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PubMed code 16603352

Compile data set for download or QSAR
Found 89 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185178
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)30-19-7-9-23-22(17-19)26(35-34-23)27-31-24-10-8-21(18-25(24)32-27)37-15-11-20(12-16-37)36-13-5-4-6-14-36/h7-10,17-18,20H,4-6,11-16H2,1-3H3,(H,31,32)(H,34,35)(H2,30,33,38)
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n/an/a 1n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185178
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)30-19-7-9-23-22(17-19)26(35-34-23)27-31-24-10-8-21(18-25(24)32-27)37-15-11-20(12-16-37)36-13-5-4-6-14-36/h7-10,17-18,20H,4-6,11-16H2,1-3H3,(H,31,32)(H,34,35)(H2,30,33,38)
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n/an/a 1n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185181
PNG
(5-(4-(piperidin-1-yl)piperidin-1-yl)-2-(6-(trifluo...)
Show SMILES FC(F)(F)c1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C25H27F3N6/c26-25(27,28)16-4-6-19-21(14-16)31-32-23(19)24-29-20-7-5-18(15-22(20)30-24)34-12-8-17(9-13-34)33-10-2-1-3-11-33/h4-7,14-15,17H,1-3,8-13H2,(H,29,30)(H,31,32)
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n/an/a 2n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185181
PNG
(5-(4-(piperidin-1-yl)piperidin-1-yl)-2-(6-(trifluo...)
Show SMILES FC(F)(F)c1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C25H27F3N6/c26-25(27,28)16-4-6-19-21(14-16)31-32-23(19)24-29-20-7-5-18(15-22(20)30-24)34-12-8-17(9-13-34)33-10-2-1-3-11-33/h4-7,14-15,17H,1-3,8-13H2,(H,29,30)(H,31,32)
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n/an/a 2n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185173
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1cccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c12
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)32-22-8-7-9-23-25(22)26(35-34-23)27-30-21-11-10-20(18-24(21)31-27)37-16-12-19(13-17-37)36-14-5-4-6-15-36/h7-11,18-19H,4-6,12-17H2,1-3H3,(H,30,31)(H,34,35)(H2,32,33,38)
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n/an/a 3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185182
PNG
(2-(5-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-12-27-26(20-25)30(35-34-27)31-32-28-11-9-24(19-29(28)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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n/an/a 3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185173
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1cccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c12
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)32-22-8-7-9-23-25(22)26(35-34-23)27-30-21-11-10-20(18-24(21)31-27)37-16-12-19(13-17-37)36-14-5-4-6-15-36/h7-11,18-19H,4-6,12-17H2,1-3H3,(H,30,31)(H,34,35)(H2,32,33,38)
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n/an/a 4n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185178
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)30-19-7-9-23-22(17-19)26(35-34-23)27-31-24-10-8-21(18-25(24)32-27)37-15-11-20(12-16-37)36-13-5-4-6-14-36/h7-10,17-18,20H,4-6,11-16H2,1-3H3,(H,31,32)(H,34,35)(H2,30,33,38)
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n/an/a 5n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185182
PNG
(2-(5-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-12-27-26(20-25)30(35-34-27)31-32-28-11-9-24(19-29(28)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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n/an/a 8n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185177
PNG
(2-(1H-indazol-3-yl)-N-methyl-N-(1-methylpiperidin-...)
Show SMILES CN(C1CCN(C)CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C21H24N6/c1-26-11-9-14(10-12-26)27(2)15-7-8-18-19(13-15)23-21(22-18)20-16-5-3-4-6-17(16)24-25-20/h3-8,13-14H,9-12H2,1-2H3,(H,22,23)(H,24,25)
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n/an/a 8n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185169
PNG
(2-(5-phenoxy-1H-indazol-3-yl)-5-(4-(piperidin-1-yl...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(Oc3ccccc3)cc12
Show InChI InChI=1S/C30H32N6O/c1-3-7-23(8-4-1)37-24-10-12-26-25(20-24)29(34-33-26)30-31-27-11-9-22(19-28(27)32-30)36-17-13-21(14-18-36)35-15-5-2-6-16-35/h1,3-4,7-12,19-21H,2,5-6,13-18H2,(H,31,32)(H,33,34)
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n/an/a 8n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185172
PNG
(2-(6-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C24H27FN6/c25-16-4-6-19-21(14-16)28-29-23(19)24-26-20-7-5-18(15-22(20)27-24)31-12-8-17(9-13-31)30-10-2-1-3-11-30/h4-7,14-15,17H,1-3,8-13H2,(H,26,27)(H,28,29)
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n/an/a 10n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185184
PNG
(2-(6-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-11-26-28(20-25)34-35-30(26)31-32-27-12-9-24(19-29(27)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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n/an/a 11n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185183
PNG
(CHEMBL380372 | methyl 3-(5-(4-(piperidin-1-yl)pipe...)
Show SMILES COC(=O)c1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C26H30N6O2/c1-34-26(33)17-5-7-21-20(15-17)24(30-29-21)25-27-22-8-6-19(16-23(22)28-25)32-13-9-18(10-14-32)31-11-3-2-4-12-31/h5-8,15-16,18H,2-4,9-14H2,1H3,(H,27,28)(H,29,30)
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n/an/a 15n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185169
PNG
(2-(5-phenoxy-1H-indazol-3-yl)-5-(4-(piperidin-1-yl...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(Oc3ccccc3)cc12
Show InChI InChI=1S/C30H32N6O/c1-3-7-23(8-4-1)37-24-10-12-26-25(20-24)29(34-33-26)30-31-27-11-9-22(19-28(27)32-30)36-17-13-21(14-18-36)35-15-5-2-6-16-35/h1,3-4,7-12,19-21H,2,5-6,13-18H2,(H,31,32)(H,33,34)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185171
PNG
(CHEMBL379108 | N-(cyclohexylmethyl)-3-(5-(4-(piper...)
Show SMILES C(Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)C1CCCCC1
Show InChI InChI=1S/C31H41N7/c1-3-7-22(8-4-1)21-32-23-9-11-27-26(19-23)30(36-35-27)31-33-28-12-10-25(20-29(28)34-31)38-17-13-24(14-18-38)37-15-5-2-6-16-37/h9-12,19-20,22,24,32H,1-8,13-18,21H2,(H,33,34)(H,35,36)
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n/an/a 16n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185177
PNG
(2-(1H-indazol-3-yl)-N-methyl-N-(1-methylpiperidin-...)
Show SMILES CN(C1CCN(C)CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C21H24N6/c1-26-11-9-14(10-12-26)27(2)15-7-8-18-19(13-15)23-21(22-18)20-16-5-3-4-6-17(16)24-25-20/h3-8,13-14H,9-12H2,1-2H3,(H,22,23)(H,24,25)
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n/an/a 18n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185171
PNG
(CHEMBL379108 | N-(cyclohexylmethyl)-3-(5-(4-(piper...)
Show SMILES C(Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)C1CCCCC1
Show InChI InChI=1S/C31H41N7/c1-3-7-22(8-4-1)21-32-23-9-11-27-26(19-23)30(36-35-27)31-33-28-12-10-25(20-29(28)34-31)38-17-13-24(14-18-38)37-15-5-2-6-16-37/h9-12,19-20,22,24,32H,1-8,13-18,21H2,(H,33,34)(H,35,36)
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n/an/a 21n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185184
PNG
(2-(6-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-11-26-28(20-25)34-35-30(26)31-32-27-12-9-24(19-29(27)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185184
PNG
(2-(6-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-11-26-28(20-25)34-35-30(26)31-32-27-12-9-24(19-29(27)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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n/an/a 23n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50181305
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H12N4O/c17-14-9-5-1-2-6-10(9)20-16(21)13(14)15-18-11-7-3-4-8-12(11)19-15/h1-8H,(H,18,19)(H3,17,20,21)
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n/an/a 25n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185172
PNG
(2-(6-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C24H27FN6/c25-16-4-6-19-21(14-16)28-29-23(19)24-26-20-7-5-18(15-22(20)27-24)31-12-8-17(9-13-31)30-10-2-1-3-11-30/h4-7,14-15,17H,1-3,8-13H2,(H,26,27)(H,28,29)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185172
PNG
(2-(6-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C24H27FN6/c25-16-4-6-19-21(14-16)28-29-23(19)24-26-20-7-5-18(15-22(20)27-24)31-12-8-17(9-13-31)30-10-2-1-3-11-30/h4-7,14-15,17H,1-3,8-13H2,(H,26,27)(H,28,29)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185169
PNG
(2-(5-phenoxy-1H-indazol-3-yl)-5-(4-(piperidin-1-yl...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(Oc3ccccc3)cc12
Show InChI InChI=1S/C30H32N6O/c1-3-7-23(8-4-1)37-24-10-12-26-25(20-24)29(34-33-26)30-31-27-11-9-22(19-28(27)32-30)36-17-13-21(14-18-36)35-15-5-2-6-16-35/h1,3-4,7-12,19-21H,2,5-6,13-18H2,(H,31,32)(H,33,34)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185170
PNG
(2-(1H-indazol-3-yl)-5-(4-(piperidin-1-yl)piperidin...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C24H28N6/c1-4-12-29(13-5-1)17-10-14-30(15-11-17)18-8-9-21-22(16-18)26-24(25-21)23-19-6-2-3-7-20(19)27-28-23/h2-3,6-9,16-17H,1,4-5,10-15H2,(H,25,26)(H,27,28)
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n/an/a 28n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185182
PNG
(2-(5-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-12-27-26(20-25)30(35-34-27)31-32-28-11-9-24(19-29(28)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185183
PNG
(CHEMBL380372 | methyl 3-(5-(4-(piperidin-1-yl)pipe...)
Show SMILES COC(=O)c1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C26H30N6O2/c1-34-26(33)17-5-7-21-20(15-17)24(30-29-21)25-27-22-8-6-19(16-23(22)28-25)32-13-9-18(10-14-32)31-11-3-2-4-12-31/h5-8,15-16,18H,2-4,9-14H2,1H3,(H,27,28)(H,29,30)
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n/an/a 31n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185174
PNG
(2-(1H-indazol-3-yl)-5-(4-methylpiperazin-1-yl)-1H-...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C19H20N6/c1-24-8-10-25(11-9-24)13-6-7-16-17(12-13)21-19(20-16)18-14-4-2-3-5-15(14)22-23-18/h2-7,12H,8-11H2,1H3,(H,20,21)(H,22,23)
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n/an/a 44n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185169
PNG
(2-(5-phenoxy-1H-indazol-3-yl)-5-(4-(piperidin-1-yl...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(Oc3ccccc3)cc12
Show InChI InChI=1S/C30H32N6O/c1-3-7-23(8-4-1)37-24-10-12-26-25(20-24)29(34-33-26)30-31-27-11-9-22(19-28(27)32-30)36-17-13-21(14-18-36)35-15-5-2-6-16-35/h1,3-4,7-12,19-21H,2,5-6,13-18H2,(H,31,32)(H,33,34)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185171
PNG
(CHEMBL379108 | N-(cyclohexylmethyl)-3-(5-(4-(piper...)
Show SMILES C(Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)C1CCCCC1
Show InChI InChI=1S/C31H41N7/c1-3-7-22(8-4-1)21-32-23-9-11-27-26(19-23)30(36-35-27)31-33-28-12-10-25(20-29(28)34-31)38-17-13-24(14-18-38)37-15-5-2-6-16-37/h9-12,19-20,22,24,32H,1-8,13-18,21H2,(H,33,34)(H,35,36)
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n/an/a 44n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185186
PNG
(2-(1H-indazol-3-yl)-5-(3-(pyrrolidin-1-yl)propoxy)...)
Show SMILES C(COc1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12)CN1CCCC1
Show InChI InChI=1S/C21H23N5O/c1-2-7-17-16(6-1)20(25-24-17)21-22-18-9-8-15(14-19(18)23-21)27-13-5-12-26-10-3-4-11-26/h1-2,6-9,14H,3-5,10-13H2,(H,22,23)(H,24,25)
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n/an/a 48n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185170
PNG
(2-(1H-indazol-3-yl)-5-(4-(piperidin-1-yl)piperidin...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C24H28N6/c1-4-12-29(13-5-1)17-10-14-30(15-11-17)18-8-9-21-22(16-18)26-24(25-21)23-19-6-2-3-7-20(19)27-28-23/h2-3,6-9,16-17H,1,4-5,10-15H2,(H,25,26)(H,27,28)
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n/an/a 48n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185175
PNG
(2-(1H-indazol-3-yl)-5-morpholino-1H-benzo[d]imidaz...)
Show SMILES C1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H17N5O/c1-2-4-14-13(3-1)17(22-21-14)18-19-15-6-5-12(11-16(15)20-18)23-7-9-24-10-8-23/h1-6,11H,7-10H2,(H,19,20)(H,21,22)
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n/an/a 50n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185181
PNG
(5-(4-(piperidin-1-yl)piperidin-1-yl)-2-(6-(trifluo...)
Show SMILES FC(F)(F)c1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C25H27F3N6/c26-25(27,28)16-4-6-19-21(14-16)31-32-23(19)24-29-20-7-5-18(15-22(20)30-24)34-12-8-17(9-13-34)33-10-2-1-3-11-33/h4-7,14-15,17H,1-3,8-13H2,(H,29,30)(H,31,32)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185181
PNG
(5-(4-(piperidin-1-yl)piperidin-1-yl)-2-(6-(trifluo...)
Show SMILES FC(F)(F)c1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C25H27F3N6/c26-25(27,28)16-4-6-19-21(14-16)31-32-23(19)24-29-20-7-5-18(15-22(20)30-24)34-12-8-17(9-13-34)33-10-2-1-3-11-33/h4-7,14-15,17H,1-3,8-13H2,(H,29,30)(H,31,32)
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n/an/a 62n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185176
PNG
(2-(4-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1cccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c12)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-8-22(9-4-1)21-38-28-11-7-10-26-29(28)30(35-34-26)31-32-25-13-12-24(20-27(25)33-31)37-18-14-23(15-19-37)36-16-5-2-6-17-36/h1,3-4,7-13,20,23H,2,5-6,14-19,21H2,(H,32,33)(H,34,35)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185183
PNG
(CHEMBL380372 | methyl 3-(5-(4-(piperidin-1-yl)pipe...)
Show SMILES COC(=O)c1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C26H30N6O2/c1-34-26(33)17-5-7-21-20(15-17)24(30-29-21)25-27-22-8-6-19(16-23(22)28-25)32-13-9-18(10-14-32)31-11-3-2-4-12-31/h5-8,15-16,18H,2-4,9-14H2,1H3,(H,27,28)(H,29,30)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185173
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1cccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c12
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)32-22-8-7-9-23-25(22)26(35-34-23)27-30-21-11-10-20(18-24(21)31-27)37-16-12-19(13-17-37)36-14-5-4-6-15-36/h7-11,18-19H,4-6,12-17H2,1-3H3,(H,30,31)(H,34,35)(H2,32,33,38)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185183
PNG
(CHEMBL380372 | methyl 3-(5-(4-(piperidin-1-yl)pipe...)
Show SMILES COC(=O)c1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C26H30N6O2/c1-34-26(33)17-5-7-21-20(15-17)24(30-29-21)25-27-22-8-6-19(16-23(22)28-25)32-13-9-18(10-14-32)31-11-3-2-4-12-31/h5-8,15-16,18H,2-4,9-14H2,1H3,(H,27,28)(H,29,30)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185170
PNG
(2-(1H-indazol-3-yl)-5-(4-(piperidin-1-yl)piperidin...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C24H28N6/c1-4-12-29(13-5-1)17-10-14-30(15-11-17)18-8-9-21-22(16-18)26-24(25-21)23-19-6-2-3-7-20(19)27-28-23/h2-3,6-9,16-17H,1,4-5,10-15H2,(H,25,26)(H,27,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185178
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)30-19-7-9-23-22(17-19)26(35-34-23)27-31-24-10-8-21(18-25(24)32-27)37-15-11-20(12-16-37)36-13-5-4-6-14-36/h7-10,17-18,20H,4-6,11-16H2,1-3H3,(H,31,32)(H,34,35)(H2,30,33,38)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185174
PNG
(2-(1H-indazol-3-yl)-5-(4-methylpiperazin-1-yl)-1H-...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C19H20N6/c1-24-8-10-25(11-9-24)13-6-7-16-17(12-13)21-19(20-16)18-14-4-2-3-5-15(14)22-23-18/h2-7,12H,8-11H2,1H3,(H,20,21)(H,22,23)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185188
PNG
(5-(1H-imidazol-1-yl)-2-(1H-indazol-3-yl)-1H-benzo[...)
Show SMILES c1cn(cn1)-c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C17H12N6/c1-2-4-13-12(3-1)16(22-21-13)17-19-14-6-5-11(9-15(14)20-17)23-8-7-18-10-23/h1-10H,(H,19,20)(H,21,22)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185182
PNG
(2-(5-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-12-27-26(20-25)30(35-34-27)31-32-28-11-9-24(19-29(28)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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n/an/a 83n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185176
PNG
(2-(4-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1cccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c12)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-8-22(9-4-1)21-38-28-11-7-10-26-29(28)30(35-34-26)31-32-25-13-12-24(20-27(25)33-31)37-18-14-23(15-19-37)36-16-5-2-6-17-36/h1,3-4,7-13,20,23H,2,5-6,14-19,21H2,(H,32,33)(H,34,35)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185188
PNG
(5-(1H-imidazol-1-yl)-2-(1H-indazol-3-yl)-1H-benzo[...)
Show SMILES c1cn(cn1)-c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C17H12N6/c1-2-4-13-12(3-1)16(22-21-13)17-19-14-6-5-11(9-15(14)20-17)23-8-7-18-10-23/h1-10H,(H,19,20)(H,21,22)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185186
PNG
(2-(1H-indazol-3-yl)-5-(3-(pyrrolidin-1-yl)propoxy)...)
Show SMILES C(COc1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12)CN1CCCC1
Show InChI InChI=1S/C21H23N5O/c1-2-7-17-16(6-1)20(25-24-17)21-22-18-9-8-15(14-19(18)23-21)27-13-5-12-26-10-3-4-11-26/h1-2,6-9,14H,3-5,10-13H2,(H,22,23)(H,24,25)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185175
PNG
(2-(1H-indazol-3-yl)-5-morpholino-1H-benzo[d]imidaz...)
Show SMILES C1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H17N5O/c1-2-4-14-13(3-1)17(22-21-14)18-19-15-6-5-12(11-16(15)20-18)23-7-9-24-10-8-23/h1-6,11H,7-10H2,(H,19,20)(H,21,22)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185174
PNG
(2-(1H-indazol-3-yl)-5-(4-methylpiperazin-1-yl)-1H-...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C19H20N6/c1-24-8-10-25(11-9-24)13-6-7-16-17(12-13)21-19(20-16)18-14-4-2-3-5-15(14)22-23-18/h2-7,12H,8-11H2,1H3,(H,20,21)(H,22,23)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185179
PNG
(2-(7-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Show SMILES Fc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C24H27FN6/c25-19-6-4-5-18-22(19)28-29-23(18)24-26-20-8-7-17(15-21(20)27-24)31-13-9-16(10-14-31)30-11-2-1-3-12-30/h4-8,15-16H,1-3,9-14H2,(H,26,27)(H,28,29)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185177
PNG
(2-(1H-indazol-3-yl)-N-methyl-N-(1-methylpiperidin-...)
Show SMILES CN(C1CCN(C)CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C21H24N6/c1-26-11-9-14(10-12-26)27(2)15-7-8-18-19(13-15)23-21(22-18)20-16-5-3-4-6-17(16)24-25-20/h3-8,13-14H,9-12H2,1-2H3,(H,22,23)(H,24,25)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185175
PNG
(2-(1H-indazol-3-yl)-5-morpholino-1H-benzo[d]imidaz...)
Show SMILES C1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H17N5O/c1-2-4-14-13(3-1)17(22-21-14)18-19-15-6-5-12(11-16(15)20-18)23-7-9-24-10-8-23/h1-6,11H,7-10H2,(H,19,20)(H,21,22)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185185
PNG
(2-(1H-indazol-3-yl)-5-((4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(Cc2ccc3nc([nH]c3c2)-c2n[nH]c3ccccc23)CC1
Show InChI InChI=1S/C20H22N6/c1-25-8-10-26(11-9-25)13-14-6-7-17-18(12-14)22-20(21-17)19-15-4-2-3-5-16(15)23-24-19/h2-7,12H,8-11,13H2,1H3,(H,21,22)(H,23,24)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185186
PNG
(2-(1H-indazol-3-yl)-5-(3-(pyrrolidin-1-yl)propoxy)...)
Show SMILES C(COc1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12)CN1CCCC1
Show InChI InChI=1S/C21H23N5O/c1-2-7-17-16(6-1)20(25-24-17)21-22-18-9-8-15(14-19(18)23-21)27-13-5-12-26-10-3-4-11-26/h1-2,6-9,14H,3-5,10-13H2,(H,22,23)(H,24,25)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185174
PNG
(2-(1H-indazol-3-yl)-5-(4-methylpiperazin-1-yl)-1H-...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C19H20N6/c1-24-8-10-25(11-9-24)13-6-7-16-17(12-13)21-19(20-16)18-14-4-2-3-5-15(14)22-23-18/h2-7,12H,8-11H2,1H3,(H,20,21)(H,22,23)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185184
PNG
(2-(6-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-11-26-28(20-25)34-35-30(26)31-32-27-12-9-24(19-29(27)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185179
PNG
(2-(7-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Show SMILES Fc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C24H27FN6/c25-19-6-4-5-18-22(19)28-29-23(18)24-26-20-8-7-17(15-21(20)27-24)31-13-9-16(10-14-31)30-11-2-1-3-12-30/h4-8,15-16H,1-3,9-14H2,(H,26,27)(H,28,29)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185188
PNG
(5-(1H-imidazol-1-yl)-2-(1H-indazol-3-yl)-1H-benzo[...)
Show SMILES c1cn(cn1)-c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C17H12N6/c1-2-4-13-12(3-1)16(22-21-13)17-19-14-6-5-11(9-15(14)20-17)23-8-7-18-10-23/h1-10H,(H,19,20)(H,21,22)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185175
PNG
(2-(1H-indazol-3-yl)-5-morpholino-1H-benzo[d]imidaz...)
Show SMILES C1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H17N5O/c1-2-4-14-13(3-1)17(22-21-14)18-19-15-6-5-12(11-16(15)20-18)23-7-9-24-10-8-23/h1-6,11H,7-10H2,(H,19,20)(H,21,22)
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n/an/a 260n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185185
PNG
(2-(1H-indazol-3-yl)-5-((4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(Cc2ccc3nc([nH]c3c2)-c2n[nH]c3ccccc23)CC1
Show InChI InChI=1S/C20H22N6/c1-25-8-10-26(11-9-25)13-14-6-7-17-18(12-14)22-20(21-17)19-15-4-2-3-5-16(15)23-24-19/h2-7,12H,8-11,13H2,1H3,(H,21,22)(H,23,24)
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n/an/a 260n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185185
PNG
(2-(1H-indazol-3-yl)-5-((4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(Cc2ccc3nc([nH]c3c2)-c2n[nH]c3ccccc23)CC1
Show InChI InChI=1S/C20H22N6/c1-25-8-10-26(11-9-25)13-14-6-7-17-18(12-14)22-20(21-17)19-15-4-2-3-5-16(15)23-24-19/h2-7,12H,8-11,13H2,1H3,(H,21,22)(H,23,24)
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n/an/a 270n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185172
PNG
(2-(6-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C24H27FN6/c25-16-4-6-19-21(14-16)28-29-23(19)24-26-20-7-5-18(15-22(20)27-24)31-12-8-17(9-13-31)30-10-2-1-3-11-30/h4-7,14-15,17H,1-3,8-13H2,(H,26,27)(H,28,29)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185179
PNG
(2-(7-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Show SMILES Fc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C24H27FN6/c25-19-6-4-5-18-22(19)28-29-23(18)24-26-20-8-7-17(15-21(20)27-24)31-13-9-16(10-14-31)30-11-2-1-3-12-30/h4-8,15-16H,1-3,9-14H2,(H,26,27)(H,28,29)
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n/an/a 330n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185173
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1cccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c12
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)32-22-8-7-9-23-25(22)26(35-34-23)27-30-21-11-10-20(18-24(21)31-27)37-16-12-19(13-17-37)36-14-5-4-6-15-36/h7-11,18-19H,4-6,12-17H2,1-3H3,(H,30,31)(H,34,35)(H2,32,33,38)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185186
PNG
(2-(1H-indazol-3-yl)-5-(3-(pyrrolidin-1-yl)propoxy)...)
Show SMILES C(COc1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12)CN1CCCC1
Show InChI InChI=1S/C21H23N5O/c1-2-7-17-16(6-1)20(25-24-17)21-22-18-9-8-15(14-19(18)23-21)27-13-5-12-26-10-3-4-11-26/h1-2,6-9,14H,3-5,10-13H2,(H,22,23)(H,24,25)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185177
PNG
(2-(1H-indazol-3-yl)-N-methyl-N-(1-methylpiperidin-...)
Show SMILES CN(C1CCN(C)CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C21H24N6/c1-26-11-9-14(10-12-26)27(2)15-7-8-18-19(13-15)23-21(22-18)20-16-5-3-4-6-17(16)24-25-20/h3-8,13-14H,9-12H2,1-2H3,(H,22,23)(H,24,25)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185176
PNG
(2-(4-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1cccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c12)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-8-22(9-4-1)21-38-28-11-7-10-26-29(28)30(35-34-26)31-32-25-13-12-24(20-27(25)33-31)37-18-14-23(15-19-37)36-16-5-2-6-17-36/h1,3-4,7-13,20,23H,2,5-6,14-19,21H2,(H,32,33)(H,34,35)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185170
PNG
(2-(1H-indazol-3-yl)-5-(4-(piperidin-1-yl)piperidin...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C24H28N6/c1-4-12-29(13-5-1)17-10-14-30(15-11-17)18-8-9-21-22(16-18)26-24(25-21)23-19-6-2-3-7-20(19)27-28-23/h2-3,6-9,16-17H,1,4-5,10-15H2,(H,25,26)(H,27,28)
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n/an/a 690n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM16590
PNG
(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C14H10N4/c1-2-6-10-9(5-1)13(18-17-10)14-15-11-7-3-4-8-12(11)16-14/h1-8H,(H,15,16)(H,17,18)
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n/an/a 720n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185167
PNG
(2-(1H-indazol-3-yl)-4-morpholino-1H-benzo[d]imidaz...)
Show SMILES C1CN(CCO1)c1cccc2[nH]c(nc12)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H17N5O/c1-2-5-13-12(4-1)16(22-21-13)18-19-14-6-3-7-15(17(14)20-18)23-8-10-24-11-9-23/h1-7H,8-11H2,(H,19,20)(H,21,22)
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n/an/a 830n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM16590
PNG
(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C14H10N4/c1-2-6-10-9(5-1)13(18-17-10)14-15-11-7-3-4-8-12(11)16-14/h1-8H,(H,15,16)(H,17,18)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185188
PNG
(5-(1H-imidazol-1-yl)-2-(1H-indazol-3-yl)-1H-benzo[...)
Show SMILES c1cn(cn1)-c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C17H12N6/c1-2-4-13-12(3-1)16(22-21-13)17-19-14-6-5-11(9-15(14)20-17)23-8-7-18-10-23/h1-10H,(H,19,20)(H,21,22)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185171
PNG
(CHEMBL379108 | N-(cyclohexylmethyl)-3-(5-(4-(piper...)
Show SMILES C(Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)C1CCCCC1
Show InChI InChI=1S/C31H41N7/c1-3-7-22(8-4-1)21-32-23-9-11-27-26(19-23)30(36-35-27)31-33-28-12-10-25(20-29(28)34-31)38-17-13-24(14-18-38)37-15-5-2-6-16-37/h9-12,19-20,22,24,32H,1-8,13-18,21H2,(H,33,34)(H,35,36)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185176
PNG
(2-(4-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1cccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c12)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-8-22(9-4-1)21-38-28-11-7-10-26-29(28)30(35-34-26)31-32-25-13-12-24(20-27(25)33-31)37-18-14-23(15-19-37)36-16-5-2-6-17-36/h1,3-4,7-13,20,23H,2,5-6,14-19,21H2,(H,32,33)(H,34,35)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185185
PNG
(2-(1H-indazol-3-yl)-5-((4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(Cc2ccc3nc([nH]c3c2)-c2n[nH]c3ccccc23)CC1
Show InChI InChI=1S/C20H22N6/c1-25-8-10-26(11-9-25)13-14-6-7-17-18(12-14)22-20(21-17)19-15-4-2-3-5-16(15)23-24-19/h2-7,12H,8-11,13H2,1H3,(H,21,22)(H,23,24)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185179
PNG
(2-(7-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Show SMILES Fc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C24H27FN6/c25-19-6-4-5-18-22(19)28-29-23(18)24-26-20-8-7-17(15-21(20)27-24)31-13-9-16(10-14-31)30-11-2-1-3-12-30/h4-8,15-16H,1-3,9-14H2,(H,26,27)(H,28,29)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185167
PNG
(2-(1H-indazol-3-yl)-4-morpholino-1H-benzo[d]imidaz...)
Show SMILES C1CN(CCO1)c1cccc2[nH]c(nc12)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H17N5O/c1-2-5-13-12(4-1)16(22-21-13)18-19-14-6-3-7-15(17(14)20-18)23-8-10-24-11-9-23/h1-7H,8-11H2,(H,19,20)(H,21,22)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185168
PNG
(2-(7-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-8-22(9-4-1)21-38-28-11-7-10-25-29(28)34-35-30(25)31-32-26-13-12-24(20-27(26)33-31)37-18-14-23(15-19-37)36-16-5-2-6-17-36/h1,3-4,7-13,20,23H,2,5-6,14-19,21H2,(H,32,33)(H,34,35)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185187
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)32-23-9-7-8-21-25(23)34-35-26(21)27-30-22-11-10-20(18-24(22)31-27)37-16-12-19(13-17-37)36-14-5-4-6-15-36/h7-11,18-19H,4-6,12-17H2,1-3H3,(H,30,31)(H,34,35)(H2,32,33,38)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185187
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)32-23-9-7-8-21-25(23)34-35-26(21)27-30-22-11-10-20(18-24(22)31-27)37-16-12-19(13-17-37)36-14-5-4-6-15-36/h7-11,18-19H,4-6,12-17H2,1-3H3,(H,30,31)(H,34,35)(H2,32,33,38)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185167
PNG
(2-(1H-indazol-3-yl)-4-morpholino-1H-benzo[d]imidaz...)
Show SMILES C1CN(CCO1)c1cccc2[nH]c(nc12)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H17N5O/c1-2-5-13-12(4-1)16(22-21-13)18-19-14-6-3-7-15(17(14)20-18)23-8-10-24-11-9-23/h1-7H,8-11H2,(H,19,20)(H,21,22)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185187
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)32-23-9-7-8-21-25(23)34-35-26(21)27-30-22-11-10-20(18-24(22)31-27)37-16-12-19(13-17-37)36-14-5-4-6-15-36/h7-11,18-19H,4-6,12-17H2,1-3H3,(H,30,31)(H,34,35)(H2,32,33,38)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50185168
PNG
(2-(7-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-8-22(9-4-1)21-38-28-11-7-10-25-29(28)34-35-30(25)31-32-26-13-12-24(20-27(26)33-31)37-18-14-23(15-19-37)36-16-5-2-6-17-36/h1,3-4,7-13,20,23H,2,5-6,14-19,21H2,(H,32,33)(H,34,35)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185187
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)32-23-9-7-8-21-25(23)34-35-26(21)27-30-22-11-10-20(18-24(22)31-27)37-16-12-19(13-17-37)36-14-5-4-6-15-36/h7-11,18-19H,4-6,12-17H2,1-3H3,(H,30,31)(H,34,35)(H2,32,33,38)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50185167
PNG
(2-(1H-indazol-3-yl)-4-morpholino-1H-benzo[d]imidaz...)
Show SMILES C1CN(CCO1)c1cccc2[nH]c(nc12)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H17N5O/c1-2-5-13-12(4-1)16(22-21-13)18-19-14-6-3-7-15(17(14)20-18)23-8-10-24-11-9-23/h1-7H,8-11H2,(H,19,20)(H,21,22)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50185168
PNG
(2-(7-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-8-22(9-4-1)21-38-28-11-7-10-25-29(28)34-35-30(25)31-32-26-13-12-24(20-27(26)33-31)37-18-14-23(15-19-37)36-16-5-2-6-17-36/h1,3-4,7-13,20,23H,2,5-6,14-19,21H2,(H,32,33)(H,34,35)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50185168
PNG
(2-(7-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1cccc2c(n[nH]c12)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-8-22(9-4-1)21-38-28-11-7-10-25-29(28)34-35-30(25)31-32-26-13-12-24(20-27(26)33-31)37-18-14-23(15-19-37)36-16-5-2-6-17-36/h1,3-4,7-13,20,23H,2,5-6,14-19,21H2,(H,32,33)(H,34,35)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM16590
PNG
(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C14H10N4/c1-2-6-10-9(5-1)13(18-17-10)14-15-11-7-3-4-8-12(11)16-14/h1-8H,(H,15,16)(H,17,18)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM16590
PNG
(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C14H10N4/c1-2-6-10-9(5-1)13(18-17-10)14-15-11-7-3-4-8-12(11)16-14/h1-8H,(H,15,16)(H,17,18)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.069
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%