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PubMed code 16458503

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182014
PNG
(7-(pyridin-2-yl)-N-(3,4,5-trimethoxyphenyl)-6,7-di...)
Show SMILES COc1cc(Nc2ncc3CCN(c3n2)c2ccccn2)cc(OC)c1OC
Show InChI InChI=1S/C20H21N5O3/c1-26-15-10-14(11-16(27-2)18(15)28-3)23-20-22-12-13-7-9-25(19(13)24-20)17-6-4-5-8-21-17/h4-6,8,10-12H,7,9H2,1-3H3,(H,22,23,24)
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n/an/a 100n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182013
PNG
(5-bromo-N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphen...)
Show SMILES COc1cc(Nc2ncc(Br)c(Nc3ccccn3)n2)cc(OC)c1OC
Show InChI InChI=1S/C18H18BrN5O3/c1-25-13-8-11(9-14(26-2)16(13)27-3)22-18-21-10-12(19)17(24-18)23-15-6-4-5-7-20-15/h4-10H,1-3H3,(H2,20,21,22,23,24)
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Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181998
PNG
(7-(pyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)-7H-pyr...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4cccnc4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C20H19N5O3/c1-26-16-9-14(10-17(27-2)18(16)28-3)23-20-22-11-13-6-8-25(19(13)24-20)15-5-4-7-21-12-15/h4-12H,1-3H3,(H,22,23,24)
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n/an/a 100n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181975
PNG
(8-(pyridin-2-yl)-N-(3,4,5-trimethoxyphenyl)-5,6,7,...)
Show SMILES COc1cc(Nc2ncc3CCCN(c4ccccn4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C21H23N5O3/c1-27-16-11-15(12-17(28-2)19(16)29-3)24-21-23-13-14-7-6-10-26(20(14)25-21)18-8-4-5-9-22-18/h4-5,8-9,11-13H,6-7,10H2,1-3H3,(H,23,24,25)
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n/an/a 200n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181987
PNG
(CHEMBL204933 | ethyl 2-(4-(pyridin-2-ylamino)-2-(3...)
Show SMILES CCOC(=O)Cc1cnc(Nc2cc(OC)c(OC)c(OC)c2)nc1Nc1ccccn1
Show InChI InChI=1S/C22H25N5O5/c1-5-32-19(28)10-14-13-24-22(27-21(14)26-18-8-6-7-9-23-18)25-15-11-16(29-2)20(31-4)17(12-15)30-3/h6-9,11-13H,5,10H2,1-4H3,(H2,23,24,25,26,27)
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Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182010
PNG
(7-(pyridin-2-yl)-N-(2,4,6-trimethoxyphenyl)-7H-pyr...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4ccccn4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C20H19N5O3/c1-26-15-10-14(11-16(27-2)18(15)28-3)23-20-22-12-13-7-9-25(19(13)24-20)17-6-4-5-8-21-17/h4-12H,1-3H3,(H,22,23,24)
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n/an/a 200n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182006
PNG
(8-(pyridin-2-yl)-2-(3,4,5-trimethoxyphenylamino)-5...)
Show SMILES COc1cc(Nc2ncc3CCC(O)N(c4ccccn4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C21H23N5O4/c1-28-15-10-14(11-16(29-2)19(15)30-3)24-21-23-12-13-7-8-18(27)26(20(13)25-21)17-6-4-5-9-22-17/h4-6,9-12,18,27H,7-8H2,1-3H3,(H,23,24,25)
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Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181983
PNG
(CHEMBL377957 | N-(5-methoxy-2-methylphenyl)-7-(pyr...)
Show SMILES COc1ccc(C)c(Nc2ncc3ccn(-c4ccccn4)c3n2)c1
Show InChI InChI=1S/C19H17N5O/c1-13-6-7-15(25-2)11-16(13)22-19-21-12-14-8-10-24(18(14)23-19)17-5-3-4-9-20-17/h3-12H,1-2H3,(H,21,22,23)
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n/an/a 200n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181979
PNG
(7-(4-methoxypyridin-3-yl)-N-(3,4,5-trimethoxypheny...)
Show SMILES COc1ccncc1-n1ccc2cnc(Nc3cc(OC)c(OC)c(OC)c3)nc12
Show InChI InChI=1S/C21H21N5O4/c1-27-16-5-7-22-12-15(16)26-8-6-13-11-23-21(25-20(13)26)24-14-9-17(28-2)19(30-4)18(10-14)29-3/h5-12H,1-4H3,(H,23,24,25)
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n/an/a 300n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181968
PNG
(7-(pyridin-2-yl)-N-(5,6,7,8-tetrahydronaphthalen-1...)
Show SMILES C1CCc2c(C1)cccc2Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C21H19N5/c1-2-8-17-15(6-1)7-5-9-18(17)24-21-23-14-16-11-13-26(20(16)25-21)19-10-3-4-12-22-19/h3-5,7,9-14H,1-2,6,8H2,(H,23,24,25)
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n/an/a 300n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182002
PNG
(4-methyl-3-(7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyri...)
Show SMILES Cc1ccc(cc1Nc1ncc2ccn(-c3ccccn3)c2n1)C(N)=O
Show InChI InChI=1S/C19H16N6O/c1-12-5-6-13(17(20)26)10-15(12)23-19-22-11-14-7-9-25(18(14)24-19)16-4-2-3-8-21-16/h2-11H,1H3,(H2,20,26)(H,22,23,24)
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n/an/a 400n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181981
PNG
(7-(4-chloropyridin-3-yl)-N-(3,4,5-trimethoxyphenyl...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4cnccc4Cl)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C20H18ClN5O3/c1-27-16-8-13(9-17(28-2)18(16)29-3)24-20-23-10-12-5-7-26(19(12)25-20)15-11-22-6-4-14(15)21/h4-11H,1-3H3,(H,23,24,25)
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Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181969
PNG
(7-(pyridin-2-yl)-N-o-tolyl-7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES Cc1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C18H15N5/c1-13-6-2-3-7-15(13)21-18-20-12-14-9-11-23(17(14)22-18)16-8-4-5-10-19-16/h2-12H,1H3,(H,20,21,22)
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n/an/a 500n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181999
PNG
(7-(thiazol-2-yl)-N-(3,4,5-trimethoxyphenyl)-7H-pyr...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4nccs4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C18H17N5O3S/c1-24-13-8-12(9-14(25-2)15(13)26-3)21-17-20-10-11-4-6-23(16(11)22-17)18-19-5-7-27-18/h4-10H,1-3H3,(H,20,21,22)
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n/an/a 500n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181982
PNG
(CHEMBL208042 | N-(3-methoxyphenyl)-7-(pyridin-2-yl...)
Show SMILES COc1cccc(Nc2ncc3ccn(-c4ccccn4)c3n2)c1
Show InChI InChI=1S/C18H15N5O/c1-24-15-6-4-5-14(11-15)21-18-20-12-13-8-10-23(17(13)22-18)16-7-2-3-9-19-16/h2-12H,1H3,(H,20,21,22)
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n/an/a 600n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181986
PNG
(CHEMBL206853 | N-(2-methyl-5-(quinoxalin-2-yl)phen...)
Show SMILES Cc1ccc(cc1Nc1ncc2ccn(-c3ccccn3)c2n1)-c1cnc2ccccc2n1
Show InChI InChI=1S/C26H19N7/c1-17-9-10-18(23-16-28-20-6-2-3-7-21(20)30-23)14-22(17)31-26-29-15-19-11-13-33(25(19)32-26)24-8-4-5-12-27-24/h2-16H,1H3,(H,29,31,32)
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n/an/a 600n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182015
PNG
(CHEMBL206322 | N-(2-methoxyphenyl)-7-(pyridin-2-yl...)
Show SMILES COc1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C18H15N5O/c1-24-15-7-3-2-6-14(15)21-18-20-12-13-9-11-23(17(13)22-18)16-8-4-5-10-19-16/h2-12H,1H3,(H,20,21,22)
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n/an/a 700n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182007
PNG
(7-(pyridin-2-yl)-N-m-tolyl-7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES Cc1cccc(Nc2ncc3ccn(-c4ccccn4)c3n2)c1
Show InChI InChI=1S/C18H15N5/c1-13-5-4-6-15(11-13)21-18-20-12-14-8-10-23(17(14)22-18)16-7-2-3-9-19-16/h2-12H,1H3,(H,20,21,22)
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n/an/a 700n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182005
PNG
(CHEMBL207935 | N-(2-chlorophenyl)-7-(pyridin-2-yl)...)
Show SMILES Clc1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C17H12ClN5/c18-13-5-1-2-6-14(13)21-17-20-11-12-8-10-23(16(12)22-17)15-7-3-4-9-19-15/h1-11H,(H,20,21,22)
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n/an/a 700n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182018
PNG
(7-(2-chloropyrimidin-4-yl)-N-(3,4,5-trimethoxyphen...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4ccnc(Cl)n4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C19H17ClN6O3/c1-27-13-8-12(9-14(28-2)16(13)29-3)23-19-22-10-11-5-7-26(17(11)25-19)15-4-6-21-18(20)24-15/h4-10H,1-3H3,(H,22,23,25)
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n/an/a 800n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182012
PNG
(7-(4-fluoropyridin-3-yl)-N-(3,4,5-trimethoxyphenyl...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4cnccc4F)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C20H18FN5O3/c1-27-16-8-13(9-17(28-2)18(16)29-3)24-20-23-10-12-5-7-26(19(12)25-20)15-11-22-6-4-14(15)21/h4-11H,1-3H3,(H,23,24,25)
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n/an/a 800n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181988
PNG
(7-(2-chloropyridin-4-yl)-N-(3,4,5-trimethoxyphenyl...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4ccnc(Cl)c4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C20H18ClN5O3/c1-27-15-8-13(9-16(28-2)18(15)29-3)24-20-23-11-12-5-7-26(19(12)25-20)14-4-6-22-17(21)10-14/h4-11H,1-3H3,(H,23,24,25)
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n/an/a 800n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181994
PNG
(CHEMBL382637 | N-(2-ethylphenyl)-7-(pyridin-2-yl)-...)
Show SMILES CCc1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C19H17N5/c1-2-14-7-3-4-8-16(14)22-19-21-13-15-10-12-24(18(15)23-19)17-9-5-6-11-20-17/h3-13H,2H2,1H3,(H,21,22,23)
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n/an/a 900n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182009
PNG
(CHEMBL381308 | N-(2-(methylthio)phenyl)-7-(pyridin...)
Show SMILES CSc1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C18H15N5S/c1-24-15-7-3-2-6-14(15)21-18-20-12-13-9-11-23(17(13)22-18)16-8-4-5-10-19-16/h2-12H,1H3,(H,20,21,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182019
PNG
(CHEMBL378596 | N-(2-fluorophenyl)-7-(pyridin-2-yl)...)
Show SMILES Fc1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C17H12FN5/c18-13-5-1-2-6-14(13)21-17-20-11-12-8-10-23(16(12)22-17)15-7-3-4-9-19-15/h1-11H,(H,20,21,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181977
PNG
(CHEMBL203020 | N-(2-bromophenyl)-7-(pyridin-2-yl)-...)
Show SMILES Brc1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C17H12BrN5/c18-13-5-1-2-6-14(13)21-17-20-11-12-8-10-23(16(12)22-17)15-7-3-4-9-19-15/h1-11H,(H,20,21,22)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181966
PNG
(CHEMBL381609 | N-(3-(methylthio)phenyl)-7-(pyridin...)
Show SMILES CSc1cccc(Nc2ncc3ccn(-c4ccccn4)c3n2)c1
Show InChI InChI=1S/C18H15N5S/c1-24-15-6-4-5-14(11-15)21-18-20-12-13-8-10-23(17(13)22-18)16-7-2-3-9-19-16/h2-12H,1H3,(H,20,21,22)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181976
PNG
(CHEMBL383834 | N-(5-iodo-2-methylphenyl)-7-(pyridi...)
Show SMILES Cc1ccc(I)cc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C18H14IN5/c1-12-5-6-14(19)10-15(12)22-18-21-11-13-7-9-24(17(13)23-18)16-4-2-3-8-20-16/h2-11H,1H3,(H,21,22,23)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181973
PNG
(7-(pyridin-2-yl)-N-(2-(trifluoromethyl)phenyl)-7H-...)
Show SMILES FC(F)(F)c1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C18H12F3N5/c19-18(20,21)13-5-1-2-6-14(13)24-17-23-11-12-8-10-26(16(12)25-17)15-7-3-4-9-22-15/h1-11H,(H,23,24,25)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182000
PNG
(7-(2-(pyridin-4-yl)ethyl)-N-(3,4,5-trimethoxypheny...)
Show SMILES COc1cc(Nc2ncc3ccn(CCc4ccncc4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23N5O3/c1-28-18-12-17(13-19(29-2)20(18)30-3)25-22-24-14-16-7-11-27(21(16)26-22)10-6-15-4-8-23-9-5-15/h4-5,7-9,11-14H,6,10H2,1-3H3,(H,24,25,26)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181997
PNG
(7-(pyridin-3-ylmethyl)-N-(3,4,5-trimethoxyphenyl)-...)
Show SMILES COc1cc(Nc2ncc3ccn(Cc4cccnc4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C21H21N5O3/c1-27-17-9-16(10-18(28-2)19(17)29-3)24-21-23-12-15-6-8-26(20(15)25-21)13-14-5-4-7-22-11-14/h4-12H,13H2,1-3H3,(H,23,24,25)
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n/an/a 7.90E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181978
PNG
(CHEMBL203676 | N-(4-iodo-2-methylphenyl)-7-(pyridi...)
Show SMILES Cc1cc(I)ccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C18H14IN5/c1-12-10-14(19)5-6-15(12)22-18-21-11-13-7-9-24(17(13)23-18)16-4-2-3-8-20-16/h2-11H,1H3,(H,21,22,23)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181990
PNG
(7-(pyridin-4-yl)-N-(3,4,5-trimethoxyphenyl)-7H-pyr...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4ccncc4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C20H19N5O3/c1-26-16-10-14(11-17(27-2)18(16)28-3)23-20-22-12-13-6-9-25(19(13)24-20)15-4-7-21-8-5-15/h4-12H,1-3H3,(H,22,23,24)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182003
PNG
(7-(2-(pyridin-3-yl)ethyl)-N-(3,4,5-trimethoxypheny...)
Show SMILES COc1cc(Nc2ncc3ccn(CCc4cccnc4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23N5O3/c1-28-18-11-17(12-19(29-2)20(18)30-3)25-22-24-14-16-7-10-27(21(16)26-22)9-6-15-5-4-8-23-13-15/h4-5,7-8,10-14H,6,9H2,1-3H3,(H,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181992
PNG
(7-(4-chloropyrimidin-2-yl)-N-(3,4,5-trimethoxyphen...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4nccc(Cl)n4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C19H17ClN6O3/c1-27-13-8-12(9-14(28-2)16(13)29-3)23-18-22-10-11-5-7-26(17(11)25-18)19-21-6-4-15(20)24-19/h4-10H,1-3H3,(H,22,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181985
PNG
(7-(5-methylpyridin-2-yl)-N-(3,4,5-trimethoxyphenyl...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4ccc(C)cn4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C21H21N5O3/c1-13-5-6-18(22-11-13)26-8-7-14-12-23-21(25-20(14)26)24-15-9-16(27-2)19(29-4)17(10-15)28-3/h5-12H,1-4H3,(H,23,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182008
PNG
(CHEMBL203675 | N-(5-bromo-2-methylphenyl)-7-(pyrid...)
Show SMILES Cc1ccc(Br)cc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C18H14BrN5/c1-12-5-6-14(19)10-15(12)22-18-21-11-13-7-9-24(17(13)23-18)16-4-2-3-8-20-16/h2-11H,1H3,(H,21,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182004
PNG
(7-(pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-7H-...)
Show SMILES FC(F)(F)c1ccc(Nc2ncc3ccn(-c4ccccn4)c3n2)cc1
Show InChI InChI=1S/C18H12F3N5/c19-18(20,21)13-4-6-14(7-5-13)24-17-23-11-12-8-10-26(16(12)25-17)15-3-1-2-9-22-15/h1-11H,(H,23,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181972
PNG
(CHEMBL205943 | N-(2-methyl-5-nitrophenyl)-7-(pyrid...)
Show SMILES Cc1ccc(cc1Nc1ncc2ccn(-c3ccccn3)c2n1)[N+]([O-])=O
Show InChI InChI=1S/C18H14N6O2/c1-12-5-6-14(24(25)26)10-15(12)21-18-20-11-13-7-9-23(17(13)22-18)16-4-2-3-8-19-16/h2-11H,1H3,(H,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181991
PNG
((4-methyl-3-(7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyr...)
Show SMILES Cc1ccc(CO)cc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C19H17N5O/c1-13-5-6-14(12-25)10-16(13)22-19-21-11-15-7-9-24(18(15)23-19)17-4-2-3-8-20-17/h2-11,25H,12H2,1H3,(H,21,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182016
PNG
(2-morpholino-7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyr...)
Show SMILES C1CN(CCO1)c1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C15H15N5O/c1-2-5-16-13(3-1)20-6-4-12-11-17-15(18-14(12)20)19-7-9-21-10-8-19/h1-6,11H,7-10H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182011
PNG
(CHEMBL206796 | ethyl 2-(4-chloro-2-(3,4,5-trimetho...)
Show SMILES CCOC(=O)Cc1cnc(Nc2cc(OC)c(OC)c(OC)c2)nc1Cl
Show InChI InChI=1S/C17H20ClN3O5/c1-5-26-14(22)6-10-9-19-17(21-16(10)18)20-11-7-12(23-2)15(25-4)13(8-11)24-3/h7-9H,5-6H2,1-4H3,(H,19,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182001
PNG
(3-(7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-y...)
Show SMILES Oc1cccc(Nc2ncc3ccn(-c4ccccn4)c3n2)c1
Show InChI InChI=1S/C17H13N5O/c23-14-5-3-4-13(10-14)20-17-19-11-12-7-9-22(16(12)21-17)15-6-1-2-8-18-15/h1-11,23H,(H,19,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181967
PNG
(8-(pyridin-2-yl)-2-(3,4,5-trimethoxyphenylamino)-5...)
Show SMILES COc1cc(Nc2ncc3CCC(=O)N(c4ccccn4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C21H21N5O4/c1-28-15-10-14(11-16(29-2)19(15)30-3)24-21-23-12-13-7-8-18(27)26(20(13)25-21)17-6-4-5-9-22-17/h4-6,9-12H,7-8H2,1-3H3,(H,23,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181980
PNG
(2-(4-methylpiperazin-1-yl)-7-(pyridin-2-yl)-7H-pyr...)
Show SMILES CN1CCN(CC1)c1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C16H18N6/c1-20-8-10-21(11-9-20)16-18-12-13-5-7-22(15(13)19-16)14-4-2-3-6-17-14/h2-7,12H,8-11H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181971
PNG
(CHEMBL426673 | N-(benzo[d][1,3]dioxol-5-yl)-7-(pyr...)
Show SMILES C1Oc2ccc(Nc3ncc4ccn(-c5ccccn5)c4n3)cc2O1
Show InChI InChI=1S/C18H13N5O2/c1-2-7-19-16(3-1)23-8-6-12-10-20-18(22-17(12)23)21-13-4-5-14-15(9-13)25-11-24-14/h1-10H,11H2,(H,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50182017
PNG
(7-(pyridin-2-yl)-2-(3,4,5-trimethoxyphenylamino)-5...)
Show SMILES COc1cc(Nc2ncc3CC(=O)N(c3n2)c2ccccn2)cc(OC)c1OC
Show InChI InChI=1S/C20H19N5O4/c1-27-14-9-13(10-15(28-2)18(14)29-3)23-20-22-11-12-8-17(26)25(19(12)24-20)16-6-4-5-7-21-16/h4-7,9-11H,8H2,1-3H3,(H,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181995
PNG
(CHEMBL381998 | N-(3,4,5-trimethoxybenzyl)-7-(pyrid...)
Show SMILES COc1cc(CNc2ncc3ccn(-c4ccccn4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C21H21N5O3/c1-27-16-10-14(11-17(28-2)19(16)29-3)12-23-21-24-13-15-7-9-26(20(15)25-21)18-6-4-5-8-22-18/h4-11,13H,12H2,1-3H3,(H,23,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181996
PNG
(8-(pyridin-2-yl)-2-(3,4,5-trimethoxyphenylamino)py...)
Show SMILES COc1cc(Nc2ncc3ccc(=O)n(-c4ccccn4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C21H19N5O4/c1-28-15-10-14(11-16(29-2)19(15)30-3)24-21-23-12-13-7-8-18(27)26(20(13)25-21)17-6-4-5-9-22-17/h4-12H,1-3H3,(H,23,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181993
PNG
(1-(3-(7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES O=C1CCCN1CCCNc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C18H20N6O/c25-16-6-3-10-23(16)11-4-9-20-18-21-13-14-7-12-24(17(14)22-18)15-5-1-2-8-19-15/h1-2,5,7-8,12-13H,3-4,6,9-11H2,(H,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181984
PNG
(CHEMBL380116 | N-(2-isopropylphenyl)-7-(pyridin-2-...)
Show SMILES CC(C)c1ccccc1Nc1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C20H19N5/c1-14(2)16-7-3-4-8-17(16)23-20-22-13-15-10-12-25(19(15)24-20)18-9-5-6-11-21-18/h3-14H,1-2H3,(H,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181974
PNG
(CHEMBL208169 | N-(1H-indol-6-yl)-7-(pyridin-2-yl)-...)
Show SMILES N(c1ccc2cc[nH]c2c1)c1ncc2ccn(-c3ccccn3)c2n1
Show InChI InChI=1S/C19H14N6/c1-2-8-21-17(3-1)25-10-7-14-12-22-19(24-18(14)25)23-15-5-4-13-6-9-20-16(13)11-15/h1-12,20H,(H,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181970
PNG
(7-(thiophen-2-yl)-N-(3,4,5-trimethoxyphenyl)-7H-py...)
Show SMILES COc1cc(Nc2ncc3ccn(-c4cccs4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C19H18N4O3S/c1-24-14-9-13(10-15(25-2)17(14)26-3)21-19-20-11-12-6-7-23(18(12)22-19)16-5-4-8-27-16/h4-11H,1-3H3,(H,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50181989
PNG
(CHEMBL204982 | N-benzyl-7-(pyridin-2-yl)-7H-pyrrol...)
Show SMILES C(Nc1ncc2ccn(-c3ccccn3)c2n1)c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-6-14(7-3-1)12-20-18-21-13-15-9-11-23(17(15)22-18)16-8-4-5-10-19-16/h1-11,13H,12H2,(H,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibitory activity against FAK


Bioorg Med Chem Lett 16: 2173-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.053
BindingDB Entry DOI: 10.7270/Q2319VGX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%