BindingDB logo
myBDB logout

PubMed code 16697193

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187007
PNG
(5-chloro-3-(3,4-dioxo-2-(phenylamino)cyclobut-1-en...)
Show SMILES CN(C)C(=O)c1cc(Cl)cc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C19H16ClN3O4/c1-23(2)19(27)12-8-10(20)9-13(16(12)24)22-15-14(17(25)18(15)26)21-11-6-4-3-5-7-11/h3-9,21-22,24H,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187004
PNG
(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C19H17N3O4/c1-22(2)19(26)12-9-6-10-13(16(12)23)21-15-14(17(24)18(15)25)20-11-7-4-3-5-8-11/h3-10,20-21,23H,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187002
PNG
(4-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Show SMILES Oc1cc(ccc1Nc1c(Nc2ccccc2)c(=O)c1=O)C#N
Show InChI InChI=1S/C17H11N3O3/c18-9-10-6-7-12(13(21)8-10)20-15-14(16(22)17(15)23)19-11-4-2-1-3-5-11/h1-8,19-21H
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187003
PNG
(3-(3,4-dioxo-2-(pentan-3-ylamino)cyclobut-1-enylam...)
Show SMILES CCC(CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C18H23N3O4/c1-5-10(6-2)19-13-14(17(24)16(13)23)20-12-9-7-8-11(15(12)22)18(25)21(3)4/h7-10,19-20,22H,5-6H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50186997
PNG
(3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylam...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC3CCCC3)c(=O)c2=O)c1O
Show InChI InChI=1S/C18H21N3O4/c1-21(2)18(25)11-8-5-9-12(15(11)22)20-14-13(16(23)17(14)24)19-10-6-3-4-7-10/h5,8-10,19-20,22H,3-4,6-7H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187016
PNG
(2-hydroxy-3-(2-(isopropylamino)-3,4-dioxocyclobut-...)
Show SMILES CC(C)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C16H19N3O4/c1-8(2)17-11-12(15(22)14(11)21)18-10-7-5-6-9(13(10)20)16(23)19(3)4/h5-8,17-18,20H,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187015
PNG
(3-(2-(cyclohexylamino)-3,4-dioxocyclobut-1-enylami...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC3CCCCC3)c(=O)c2=O)c1O
Show InChI InChI=1S/C19H23N3O4/c1-22(2)19(26)12-9-6-10-13(16(12)23)21-15-14(17(24)18(15)25)20-11-7-4-3-5-8-11/h6,9-11,20-21,23H,3-5,7-8H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187014
PNG
(3-(2-(tert-butylamino)-3,4-dioxocyclobut-1-enylami...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C)(C)C)c(=O)c2=O)c1O
Show InChI InChI=1S/C17H21N3O4/c1-17(2,3)19-12-11(14(22)15(12)23)18-10-8-6-7-9(13(10)21)16(24)20(4)5/h6-8,18-19,21H,1-5H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187010
PNG
(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Show SMILES CNC(=O)c1cccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C18H15N3O4/c1-19-18(25)11-8-5-9-12(15(11)22)21-14-13(16(23)17(14)24)20-10-6-3-2-4-7-10/h2-9,20-22H,1H3,(H,19,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187011
PNG
(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Show SMILES NC(=O)c1cccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C17H13N3O4/c18-17(24)10-7-4-8-11(14(10)21)20-13-12(15(22)16(13)23)19-9-5-2-1-3-6-9/h1-8,19-21H,(H2,18,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187001
PNG
(3-(2-hydroxy-4-nitrophenylamino)-4-(phenylamino)cy...)
Show SMILES Oc1cc(ccc1Nc1c(Nc2ccccc2)c(=O)c1=O)[N+]([O-])=O
Show InChI InChI=1S/C16H11N3O5/c20-12-8-10(19(23)24)6-7-11(12)18-14-13(15(21)16(14)22)17-9-4-2-1-3-5-9/h1-8,17-18,20H
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50186999
PNG
(3-(2-(furan-2-ylmethylamino)-3,4-dioxocyclobut-1-e...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NCc3ccco3)c(=O)c2=O)c1O
Show InChI InChI=1S/C18H17N3O5/c1-21(2)18(25)11-6-3-7-12(15(11)22)20-14-13(16(23)17(14)24)19-9-10-5-4-8-26-10/h3-8,19-20,22H,9H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187017
PNG
(CHEMBL380052 | methyl 3-(3,4-dioxo-2-(phenylamino)...)
Show SMILES COC(=O)c1cccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C18H14N2O5/c1-25-18(24)11-8-5-9-12(15(11)21)20-14-13(16(22)17(14)23)19-10-6-3-2-4-7-10/h2-9,19-21H,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 53n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50186998
PNG
(3-(2-hydroxy-5-nitrophenylamino)-4-(phenylamino)cy...)
Show SMILES Oc1ccc(cc1Nc1c(Nc2ccccc2)c(=O)c1=O)[N+]([O-])=O
Show InChI InChI=1S/C16H11N3O5/c20-12-7-6-10(19(23)24)8-11(12)18-14-13(15(21)16(14)22)17-9-4-2-1-3-5-9/h1-8,17-18,20H
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187019
PNG
(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Show SMILES CCNC(=O)c1cccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C19H17N3O4/c1-2-20-19(26)12-9-6-10-13(16(12)23)22-15-14(17(24)18(15)25)21-11-7-4-3-5-8-11/h3-10,21-23H,2H2,1H3,(H,20,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 65n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187009
PNG
(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Show SMILES Oc1ccc(cc1Nc1c(Nc2ccccc2)c(=O)c1=O)C#N
Show InChI InChI=1S/C17H11N3O3/c18-9-10-6-7-13(21)12(8-10)20-15-14(16(22)17(15)23)19-11-4-2-1-3-5-11/h1-8,19-21H
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 74n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187012
PNG
(CHEMBL436940 | N-benzyl-3-(3,4-dioxo-2-(phenylamin...)
Show SMILES Oc1c(Nc2c(Nc3ccccc3)c(=O)c2=O)cccc1C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H19N3O4/c28-21-17(24(31)25-14-15-8-3-1-4-9-15)12-7-13-18(21)27-20-19(22(29)23(20)30)26-16-10-5-2-6-11-16/h1-13,26-28H,14H2,(H,25,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 139n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187020
PNG
(3-(3,4-dioxo-2-(tetrahydro-2H-pyran-4-ylamino)cycl...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC3CCOCC3)c(=O)c2=O)c1O
Show InChI InChI=1S/C18H21N3O5/c1-21(2)18(25)11-4-3-5-12(15(11)22)20-14-13(16(23)17(14)24)19-10-6-8-26-9-7-10/h3-5,10,19-20,22H,6-9H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 171n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187006
PNG
(3-(2-hydroxyphenylamino)-4-(phenylamino)cyclobut-3...)
Show SMILES Oc1ccccc1Nc1c(Nc2ccccc2)c(=O)c1=O
Show InChI InChI=1S/C16H12N2O3/c19-12-9-5-4-8-11(12)18-14-13(15(20)16(14)21)17-10-6-2-1-3-7-10/h1-9,17-19H
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 476n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187008
PNG
((R)-3-(2-(2,3-dihydro-1H-inden-1-ylamino)-3,4-diox...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@@H]3CCc4ccccc34)c(=O)c2=O)c1O
Show InChI InChI=1S/C22H21N3O4/c1-25(2)22(29)14-8-5-9-16(19(14)26)24-18-17(20(27)21(18)28)23-15-11-10-12-6-3-4-7-13(12)15/h3-9,15,23-24,26H,10-11H2,1-2H3/t15-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 548n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187021
PNG
(3-(3,4-dioxo-2-(phenethylamino)cyclobut-1-enylamin...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NCCc3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C21H21N3O4/c1-24(2)21(28)14-9-6-10-15(18(14)25)23-17-16(19(26)20(17)27)22-12-11-13-7-4-3-5-8-13/h3-10,22-23,25H,11-12H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 926n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187000
PNG
(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Show SMILES OC(=O)c1cccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C17H12N2O5/c20-14-10(17(23)24)7-4-8-11(14)19-13-12(15(21)16(13)22)18-9-5-2-1-3-6-9/h1-8,18-20H,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187013
PNG
(4-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Show SMILES OC(=O)c1ccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c(O)c1
Show InChI InChI=1S/C17H12N2O5/c20-12-8-9(17(23)24)6-7-11(12)19-14-13(15(21)16(14)22)18-10-4-2-1-3-5-10/h1-8,18-20H,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187018
PNG
(2-hydroxy-N,N-dimethyl-3-(2-(methyl(phenyl)amino)-...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(N(C)c3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C20H19N3O4/c1-22(2)20(27)13-10-7-11-14(17(13)24)21-15-16(19(26)18(15)25)23(3)12-8-5-4-6-9-12/h4-11,21,24H,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.20E+3n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187005
PNG
(3-(4-nitrophenylamino)-4-(phenylamino)cyclobut-3-e...)
Show SMILES [O-][N+](=O)c1ccc(Nc2c(Nc3ccccc3)c(=O)c2=O)cc1
Show InChI InChI=1S/C16H11N3O4/c20-15-13(17-10-4-2-1-3-5-10)14(16(15)21)18-11-6-8-12(9-7-11)19(22)23/h1-9,17-18H
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 8.60E+3n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50187022
PNG
(3-((2-hydroxyphenyl)(methyl)amino)-4-(phenylamino)...)
Show SMILES CN(c1c(Nc2ccccc2)c(=O)c1=O)c1ccccc1O
Show InChI InChI=1S/C17H14N2O3/c1-19(12-9-5-6-10-13(12)20)15-14(16(21)17(15)22)18-11-7-3-2-4-8-11/h2-10,18,20H,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.86E+4n/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells


Bioorg Med Chem Lett 16: 4107-10 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.082
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%