Affinity Data by PubMed id=16610795

PubMed code 16610795

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50185292 (6-Benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic A...) Show SMILES CCOC(=O)c1cnc2ccc(Cc3ccccc3)cc2c1O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha1 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50185296 (6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone \| C...) Show SMILES CCc1ccc2ncc(C(=O)OCCC(C)C)c(O)c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha1 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50185292 (6-Benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic A...) Show SMILES CCOC(=O)c1cnc2ccc(Cc3ccccc3)cc2c1O Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha3 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50000766 (CHEMBL12 \| DIAZEPAM \| US9271961, Diazepam) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha1 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50000766 (CHEMBL12 \| DIAZEPAM \| US9271961, Diazepam) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha3 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50185293 (6-bromo-3-ethoxycarbonyl-4-quinolone \| CHEMBL20525...) Show SMILES CCOC(=O)c1cnc2ccc(Br)cc2c1O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha1 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50185293 (6-bromo-3-ethoxycarbonyl-4-quinolone \| CHEMBL20525...) Show SMILES CCOC(=O)c1cnc2ccc(Br)cc2c1O Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha3 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM26266 (Ambien \| CHEMBL911 \| Dalparan \| N,N-dimethyl-2-[6-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha1 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50185296 (6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone \| C...) Show SMILES CCc1ccc2ncc(C(=O)OCCC(C)C)c(O)c2c1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha3 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2 (Homo sapiens (Human))	BDBM26266 (Ambien \| CHEMBL911 \| Dalparan \| N,N-dimethyl-2-[6-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.85E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]Flumazenil from human GABA-Aalpha3 receptor plus beta-2-gamma-2 expressed in HEK293 cells				J Med Chem 49: 2526-33 (2006) Article DOI: 10.1021/jm058057p BindingDB Entry DOI: 10.7270/Q2KH0MZ2
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%