Affinity Data by PubMed id=1673158

PubMed code 1673158

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50007538 (8-(2-Azetidin-1-yl-ethyl)-3-chloro-6-methyl-7,8-di...) Show SMILES CN1C[C@@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50007542 (3-Chloro-8-(2-dimethylamino-ethyl)-6-methyl-7,8-di...) Show SMILES CN(C)CC[C@@H]1CN(C)C(=S)c2cc(Cl)cnc2O1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM35938 (1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...) Show SMILES CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50007536 (CHEMBL24517 \| [3-(5-Chloro-pyridin-2-yl)-3-pyridin...) Show SMILES CN(C)CCC(c1ccccn1)c1ccc(Cl)cn1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50007539 (8-(2-Dimethylamino-ethyl)-6-methyl-7,8-dihydro-6H-...) Show SMILES CN(C)CC[C@@H]1CN(C)C(=S)c2cccnc2O1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50007540 (CHEMBL279907 \| [3-(4-Chloro-phenyl)-3-(5-chloro-py...) Show SMILES CN(C)CCC(c1ccc(Cl)cc1)c1ccc(Cl)cn1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50007535 (8-(2-Azetidin-1-yl-ethyl)-3-chloro-6-methyl-7,8-di...) Show SMILES CN1C[C@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50007541 (3-Chloro-8-(2-dimethylamino-ethyl)-6-methyl-7,8-di...) Show SMILES CN(C)CC[C@H]1CN(C)C(=S)c2cc(Cl)cnc2O1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50007537 (8-(2-Dimethylamino-ethyl)-6-methyl-7,8-dihydro-6H-...) Show SMILES CN(C)CC[C@H]1CN(C)C(=S)c2cccnc2O1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
A. H. Robins Company, Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortex				J Med Chem 34: 1314-28 (1991) BindingDB Entry DOI: 10.7270/Q23F4NMG
A. H. Robins Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%