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PubMed code 16446087

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181308
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccncc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-6-8-27(9-7-26)12-2-3-14-15(10-12)24-19(23-14)17-18(21)13-4-5-22-11-16(13)25-20(17)28/h2-5,10-11H,6-9H2,1H3,(H,23,24)(H3,21,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181319
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-3-4-21-10-15(12)24-19(26)16(17)18-22-13-2-1-11(9-14(13)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181308
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccncc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-6-8-27(9-7-26)12-2-3-14-15(10-12)24-19(23-14)17-18(21)13-4-5-22-11-16(13)25-20(17)28/h2-5,10-11H,6-9H2,1H3,(H,23,24)(H3,21,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181313
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H11N5O/c16-13-8-5-6-17-7-11(8)20-15(21)12(13)14-18-9-3-1-2-4-10(9)19-14/h1-7H,(H,18,19)(H3,16,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181308
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccncc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-6-8-27(9-7-26)12-2-3-14-15(10-12)24-19(23-14)17-18(21)13-4-5-22-11-16(13)25-20(17)28/h2-5,10-11H,6-9H2,1H3,(H,23,24)(H3,21,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181311
PNG
(4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C20H19N5O2/c21-18-13-3-1-2-4-14(13)24-20(26)17(18)19-22-15-6-5-12(11-16(15)23-19)25-7-9-27-10-8-25/h1-6,11H,7-10H2,(H,22,23)(H3,21,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181313
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H11N5O/c16-13-8-5-6-17-7-11(8)20-15(21)12(13)14-18-9-3-1-2-4-10(9)19-14/h1-7H,(H,18,19)(H3,16,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181319
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-3-4-21-10-15(12)24-19(26)16(17)18-22-13-2-1-11(9-14(13)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181303
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naph...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C14H10N6O/c15-11-7-3-5-16-6-9(7)19-14(21)10(11)13-18-8-2-1-4-17-12(8)20-13/h1-6H,(H3,15,19,21)(H,17,18,20)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181312
PNG
(4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2...)
Show SMILES Nc1c(-c2nc3nc(ccc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C19H18N6O2/c20-16-11-3-1-2-4-12(11)22-19(26)15(16)18-21-13-5-6-14(23-17(13)24-18)25-7-9-27-10-8-25/h1-6H,7-10H2,(H3,20,22,26)(H,21,23,24)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181320
PNG
(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C21H22N6O/c1-26-8-10-27(11-9-26)13-6-7-16-17(12-13)24-20(23-16)18-19(22)14-4-2-3-5-15(14)25-21(18)28/h2-7,12H,8-11H2,1H3,(H,23,24)(H3,22,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181313
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H11N5O/c16-13-8-5-6-17-7-11(8)20-15(21)12(13)14-18-9-3-1-2-4-10(9)19-14/h1-7H,(H,18,19)(H3,16,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181315
PNG
(4-amino-3-(5-(4-methylpiperazin-1-yl)-3H-imidazo[4...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]c(nc2n1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-8-10-27(11-9-26)15-7-6-14-18(24-15)25-19(22-14)16-17(21)12-4-2-3-5-13(12)23-20(16)28/h2-7H,8-11H2,1H3,(H3,21,23,28)(H,22,24,25)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181319
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-3-4-21-10-15(12)24-19(26)16(17)18-22-13-2-1-11(9-14(13)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181312
PNG
(4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2...)
Show SMILES Nc1c(-c2nc3nc(ccc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C19H18N6O2/c20-16-11-3-1-2-4-12(11)22-19(26)15(16)18-21-13-5-6-14(23-17(13)24-18)25-7-9-27-10-8-25/h1-6H,7-10H2,(H3,20,22,26)(H,21,23,24)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181320
PNG
(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C21H22N6O/c1-26-8-10-27(11-9-26)13-6-7-16-17(12-13)24-20(23-16)18-19(22)14-4-2-3-5-15(14)25-21(18)28/h2-7,12H,8-11H2,1H3,(H,23,24)(H3,22,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181303
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naph...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C14H10N6O/c15-11-7-3-5-16-6-9(7)19-14(21)10(11)13-18-8-2-1-4-17-12(8)20-13/h1-6H,(H3,15,19,21)(H,17,18,20)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181311
PNG
(4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C20H19N5O2/c21-18-13-3-1-2-4-14(13)24-20(26)17(18)19-22-15-6-5-12(11-16(15)23-19)25-7-9-27-10-8-25/h1-6,11H,7-10H2,(H,22,23)(H3,21,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181320
PNG
(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C21H22N6O/c1-26-8-10-27(11-9-26)13-6-7-16-17(12-13)24-20(23-16)18-19(22)14-4-2-3-5-15(14)25-21(18)28/h2-7,12H,8-11H2,1H3,(H,23,24)(H3,22,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181315
PNG
(4-amino-3-(5-(4-methylpiperazin-1-yl)-3H-imidazo[4...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]c(nc2n1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-8-10-27(11-9-26)15-7-6-14-18(24-15)25-19(22-14)16-17(21)12-4-2-3-5-13(12)23-20(16)28/h2-7H,8-11H2,1H3,(H3,21,23,28)(H,22,24,25)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181314
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)quinolin-...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C15H11N5O/c16-12-8-4-1-2-5-9(8)19-15(21)11(12)14-18-10-6-3-7-17-13(10)20-14/h1-7H,(H3,16,19,21)(H,17,18,20)
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n/an/a 16n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181306
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccncc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-10-21-4-3-13(12)24-19(26)16(17)18-22-14-2-1-11(9-15(14)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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n/an/a 18n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181311
PNG
(4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C20H19N5O2/c21-18-13-3-1-2-4-14(13)24-20(26)17(18)19-22-15-6-5-12(11-16(15)23-19)25-7-9-27-10-8-25/h1-6,11H,7-10H2,(H,22,23)(H3,21,24,26)
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n/an/a 21n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181314
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)quinolin-...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C15H11N5O/c16-12-8-4-1-2-5-9(8)19-15(21)11(12)14-18-10-6-3-7-17-13(10)20-14/h1-7H,(H3,16,19,21)(H,17,18,20)
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n/an/a 22n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181315
PNG
(4-amino-3-(5-(4-methylpiperazin-1-yl)-3H-imidazo[4...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]c(nc2n1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-8-10-27(11-9-26)15-7-6-14-18(24-15)25-19(22-14)16-17(21)12-4-2-3-5-13(12)23-20(16)28/h2-7H,8-11H2,1H3,(H3,21,23,28)(H,22,24,25)
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n/an/a 24n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181314
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)quinolin-...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C15H11N5O/c16-12-8-4-1-2-5-9(8)19-15(21)11(12)14-18-10-6-3-7-17-13(10)20-14/h1-7H,(H3,16,19,21)(H,17,18,20)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181305
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H12N4O/c17-14-9-5-1-2-6-10(9)20-16(21)13(14)15-18-11-7-3-4-8-12(11)19-15/h1-8H,(H,18,19)(H3,17,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181320
PNG
(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C21H22N6O/c1-26-8-10-27(11-9-26)13-6-7-16-17(12-13)24-20(23-16)18-19(22)14-4-2-3-5-15(14)25-21(18)28/h2-7,12H,8-11H2,1H3,(H,23,24)(H3,22,25,28)
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n/an/a 27n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181305
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H12N4O/c17-14-9-5-1-2-6-10(9)20-16(21)13(14)15-18-11-7-3-4-8-12(11)19-15/h1-8H,(H,18,19)(H3,17,20,21)
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n/an/a 28n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181303
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naph...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C14H10N6O/c15-11-7-3-5-16-6-9(7)19-14(21)10(11)13-18-8-2-1-4-17-12(8)20-13/h1-6H,(H3,15,19,21)(H,17,18,20)
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n/an/a 30n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181315
PNG
(4-amino-3-(5-(4-methylpiperazin-1-yl)-3H-imidazo[4...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]c(nc2n1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-8-10-27(11-9-26)15-7-6-14-18(24-15)25-19(22-14)16-17(21)12-4-2-3-5-13(12)23-20(16)28/h2-7H,8-11H2,1H3,(H3,21,23,28)(H,22,24,25)
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n/an/a 30n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181307
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ncccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-7-9-27(10-8-26)12-4-5-13-15(11-12)24-19(23-13)16-17(21)18-14(25-20(16)28)3-2-6-22-18/h2-6,11H,7-10H2,1H3,(H,23,24)(H3,21,25,28)
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n/an/a 33n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181306
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccncc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-10-21-4-3-13(12)24-19(26)16(17)18-22-14-2-1-11(9-15(14)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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n/an/a 37n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181311
PNG
(4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C20H19N5O2/c21-18-13-3-1-2-4-14(13)24-20(26)17(18)19-22-15-6-5-12(11-16(15)23-19)25-7-9-27-10-8-25/h1-6,11H,7-10H2,(H,22,23)(H3,21,24,26)
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n/an/a 38n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181307
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ncccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-7-9-27(10-8-26)12-4-5-13-15(11-12)24-19(23-13)16-17(21)18-14(25-20(16)28)3-2-6-22-18/h2-6,11H,7-10H2,1H3,(H,23,24)(H3,21,25,28)
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n/an/a 43n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181308
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccncc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-6-8-27(9-7-26)12-2-3-14-15(10-12)24-19(23-14)17-18(21)13-4-5-22-11-16(13)25-20(17)28/h2-5,10-11H,6-9H2,1H3,(H,23,24)(H3,21,25,28)
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n/an/a 43n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181305
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H12N4O/c17-14-9-5-1-2-6-10(9)20-16(21)13(14)15-18-11-7-3-4-8-12(11)19-15/h1-8H,(H,18,19)(H3,17,20,21)
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n/an/a 44n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181312
PNG
(4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2...)
Show SMILES Nc1c(-c2nc3nc(ccc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C19H18N6O2/c20-16-11-3-1-2-4-12(11)22-19(26)15(16)18-21-13-5-6-14(23-17(13)24-18)25-7-9-27-10-8-25/h1-6H,7-10H2,(H3,20,22,26)(H,21,23,24)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181312
PNG
(4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2...)
Show SMILES Nc1c(-c2nc3nc(ccc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C19H18N6O2/c20-16-11-3-1-2-4-12(11)22-19(26)15(16)18-21-13-5-6-14(23-17(13)24-18)25-7-9-27-10-8-25/h1-6H,7-10H2,(H3,20,22,26)(H,21,23,24)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181303
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naph...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C14H10N6O/c15-11-7-3-5-16-6-9(7)19-14(21)10(11)13-18-8-2-1-4-17-12(8)20-13/h1-6H,(H3,15,19,21)(H,17,18,20)
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n/an/a 49n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181314
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)quinolin-...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C15H11N5O/c16-12-8-4-1-2-5-9(8)19-15(21)11(12)14-18-10-6-3-7-17-13(10)20-14/h1-7H,(H3,16,19,21)(H,17,18,20)
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n/an/a 51n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181307
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ncccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-7-9-27(10-8-26)12-4-5-13-15(11-12)24-19(23-13)16-17(21)18-14(25-20(16)28)3-2-6-22-18/h2-6,11H,7-10H2,1H3,(H,23,24)(H3,21,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181313
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H11N5O/c16-13-8-5-6-17-7-11(8)20-15(21)12(13)14-18-9-3-1-2-4-10(9)19-14/h1-7H,(H,18,19)(H3,16,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181306
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccncc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-10-21-4-3-13(12)24-19(26)16(17)18-22-14-2-1-11(9-15(14)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181319
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-3-4-21-10-15(12)24-19(26)16(17)18-22-13-2-1-11(9-14(13)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181307
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ncccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-7-9-27(10-8-26)12-4-5-13-15(11-12)24-19(23-13)16-17(21)18-14(25-20(16)28)3-2-6-22-18/h2-6,11H,7-10H2,1H3,(H,23,24)(H3,21,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181306
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccncc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-10-21-4-3-13(12)24-19(26)16(17)18-22-14-2-1-11(9-15(14)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181305
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H12N4O/c17-14-9-5-1-2-6-10(9)20-16(21)13(14)15-18-11-7-3-4-8-12(11)19-15/h1-8H,(H,18,19)(H3,17,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181302
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)thieno[2,3-b]p...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2sccc12
Show InChI InChI=1S/C14H10N4OS/c15-11-7-5-6-20-14(7)18-13(19)10(11)12-16-8-3-1-2-4-9(8)17-12/h1-6H,(H,16,17)(H3,15,18,19)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181317
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181302
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)thieno[2,3-b]p...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2sccc12
Show InChI InChI=1S/C14H10N4OS/c15-11-7-5-6-20-14(7)18-13(19)10(11)12-16-8-3-1-2-4-9(8)17-12/h1-6H,(H,16,17)(H3,15,18,19)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181304
PNG
(7-amino-6-(1H-benzo[d]imidazol-2-yl)-3H-imidazo[4,...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2nc[nH]c12
Show InChI InChI=1S/C13H10N6O/c14-9-8(13(20)19-12-10(9)15-5-16-12)11-17-6-3-1-2-4-7(6)18-11/h1-5H,(H,17,18)(H4,14,15,16,19,20)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181317
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181310
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,7-naphthy...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H10N4O2/c20-13-8-5-6-16-7-11(8)19-15(21)12(13)14-17-9-3-1-2-4-10(9)18-14/h1-7H,(H,17,18)(H2,19,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181310
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,7-naphthy...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H10N4O2/c20-13-8-5-6-16-7-11(8)19-15(21)12(13)14-17-9-3-1-2-4-10(9)18-14/h1-7H,(H,17,18)(H2,19,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181317
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181318
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2n[nH]cc12
Show InChI InChI=1S/C13H10N6O/c14-10-6-5-15-19-11(6)18-13(20)9(10)12-16-7-3-1-2-4-8(7)17-12/h1-5H,(H,16,17)(H4,14,15,18,19,20)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181302
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)thieno[2,3-b]p...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2sccc12
Show InChI InChI=1S/C14H10N4OS/c15-11-7-5-6-20-14(7)18-13(19)10(11)12-16-8-3-1-2-4-9(8)17-12/h1-6H,(H,16,17)(H3,15,18,19)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181317
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181318
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2n[nH]cc12
Show InChI InChI=1S/C13H10N6O/c14-10-6-5-15-19-11(6)18-13(20)9(10)12-16-7-3-1-2-4-8(7)17-12/h1-5H,(H,16,17)(H4,14,15,18,19,20)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181304
PNG
(7-amino-6-(1H-benzo[d]imidazol-2-yl)-3H-imidazo[4,...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2nc[nH]c12
Show InChI InChI=1S/C13H10N6O/c14-9-8(13(20)19-12-10(9)15-5-16-12)11-17-6-3-1-2-4-7(6)18-11/h1-5H,(H,17,18)(H4,14,15,16,19,20)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181316
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)-1-methyl-1H-p...)
Show SMILES Cn1ncc2c(N)c(-c3nc4ccccc4[nH]3)c(=O)[nH]c12
Show InChI InChI=1S/C14H12N6O/c1-20-13-7(6-16-20)11(15)10(14(21)19-13)12-17-8-4-2-3-5-9(8)18-12/h2-6H,1H3,(H,17,18)(H3,15,19,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181310
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,7-naphthy...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H10N4O2/c20-13-8-5-6-16-7-11(8)19-15(21)12(13)14-17-9-3-1-2-4-10(9)18-14/h1-7H,(H,17,18)(H2,19,20,21)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181304
PNG
(7-amino-6-(1H-benzo[d]imidazol-2-yl)-3H-imidazo[4,...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2nc[nH]c12
Show InChI InChI=1S/C13H10N6O/c14-9-8(13(20)19-12-10(9)15-5-16-12)11-17-6-3-1-2-4-7(6)18-11/h1-5H,(H,17,18)(H4,14,15,16,19,20)
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n/an/a 602n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181302
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)thieno[2,3-b]p...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2sccc12
Show InChI InChI=1S/C14H10N4OS/c15-11-7-5-6-20-14(7)18-13(19)10(11)12-16-8-3-1-2-4-9(8)17-12/h1-6H,(H,16,17)(H3,15,18,19)
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n/an/a 691n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181318
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2n[nH]cc12
Show InChI InChI=1S/C13H10N6O/c14-10-6-5-15-19-11(6)18-13(20)9(10)12-16-7-3-1-2-4-8(7)17-12/h1-5H,(H,16,17)(H4,14,15,18,19,20)
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n/an/a 691n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181310
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,7-naphthy...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H10N4O2/c20-13-8-5-6-16-7-11(8)19-15(21)12(13)14-17-9-3-1-2-4-10(9)18-14/h1-7H,(H,17,18)(H2,19,20,21)
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n/an/a 1.59E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181304
PNG
(7-amino-6-(1H-benzo[d]imidazol-2-yl)-3H-imidazo[4,...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2nc[nH]c12
Show InChI InChI=1S/C13H10N6O/c14-9-8(13(20)19-12-10(9)15-5-16-12)11-17-6-3-1-2-4-7(6)18-11/h1-5H,(H,17,18)(H4,14,15,16,19,20)
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n/an/a 2.66E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181316
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)-1-methyl-1H-p...)
Show SMILES Cn1ncc2c(N)c(-c3nc4ccccc4[nH]3)c(=O)[nH]c12
Show InChI InChI=1S/C14H12N6O/c1-20-13-7(6-16-20)11(15)10(14(21)19-13)12-17-8-4-2-3-5-9(8)18-12/h2-6H,1H3,(H,17,18)(H3,15,19,21)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181316
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)-1-methyl-1H-p...)
Show SMILES Cn1ncc2c(N)c(-c3nc4ccccc4[nH]3)c(=O)[nH]c12
Show InChI InChI=1S/C14H12N6O/c1-20-13-7(6-16-20)11(15)10(14(21)19-13)12-17-8-4-2-3-5-9(8)18-12/h2-6H,1H3,(H,17,18)(H3,15,19,21)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181309
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,8-naphthy...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ncccc12
Show InChI InChI=1S/C15H10N4O2/c20-12-8-4-3-7-16-13(8)19-15(21)11(12)14-17-9-5-1-2-6-10(9)18-14/h1-7H,(H,17,18)(H2,16,19,20,21)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR2


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181318
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2n[nH]cc12
Show InChI InChI=1S/C13H10N6O/c14-10-6-5-15-19-11(6)18-13(20)9(10)12-16-7-3-1-2-4-8(7)17-12/h1-5H,(H,16,17)(H4,14,15,18,19,20)
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n/an/a 3.17E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181309
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,8-naphthy...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ncccc12
Show InChI InChI=1S/C15H10N4O2/c20-12-8-4-3-7-16-13(8)19-15(21)11(12)14-17-9-5-1-2-6-10(9)18-14/h1-7H,(H,17,18)(H2,16,19,20,21)
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n/an/a 3.94E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50181316
PNG
(4-amino-5-(1H-benzo[d]imidazol-2-yl)-1-methyl-1H-p...)
Show SMILES Cn1ncc2c(N)c(-c3nc4ccccc4[nH]3)c(=O)[nH]c12
Show InChI InChI=1S/C14H12N6O/c1-20-13-7(6-16-20)11(15)10(14(21)19-13)12-17-8-4-2-3-5-9(8)18-12/h2-6H,1H3,(H,17,18)(H3,15,19,21)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50181309
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,8-naphthy...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ncccc12
Show InChI InChI=1S/C15H10N4O2/c20-12-8-4-3-7-16-13(8)19-15(21)11(12)14-17-9-5-1-2-6-10(9)18-14/h1-7H,(H,17,18)(H2,16,19,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR1


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50181309
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,8-naphthy...)
Show SMILES Oc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ncccc12
Show InChI InChI=1S/C15H10N4O2/c20-12-8-4-3-7-16-13(8)19-15(21)11(12)14-17-9-5-1-2-6-10(9)18-14/h1-7H,(H,17,18)(H2,16,19,20,21)
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n/an/a 6.53E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.020
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%