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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13361 ((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet  | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13373 ((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | MMDB Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13358 ((2S)-2-{[(2R)-1-[(2S)-2-[(2R)-2-amino-3-sulfanylpr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13359 ((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13363 ((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13365 ((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13360 ((2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13362 ((2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13369 ((2S)-2-[(2S)-3-(4-hydroxy-2,5-dimethylphenyl)-2-[(...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13370 ((2S)-2-[(2R)-3-(4-hydroxy-2,5-dimethylphenyl)-2-[(...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13367 ((2S)-2-[(2S)-3-(4-hydroxy-2,3-dimethylphenyl)-2-[(...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13364 ((2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13366 ((2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13371 (CAAX Analogue 14 | Compound XIV | methyl (2S)-2-[(...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.04E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13372 (CAAX Analogue 15 | Compound XV | methyl (2S)-2-[(2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.05E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM13368 ((2S)-2-[(2R)-3-(4-hydroxy-2,3-dimethylphenyl)-2-[(...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Napoli Federico II | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 1882-90 (2006) Article DOI: 10.1021/jm0506165 BindingDB Entry DOI: 10.7270/Q22V2DCH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
