Found 78 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184486
(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C19H17N5/c1-23-12-21-14-8-7-13(11-17(14)23)18-16-6-4-10-24(16)22-19(18)15-5-2-3-9-20-15/h2-3,5,7-9,11-12H,4,6,10H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184488
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show InChI InChI=1S/C19H17N5/c1-12-4-2-5-15(22-12)19-18(17-6-3-9-24(17)23-19)13-7-8-14-16(10-13)21-11-20-14/h2,4-5,7-8,10-11H,3,6,9H2,1H3,(H,20,21) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184483
(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)Show InChI InChI=1S/C20H19N5/c1-13-5-3-6-16(22-13)20-19(17-7-4-10-25(17)23-20)14-8-9-15-18(11-14)24(2)12-21-15/h3,5-6,8-9,11-12H,4,7,10H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184483
(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)Show InChI InChI=1S/C20H19N5/c1-13-5-3-6-16(22-13)20-19(17-7-4-10-25(17)23-20)14-8-9-15-18(11-14)24(2)12-21-15/h3,5-6,8-9,11-12H,4,7,10H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184489
(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCO)c2c1 Show InChI InChI=1S/C22H23N5O/c1-15-5-2-6-18(24-15)22-21(19-7-3-11-27(19)25-22)16-8-9-17-20(13-16)26(14-23-17)10-4-12-28/h2,5-6,8-9,13-14,28H,3-4,7,10-12H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184488
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show InChI InChI=1S/C19H17N5/c1-12-4-2-5-15(22-12)19-18(17-6-3-9-24(17)23-19)13-7-8-14-16(10-13)21-11-20-14/h2,4-5,7-8,10-11H,3,6,9H2,1H3,(H,20,21) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184494
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCCC3)c2c1 Show InChI InChI=1S/C27H32N6/c1-20-8-5-9-23(29-20)27-26(24-10-6-17-33(24)30-27)21-11-12-22-25(18-21)32(19-28-22)16-7-15-31-13-3-2-4-14-31/h5,8-9,11-12,18-19H,2-4,6-7,10,13-17H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184496
(CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...)Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1 Show InChI InChI=1S/C24H28N6/c1-17-7-4-8-20(26-17)24-23(21-9-5-14-30(21)27-24)18-10-11-19-22(15-18)29(16-25-19)13-6-12-28(2)3/h4,7-8,10-11,15-16H,5-6,9,12-14H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184487
(4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCOCC3)c2c1 Show InChI InChI=1S/C26H30N6O/c1-19-5-2-6-22(28-19)26-25(23-7-3-12-32(23)29-26)20-8-9-21-24(17-20)31(18-27-21)11-4-10-30-13-15-33-16-14-30/h2,5-6,8-9,17-18H,3-4,7,10-16H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184497
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCC3)c2c1 Show InChI InChI=1S/C26H30N6/c1-19-7-4-8-22(28-19)26-25(23-9-5-16-32(23)29-26)20-10-11-21-24(17-20)31(18-27-21)15-6-14-30-12-2-3-13-30/h4,7-8,10-11,17-18H,2-3,5-6,9,12-16H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184486
(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C19H17N5/c1-23-12-21-14-8-7-13(11-17(14)23)18-16-6-4-10-24(16)22-19(18)15-5-2-3-9-20-15/h2-3,5,7-9,11-12H,4,6,10H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184489
(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCO)c2c1 Show InChI InChI=1S/C22H23N5O/c1-15-5-2-6-18(24-15)22-21(19-7-3-11-27(19)25-22)16-8-9-17-20(13-16)26(14-23-17)10-4-12-28/h2,5-6,8-9,13-14,28H,3-4,7,10-12H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184490
(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)Show InChI InChI=1S/C21H21N5O/c27-12-4-10-25-14-23-16-8-7-15(13-19(16)25)20-18-6-3-11-26(18)24-21(20)17-5-1-2-9-22-17/h1-2,5,7-9,13-14,27H,3-4,6,10-12H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184490
(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)Show InChI InChI=1S/C21H21N5O/c27-12-4-10-25-14-23-16-8-7-15(13-19(16)25)20-18-6-3-11-26(18)24-21(20)17-5-1-2-9-22-17/h1-2,5,7-9,13-14,27H,3-4,6,10-12H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184496
(CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...)Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1 Show InChI InChI=1S/C24H28N6/c1-17-7-4-8-20(26-17)24-23(21-9-5-14-30(21)27-24)18-10-11-19-22(15-18)29(16-25-19)13-6-12-28(2)3/h4,7-8,10-11,15-16H,5-6,9,12-14H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184493
(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)Show SMILES CCN(CC)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1 Show InChI InChI=1S/C26H32N6/c1-4-30(5-2)14-8-15-31-18-27-21-13-12-20(17-24(21)31)25-23-11-7-16-32(23)29-26(25)22-10-6-9-19(3)28-22/h6,9-10,12-13,17-18H,4-5,7-8,11,14-16H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184480
(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C23H26N6/c1-27(2)12-6-13-28-16-25-18-10-9-17(15-21(18)28)22-20-8-5-14-29(20)26-23(22)19-7-3-4-11-24-19/h3-4,7,9-11,15-16H,5-6,8,12-14H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184497
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCC3)c2c1 Show InChI InChI=1S/C26H30N6/c1-19-7-4-8-22(28-19)26-25(23-9-5-16-32(23)29-26)20-10-11-21-24(17-20)31(18-27-21)15-6-14-30-12-2-3-13-30/h4,7-8,10-11,17-18H,2-3,5-6,9,12-16H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184493
(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)Show SMILES CCN(CC)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1 Show InChI InChI=1S/C26H32N6/c1-4-30(5-2)14-8-15-31-18-27-21-13-12-20(17-24(21)31)25-23-11-7-16-32(23)29-26(25)22-10-6-9-19(3)28-22/h6,9-10,12-13,17-18H,4-5,7-8,11,14-16H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184494
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCCC3)c2c1 Show InChI InChI=1S/C27H32N6/c1-20-8-5-9-23(29-20)27-26(24-10-6-17-33(24)30-27)21-11-12-22-25(18-21)32(19-28-22)16-7-15-31-13-3-2-4-14-31/h5,8-9,11-12,18-19H,2-4,6-7,10,13-17H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184487
(4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCOCC3)c2c1 Show InChI InChI=1S/C26H30N6O/c1-19-5-2-6-22(28-19)26-25(23-7-3-12-32(23)29-26)20-8-9-21-24(17-20)31(18-27-21)11-4-10-30-13-15-33-16-14-30/h2,5-6,8-9,17-18H,3-4,7,10-16H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184491
(6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)Show SMILES C(CN1CCCC1)Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C25H28N6/c1-2-11-26-21(7-1)25-24(22-8-5-16-31(22)28-25)19-9-10-20-23(17-19)30(18-27-20)15-6-14-29-12-3-4-13-29/h1-2,7,9-11,17-18H,3-6,8,12-16H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184491
(6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)Show SMILES C(CN1CCCC1)Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C25H28N6/c1-2-11-26-21(7-1)25-24(22-8-5-16-31(22)28-25)19-9-10-20-23(17-19)30(18-27-20)15-6-14-29-12-3-4-13-29/h1-2,7,9-11,17-18H,3-6,8,12-16H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 246 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184490
(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)Show InChI InChI=1S/C21H21N5O/c27-12-4-10-25-14-23-16-8-7-15(13-19(16)25)20-18-6-3-11-26(18)24-21(20)17-5-1-2-9-22-17/h1-2,5,7-9,13-14,27H,3-4,6,10-12H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 352 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184486
(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C19H17N5/c1-23-12-21-14-8-7-13(11-17(14)23)18-16-6-4-10-24(16)22-19(18)15-5-2-3-9-20-15/h2-3,5,7-9,11-12H,4,6,10H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 395 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184480
(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C23H26N6/c1-27(2)12-6-13-28-16-25-18-10-9-17(15-21(18)28)22-20-8-5-14-29(20)26-23(22)19-7-3-4-11-24-19/h3-4,7,9-11,15-16H,5-6,8,12-14H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184492
(5-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)Show InChI InChI=1S/C18H15N5/c1-2-8-19-14(4-1)18-17(16-5-3-9-23(16)22-18)12-6-7-13-15(10-12)21-11-20-13/h1-2,4,6-8,10-11H,3,5,9H2,(H,20,21) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 422 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184483
(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)Show InChI InChI=1S/C20H19N5/c1-13-5-3-6-16(22-13)20-19(17-7-4-10-25(17)23-20)14-8-9-15-18(11-14)24(2)12-21-15/h3,5-6,8-9,11-12H,4,7,10H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 668 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184489
(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCO)c2c1 Show InChI InChI=1S/C22H23N5O/c1-15-5-2-6-18(24-15)22-21(19-7-3-11-27(19)25-22)16-8-9-17-20(13-16)26(14-23-17)10-4-12-28/h2,5-6,8-9,13-14,28H,3-4,7,10-12H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184490
(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)Show InChI InChI=1S/C21H21N5O/c27-12-4-10-25-14-23-16-8-7-15(13-19(16)25)20-18-6-3-11-26(18)24-21(20)17-5-1-2-9-22-17/h1-2,5,7-9,13-14,27H,3-4,6,10-12H2 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 708 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184488
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show InChI InChI=1S/C19H17N5/c1-12-4-2-5-15(22-12)19-18(17-6-3-9-24(17)23-19)13-7-8-14-16(10-13)21-11-20-14/h2,4-5,7-8,10-11H,3,6,9H2,1H3,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184486
(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C19H17N5/c1-23-12-21-14-8-7-13(11-17(14)23)18-16-6-4-10-24(16)22-19(18)15-5-2-3-9-20-15/h2-3,5,7-9,11-12H,4,6,10H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184482
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C19H17N5/c1-23-12-21-15-11-13(7-8-16(15)23)18-17-6-4-10-24(17)22-19(18)14-5-2-3-9-20-14/h2-3,5,7-9,11-12H,4,6,10H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184492
(5-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)Show InChI InChI=1S/C18H15N5/c1-2-8-19-14(4-1)18-17(16-5-3-9-23(16)22-18)12-6-7-13-15(10-12)21-11-20-13/h1-2,4,6-8,10-11H,3,5,9H2,(H,20,21) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184485
(5-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2n(CCCOC3CCCCO3)cnc2c1 Show InChI InChI=1S/C27H31N5O2/c1-19-7-4-8-21(29-19)27-26(24-9-5-14-32(24)30-27)20-11-12-23-22(17-20)28-18-31(23)13-6-16-34-25-10-2-3-15-33-25/h4,7-8,11-12,17-18,25H,2-3,5-6,9-10,13-16H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184483
(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)Show InChI InChI=1S/C20H19N5/c1-13-5-3-6-16(22-13)20-19(17-7-4-10-25(17)23-20)14-8-9-15-18(11-14)24(2)12-21-15/h3,5-6,8-9,11-12H,4,7,10H2,1-2H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184485
(5-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2n(CCCOC3CCCCO3)cnc2c1 Show InChI InChI=1S/C27H31N5O2/c1-19-7-4-8-21(29-19)27-26(24-9-5-14-32(24)30-27)20-11-12-23-22(17-20)28-18-31(23)13-6-16-34-25-10-2-3-15-33-25/h4,7-8,11-12,17-18,25H,2-3,5-6,9-10,13-16H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184489
(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCO)c2c1 Show InChI InChI=1S/C22H23N5O/c1-15-5-2-6-18(24-15)22-21(19-7-3-11-27(19)25-22)16-8-9-17-20(13-16)26(14-23-17)10-4-12-28/h2,5-6,8-9,13-14,28H,3-4,7,10-12H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184495
(1-methyl-5-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)Show InChI InChI=1S/C21H20N4/c1-14-5-3-6-17(22-14)21-20(19-7-4-11-25(19)23-21)16-8-9-18-15(13-16)10-12-24(18)2/h3,5-6,8-10,12-13H,4,7,11H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184482
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C19H17N5/c1-23-12-21-15-11-13(7-8-16(15)23)18-17-6-4-10-24(17)22-19(18)14-5-2-3-9-20-14/h2-3,5,7-9,11-12H,4,6,10H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184491
(6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)Show SMILES C(CN1CCCC1)Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C25H28N6/c1-2-11-26-21(7-1)25-24(22-8-5-16-31(22)28-25)19-9-10-20-23(17-19)30(18-27-20)15-6-14-29-12-3-4-13-29/h1-2,7,9-11,17-18H,3-6,8,12-16H2 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184484
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184484
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184487
(4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCOCC3)c2c1 Show InChI InChI=1S/C26H30N6O/c1-19-5-2-6-22(28-19)26-25(23-7-3-12-32(23)29-26)20-8-9-21-24(17-20)31(18-27-21)11-4-10-30-13-15-33-16-14-30/h2,5-6,8-9,17-18H,3-4,7,10-16H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184492
(5-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)Show InChI InChI=1S/C18H15N5/c1-2-8-19-14(4-1)18-17(16-5-3-9-23(16)22-18)12-6-7-13-15(10-12)21-11-20-13/h1-2,4,6-8,10-11H,3,5,9H2,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184491
(6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)Show SMILES C(CN1CCCC1)Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C25H28N6/c1-2-11-26-21(7-1)25-24(22-8-5-16-31(22)28-25)19-9-10-20-23(17-19)30(18-27-20)15-6-14-29-12-3-4-13-29/h1-2,7,9-11,17-18H,3-6,8,12-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184481
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C20H18N4/c1-23-12-9-14-13-15(7-8-17(14)23)19-18-6-4-11-24(18)22-20(19)16-5-2-3-10-21-16/h2-3,5,7-10,12-13H,4,6,11H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184485
(5-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2n(CCCOC3CCCCO3)cnc2c1 Show InChI InChI=1S/C27H31N5O2/c1-19-7-4-8-21(29-19)27-26(24-9-5-14-32(24)30-27)20-11-12-23-22(17-20)28-18-31(23)13-6-16-34-25-10-2-3-15-33-25/h4,7-8,11-12,17-18,25H,2-3,5-6,9-10,13-16H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184480
(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C23H26N6/c1-27(2)12-6-13-28-16-25-18-10-9-17(15-21(18)28)22-20-8-5-14-29(20)26-23(22)19-7-3-4-11-24-19/h3-4,7,9-11,15-16H,5-6,8,12-14H2,1-2H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184488
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show InChI InChI=1S/C19H17N5/c1-12-4-2-5-15(22-12)19-18(17-6-3-9-24(17)23-19)13-7-8-14-16(10-13)21-11-20-14/h2,4-5,7-8,10-11H,3,6,9H2,1H3,(H,20,21) | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184481
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C20H18N4/c1-23-12-9-14-13-15(7-8-17(14)23)19-18-6-4-11-24(18)22-20(19)16-5-2-3-10-21-16/h2-3,5,7-10,12-13H,4,6,11H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184482
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C19H17N5/c1-23-12-21-15-11-13(7-8-16(15)23)18-17-6-4-10-24(17)22-19(18)14-5-2-3-9-20-14/h2-3,5,7-9,11-12H,4,6,10H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184487
(4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCOCC3)c2c1 Show InChI InChI=1S/C26H30N6O/c1-19-5-2-6-22(28-19)26-25(23-7-3-12-32(23)29-26)20-8-9-21-24(17-20)31(18-27-21)11-4-10-30-13-15-33-16-14-30/h2,5-6,8-9,17-18H,3-4,7,10-16H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184485
(5-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2n(CCCOC3CCCCO3)cnc2c1 Show InChI InChI=1S/C27H31N5O2/c1-19-7-4-8-21(29-19)27-26(24-9-5-14-32(24)30-27)20-11-12-23-22(17-20)28-18-31(23)13-6-16-34-25-10-2-3-15-33-25/h4,7-8,11-12,17-18,25H,2-3,5-6,9-10,13-16H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184498
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)Show InChI InChI=1S/C19H16N4/c1-2-9-20-16(4-1)19-18(17-5-3-11-23(17)22-19)14-6-7-15-13(12-14)8-10-21-15/h1-2,4,6-10,12,21H,3,5,11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184495
(1-methyl-5-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)Show InChI InChI=1S/C21H20N4/c1-14-5-3-6-17(22-14)21-20(19-7-4-11-25(19)23-21)16-8-9-18-15(13-16)10-12-24(18)2/h3,5-6,8-10,12-13H,4,7,11H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184481
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C20H18N4/c1-23-12-9-14-13-15(7-8-17(14)23)19-18-6-4-11-24(18)22-20(19)16-5-2-3-10-21-16/h2-3,5,7-10,12-13H,4,6,11H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184493
(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)Show SMILES CCN(CC)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1 Show InChI InChI=1S/C26H32N6/c1-4-30(5-2)14-8-15-31-18-27-21-13-12-20(17-24(21)31)25-23-11-7-16-32(23)29-26(25)22-10-6-9-19(3)28-22/h6,9-10,12-13,17-18H,4-5,7-8,11,14-16H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184498
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)Show InChI InChI=1S/C19H16N4/c1-2-9-20-16(4-1)19-18(17-5-3-11-23(17)22-19)14-6-7-15-13(12-14)8-10-21-15/h1-2,4,6-10,12,21H,3,5,11H2 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184482
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)Show InChI InChI=1S/C19H17N5/c1-23-12-21-15-11-13(7-8-16(15)23)18-17-6-4-10-24(17)22-19(18)14-5-2-3-9-20-14/h2-3,5,7-9,11-12H,4,6,10H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184496
(CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...)Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1 Show InChI InChI=1S/C24H28N6/c1-17-7-4-8-20(26-17)24-23(21-9-5-14-30(21)27-24)18-10-11-19-22(15-18)29(16-25-19)13-6-12-28(2)3/h4,7-8,10-11,15-16H,5-6,9,12-14H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184484
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184492
(5-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)Show InChI InChI=1S/C18H15N5/c1-2-8-19-14(4-1)18-17(16-5-3-9-23(16)22-18)12-6-7-13-15(10-12)21-11-20-13/h1-2,4,6-8,10-11H,3,5,9H2,(H,20,21) | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184494
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCCC3)c2c1 Show InChI InChI=1S/C27H32N6/c1-20-8-5-9-23(29-20)27-26(24-10-6-17-33(24)30-27)21-11-12-22-25(18-21)32(19-28-22)16-7-15-31-13-3-2-4-14-31/h5,8-9,11-12,18-19H,2-4,6-7,10,13-17H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184497
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCC3)c2c1 Show InChI InChI=1S/C26H30N6/c1-19-7-4-8-22(28-19)26-25(23-9-5-16-32(23)29-26)20-10-11-21-24(17-20)31(18-27-21)15-6-14-30-12-2-3-13-30/h4,7-8,10-11,17-18H,2-3,5-6,9,12-16H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184496
(CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...)Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1 Show InChI InChI=1S/C24H28N6/c1-17-7-4-8-20(26-17)24-23(21-9-5-14-30(21)27-24)18-10-11-19-22(15-18)29(16-25-19)13-6-12-28(2)3/h4,7-8,10-11,15-16H,5-6,9,12-14H2,1-3H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184494
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCCC3)c2c1 Show InChI InChI=1S/C27H32N6/c1-20-8-5-9-23(29-20)27-26(24-10-6-17-33(24)30-27)21-11-12-22-25(18-21)32(19-28-22)16-7-15-31-13-3-2-4-14-31/h5,8-9,11-12,18-19H,2-4,6-7,10,13-17H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184495
(1-methyl-5-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)Show InChI InChI=1S/C21H20N4/c1-14-5-3-6-17(22-14)21-20(19-7-4-11-25(19)23-21)16-8-9-18-15(13-16)10-12-24(18)2/h3,5-6,8-10,12-13H,4,7,11H2,1-2H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184493
(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)Show SMILES CCN(CC)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1 Show InChI InChI=1S/C26H32N6/c1-4-30(5-2)14-8-15-31-18-27-21-13-12-20(17-24(21)31)25-23-11-7-16-32(23)29-26(25)22-10-6-9-19(3)28-22/h6,9-10,12-13,17-18H,4-5,7-8,11,14-16H2,1-3H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 20
(Homo sapiens (Human)) | BDBM50184497
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCC3)c2c1 Show InChI InChI=1S/C26H30N6/c1-19-7-4-8-22(28-19)26-25(23-9-5-16-32(23)29-26)20-10-11-21-24(17-20)31(18-27-21)15-6-14-30-12-2-3-13-30/h4,7-8,10-11,17-18H,2-3,5-6,9,12-16H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184484
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50184498
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)Show InChI InChI=1S/C19H16N4/c1-2-9-20-16(4-1)19-18(17-5-3-11-23(17)22-19)14-6-7-15-13(12-14)8-10-21-15/h1-2,4,6-10,12,21H,3,5,11H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-2
(Homo sapiens (Human)) | BDBM50184480
(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C23H26N6/c1-27(2)12-6-13-28-16-25-18-10-9-17(15-21(18)28)22-20-8-5-14-29(20)26-23(22)19-7-3-4-11-24-19/h3-4,7,9-11,15-16H,5-6,8,12-14H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50184488
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)Show InChI InChI=1S/C19H17N5/c1-12-4-2-5-15(22-12)19-18(17-6-3-9-24(17)23-19)13-7-8-14-16(10-13)21-11-20-14/h2,4-5,7-8,10-11H,3,6,9H2,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description
Inhibition of cytochrome P450 2D6 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this
Ligand-Target Pair | |
Search and Browse
