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PubMed code 16722630

Compile data set for download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
PDB
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n/an/a 33n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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n/an/a 40n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50187340
PNG
((6-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-13-4-5-14-11(6-13)8-17(20-14)18(22)16-7-10-2-3-12(19)9-15(10)21-16/h2-9,20-21H,1H3
PDB
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n/an/a 55n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of human PDGFR beta


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187345
PNG
((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-3-2-4-15-13(10)9-17(20-15)18(22)16-8-11-7-12(21)5-6-14(11)19-16/h2-9,19-21H,1H3
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n/an/a 60n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187345
PNG
((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-3-2-4-15-13(10)9-17(20-15)18(22)16-8-11-7-12(21)5-6-14(11)19-16/h2-9,19-21H,1H3
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n/an/a 70n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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n/an/a 100n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antiproliferative activity against mouse 32Dcl3 cell line expressing FLT3-ITD


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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n/an/a 100n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antiproliferative activity against mouse 32Dcl3 cell line expressing wildtype FLT3


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187369
PNG
((5-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C17H11FN2O2/c18-11-1-3-13-9(5-11)7-15(19-13)17(22)16-8-10-6-12(21)2-4-14(10)20-16/h1-8,19-21H
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n/an/a 170n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
PDB
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n/an/a 171n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of human PDGFR beta


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM6581
PNG
((5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone |...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H12N2O2/c20-12-5-6-14-11(7-12)9-16(19-14)17(21)15-8-10-3-1-2-4-13(10)18-15/h1-9,18-20H
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n/an/a 200n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187340
PNG
((6-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-13-4-5-14-11(6-13)8-17(20-14)18(22)16-7-10-2-3-12(19)9-15(10)21-16/h2-9,20-21H,1H3
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n/an/a 200n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187357
PNG
((4-Methyl-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C25H27N3O2/c1-17-6-5-7-22-20(17)16-24(27-22)25(29)23-15-18-14-19(8-9-21(18)26-23)30-13-12-28-10-3-2-4-11-28/h5-9,14-16,26-27H,2-4,10-13H2,1H3
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n/an/a 220n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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n/an/a 300n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM6573
PNG
((5-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-13-6-7-15-12(8-13)10-17(20-15)18(21)16-9-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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n/an/a 300n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM6574
PNG
((6-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-13-7-6-12-9-17(20-15(12)10-13)18(21)16-8-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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n/an/a 300n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187365
PNG
((4-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(F)cccc2[nH]1
Show InChI InChI=1S/C17H11FN2O2/c18-12-2-1-3-14-11(12)8-16(20-14)17(22)15-7-9-6-10(21)4-5-13(9)19-15/h1-8,19-21H
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n/an/a 340n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187348
PNG
((5-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C18H13FN2O2/c1-23-13-3-5-15-11(7-13)9-17(21-15)18(22)16-8-10-6-12(19)2-4-14(10)20-16/h2-9,20-21H,1H3
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n/an/a 400n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50187345
PNG
((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-3-2-4-15-13(10)9-17(20-15)18(22)16-8-11-7-12(21)5-6-14(11)19-16/h2-9,19-21H,1H3
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n/an/a 458n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of human PDGFR beta


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187356
PNG
((5-Fluoro-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C24H24FN3O2/c25-18-4-6-20-16(12-18)14-22(26-20)24(29)23-15-17-13-19(5-7-21(17)27-23)30-11-10-28-8-2-1-3-9-28/h4-7,12-15,26-27H,1-3,8-11H2
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n/an/a 500n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50187345
PNG
((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-3-2-4-15-13(10)9-17(20-15)18(22)16-8-11-7-12(21)5-6-14(11)19-16/h2-9,19-21H,1H3
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n/an/a 500n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutant


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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n/an/a 500n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutant


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187361
PNG
((4-Chloro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(Cl)cccc2[nH]1
Show InChI InChI=1S/C17H11ClN2O2/c18-12-2-1-3-14-11(12)8-16(20-14)17(22)15-7-9-6-10(21)4-5-13(9)19-15/h1-8,19-21H
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n/an/a 500n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50187345
PNG
((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-3-2-4-15-13(10)9-17(20-15)18(22)16-8-11-7-12(21)5-6-14(11)19-16/h2-9,19-21H,1H3
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n/an/a 500n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wildtype KIT


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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n/an/a 500n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wildtype KIT


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187366
PNG
((5-Methoxy-1H-indol-2-yl)-(6-methyl-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(C)cc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-11-3-4-12-9-17(21-16(12)7-11)19(22)18-10-13-8-14(23-2)5-6-15(13)20-18/h3-10,20-21H,1-2H3
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n/an/a 510n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187344
PNG
((5-Hydroxy-1H-indol-2-yl)-(6-methoxy-1H-indol-2-yl...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O3/c1-23-13-4-2-10-7-16(20-15(10)9-13)18(22)17-8-11-6-12(21)3-5-14(11)19-17/h2-9,19-21H,1H3
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n/an/a 530n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM6581
PNG
((5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone |...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H12N2O2/c20-12-5-6-14-11(7-12)9-16(19-14)17(21)15-8-10-3-1-2-4-13(10)18-15/h1-9,18-20H
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n/an/a 570n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187367
PNG
((5-Hydroxy-1H-indol-2-yl)-(6-methyl-1H-indol-2-yl)...)
Show SMILES Cc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-2-3-11-8-16(20-15(11)6-10)18(22)17-9-12-7-13(21)4-5-14(12)19-17/h2-9,19-21H,1H3
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n/an/a 580n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187364
PNG
((6-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C17H11FN2O2/c18-11-2-1-9-6-15(20-14(9)8-11)17(22)16-7-10-5-12(21)3-4-13(10)19-16/h1-8,19-21H
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n/an/a 590n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187365
PNG
((4-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(F)cccc2[nH]1
Show InChI InChI=1S/C17H11FN2O2/c18-12-2-1-3-14-11(12)8-16(20-14)17(22)15-7-9-6-10(21)4-5-13(9)19-15/h1-8,19-21H
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n/an/a 620n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187344
PNG
((5-Hydroxy-1H-indol-2-yl)-(6-methoxy-1H-indol-2-yl...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O3/c1-23-13-4-2-10-7-16(20-15(10)9-13)18(22)17-8-11-6-12(21)3-5-14(11)19-17/h2-9,19-21H,1H3
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n/an/a 650n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187373
PNG
((5-Hydroxy-1H-indol-2-yl)-(4-methoxy-1H-indol-2-yl...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O3/c1-23-17-4-2-3-14-12(17)9-16(20-14)18(22)15-8-10-7-11(21)5-6-13(10)19-15/h2-9,19-21H,1H3
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n/an/a 670n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187357
PNG
((4-Methyl-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C25H27N3O2/c1-17-6-5-7-22-20(17)16-24(27-22)25(29)23-15-18-14-19(8-9-21(18)26-23)30-13-12-28-10-3-2-4-11-28/h5-9,14-16,26-27H,2-4,10-13H2,1H3
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n/an/a 700n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187369
PNG
((5-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C17H11FN2O2/c18-11-1-3-13-9(5-11)7-15(19-13)17(22)16-8-10-6-12(21)2-4-14(10)20-16/h1-8,19-21H
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n/an/a 730n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187362
PNG
((5-Hydroxy-1H-indol-2-yl)-(5-methyl-1H-indol-2-yl)...)
Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-2-4-14-11(6-10)8-16(19-14)18(22)17-9-12-7-13(21)3-5-15(12)20-17/h2-9,19-21H,1H3
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n/an/a 740n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187349
PNG
((5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone ...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H11FN2O/c18-12-5-6-14-11(7-12)9-16(20-14)17(21)15-8-10-3-1-2-4-13(10)19-15/h1-9,19-20H
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n/an/a 760n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187353
PNG
((6-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C18H13FN2O2/c1-23-13-4-5-14-11(6-13)8-17(20-14)18(22)16-7-10-2-3-12(19)9-15(10)21-16/h2-9,20-21H,1H3
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n/an/a 840n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187348
PNG
((5-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C18H13FN2O2/c1-23-13-3-5-15-11(7-13)9-17(21-15)18(22)16-8-10-6-12(19)2-4-14(10)20-16/h2-9,20-21H,1H3
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n/an/a 880n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM6574
PNG
((6-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-13-7-6-12-9-17(20-15(12)10-13)18(21)16-8-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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n/an/a 890n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187361
PNG
((4-Chloro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(Cl)cccc2[nH]1
Show InChI InChI=1S/C17H11ClN2O2/c18-12-2-1-3-14-11(12)8-16(20-14)17(22)15-7-9-6-10(21)4-5-13(9)19-15/h1-8,19-21H
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n/an/a 920n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187373
PNG
((5-Hydroxy-1H-indol-2-yl)-(4-methoxy-1H-indol-2-yl...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O3/c1-23-17-4-2-3-14-12(17)9-16(20-14)18(22)15-8-10-7-11(21)5-6-13(10)19-15/h2-9,19-21H,1H3
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n/an/a 960n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187345
PNG
((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-3-2-4-15-13(10)9-17(20-15)18(22)16-8-11-7-12(21)5-6-14(11)19-16/h2-9,19-21H,1H3
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n/an/a 960n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187364
PNG
((6-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C17H11FN2O2/c18-11-2-1-9-6-15(20-14(9)8-11)17(22)16-7-10-5-12(21)3-4-13(10)19-16/h1-8,19-21H
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187371
PNG
((6-Methoxy-1H-indol-2-yl)-[5-(2-piperidin-1-yl-eth...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C25H27N3O3/c1-30-19-6-5-17-14-23(27-22(17)16-19)25(29)24-15-18-13-20(7-8-21(18)26-24)31-12-11-28-9-3-2-4-10-28/h5-8,13-16,26-27H,2-4,9-12H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187355
PNG
(CHEMBL207483 | di(1H-indol-2-yl)methanone)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H12N2O/c20-17(15-9-11-5-1-3-7-13(11)18-15)16-10-12-6-2-4-8-14(12)19-16/h1-10,18-19H
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM33408
PNG
(AG1295 | CHEMBL7724 | cid_2048)
Show SMILES Cc1cc2ncc(nc2cc1C)-c1ccccc1
Show InChI InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187359
PNG
((5-Fluoro-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)-...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C18H13FN2O/c1-10-3-2-4-15-13(10)9-17(21-15)18(22)16-8-11-7-12(19)5-6-14(11)20-16/h2-9,20-21H,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50187357
PNG
((4-Methyl-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C25H27N3O2/c1-17-6-5-7-22-20(17)16-24(27-22)25(29)23-15-18-14-19(8-9-21(18)26-23)30-13-12-28-10-3-2-4-11-28/h5-9,14-16,26-27H,2-4,10-13H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of human PDGFR beta


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187367
PNG
((5-Hydroxy-1H-indol-2-yl)-(6-methyl-1H-indol-2-yl)...)
Show SMILES Cc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-2-3-11-8-16(20-15(11)6-10)18(22)17-9-12-7-13(21)4-5-14(12)19-17/h2-9,19-21H,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant Abl


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187371
PNG
((6-Methoxy-1H-indol-2-yl)-[5-(2-piperidin-1-yl-eth...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C25H27N3O3/c1-30-19-6-5-17-14-23(27-22(17)16-19)25(29)24-15-18-13-20(7-8-21(18)26-24)31-12-11-28-9-3-2-4-10-28/h5-8,13-16,26-27H,2-4,9-12H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187339
PNG
((1H-indol-2-yl)-(4-methoxy-1H-indol-2-yl)methanone...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-17-8-4-7-14-12(17)10-16(20-14)18(21)15-9-11-5-2-3-6-13(11)19-15/h2-10,19-20H,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187356
PNG
((5-Fluoro-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C24H24FN3O2/c25-18-4-6-20-16(12-18)14-22(26-20)24(29)23-15-17-13-19(5-7-21(17)27-23)30-11-10-28-8-2-1-3-9-28/h4-7,12-15,26-27H,1-3,8-11H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187349
PNG
((5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone ...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H11FN2O/c18-12-5-6-14-11(7-12)9-16(20-14)17(21)15-8-10-3-1-2-4-13(10)19-15/h1-9,19-20H
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187347
PNG
((5-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-13-3-5-15-11(7-13)9-17(21-15)18(22)16-8-10-6-12(19)2-4-14(10)20-16/h2-9,20-21H,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187359
PNG
((5-Fluoro-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)-...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C18H13FN2O/c1-10-3-2-4-15-13(10)9-17(21-15)18(22)16-8-11-7-12(19)5-6-14(11)20-16/h2-9,20-21H,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187368
PNG
((5-methoxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(C)cccc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-11-4-3-5-16-14(11)10-18(21-16)19(22)17-9-12-8-13(23-2)6-7-15(12)20-17/h3-10,20-21H,1-2H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187354
PNG
(CHEMBL377873 | [5-(2-Dimethylaminoethoxy)-1H-indol...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(OCCN(C)C)ccc2[nH]1
Show InChI InChI=1S/C22H23N3O3/c1-25(2)8-9-28-17-6-7-18-15(10-17)12-21(23-18)22(26)20-11-14-4-5-16(27-3)13-19(14)24-20/h4-7,10-13,23-24H,8-9H2,1-3H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187341
PNG
((5-Hydroxy-1H-indol-2-yl)-(7-methoxy-1H-indol-2-yl...)
Show SMILES COc1cccc2cc([nH]c12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O3/c1-23-16-4-2-3-10-8-15(20-17(10)16)18(22)14-9-11-7-12(21)5-6-13(11)19-14/h2-9,19-21H,1H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM6573
PNG
((5-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-13-6-7-15-12(8-13)10-17(20-15)18(21)16-9-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187343
PNG
((4-Bromo-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)-...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(Br)cccc2[nH]1
Show InChI InChI=1S/C17H11BrN2O2/c18-12-2-1-3-14-11(12)8-16(20-14)17(22)15-7-9-6-10(21)4-5-13(9)19-15/h1-8,19-21H
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n/an/a 3.40E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187362
PNG
((5-Hydroxy-1H-indol-2-yl)-(5-methyl-1H-indol-2-yl)...)
Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-10-2-4-14-11(6-10)8-16(19-14)18(22)17-9-12-7-13(21)3-5-15(12)20-17/h2-9,19-21H,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187368
PNG
((5-methoxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(C)cccc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-11-4-3-5-16-14(11)10-18(21-16)19(22)17-9-12-8-13(23-2)6-7-15(12)20-17/h3-10,20-21H,1-2H3
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n/an/a 4.03E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Breakpoint cluster region protein /Tyrosine-protein kinase ABL


(Homo sapiens (Human))
BDBM50187351
PNG
(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of oncogenic Bcr-Abl kinase in K562 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187339
PNG
((1H-indol-2-yl)-(4-methoxy-1H-indol-2-yl)methanone...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-17-8-4-7-14-12(17)10-16(20-14)18(21)15-9-11-5-2-3-6-13(11)19-15/h2-10,19-20H,1H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187370
PNG
((7-Ethyl-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)-...)
Show SMILES CCc1cccc2cc([nH]c12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-2-11-4-3-5-12-9-17(21-18(11)12)19(23)16-10-13-8-14(22)6-7-15(13)20-16/h3-10,20-22H,2H2,1H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187355
PNG
(CHEMBL207483 | di(1H-indol-2-yl)methanone)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H12N2O/c20-17(15-9-11-5-1-3-7-13(11)18-15)16-10-12-6-2-4-8-14(12)19-16/h1-10,18-19H
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n/an/a 4.60E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187338
PNG
((7-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cccc(F)c2[nH]1
Show InChI InChI=1S/C17H11FN2O2/c18-12-3-1-2-9-7-15(20-16(9)12)17(22)14-8-10-6-11(21)4-5-13(10)19-14/h1-8,19-21H
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n/an/a 4.80E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM33408
PNG
(AG1295 | CHEMBL7724 | cid_2048)
Show SMILES Cc1cc2ncc(nc2cc1C)-c1ccccc1
Show InChI InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187358
PNG
((5-Benzyloxy-1H-indol-2-yl)-(5-fluoro-1H-indol-2-y...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C24H17FN2O2/c25-18-6-8-20-16(10-18)12-22(26-20)24(28)23-13-17-11-19(7-9-21(17)27-23)29-14-15-4-2-1-3-5-15/h1-13,26-27H,14H2
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n/an/a 5.80E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187343
PNG
((4-Bromo-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)-...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(Br)cccc2[nH]1
Show InChI InChI=1S/C17H11BrN2O2/c18-12-2-1-3-14-11(12)8-16(20-14)17(22)15-7-9-6-10(21)4-5-13(9)19-15/h1-8,19-21H
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n/an/a 6.10E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187341
PNG
((5-Hydroxy-1H-indol-2-yl)-(7-methoxy-1H-indol-2-yl...)
Show SMILES COc1cccc2cc([nH]c12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C18H14N2O3/c1-23-16-4-2-3-10-8-15(20-17(10)16)18(22)14-9-11-7-12(21)5-6-13(11)19-14/h2-9,19-21H,1H3
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n/an/a 6.60E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187354
PNG
(CHEMBL377873 | [5-(2-Dimethylaminoethoxy)-1H-indol...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(OCCN(C)C)ccc2[nH]1
Show InChI InChI=1S/C22H23N3O3/c1-25(2)8-9-28-17-6-7-18-15(10-17)12-21(23-18)22(26)20-11-14-4-5-16(27-3)13-19(14)24-20/h4-7,10-13,23-24H,8-9H2,1-3H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187353
PNG
((6-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C18H13FN2O2/c1-23-13-4-5-14-11(6-13)8-17(20-14)18(22)16-7-10-2-3-12(19)9-15(10)21-16/h2-9,20-21H,1H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187352
PNG
((4-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(F)cccc2[nH]1
Show InChI InChI=1S/C18H13FN2O2/c1-23-11-5-6-14-10(7-11)8-16(20-14)18(22)17-9-12-13(19)3-2-4-15(12)21-17/h2-9,20-21H,1H3
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n/an/a 8.10E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187363
PNG
((5-Bromo-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)-...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C18H13BrN2O2/c1-23-13-3-5-15-11(7-13)9-17(21-15)18(22)16-8-10-6-12(19)2-4-14(10)20-16/h2-9,20-21H,1H3
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n/an/a 8.50E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187340
PNG
((6-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-13-4-5-14-11(6-13)8-17(20-14)18(22)16-7-10-2-3-12(19)9-15(10)21-16/h2-9,20-21H,1H3
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n/an/a 9.40E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187363
PNG
((5-Bromo-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)-...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C18H13BrN2O2/c1-23-13-3-5-15-11(7-13)9-17(21-15)18(22)16-8-10-6-12(19)2-4-14(10)20-16/h2-9,20-21H,1H3
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n/an/a 9.90E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187350
PNG
((1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone ...)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2cc(Oc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C23H16N2O2/c26-23(21-13-15-6-4-5-9-19(15)24-21)22-14-16-12-18(10-11-20(16)25-22)27-17-7-2-1-3-8-17/h1-14,24-25H
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187370
PNG
((7-Ethyl-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)-...)
Show SMILES CCc1cccc2cc([nH]c12)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-2-11-4-3-5-12-9-17(21-18(11)12)19(23)16-10-13-8-14(22)6-7-15(13)20-16/h3-10,20-22H,2H2,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187366
PNG
((5-Methoxy-1H-indol-2-yl)-(6-methyl-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(C)cc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-11-3-4-12-9-17(21-16(12)7-11)19(22)18-10-13-8-14(23-2)5-6-15(13)20-18/h3-10,20-21H,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187352
PNG
((4-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(F)cccc2[nH]1
Show InChI InChI=1S/C18H13FN2O2/c1-23-11-5-6-14-10(7-11)8-16(20-14)18(22)17-9-12-13(19)3-2-4-15(12)21-17/h2-9,20-21H,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187350
PNG
((1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone ...)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2cc(Oc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C23H16N2O2/c26-23(21-13-15-6-4-5-9-19(15)24-21)22-14-16-12-18(10-11-20(16)25-22)27-17-7-2-1-3-8-17/h1-14,24-25H
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187357
PNG
((4-Methyl-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Show SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C25H27N3O2/c1-17-6-5-7-22-20(17)16-24(27-22)25(29)23-15-18-14-19(8-9-21(18)26-23)30-13-12-28-10-3-2-4-11-28/h5-9,14-16,26-27H,2-4,10-13H2,1H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187374
PNG
((5-Benzyloxy-1H-indol-2-yl)-(6-methoxy-1H-indol-2-...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C25H20N2O3/c1-29-19-8-7-17-12-23(27-22(17)14-19)25(28)24-13-18-11-20(9-10-21(18)26-24)30-15-16-5-3-2-4-6-16/h2-14,26-27H,15H2,1H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187372
PNG
((4-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(Cl)cccc2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-11-5-6-14-10(7-11)8-16(20-14)18(22)17-9-12-13(19)3-2-4-15(12)21-17/h2-9,20-21H,1H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187375
PNG
((5-Methoxy-1H-indol-2-yl)-(5-methyl-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(C)ccc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-11-3-5-15-12(7-11)9-17(20-15)19(22)18-10-13-8-14(23-2)4-6-16(13)21-18/h3-10,20-21H,1-2H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187347
PNG
((5-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-13-3-5-15-11(7-13)9-17(21-15)18(22)16-8-10-6-12(19)2-4-14(10)20-16/h2-9,20-21H,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187340
PNG
((6-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-13-4-5-14-11(6-13)8-17(20-14)18(22)16-7-10-2-3-12(19)9-15(10)21-16/h2-9,20-21H,1H3
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n/an/a 2.39E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187374
PNG
((5-Benzyloxy-1H-indol-2-yl)-(6-methoxy-1H-indol-2-...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C25H20N2O3/c1-29-19-8-7-17-12-23(27-22(17)14-19)25(28)24-13-18-11-20(9-10-21(18)26-24)30-15-16-5-3-2-4-6-16/h2-14,26-27H,15H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187372
PNG
((4-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2c(Cl)cccc2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-11-5-6-14-10(7-11)8-16(20-14)18(22)17-9-12-13(19)3-2-4-15(12)21-17/h2-9,20-21H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187360
PNG
((7-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cccc(Cl)c2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-12-5-6-14-11(7-12)9-15(20-14)18(22)16-8-10-3-2-4-13(19)17(10)21-16/h2-9,20-21H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187346
PNG
((5-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(Cc3cc4cc(F)ccc4[nH]3)cc2c1
Show InChI InChI=1S/C18H15FN2O/c1-22-16-3-5-18-12(9-16)8-15(21-18)10-14-7-11-6-13(19)2-4-17(11)20-14/h2-9,20-21H,10H2,1H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187338
PNG
((7-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cccc(F)c2[nH]1
Show InChI InChI=1S/C17H11FN2O2/c18-12-3-1-2-9-7-15(20-16(9)12)17(22)14-8-10-6-11(21)4-5-13(10)19-14/h1-8,19-21H
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187360
PNG
((7-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cccc(Cl)c2[nH]1
Show InChI InChI=1S/C18H13ClN2O2/c1-23-12-5-6-14-11(7-12)9-15(20-14)18(22)16-8-10-3-2-4-13(19)17(10)21-16/h2-9,20-21H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187342
PNG
((1H-Indol-2-yl)-(5-methoxy-1H-indol-2-yl)-methane ...)
Show SMILES COc1ccc2[nH]c(Cc3cc4ccccc4[nH]3)cc2c1
Show InChI InChI=1S/C18H16N2O/c1-21-16-6-7-18-13(10-16)9-15(20-18)11-14-8-12-4-2-3-5-17(12)19-14/h2-10,19-20H,11H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187358
PNG
((5-Benzyloxy-1H-indol-2-yl)-(5-fluoro-1H-indol-2-y...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C24H17FN2O2/c25-18-6-8-20-16(10-18)12-22(26-20)24(28)23-13-17-11-19(7-9-21(17)27-23)29-14-15-4-2-1-3-5-15/h1-13,26-27H,14H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187342
PNG
((1H-Indol-2-yl)-(5-methoxy-1H-indol-2-yl)-methane ...)
Show SMILES COc1ccc2[nH]c(Cc3cc4ccccc4[nH]3)cc2c1
Show InChI InChI=1S/C18H16N2O/c1-21-16-6-7-18-13(10-16)9-15(20-18)11-14-8-12-4-2-3-5-17(12)19-14/h2-10,19-20H,11H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50187346
PNG
((5-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(Cc3cc4cc(F)ccc4[nH]3)cc2c1
Show InChI InChI=1S/C18H15FN2O/c1-22-16-3-5-18-12(9-16)8-15(21-18)10-14-7-11-6-13(19)2-4-17(11)20-14/h2-9,20-21H,10H2,1H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 in EOL1 cells


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50187375
PNG
((5-Methoxy-1H-indol-2-yl)-(5-methyl-1H-indol-2-yl)...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(C)ccc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-11-3-5-15-12(7-11)9-17(20-15)19(22)18-10-13-8-14(23-2)4-6-16(13)21-18/h3-10,20-21H,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts


J Med Chem 49: 3101-15 (2006)


Article DOI: 10.1021/jm058033i
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%