20)9-17(16)15-6-7-19(23)21(8-15)27-11-14-4-5-14/h6-10,12,14H,4-5,11H2,1-3H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180710
(6(3-butoxy-4-chloro-phenyl)-7-isopropyl-2-methyl-3...)Show SMILES CCCCOc1cc(ccc1Cl)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C22H25ClN2O2/c1-5-6-9-27-21-10-15(7-8-19(21)23)17-11-18-20(12-16(17)13(2)3)24-14(4)25-22(18)26/h7-8,10-13H,5-6,9H2,1-4H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50180708
(7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...)Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1 Show InChI InChI=1S/C17H17N3OS/c1-17(2,3)13-11(10-7-5-4-6-8-10)9-12-14(18-13)19-16(22)20-15(12)21/h4-9H,1-3H3,(H2,18,19,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in rat TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180718
(6-(3-chloro-5-methoxy-phenyl)-7-isopropyl-2-methyl...)Show SMILES COc1cc(Cl)cc(c1)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C19H19ClN2O2/c1-10(2)15-9-18-17(19(23)22-11(3)21-18)8-16(15)12-5-13(20)7-14(6-12)24-4/h5-10H,1-4H3,(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180708
(7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...)Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1 Show InChI InChI=1S/C17H17N3OS/c1-17(2,3)13-11(10-7-5-4-6-8-10)9-12-14(18-13)19-16(22)20-15(12)21/h4-9H,1-3H3,(H2,18,19,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50212312
(6(4-chloro-3-cyclopropylmethoxy-phenyl)-7-isopropy...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C22H23ClN2O2/c1-12(2)16-10-20-18(22(26)25-13(3)24-20)9-17(16)15-6-7-19(23)21(8-15)27-11-14-4-5-14/h6-10,12,14H,4-5,11H2,1-3H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of low pH activation of rat TRPV1 |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180702
(2-amino-6-(4-chloro-phenyl)-7-isopropyl-3H-quinazo...)Show InChI InChI=1S/C17H16ClN3O/c1-9(2)12-8-15-14(16(22)21-17(19)20-15)7-13(12)10-3-5-11(18)6-4-10/h3-9H,1-2H3,(H3,19,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 133 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180704
(6(4-chloro-3-cyclobutylmethoxy-phenyl)-7-isopropyl...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(Cl)c(OCC2CCC2)c1 Show InChI InChI=1S/C23H25ClN2O2/c1-13(2)17-11-21-19(23(27)26-14(3)25-21)10-18(17)16-7-8-20(24)22(9-16)28-12-15-5-4-6-15/h7-11,13,15H,4-6,12H2,1-3H3,(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 144 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180712
(6-(4-chloro-3-isopropoxy-phenyl)-7-isopropyl-2-met...)Show SMILES CC(C)Oc1cc(ccc1Cl)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C21H23ClN2O2/c1-11(2)15-10-19-17(21(25)24-13(5)23-19)9-16(15)14-6-7-18(22)20(8-14)26-12(3)4/h6-12H,1-5H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 201 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180713
(6-[4-chloro3-(2-methoxy-ethoxy)-phenyl]-7-isopropy...)Show SMILES COCCOc1cc(ccc1Cl)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C21H23ClN2O3/c1-12(2)15-11-19-17(21(25)24-13(3)23-19)10-16(15)14-5-6-18(22)20(9-14)27-8-7-26-4/h5-6,9-12H,7-8H2,1-4H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 216 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180714
(6(3-ethoxy-4-methoxy-phenyl)-7-isopropyl-2-methyl-...)Show SMILES CCOc1cc(ccc1OC)-c1cc2c(cc1C(C)C)nc(C)[nH]c2=O Show InChI InChI=1S/C21H24N2O3/c1-6-26-20-9-14(7-8-19(20)25-5)16-10-17-18(11-15(16)12(2)3)22-13(4)23-21(17)24/h7-12H,6H2,1-5H3,(H,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 286 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM20284
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180696
(6-[4-chloro-3-(2-dimethylamino-ethoxy)-phenyl]-7-i...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1cccc(OCCN(C)C)c1 Show InChI InChI=1S/C22H27N3O2/c1-14(2)18-13-21-20(22(26)24-15(3)23-21)12-19(18)16-7-6-8-17(11-16)27-10-9-25(4)5/h6-8,11-14H,9-10H2,1-5H3,(H,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 487 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180697
(6-[4-chloro-3-(2-hydroxy-ethoxy)-phenyl]-7-isoprop...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(Cl)c(OCCO)c1 Show InChI InChI=1S/C20H21ClN2O3/c1-11(2)14-10-18-16(20(25)23-12(3)22-18)9-15(14)13-4-5-17(21)19(8-13)26-7-6-24/h4-5,8-11,24H,6-7H2,1-3H3,(H,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 557 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180716
(6-(4-chloro-phenyl)-2-ethyl-7-isopropyl-3H-quinazo...)Show SMILES CCc1nc2cc(C(C)C)c(cc2c(=O)[nH]1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H19ClN2O/c1-4-18-21-17-10-14(11(2)3)15(9-16(17)19(23)22-18)12-5-7-13(20)8-6-12/h5-11H,4H2,1-3H3,(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180709
(CHEMBL201141 | [2-chloro-5-(7-isopropyl-2-methyl-4...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(Cl)c(OCC(O)=O)c1 Show InChI InChI=1S/C20H19ClN2O4/c1-10(2)13-8-17-15(20(26)23-11(3)22-17)7-14(13)12-4-5-16(21)18(6-12)27-9-19(24)25/h4-8,10H,9H2,1-3H3,(H,24,25)(H,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50180705
(6-(4-chloro-3-hydroxy-phenyl)-7-isopropyl-2-methyl...)Show SMILES CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(Cl)c(O)c1 Show InChI InChI=1S/C18H17ClN2O2/c1-9(2)12-8-16-14(18(23)21-10(3)20-16)7-13(12)11-4-5-15(19)17(22)6-11/h4-9,22H,1-3H3,(H,20,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay |
J Med Chem 49: 471-4 (2006)
Article DOI: 10.1021/jm051058x
BindingDB Entry DOI: 10.7270/Q2RX9BNT |
More data for this
Ligand-Target Pair | |
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