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PubMed code 16451050

Compile data set for download or QSAR
Found 111 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181395
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m1/s1
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n/an/a 0.120n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181392
PNG
((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Show SMILES O=C(NCCCN1CCC2(CC1)OCc1ccccc21)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1
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n/an/a 0.150n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181395
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m1/s1
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n/an/a 0.220n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181392
PNG
((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Show SMILES O=C(NCCCN1CCC2(CC1)OCc1ccccc21)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1
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n/an/a 0.270n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nociceptin receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181374
PNG
(2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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n/an/a 4n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181382
PNG
(CHEMBL199639 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O[C@@H](Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O2/c28-23(19-20-7-2-1-3-8-20)24(29)26-15-6-16-27-17-13-25(14-18-27)12-11-21-9-4-5-10-22(21)25/h1-5,7-10,23,28H,6,11-19H2,(H,26,29)/t23-/m0/s1
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n/an/a 7.5n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181374
PNG
(2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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n/an/a 8.20n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181380
PNG
(CHEMBL413571 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C29H32N2O/c32-28(26-13-6-5-12-25(26)23-9-2-1-3-10-23)30-19-8-20-31-21-17-29(18-22-31)16-15-24-11-4-7-14-27(24)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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n/an/a 8.30n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181380
PNG
(CHEMBL413571 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C29H32N2O/c32-28(26-13-6-5-12-25(26)23-9-2-1-3-10-23)30-19-8-20-31-21-17-29(18-22-31)16-15-24-11-4-7-14-27(24)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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n/an/a 10n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181382
PNG
(CHEMBL199639 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O[C@@H](Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O2/c28-23(19-20-7-2-1-3-8-20)24(29)26-15-6-16-27-17-13-25(14-18-27)12-11-21-9-4-5-10-22(21)25/h1-5,7-10,23,28H,6,11-19H2,(H,26,29)/t23-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181366
PNG
(2-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperi...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Cc1ccccc1
Show InChI InChI=1S/C30H34N2O/c33-29(27-13-6-4-12-26(27)23-24-9-2-1-3-10-24)31-19-8-20-32-21-17-30(18-22-32)16-15-25-11-5-7-14-28(25)30/h1-7,9-14H,8,15-23H2,(H,31,33)
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n/an/a 21n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181378
PNG
((4R)-3-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-p...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1COC(=O)N1Cc1ccccc1
Show InChI InChI=1S/C27H33N3O3/c31-25(24-20-33-26(32)30(24)19-21-7-2-1-3-8-21)28-15-6-16-29-17-13-27(14-18-29)12-11-22-9-4-5-10-23(22)27/h1-5,7-10,24H,6,11-20H2,(H,28,31)/t24-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181402
PNG
((4S,5S)-4-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1OC(=O)N[C@H]1Cc1ccccc1
Show InChI InChI=1S/C27H33N3O3/c31-25(24-23(29-26(32)33-24)19-20-7-2-1-3-8-20)28-15-6-16-30-17-13-27(14-18-30)12-11-21-9-4-5-10-22(21)27/h1-5,7-10,23-24H,6,11-19H2,(H,28,31)(H,29,32)/t23-,24-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181379
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181379
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181420
PNG
((2R)-1-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-p...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCC(=O)N1Cc1ccccc1
Show InChI InChI=1S/C28H35N3O2/c32-26-12-11-25(31(26)21-22-7-2-1-3-8-22)27(33)29-17-6-18-30-19-15-28(16-20-30)14-13-23-9-4-5-10-24(23)28/h1-5,7-10,25H,6,11-21H2,(H,29,33)/t25-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181364
PNG
(2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C30H34N2O2/c33-29(26-12-5-7-14-28(26)34-23-24-9-2-1-3-10-24)31-19-8-20-32-21-17-30(18-22-32)16-15-25-11-4-6-13-27(25)30/h1-7,9-14H,8,15-23H2,(H,31,33)
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n/an/a 83n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181364
PNG
(2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C30H34N2O2/c33-29(26-12-5-7-14-28(26)34-23-24-9-2-1-3-10-24)31-19-8-20-32-21-17-30(18-22-32)16-15-25-11-4-6-13-27(25)30/h1-7,9-14H,8,15-23H2,(H,31,33)
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n/an/a 110n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181367
PNG
(CHEMBL380786 | benzyl (4R)-4-[(3-{2,3-dihydrospiro...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1COCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C28H35N3O4/c32-26(25-20-34-21-31(25)27(33)35-19-22-7-2-1-3-8-22)29-15-6-16-30-17-13-28(14-18-30)12-11-23-9-4-5-10-24(23)28/h1-5,7-10,25H,6,11-21H2,(H,29,32)/t25-/m1/s1
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n/an/a 131n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181403
PNG
(CHEMBL202059 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(CSc1ccccc1)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C24H30N2OS/c27-23(19-28-21-8-2-1-3-9-21)25-15-6-16-26-17-13-24(14-18-26)12-11-20-7-4-5-10-22(20)24/h1-5,7-10H,6,11-19H2,(H,25,27)
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n/an/a 170n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181389
PNG
(CHEMBL202220 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Nc1ccccc1
Show InChI InChI=1S/C29H33N3O/c33-28(25-12-5-7-14-27(25)31-24-10-2-1-3-11-24)30-19-8-20-32-21-17-29(18-22-32)16-15-23-9-4-6-13-26(23)29/h1-7,9-14,31H,8,15-22H2,(H,30,33)
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n/an/a 230n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181390
PNG
(2-(1,3-benzothiazol-2-ylsulfanyl)-N-(3-{2,3-dihydr...)
Show SMILES O=C(CSc1nc2ccccc2s1)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H29N3OS2/c29-23(18-30-24-27-21-8-3-4-9-22(21)31-24)26-14-5-15-28-16-12-25(13-17-28)11-10-19-6-1-2-7-20(19)25/h1-4,6-9H,5,10-18H2,(H,26,29)
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n/an/a 290n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181381
PNG
(CHEMBL202604 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H29N3O2/c30-24(21-18-28-23-9-4-2-7-20(21)23)25(31)27-14-5-15-29-16-12-26(13-17-29)11-10-19-6-1-3-8-22(19)26/h1-4,6-9,18,28H,5,10-17H2,(H,27,31)
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n/an/a 330n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181396
PNG
(CHEMBL202091 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(Cc1cccc(Oc2ccccc2)c1)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C30H34N2O2/c33-29(23-24-8-6-12-27(22-24)34-26-10-2-1-3-11-26)31-18-7-19-32-20-16-30(17-21-32)15-14-25-9-4-5-13-28(25)30/h1-6,8-13,22H,7,14-21,23H2,(H,31,33)
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n/an/a 340n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181375
PNG
(CHEMBL426303 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(CCCc1ccccc1)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C26H34N2O/c29-25(13-6-10-22-8-2-1-3-9-22)27-18-7-19-28-20-16-26(17-21-28)15-14-23-11-4-5-12-24(23)26/h1-5,8-9,11-12H,6-7,10,13-21H2,(H,27,29)
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n/an/a 350n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181426
PNG
(CHEMBL202094 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(CCc1c[nH]c2ccccc12)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C27H33N3O/c31-26(11-10-22-20-29-25-9-4-2-7-23(22)25)28-16-5-17-30-18-14-27(15-19-30)13-12-21-6-1-3-8-24(21)27/h1-4,6-9,20,29H,5,10-19H2,(H,28,31)
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n/an/a 360n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181391
PNG
(CHEMBL425225 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)\C=C\c1ccccc1
Show InChI InChI=1S/C25H30N2O/c28-24(12-11-21-7-2-1-3-8-21)26-17-6-18-27-19-15-25(16-20-27)14-13-22-9-4-5-10-23(22)25/h1-5,7-12H,6,13-20H2,(H,26,28)/b12-11+
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n/an/a 540n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181388
PNG
(CHEMBL201694 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES OC(c1ccccc1)c1ccccc1C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C30H34N2O2/c33-28(24-10-2-1-3-11-24)25-12-5-6-13-26(25)29(34)31-19-8-20-32-21-17-30(18-22-32)16-15-23-9-4-7-14-27(23)30/h1-7,9-14,28,33H,8,15-22H2,(H,31,34)
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n/an/a 580n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181400
PNG
(CHEMBL202575 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C29H38N2O/c32-27(29(15-7-2-8-16-29)25-11-3-1-4-12-25)30-20-9-21-31-22-18-28(19-23-31)17-14-24-10-5-6-13-26(24)28/h1,3-6,10-13H,2,7-9,14-23H2,(H,30,32)
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n/an/a 630n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181373
PNG
((2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Show SMILES O=C(CCc1ccccc1)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O/c28-24(12-11-21-7-2-1-3-8-21)26-17-6-18-27-19-15-25(16-20-27)14-13-22-9-4-5-10-23(22)25/h1-5,7-10H,6,11-20H2,(H,26,28)
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n/an/a 730n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181421
PNG
(2-(4-chlorophenoxy)-N-(3-{2,3-dihydrospiro[indene-...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C26H33ClN2O2/c1-25(2,31-22-10-8-21(27)9-11-22)24(30)28-16-5-17-29-18-14-26(15-19-29)13-12-20-6-3-4-7-23(20)26/h3-4,6-11H,5,12-19H2,1-2H3,(H,28,30)
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n/an/a 870n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181371
PNG
(CHEMBL383489 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES CC(Oc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O2/c1-20(29-22-9-3-2-4-10-22)24(28)26-16-7-17-27-18-14-25(15-19-27)13-12-21-8-5-6-11-23(21)25/h2-6,8-11,20H,7,12-19H2,1H3,(H,26,28)
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n/an/a 900n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50181395
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m1/s1
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n/an/a 950n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181398
PNG
(CHEMBL381508 | tert-butyl N-{1-[(3-{2,3-dihydrospi...)
Show SMILES CC(C)(C)OC(=O)NC1(CCCCC1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C28H43N3O3/c1-26(2,3)34-25(33)30-28(13-7-4-8-14-28)24(32)29-18-9-19-31-20-16-27(17-21-31)15-12-22-10-5-6-11-23(22)27/h5-6,10-11H,4,7-9,12-21H2,1-3H3,(H,29,32)(H,30,33)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181397
PNG
(CHEMBL201163 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1CC1c1ccccc1
Show InChI InChI=1S/C26H32N2O/c29-25(23-19-22(23)20-7-2-1-3-8-20)27-15-6-16-28-17-13-26(14-18-28)12-11-21-9-4-5-10-24(21)26/h1-5,7-10,22-23H,6,11-19H2,(H,27,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181404
PNG
(2-cyclohexyl-N-(3-{2,3-dihydrospiro[indene-1,4'-pi...)
Show SMILES OC(C1CCCCC1)(C(=O)NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1
Show InChI InChI=1S/C30H40N2O2/c33-28(30(34,25-11-3-1-4-12-25)26-13-5-2-6-14-26)31-20-9-21-32-22-18-29(19-23-32)17-16-24-10-7-8-15-27(24)29/h1,3-4,7-8,10-12,15,26,34H,2,5-6,9,13-14,16-23H2,(H,31,33)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181405
PNG
(CHEMBL381507 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES Cc1onc(c1C(=O)NCCCN1CCC2(CCc3ccccc23)CC1)-c1ccccc1
Show InChI InChI=1S/C27H31N3O2/c1-20-24(25(29-32-20)22-9-3-2-4-10-22)26(31)28-16-7-17-30-18-14-27(15-19-30)13-12-21-8-5-6-11-23(21)27/h2-6,8-11H,7,12-19H2,1H3,(H,28,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181417
PNG
(CHEMBL370599 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1cccc-2c1Cc1ccccc-21
Show InChI InChI=1S/C30H32N2O/c33-29(26-11-5-10-25-24-9-3-1-8-23(24)21-27(25)26)31-17-6-18-32-19-15-30(16-20-32)14-13-22-7-2-4-12-28(22)30/h1-5,7-12H,6,13-21H2,(H,31,33)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181425
PNG
(2-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperi...)
Show SMILES CC(C)(C)C(Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C29H40N2O/c1-28(2,3)26(22-23-10-5-4-6-11-23)27(32)30-18-9-19-31-20-16-29(17-21-31)15-14-24-12-7-8-13-25(24)29/h4-8,10-13,26H,9,14-22H2,1-3H3,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181428
PNG
(CHEMBL201925 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES CC1=Cc2ccccc2C1C(=O)NCCCN1CCC2(CCc3ccccc23)CC1 |t:1|
Show InChI InChI=1S/C27H32N2O/c1-20-19-22-8-2-4-9-23(22)25(20)26(30)28-15-6-16-29-17-13-27(14-18-29)12-11-21-7-3-5-10-24(21)27/h2-5,7-10,19,25H,6,11-18H2,1H3,(H,28,30)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181368
PNG
(2-(2,3-dihydro-1H-inden-2-yl)-N-(3-{2,3-dihydrospi...)
Show SMILES O=C(CC1Cc2ccccc2C1)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C27H34N2O/c30-26(20-21-18-23-7-1-2-8-24(23)19-21)28-14-5-15-29-16-12-27(13-17-29)11-10-22-6-3-4-9-25(22)27/h1-4,6-9,21H,5,10-20H2,(H,28,30)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181386
PNG
(CHEMBL372332 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(Cc1ccc2ccccc2c1)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C28H32N2O/c31-27(21-22-10-11-23-6-1-2-8-25(23)20-22)29-16-5-17-30-18-14-28(15-19-30)13-12-24-7-3-4-9-26(24)28/h1-4,6-11,20H,5,12-19,21H2,(H,29,31)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181399
PNG
(CHEMBL427376 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1Cc2ccccc2N1c1ccccc1
Show InChI InChI=1S/C31H35N3O/c35-30(29-23-25-10-5-7-14-28(25)34(29)26-11-2-1-3-12-26)32-19-8-20-33-21-17-31(18-22-33)16-15-24-9-4-6-13-27(24)31/h1-7,9-14,29H,8,15-23H2,(H,32,35)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181406
PNG
(1-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1CCCCC1C(=O)Nc1ccccc1
Show InChI InChI=1S/C30H39N3O2/c34-28(25-12-5-6-13-26(25)29(35)32-24-10-2-1-3-11-24)31-19-8-20-33-21-17-30(18-22-33)16-15-23-9-4-7-14-27(23)30/h1-4,7,9-11,14,25-26H,5-6,8,12-13,15-22H2,(H,31,34)(H,32,35)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181401
PNG
((2S)-1-benzoyl-N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@@H]1CCCN1C(=O)c1ccccc1
Show InChI InChI=1S/C28H35N3O2/c32-26(25-12-6-19-31(25)27(33)23-9-2-1-3-10-23)29-17-7-18-30-20-15-28(16-21-30)14-13-22-8-4-5-11-24(22)28/h1-5,8-11,25H,6-7,12-21H2,(H,29,32)/t25-/m0/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181430
PNG
(5-(4-chlorophenyl)-N-(3-{2,3-dihydrospiro[indene-1...)
Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C27H29ClN2O2/c28-22-8-6-21(7-9-22)24-10-11-25(32-24)26(31)29-16-3-17-30-18-14-27(15-19-30)13-12-20-4-1-2-5-23(20)27/h1-2,4-11H,3,12-19H2,(H,29,31)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181377
PNG
((2R)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C29H32N2O2/c32-28(24-9-6-12-26(22-24)33-25-10-2-1-3-11-25)30-18-7-19-31-20-16-29(17-21-31)15-14-23-8-4-5-13-27(23)29/h1-6,8-13,22H,7,14-21H2,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181385
PNG
((2Z)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Show SMILES COc1ccccc1\C=C/C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C26H32N2O2/c1-30-24-10-5-3-8-22(24)11-12-25(29)27-17-6-18-28-19-15-26(16-20-28)14-13-21-7-2-4-9-23(21)26/h2-5,7-12H,6,13-20H2,1H3,(H,27,29)/b12-11-
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181408
PNG
(CHEMBL202455 | N-[(1S,2R)-2-[(3-{2,3-dihydrospiro[...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@@H]1CCCC[C@@H]1NC(=O)c1ccccc1
Show InChI InChI=1S/C30H39N3O2/c34-28(24-10-2-1-3-11-24)32-27-14-7-5-12-25(27)29(35)31-19-8-20-33-21-17-30(18-22-33)16-15-23-9-4-6-13-26(23)30/h1-4,6,9-11,13,25,27H,5,7-8,12,14-22H2,(H,31,35)(H,32,34)/t25-,27+/m1/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181409
PNG
((2Z)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Show SMILES CC(=O)N\C(=C/c1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-21(31)29-25(20-22-8-3-2-4-9-22)26(32)28-16-7-17-30-18-14-27(15-19-30)13-12-23-10-5-6-11-24(23)27/h2-6,8-11,20H,7,12-19H2,1H3,(H,28,32)(H,29,31)/b25-20-
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181415
PNG
(2-benzoyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piper...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1C(=O)c1ccccc1
Show InChI InChI=1S/C30H32N2O2/c33-28(24-10-2-1-3-11-24)25-12-5-6-13-26(25)29(34)31-19-8-20-32-21-17-30(18-22-32)16-15-23-9-4-7-14-27(23)30/h1-7,9-14H,8,15-22H2,(H,31,34)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181407
PNG
(CHEMBL203247 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1CCc2ccccc2C1
Show InChI InChI=1S/C27H34N2O/c30-26(24-11-10-21-6-1-2-8-23(21)20-24)28-16-5-17-29-18-14-27(15-19-29)13-12-22-7-3-4-9-25(22)27/h1-4,6-9,24H,5,10-20H2,(H,28,30)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181414
PNG
(CHEMBL201103 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES OC(c1ccccc1)c1cccnc1C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C29H33N3O2/c33-27(23-9-2-1-3-10-23)24-11-6-17-30-26(24)28(34)31-18-7-19-32-20-15-29(16-21-32)14-13-22-8-4-5-12-25(22)29/h1-6,8-12,17,27,33H,7,13-16,18-21H2,(H,31,34)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181410
PNG
((2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)\C=C\c1c[nH]c2ccccc12
Show InChI InChI=1S/C27H31N3O/c31-26(11-10-22-20-29-25-9-4-2-7-23(22)25)28-16-5-17-30-18-14-27(15-19-30)13-12-21-6-1-3-8-24(21)27/h1-4,6-11,20,29H,5,12-19H2,(H,28,31)/b11-10+
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181422
PNG
(3-(2H-1,3-benzodioxol-5-yl)-N-(3-{2,3-dihydrospiro...)
Show SMILES O=C(Cc1ccc2OCOc2c1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C26H30N2O4/c29-22(16-19-6-7-23-24(17-19)32-18-31-23)25(30)27-12-3-13-28-14-10-26(11-15-28)9-8-20-4-1-2-5-21(20)26/h1-2,4-7,17H,3,8-16,18H2,(H,27,30)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181418
PNG
(2-(2,4-dichlorophenoxy)-N-(3-{2,3-dihydrospiro[ind...)
Show SMILES CC(Oc1ccc(Cl)cc1Cl)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H30Cl2N2O2/c1-18(31-23-8-7-20(26)17-22(23)27)24(30)28-13-4-14-29-15-11-25(12-16-29)10-9-19-5-2-3-6-21(19)25/h2-3,5-8,17-18H,4,9-16H2,1H3,(H,28,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181370
PNG
(CHEMBL202438 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1Cc2ccccc2C1
Show InChI InChI=1S/C26H32N2O/c29-25(23-18-21-7-1-2-8-22(21)19-23)27-14-5-15-28-16-12-26(13-17-28)11-10-20-6-3-4-9-24(20)26/h1-4,6-9,23H,5,10-19H2,(H,27,29)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181372
PNG
(CHEMBL201964 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1(CCCC1)c1ccccc1
Show InChI InChI=1S/C28H36N2O/c31-26(28(14-6-7-15-28)24-10-2-1-3-11-24)29-19-8-20-30-21-17-27(18-22-30)16-13-23-9-4-5-12-25(23)27/h1-5,9-12H,6-8,13-22H2,(H,29,31)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181384
PNG
(CHEMBL370342 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES COC(C(=O)NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1
Show InChI InChI=1S/C25H32N2O2/c1-29-23(21-9-3-2-4-10-21)24(28)26-16-7-17-27-18-14-25(15-19-27)13-12-20-8-5-6-11-22(20)25/h2-6,8-11,23H,7,12-19H2,1H3,(H,26,28)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181383
PNG
(CHEMBL202067 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C(Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H36N2O/c34-30(28(26-12-5-2-6-13-26)24-25-10-3-1-4-11-25)32-20-9-21-33-22-18-31(19-23-33)17-16-27-14-7-8-15-29(27)31/h1-8,10-15,28H,9,16-24H2,(H,32,34)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181369
PNG
(CHEMBL372353 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1CC(=O)c2ccccc12
Show InChI InChI=1S/C26H30N2O2/c29-24-18-22(20-7-2-3-8-21(20)24)25(30)27-14-5-15-28-16-12-26(13-17-28)11-10-19-6-1-4-9-23(19)26/h1-4,6-9,22H,5,10-18H2,(H,27,30)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181429
PNG
(CHEMBL202541 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C26H35N5O/c32-24(22-8-17-31(18-9-22)25-28-13-3-14-29-25)27-15-4-16-30-19-11-26(12-20-30)10-7-21-5-1-2-6-23(21)26/h1-3,5-6,13-14,22H,4,7-12,15-20H2,(H,27,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181431
PNG
(CHEMBL203469 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(Cc1ccccc1)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C24H30N2O/c27-23(19-20-7-2-1-3-8-20)25-15-6-16-26-17-13-24(14-18-26)12-11-21-9-4-5-10-22(21)24/h1-5,7-10H,6,11-19H2,(H,25,27)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181423
PNG
((2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Show SMILES Cc1ccc(cc1)C(=O)\C=C\C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C27H32N2O2/c1-21-7-9-23(10-8-21)25(30)11-12-26(31)28-17-4-18-29-19-15-27(16-20-29)14-13-22-5-2-3-6-24(22)27/h2-3,5-12H,4,13-20H2,1H3,(H,28,31)/b12-11+
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181393
PNG
((2S,3R)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperid...)
Show SMILES C[C@@H](O)[C@H](NC(=O)c1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C27H35N3O3/c1-20(31)24(29-25(32)22-9-3-2-4-10-22)26(33)28-16-7-17-30-18-14-27(15-19-30)13-12-21-8-5-6-11-23(21)27/h2-6,8-11,20,24,31H,7,12-19H2,1H3,(H,28,33)(H,29,32)/t20-,24+/m1/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181365
PNG
(CHEMBL381240 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES COc1ccc2C(=O)C(CC(=O)NCCCN3CCC4(CCc5ccccc45)CC3)Cc2c1
Show InChI InChI=1S/C28H34N2O3/c1-33-23-7-8-24-21(18-23)17-22(27(24)32)19-26(31)29-13-4-14-30-15-11-28(12-16-30)10-9-20-5-2-3-6-25(20)28/h2-3,5-8,18,22H,4,9-17,19H2,1H3,(H,29,31)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181432
PNG
(CHEMBL202092 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES FC(F)(F)c1c(cnn1-c1ccccc1)C(=O)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C28H29F3N4O2/c29-28(30,31)25-22(19-33-35(25)21-8-2-1-3-9-21)24(36)26(37)32-15-6-16-34-17-13-27(14-18-34)12-11-20-7-4-5-10-23(20)27/h1-5,7-10,19H,6,11-18H2,(H,32,37)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181424
PNG
(CHEMBL373020 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES CN(CC(=O)NCCCN1CCC2(CCc3ccccc23)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H33N3O2/c1-28(25(31)22-9-3-2-4-10-22)20-24(30)27-16-7-17-29-18-14-26(15-19-29)13-12-21-8-5-6-11-23(21)26/h2-6,8-11H,7,12-20H2,1H3,(H,27,30)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181394
PNG
(CHEMBL202280 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ncccc1-c1ccccc1
Show InChI InChI=1S/C28H31N3O/c32-27(26-24(11-6-17-29-26)22-8-2-1-3-9-22)30-18-7-19-31-20-15-28(16-21-31)14-13-23-10-4-5-12-25(23)28/h1-6,8-12,17H,7,13-16,18-21H2,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181427
PNG
(CHEMBL383576 | N-[(1S,2S)-2-[(3-{2,3-dihydrospiro[...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCCC[C@@H]1NC(=O)c1ccccc1
Show InChI InChI=1S/C30H39N3O2/c34-28(24-10-2-1-3-11-24)32-27-14-7-5-12-25(27)29(35)31-19-8-20-33-21-17-30(18-22-33)16-15-23-9-4-6-13-26(23)30/h1-4,6,9-11,13,25,27H,5,7-8,12,14-22H2,(H,31,35)(H,32,34)/t25-,27-/m0/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181419
PNG
(CHEMBL370866 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C26H28N2O3/c29-22-18-24(31-23-9-4-2-7-20(22)23)25(30)27-14-5-15-28-16-12-26(13-17-28)11-10-19-6-1-3-8-21(19)26/h1-4,6-9,18H,5,10-17H2,(H,27,30)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181415
PNG
(2-benzoyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piper...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1C(=O)c1ccccc1
Show InChI InChI=1S/C30H32N2O2/c33-28(24-10-2-1-3-11-24)25-12-5-6-13-26(25)29(34)31-19-8-20-32-21-17-30(18-22-32)16-15-23-9-4-7-14-27(23)30/h1-7,9-14H,8,15-22H2,(H,31,34)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181411
PNG
(CHEMBL369962 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1Cc2ccccc12
Show InChI InChI=1S/C25H30N2O/c28-24(22-18-20-7-1-3-8-21(20)22)26-14-5-15-27-16-12-25(13-17-27)11-10-19-6-2-4-9-23(19)25/h1-4,6-9,22H,5,10-18H2,(H,26,28)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181413
PNG
(CHEMBL202435 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ncccc1Oc1ccccc1
Show InChI InChI=1S/C28H31N3O2/c32-27(26-25(12-6-17-29-26)33-23-9-2-1-3-10-23)30-18-7-19-31-20-15-28(16-21-31)14-13-22-8-4-5-11-24(22)28/h1-6,8-12,17H,7,13-16,18-21H2,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181376
PNG
(CHEMBL372774 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O[C@H](Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O2/c28-23(19-20-7-2-1-3-8-20)24(29)26-15-6-16-27-17-13-25(14-18-27)12-11-21-9-4-5-10-22(21)25/h1-5,7-10,23,28H,6,11-19H2,(H,26,29)/t23-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181387
PNG
(CHEMBL201104 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES CC(NC(=O)c1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C26H33N3O2/c1-20(28-25(31)22-9-3-2-4-10-22)24(30)27-16-7-17-29-18-14-26(15-19-29)13-12-21-8-5-6-11-23(21)26/h2-6,8-11,20H,7,12-19H2,1H3,(H,27,30)(H,28,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181412
PNG
(CHEMBL200987 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H30N2O2/c28-23(19-20-7-2-1-3-8-20)24(29)26-15-6-16-27-17-13-25(14-18-27)12-11-21-9-4-5-10-22(21)25/h1-5,7-10H,6,11-19H2,(H,26,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181416
PNG
(CHEMBL372726 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Show SMILES O=C(Cc1cccc2ccccc12)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C28H32N2O/c31-27(21-24-10-5-9-22-7-1-3-11-25(22)24)29-17-6-18-30-19-15-28(16-20-30)14-13-23-8-2-4-12-26(23)28/h1-5,7-12H,6,13-21H2,(H,29,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50181364
PNG
(2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C30H34N2O2/c33-29(26-12-5-7-14-28(26)34-23-24-9-2-1-3-10-24)31-19-8-20-32-21-17-30(18-22-32)16-15-25-11-4-6-13-27(25)30/h1-7,9-14H,8,15-23H2,(H,31,33)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50181392
PNG
((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Show SMILES O=C(NCCCN1CCC2(CC1)OCc1ccccc21)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50181380
PNG
(CHEMBL413571 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C29H32N2O/c32-28(26-13-6-5-12-25(26)23-9-2-1-3-10-23)30-19-8-20-31-21-17-29(18-22-31)16-15-24-11-4-7-14-27(24)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50181395
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50181392
PNG
((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Show SMILES O=C(NCCCN1CCC2(CC1)OCc1ccccc21)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1
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n/an/a 6.70E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50181382
PNG
(CHEMBL199639 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O[C@@H](Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O2/c28-23(19-20-7-2-1-3-8-20)24(29)26-15-6-16-27-17-13-25(14-18-27)12-11-21-9-4-5-10-22(21)25/h1-5,7-10,23,28H,6,11-19H2,(H,26,29)/t23-/m0/s1
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n/an/a 6.90E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50181379
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m0/s1
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n/an/a 7.90E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50181374
PNG
(2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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n/an/a 9.60E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50181379
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50181364
PNG
(2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C30H34N2O2/c33-29(26-12-5-7-14-28(26)34-23-24-9-2-1-3-10-24)31-19-8-20-32-21-17-30(18-22-32)16-15-25-11-4-6-13-27(25)30/h1-7,9-14H,8,15-23H2,(H,31,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50181392
PNG
((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Show SMILES O=C(NCCCN1CCC2(CC1)OCc1ccccc21)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50181382
PNG
(CHEMBL199639 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O[C@@H](Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O2/c28-23(19-20-7-2-1-3-8-20)24(29)26-15-6-16-27-17-13-25(14-18-27)12-11-21-9-4-5-10-22(21)25/h1-5,7-10,23,28H,6,11-19H2,(H,26,29)/t23-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50181380
PNG
(CHEMBL413571 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C29H32N2O/c32-28(26-13-6-5-12-25(26)23-9-2-1-3-10-23)30-19-8-20-31-21-17-29(18-22-31)16-15-24-11-4-7-14-27(24)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50181395
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m1/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50181374
PNG
(2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50181374
PNG
(2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50181379
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m0/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50181380
PNG
(CHEMBL413571 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C29H32N2O/c32-28(26-13-6-5-12-25(26)23-9-2-1-3-10-23)30-19-8-20-31-21-17-29(18-22-31)16-15-24-11-4-7-14-27(24)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50181382
PNG
(CHEMBL199639 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O[C@@H](Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O2/c28-23(19-20-7-2-1-3-8-20)24(29)26-15-6-16-27-17-13-25(14-18-27)12-11-21-9-4-5-10-22(21)25/h1-5,7-10,23,28H,6,11-19H2,(H,26,29)/t23-/m0/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50181364
PNG
(2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C30H34N2O2/c33-29(26-12-5-7-14-28(26)34-23-24-9-2-1-3-10-24)31-19-8-20-32-21-17-30(18-22-32)16-15-25-11-4-6-13-27(25)30/h1-7,9-14H,8,15-23H2,(H,31,33)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181374
PNG
(2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181382
PNG
(CHEMBL199639 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O[C@@H](Cc1ccccc1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C25H32N2O2/c28-23(19-20-7-2-1-3-8-20)24(29)26-15-6-16-27-17-13-25(14-18-27)12-11-21-9-4-5-10-22(21)25/h1-5,7-10,23,28H,6,11-19H2,(H,26,29)/t23-/m0/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181364
PNG
(2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C30H34N2O2/c33-29(26-12-5-7-14-28(26)34-23-24-9-2-1-3-10-24)31-19-8-20-32-21-17-30(18-22-32)16-15-25-11-4-6-13-27(25)30/h1-7,9-14H,8,15-23H2,(H,31,33)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181395
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181380
PNG
(CHEMBL413571 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C29H32N2O/c32-28(26-13-6-5-12-25(26)23-9-2-1-3-10-23)30-19-8-20-31-21-17-29(18-22-31)16-15-24-11-4-7-14-27(24)29/h1-7,9-14H,8,15-22H2,(H,30,32)
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181392
PNG
((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Show SMILES O=C(NCCCN1CCC2(CC1)OCc1ccccc21)[C@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nociceptin receptor


(Homo sapiens (Human))
BDBM50181379
PNG
(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C28H37N3O/c32-27(26-12-6-19-31(26)22-23-8-2-1-3-9-23)29-17-7-18-30-20-15-28(16-21-30)14-13-24-10-4-5-11-25(24)28/h1-5,8-11,26H,6-7,12-22H2,(H,29,32)/t26-/m0/s1
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells


J Med Chem 49: 847-9 (2006)


Article DOI: 10.1021/jm0509851
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%